Clinical trials: Acute Coronary Disease
Acute Coronary Syndrome
Effect of Dalcetrapib on CV Risk in a Genetically Defined Population With a Recent ACS
This is a placebo-controlled, randomized, double-blind, parallel group, phase 3 multicenter study in subjects recently hospitalized for ACS and with the appropriate genetic profile.
- Trial name
- dal-GenE-2 (NCT05918861)
- Testing
- Dalcetrapib
- Where
- 231 sites in United States, Canada and 1 more
- Volunteers
- 2,000 people
- Sponsor
- DalCor Pharmaceuticals
Type 1 Diabetes Mellitus, Diabetic Ketoacidosis
Biomarkers of Acute Organ Injury in Pediatric Newly Diagnosed Type 1 Diabetes
Diabetic ketoacidosis (DKA) is a severe metabolic complication in children with newly diagnosed type 1 diabetes mellitus (T1DM) and may be associated with early injury of vital organs such as the kidneys and the heart.
- Trial name
- NCT07483879
- Testing
- Biomarker and Echocardiographic Assessment
- Where
- Greece
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Acute Kidney Injury, Pediatric Cardiac Surgery
The Effect of Preoperative Albumin Administration on Postoperative Acute Kidney Injury in Pediatric Patients With Hypoalbuminemia Undergoing Cardiac Surgery
The study aims to evaluate whether preoperative albumin supplementation in pediatric patients with hypoalbuminemia undergoing cardiac surgery can reduce inflammatory responses and prevent acute kidney injury (AKI) following…
- Trial name
- NCT06710353
- Testing
- Albumin solution, Crystalloid solutions
- Where
- South Korea
- Volunteers
- 190 people
- Sponsor
- Seoul National University Hospital
STEMI - ST Elevation Myocardial Infarction, Percutaneous Coronary Intervention
Non Culprit Functional Evaluation With 3D Angio QFR in STEMI PCI Procedure
Reliability of 3D angio QFR functional evaluation of all non culprit lesions >50% in STEMI patients during first acute procedure
- Conditions
- STEMI - ST Elevation Myocardial Infarction, Percutaneous Coronary Intervention, Coronary Artery Disease
- Trial name
- NCT02998853
- Testing
- QFR measurement by dedicated workstation on xrays angio selected runs
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Azienda Ospedaliera Sant'Anna e San Sebastiano
Atherosclerosis, Stroke, Ischemic
Adherence to Secondary Prevention Guidelines for Cardiovascular Risk
The present observational study aims to determine the degree of adherence to the recommendations of clinical guidelines regarding the prevention of cardiovascular complications in patients hospitalized due to a cardiovascular…
- Conditions
- Atherosclerosis, Stroke, Ischemic, Acute Coronary Syndrome, Ischemic Heart Disease
- Trial name
- NCT06450561
- Testing
- cardiovascular event
- Where
- Spain
- Volunteers
- 129 people
- Sponsor
- Consorci Sanitari de l'Alt Penedès i Garraf
Acute Coronary Syndrome
PK/PD Study of Vicagrel and Clopidogrel in Healthy Subjects With Different CYP2C19 Metabolizers
This clinical study will adopt an open-label, randomized, multiple-dose, two-crossover design to explore the pharmacokinetic and pharmacodynamic profiles of Vicagrel Capsules and Clopidogrel Tablets in Healthy Subjects with…
- Trial name
- NCT05162053
- Testing
- vicagrel Capsules, Clopidogrel Tablets
- Where
- 3 sites in United States, China
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Jiangsu vcare pharmaceutical technology co., LTD
STEMI, Acute Myocardial Infarction
Resistance STEMI Study
In acute myocardial infarction, early restoration of blood flow to the jeopardized myocardium is of paramount importance to limit infarct size and to improve long term outcome.
- Trial name
- NCT03439150
- Testing
- Absolute flow and resistance measurement
- Where
- Netherlands
- Volunteers
- 5 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Coronary Artery Disease
CHoice of Optimal Anti-Thrombotic Strategy in Patients Undergoing Implantation of Coronary Drug-Eluting Stents 4
This study is multi-center, open label, two-by-two factorial, randomized, noninferiority trial to compare the efficacy and safety of polymer-free cobalt-chromium thin drug-coated stents (BioFreedom Ultra) with biodegradable…
- Trial name
- SMART-CHOICE4 (NCT05066789)
- Testing
- Type of stent, Duration of DAPT
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Samsung Medical Center
Acute Cardiogenic Shock
Transient Circulatory Support in Cardiogenic Shock
The purpose of this multicenter prospective study is to determine if the decision of transient circulatory support (TCS) in cardiogenic shock is relevant.
- Trial name
- ALLOASSIST (NCT03528291)
- Where
- France
- Volunteers
- 240 people
- Sponsor
- University Hospital, Montpellier
Acute Coronary Syndrome
Evaluation of Cardiovascular Outcomes in Patients With Type 2 Diabetes After Acute Coronary Syndrome During Treatment With AVE0010 (Lixisenatide)
Primary Objective: To demonstrate that lixisenatide can reduce cardiovascular (CV) morbidity and mortality (composite endpoint of CV death, non-fatal myocardial infarction (MI), non-fatal stroke, hospitalization for unstable…
- Trial name
- ELIXA (NCT01147250)
- Testing
- Lixisenatide (AVE0010)
- Where
- 829 sites in United States, Argentina and 47 more
- Volunteers
- 6,068 people
- Sponsor
- Sanofi
Coronary Artery Disease
Noninferiority Trial Of Sirolimus With Ascorbic Acid Versus Everolimus in All-comers
The objective of this study is to demonstrate the primary hypothesis that, in patients with chronic and acute coronary syndromes requiring percutaneous coronary intervention (PCI), the novel sirolimus-ascorbic acid eluting stent…
- Trial name
- NOVA (NCT07566091)
- Testing
- Sirolimus-Ascorbic Acid Eluting Stent, Everolimus-Eluting Stent
- Where
- South Korea
- Volunteers
- 2,034 people
- Sponsor
- Jung-min Ahn
Obstructive Sleep Apnea, Acute Coronary Syndrome
Attentional Capacity and Working Memory in Coronary Artery Disease Patients: Impact of the Presence of a Sleep Apnea Syndrome and Chronic Effects of Treatment With CPAP
The presence of Obstructive Sleep Apnea Syndrome (OSAS) has a high frequency in patients victims of a coronary artery disease (CAD) (myocardial infarction, revascularization).
- Trial name
- CAPCORSAS (NCT02533050)
- Testing
- CPAP treatment
- Where
- France
- Volunteers
- 9 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Acute Kidney Injury
Influence of Albumin on Acute Renal Dysfunction Associated With Cardiac Surgery Under Extracorporeal Circulation
Acute renal dysfunction associated with cardiac surgery (DRA-ACC) in our hospital population affects 39% of patients, being an important cause of morbidity and mortality, increasing the need for dialysis and assuming a…
- Trial name
- NCT03373318
- Testing
- Human albumin, Plasmalyte
- Where
- Spain
- Volunteers
- 250 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Heart Failure, Cardiomyopathies
Multimodal Physiologic State Intelligence Study
The OMNIPHYS study will investigate whether multimodal ultrasound and other routinely collected clinical and physiologic data can be combined with artificial intelligence to characterize changes in a person's physiologic state…
- Conditions
- Heart Failure, Cardiomyopathies, Pulmonary Hypertension, Myocarditis; Acute or Subacute
- Trial name
- OMNIPHYS (NCT07814118)
- Testing
- OMNIPHYS Multimodal Ultrasound Imaging System
- Where
- United States
- Volunteers
- 25,000 people, healthy volunteers welcome
- Sponsor
- Truway Health, Inc.
Acute Coronary Syndrome
Thrombus Aspiration and Pathology and OCT Study
Most acute coronary syndromes (ACS) are caused by plaque complications triggering thrombotic events in the culprit plaques. Plaque complications include plaque rupture (Ruptured Fibrous Cap-RFC) with exposure of highly…
- Trial name
- TAPOS (NCT07151976)
- Testing
- PCI
- Where
- Japan
- Volunteers
- 200 people
- Sponsor
- Fujita Health University
Heart Failure
Mechanism and Effects of Manipulating Chloride Homeostasis in Acute Heart Failure
The purpose of this study is to understand the effects of chloride supplementation on volume-overloaded acute heart failure patients concomitantly treated with IV diuretics.
- Trial name
- NCT03446651
- Testing
- Lysine Chloride
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Yale University
Acute Kidney Injury
Study of the Relaxin Agonist R2R01 in Patients at High Risk for Cardiac Surgery Associated- Acute Kidney Injury
This is a Phase 2, dose-ranging, double-blind, double-dummy, placebo-controlled, randomized study preceded by an open label safety run-in, in patients at high risk for Cardiac Surgery Associated - Acute Kidney Injury (CSA-AKI)…
- Trial name
- CSA-AKI (NCT07625553)
- Testing
- R2R01
- Where
- Italy
- Volunteers
- 430 people
- Sponsor
- River 2 Renal Corp.
Myocardial Infarction
Post-conditioning to Reduce Infarct Size
When angioplasty (PTCA) and stenting of the blood vessels of the heart is the treatment for a Heart Attack, there is damage to the heart muscle that is caused by the sudden opening of the blood vessels.
- Trial name
- NCT00755469
- Testing
- Post-conditioning
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Minneapolis Heart Institute Foundation
Myocardial Infarction
Efficacy of Everolimus-Eluting Versus Zotarolimus-Eluting Sten for Coronary Lesions in Acute Myocardial Infarction
Most of the previous data regarding the efficacy of the everolimus-eluting stent (EES) was derived from studies comparing EES with bare metal stent (BMS) or EES with paclitaxel-eluting (PES).
- Trial name
- EVERZOTA (NCT01347554)
- Testing
- Everolimus eluting stent, Zotarolimus eluting stent
- Where
- South Korea
- Volunteers
- 461 people
- Sponsor
- Yonsei University
Congestive Heart Failure, Non-ischemic Cardiomyopathy
Study of the Acute Effects of Triheptanoin in Heart Failure
Patients with dilated cardiomyopathy who present for indwelling right heart catheterization will be enrolled and randomized to either control or triheptanoin oil for five days. Hemodynamics will be assess serially.
- Trial name
- ACETO-TCA (NCT01787851)
- Testing
- Triheptanoin oil
- Where
- United States
- Sponsor
- University of Texas Southwestern Medical Center
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