Clinical trials: Acute Coronary Disease
Chronic Coronary Syndrome, Coronary Artery Disease
Feasibility of a Deep Learning-based Algorithm for Non-invasive Assessment of Vulnerable Coronary Plaque
The primary objective of this study is to assess the accuracy in terms of sensitivity, specificity, negative and positive predicted values of the DL-based algorithm with respect to correct identification of the plaque and…
- Conditions
- Chronic Coronary Syndrome, Coronary Artery Disease, Stable Angina, Acute Coronary Syndrome
- Trial name
- FOCUS DL (NCT06186336)
- Testing
- Deep Learning-based Vulnerable Plaque Detection and Assessment Tool
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- GE Healthcare
Diabetes Mellitus, Type 2, Myocardial Infarction
GLP-1RAs) and SGLT2is Combination Therapy and MACEs in Patients with Type 2 Diabetes.
Management of type 2 diabetes mellitus (T2DM) has evolved from a glucocentric to a cardiometabolic approach. Both glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose cotransporter-2 inhibitors (SGLT2is) reduce…
- Trial name
- NCT06017544
- Testing
- PCI
- Where
- Italy
- Volunteers
- 257 people
- Sponsor
- University of Campania Luigi Vanvitelli
Acute Kidney Injury
Neutrophil Gelatinase Associated Liocalin in Predicting AKI in Coronary Artery Disease
The aim of this work is to assess the clinical significance of serum levels of neutrophil gelatinase-associated lipocalin (NGAL) to predict AKI in patients exposed to PCI.
- Trial name
- NCT03266367
- Testing
- Neutrophil gelatinase-associated lipocalin (NAGL)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Assiut University
Rheumatic Heart Disease, Rheumatic Heart Disease in Children
Clinical Trial Phase I/IIa to Evaluate the Safety and Immunogenicity of StreptInCor
This is a Phase I/IIa, randomized, double-blind, placebo-controlled, dose-escalation clinical trial to test the candidate vaccine StreptInCor.
- Conditions
- Rheumatic Heart Disease, Rheumatic Heart Disease in Children, Vaccine Adverse Reaction, Rheumatic Diseases
- Trial name
- StreptInCorVac (NCT07078357)
- Testing
- StrepIncor
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Cardiovascular Diseases, Coronary Disease
Intravenous Streptokinase in Acute Myocardial Infarction
To determine whether the administration of intravenous streptokinase (SK) early in the course of acute, transmural myocardial infarction would limit myocardial damage.
- Conditions
- Cardiovascular Diseases, Coronary Disease, Heart Diseases, Myocardial Infarction
- Trial name
- NCT00000507
- Testing
- streptokinase
- Sponsor
- University of Washington
Acute Ischemic Stroke, Atrial Fibrillation
Early Versus Late Initiation of Anticoagulation in Mild-to-moderate AIS Patients With NVAF
The goal of this clinical trial is to compare the effectiveness between early and late initiation of anticoagulation therapy in acute ischemic stroke (AIS) patients with non-valvular atrial fibrillation (NVAF).
- Trial name
- ASAP (NCT06057467)
- Testing
- Anticoagulation Agents
- Where
- 2 sites in China
- Volunteers
- 2,351 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Acute Coronary Syndrome
A2 AR as a Novel Biomarkers for Physician Decision-making Improvement Evaluation's Patients With Suspected Acute Coronary Syndrome But Negative Troponin.
One proposed strategy is the stratification of troponin-negative patients with biomarker testing at presentation to facilitate the clinically-appropriate rapid discharge from the emergency department of patients who present with…
- Trial name
- NCT03218007
- Testing
- blood samples
- Where
- France
- Volunteers
- 83 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Venous Congestion, Heart Failure Acute
Vexus Assessment and Natriuresis-guided Diuretic Therapy in Acute Heart Failure
This study evaluates whether natriuresis-guided diuretic therapy improves outcomes in patients with acute heart failure (AHF) and severe congestion.
- Conditions
- Venous Congestion, Heart Failure Acute, VExUS, Diuretics
- Trial name
- VANTAGE-HF (NCT07558798)
- Testing
- Natriuresis-guided escalation of loop diuretics
- Where
- 2 sites in Norway
- Volunteers
- 270 people
- Sponsor
- University Hospital, Akershus
Depression, Acute Coronary Syndrome
The Effect of MElatonin on Depression, Anxiety, CIrcadian and Sleep Disturbances in Patients After Acute Myocardial Syndrome
The objective of the study is to investigate whether prophylactic treatment with melatonin has an effect on depressive symptoms. Secondarily melatonin's effect on anxiety, sleep and circadian disturbances will be investigated.
- Trial name
- MEDACIS (NCT02451293)
- Testing
- Melatonin (N-acetyl-5-methoxytryptamine)
- Where
- 6 sites in Denmark
- Volunteers
- 252 people
- Sponsor
- Zealand University Hospital
Aortic Valve Stenosis
Determination of the Acute Effects of Aortic Stenosis on Coronary Artery Haemodynamics
Narrowing of the main valve which controls blood leaving the heart leads to a marked increase in death. To overcome this narrowing the heart muscle thickens abnormally and contracts more vigorously.
- Trial name
- NCT01118442
- Where
- United Kingdom
- Volunteers
- 6 people
- Sponsor
- Imperial College London
Nonfatal Myocardial Infarction, Coronary Death
Association Between Low Dose Acetylsalicylic Acid (ASA) and Proton Pump Inhibitors and Risk of Acute Myocardial Infarction or Coronary Heart Disease Death
The purpose of this study is to estimate the risk of myocardial infarction (MI)/coronary death associated with use of monotherapy low dose ASA (single antiplatelet) as well as concomitant use of monotherapy low dose ASA and…
- Trial name
- NCT01360073
- Where
- 2 sites in Spain, Sweden
- Volunteers
- 42,542 people
- Sponsor
- AstraZeneca
Heart Failure, Systolic, Morality
Impact of Cardiac Rehabilitation on Acute Heart Failure Patients With Cognitive Impairment
In heart failure patients, neuropsychological disorders have been prospectively linked to frequent hospitalizations, recurrent cardiac events, and mortality.
- Conditions
- Heart Failure, Systolic, Morality, Cognitive Impairment
- Trial name
- NCT05726565
- Testing
- multidisciplinary cardiac rehabilitation
- Where
- Taiwan
- Volunteers
- 247 people
- Sponsor
- Chang Gung Memorial Hospital
Acute Coronary Syndrome, Chronic Heart Failure
Influenza Vaccination During Coronavirus Disease 2019 Outbreak After Acute Coronary Syndrome and Chronic Heart Failure
Study Description: Background: Well-known fact that the number of cardiovascular diseases is on the rise during influenza epidemic.
- Trial name
- IV-ACS&CHF (NCT05232292)
- Testing
- Ultrix Quadri
- Where
- Russia
- Volunteers
- 200 people
- Sponsor
- Samara Regional Cardiology Dispensary
Coronary Heart Disease, Cardiovascular Risk Factor
Individual Variability of Coronary Heart Disease Risk Markers and Sleep Responses to Exercise
The aim of this study is to examine the reproducibility of postprandial coronary heart disease (CHD) risk marker and sleep responses to acute exercise bouts and to quantify the magnitude of individual variability in responses…
- Conditions
- Coronary Heart Disease, Cardiovascular Risk Factor, Arterial Stiffness, Blood Pressure
- Trial name
- NCT05022498
- Testing
- Exercise
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Acute Coronary Syndrome
Suxiao Jiuxin Pills in Microvascular Obstruction in Patients With Acute Coronary Syndrome
Microvascular obstruction is the severe complication of percutaneous coronary intervention (PCI) in patients with acute coronary syndrome. Microvascular obstruction after PCI is often association with poor prognosis.
- Trial name
- NCT04814121
- Testing
- Suxiao Jiuxin Pills
- Volunteers
- 198 people
- Sponsor
- Guangzhou University of Traditional Chinese Medicine
Recurrent Pregnancy Loss, Anxiety Disorders
Right Prefrontal Autonomic Mapping in Recurrent Pregnancy Loss With Comorbid Anxiety
Recurrent pregnancy loss is often accompanied by substantial anxiety and may also be associated with autonomic imbalance and increased long-term cardiovascular vulnerability.
- Trial name
- NCT06968026
- Testing
- repetitive transcranial magnetic stimulation(rTMS)
- Where
- 4 sites in China
- Volunteers
- 55 people
- Sponsor
- Shenyang Jinghua Hospital
Atrial Fibrillation, Stroke
DOAC in Chinese Patients With Atrial Fibrillation
Direct oral anticoagulants (DOACs) have emerged as safe and efficacious ischemic stroke prophylaxis for non-valvular atrial fibrillation (NVAF).
- Conditions
- Atrial Fibrillation, Stroke, Stroke, Acute, Brain Diseases
- Trial name
- DOAC-REAL (NCT05378035)
- Testing
- Blood Tests
- Where
- Hong Kong
- Volunteers
- 427 people
- Sponsor
- Chinese University of Hong Kong
Acute Decompensated Heart Failure
Impact of Hypertonic Saline Solution on Acute Decompensated Heart Failure
Acute decompensated heart failure (HF) is one of the most common cardiologic issues in emergency departments. Loop diuretics have long been recognized as the key for the treatment of Acute Decompensated Heart Failure…
- Trial name
- HSS (NCT05298098)
- Testing
- Hypertonic Saline Solution
- Where
- Tunisia
- Volunteers
- 600 people
- Sponsor
- University of Monastir
Acute Kidney Injury, IHD
The Effect of Spironolactone on Acute Kidney Injury in Patients Undergoing Coronary Angiography
an interventional study to measure the possible effects of spironolactone ( an aldosterone antagonist) on the incidence of acute kidney injury after coronary angiography
- Conditions
- Acute Kidney Injury, IHD, Contrast-induced Nephropathy
- Trial name
- NCT03329443
- Testing
- Spironolactone
- Where
- Iraq
- Volunteers
- 490 people
- Sponsor
- Alhasan Mujtaba Abdul-Wahid
Acute Coronary Syndromes
Evaluation of the Role of Brain Natriuretic Peptide in Acute Coronary Syndrome .
The measurements of the natriuretic peptide are useful and beneficial for risk stratification irrespective of the cause during admission time or during hospital stay course.
- Trial name
- NCT06734416
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
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