Clinical trials: Acute Coronary Disease
Conditions, Infections
Analysis of the Virtual Acute Care at Home Experience
The purpose of this study is to examine the implementation, intervention effectiveness, and dissemination of a digital acute care delivery model for improving selected health outcomes in the Hospital at Home population.
- Conditions
- Conditions, Infections, Heart Failure, Renal and Urinary Disorders
- Trial name
- HaH (NCT05952999)
- Testing
- Digital Care Solution as supportive personalized care, Traditional Hospital Level Care
- Where
- United States
- Volunteers
- 9,654 people
- Sponsor
- OSF Healthcare System
Cardiovascular Disease
Genotype Guided Comparison of Clopidogrel and Prasugrel Outcomes Study
The primary objective of this trial is to demonstrate the non-inferiority of clopidogrel compared to prasugrel over 6 months in cardiovascular disease patients when the clopidogrel cohort is limited to the estimated 70% of the…
- Trial name
- GeCCO (NCT00995514)
- Where
- United States
- Volunteers
- 4,471 people
- Sponsor
- Medco Health Solutions, Inc.
Acute Renal Failure
A New Way to Detect Acute Kidney Injury
Acute renal failure after cardiac surgery is a common postoperative complication, affecting approximately 20% of patients. It is associated with an increase in short-term mortality and an increase in hospital stay; but is also…
- Trial name
- VEX-CARDS (NCT07198906)
- Testing
- Determination of VEXUS score and onset of chronic renal failure
- Where
- France
- Sponsor
- University Hospital, Rouen
Myocardial Infarction
Incheon-Bucheon Cohort of Patients Undergoing Primary PCI for Acute STEMI
INcheon-Bucheon cohorT of patients undERgoing primary percutaneous coronary intervention for acute ST-ELevation myocardiaL infARction (INTERSTELLAR) registry is a retrospective, observational, 4-regional-hospital based registry…
- Trial name
- NCT02804958
- Testing
- STEMI treated with primary PCI
- Where
- 4 sites in South Korea
- Volunteers
- 1,537 people
- Sponsor
- Gachon University Gil Medical Center
Acute Heart Failure (AHF)
Exogenous KETOne Supplements in Patients Hospitalized for Acute Heart Failure
This is a multicenter, randomized, double-blind, placebo-controlled trial to investigate the clinical efficacy of treatment with exogenous dietary ketone supplement containing 1,3-butanediol in patients hospitalized with acute…
- Trial name
- KETO-AHF (NCT06653725)
- Testing
- 1,3-butanediol
- Where
- 8 sites in Denmark
- Volunteers
- 250 people
- Sponsor
- Aarhus University Hospital
Left-Sided Breast Cancer, Radiation Toxicity
Hybrid PET/MR Imaging of Acute Cardiac Inflammation After Left-Sided Breast Cancer Radiotherapy
Radiation therapy (RT) of the breast is a critical component of modern breast cancer treatment. RT treatments have led to improved local control and overall survival of breast cancer patients.
- Trial name
- RICT-BREAST (NCT03748030)
- Testing
- Confirmed Left-Sided Breast Cancer
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Heart Failure
High Versus Low SpO2 Oxygen Therapy in Patients With Acute Heart Failure
The primary objective of this pilot trial is to determine whether inpatients presenting to the Emergency Department (ED) with symptoms suggestive of Acute Heart Failure (AHF), who receive supplemental oxygen adjusted at either a…
- Trial name
- HiLo (NCT02518828)
- Testing
- High SpO2, Low SpO2
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of Alberta
Acute Coronary Syndrome, Angina Pectoris
DUrable Polymer-based STent CHallenge of Promus Element Versus ReSolute Integrity in an All Comers Population
The introduction of drug-eluting stents (DES) in the treatment of coronary artery disease has led to a significant reduction in morbidity but there are further demands on DES performance.
- Conditions
- Acute Coronary Syndrome, Angina Pectoris, Angina, Unstable, Myocardial Infarction
- Trial name
- DUTCH PEERS (NCT01331707)
- Testing
- Resolute Integrity (Zotarolimus-eluting stent), Promus Element (Everolimus-eluting stent)
- Where
- 4 sites in Netherlands
- Volunteers
- 1,811 people
- Sponsor
- Foundation of Cardiovascular Research and Education Enschede
Acute Coronary Syndrome
Reduced in Bed Rest After Coronary Arteriography or Coronary Angioplasty
This is a randomized clinical trial with a control group, based on the guidelines of the CONSORT 2010. The interventional group will be in a bed rest for two hours after introducer removal in patients submitted a coronary…
- Trial name
- NCT02635906
- Testing
- 2 hours, 4 hours
- Where
- Brazil
- Volunteers
- 150 people
- Sponsor
- Federal University of São Paulo
Atherosclerosis, Acute Coronary Syndrome (ACS)
Cangrelor Versus Standard Therapy to Achieve Optimal Management of Platelet Inhibition.
The primary objective of this study is to demonstrate that the efficacy of cangrelor (combined with usual care) is superior to that of usual care, in subjects requiring percutaneous coronary intervention (PCI) as measured by a…
- Trial name
- Platform (NCT00385138)
- Testing
- Cangrelor, clopidogrel
- Where
- United States
- Volunteers
- 5,364 people
- Sponsor
- The Medicines Company
Thrombosis, Acute Coronary Syndrome
Safety, Pharmacokinetic and -Dynamic Study of PR-15, an Inhibitor of Platelet Adhesion
Primary objective: To evaluate safety and tolerability, adverse events (AEs), vital signs, ECG, bleeding time, evaluation of antibody titer and safety laboratory tests Secondary objectives: To evaluate the pharmacokinetics and…
- Conditions
- Thrombosis, Acute Coronary Syndrome, Myocardial Infarction, Stroke
- Trial name
- PR-15/01 (NCT01042964)
- Testing
- revacept (PR-15)
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- AdvanceCor GmbH
Acute Coronary Syndrome
AngioSeal Versus Radial Approach in Acute Coronary Syndrome
Among non-ST-segment elevation acute coronary syndrome patients submitted to early invasive strategy and randomized for the transfemoral or transradial approach, the AngioSeal vascular closure device would decrease the prevalence…
- Trial name
- ARISE (NCT01653587)
- Testing
- Percutaneous coronary intervention
- Where
- Brazil
- Volunteers
- 240 people
- Sponsor
- Irmandade Santa Casa Misericórdia Marília
Pulmonary Embolism, Venous Thromboembolism
Prognostic Value of 2026 AHA/ACC Clinical Categorization in Acute Pulmonary Embolism Patients Presenting to the Emergency Department
Background: The 2026 American Heart Association/American College of Cardiology (AHA/ACC) Pulmonary Embolism Guideline (Creager et al., Circulation 2026) introduced a novel five-category (A-E) clinical classification system with…
- Conditions
- Pulmonary Embolism, Venous Thromboembolism, Acute Pulmonary Embolism
- Trial name
- APEX-2026 (NCT07805616)
- Testing
- 2026 AHA/ACC Clinical Risk Categorization
- Where
- Turkey (Türkiye)
- Volunteers
- 600 people
- Sponsor
- Marmara University Pendik Training and Research Hospital
Acute Kidney Injury
Application of Intraoperative Transesophageal Echocardiography Imaging of Vein and CLCVP in Early Prediction and Intervention CSA-AKI
The goal of this clinical trial is to learn about in postoperative acute kidney injury in cardiac surgery. The main questions it aims to answer are: Intraoperative Transesophageal Ultrasound Doppler venous imaging can be used to…
- Trial name
- NCT05682716
- Testing
- Controlled low central venous pressure (CLCVP) technology, Nitroglycerin
- Where
- China
- Volunteers
- 137 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Stable Angina or Acute Coronary Syndrome Considered for Percutaneous Coronary Intervention With Dyslipidemia or Hypertension
Neointimal Coverage After Implantation of Biolimus Eluting Stent With Biodegradable Polymer: Optical Coherence Tomographic Assessment According to the Treatment of Dyslipidemia and Hypertension and the Types of Implanted Drug-eluting Stents
There has been little research on neointimal coverage and malapposition after BES implantation using OCT in human coronary artery. Furthermore, specific drug may possibly influence the vascular healing after stent implantation.
- Trial name
- NCT01502904
- Testing
- Sirolimus-eluting stent, Biolimus-eluting stents, pravastatin 20mg/day after DES implantation
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- Yonsei University
Acute Coronary Syndrome, High Bleeding Risk
LEADERS FREE II: BioFreedom™ Pivotal Study
This study aims to confirm non-inferiority of the BioFreedom™ Drug Coated Stent to the Gazelle™ Bare Metal Stent arm of the Leaders Free study (NCT01623180) in high bleeding risk patients.
- Trial name
- NCT02843633
- Testing
- BioFreedom™ Drug Coated Coronary Stent System, Antiplatelet Drug
- Where
- 66 sites in United States, Canada and 5 more
- Volunteers
- 1,203 people
- Sponsor
- Biosensors Europe SA
Acute Coronary Syndrome
Clinical Pharmacist-led Discharge Education Service in Acute Coronary Syndrome
To evaluate the impact of clinical pharmacist-led discharge education service in patients with acute coronary syndrome.
- Trial name
- NCT05153707
- Testing
- Discharge Education Program
- Where
- Turkey (Türkiye)
- Volunteers
- 177 people
- Sponsor
- Marmara University
Restenosis, Tight Glycemic Control
Tight Glycemic Control During Angioplasty Revascularization Reduces Coronary Stent Restenosis
A multicentric study will evaluate whether peri-procedural tight glycemic control during angioplasty revascularization for acute coronary syndrome (ACS) reduces circulating inflammatory cytokines and thrombus formation in…
- Trial name
- NCT01016509
- Testing
- Insulin
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- University of Campania Luigi Vanvitelli
Myocardial Infarction
Left Atrial Distensibility and Left Ventricular Filling Pressure in Acute Myocardial Infarction
Left atrial volume (LAV) provides the significant prognostic information in the general population and patients with heart disease, including acute myocardial infarction, left ventricular dysfunction, mitral regurgitation…
- Trial name
- NCT01168609
- Testing
- Primary percutaneous coronary intervention
- Where
- Taiwan
- Volunteers
- 521 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Acute Myocardial Infarction, Heart Failure
"ESTIMATION Study" for Endocardial Mesenchymal Stem Cells Implantation in Patients After Acute Myocardial Infarction
The investigators hypothesised that endocardial stem cells implantation following after percutaneous coronary intervention (PCI) could reduce the scar formation and increase reverse remodeling in patients with primary acute…
- Trial name
- ESTIMATION (NCT01394432)
- Where
- Russia
- Volunteers
- 50 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.