Clinical trials: Acute Coronary Disease
Valvular Heart Disease
The Impact of Sleep-disordered Breathing on the Incidence of Postoperative Acute Kidney Injury in Patients Undergoing Valvular Heart Surgery
Sleep-disordered breathing has a prevalence of 30~80% in patients with heart diseases. Various studies have revealed a correlation between the incidence and various diseases such as heart failure, hypertension, diabetes, and…
- Trial name
- NCT04080219
- Where
- South Korea
- Volunteers
- 414 people
- Sponsor
- Yonsei University
Low Risk Acute Coronary Syndrome
Low Risk Acute Coronary Syndrome
A large number of patients are diagnosed with low risk ACS, and these individuals are at significant cardiovascular risk. Though guidelines recommend stress testing to manage low risk ACS patients, evidence supporting this…
- Trial name
- LOW ACT (NCT01703156)
- Testing
- Stress Test, No Stress Test
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Oklahoma
Sleep Disordered Breathing (SDB)
Metabolic Characteristics and Prognostic Model of Acute Coronary Syndrome Complicated With Obstructive Sleep Apnea
Obstructive sleep apnea (OSA) significantly increases the risk of cardiovascular events in patients with acute coronary syndrome (ACS), yet the underlying metabolic mechanisms remain unclear.
- Trial name
- OSA-ACS-Met (NCT07398430)
- Testing
- Biological Sample Collection
- Volunteers
- 1,200 people
- Sponsor
- Beijing Hospital
Brain Injuries, Acute, Brain Injuries, Traumatic
Antiseizure Medication in Seizure Networks at Early Acute Brain Injury
The goal of this clinical trial is to explore the effect of FDA-approved antiseizure drugs in the brain connectivity patterns of severe and moderate acute brain injury patients with suppression of consciousness.
- Conditions
- Brain Injuries, Acute, Brain Injuries, Traumatic, Brain Ischemia, Brain Hypoxia
- Trial name
- NCT06081283
- Testing
- Phenobarbital Sodium Injection, Levetiracetam, Lacosamide Injectable Product
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of North Carolina, Chapel Hill
Acute Coronary Syndrome, Myocardial Infarction
Utilization of Diagnostic Ultrasound in the Detection and Therapy of Acute Coronary Syndromes
The study will see if mechanical impulses delivered by an echocardiographic probe during a continuous infusion of MRX 801 are capable of improving blood flow in smaller heart vessels in patients with acute coronary syndromes.
- Trial name
- NCT00955136
- Testing
- Use of intermittent high MI impulses during echocardiogram
- Sponsor
- University of Nebraska
Uric Acid
Uric Acid and Surgical Prognosis
Preoperative serum uric acid significantly impacted mortality and morbidity in non-cardiac surgery.
- Trial name
- NCT06837545
- Testing
- No Intervention (Observational Study)
- Where
- South Korea
- Volunteers
- 309,353 people
- Sponsor
- Asan Medical Center
Acute Coronary Syndrome, Myocardial Ischemia
Non Invasive Extra-corporeal ECG Signal Analysis Algorithm( NID Algorithm) for Myocardial Ischemia
The NIA algorithm is similar to the traditional 12-lead ECG equipment. By analyzing patient data, NIA algorithm provides more detailed results compared to traditional 12-lead ECG.
- Trial name
- NCT02579512
- Testing
- Extra-corporeal ECG signal analysis
- Where
- Taiwan
- Volunteers
- 500 people
- Sponsor
- Taichung Veterans General Hospital
Acute Coronary Syndrome, Hypertension
DASH Diet, Quality of Life and Cardiac Parameters of Patients With Acute Coronary Syndrome
The clinical trail study aimed to determine effect of DASH eating plan on cardiac parameters and quality of life in hypertensive individuals diagnosed with acute coronary syndrome. The main questions it aims to answer are: 1.
- Trial name
- NCT06485765
- Testing
- Diet planning
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Bandırma Onyedi Eylül University
Acute Heart Failure (AHF), Heart Failure
Urinary Chloride and Sodium Changes and Residual Congestion in Acute Heart Failure
The goal of this observational study is to learn how changes in urinary sodium and chloride levels relate to fluid overload and short-term outcomes in patients hospitalized with acute heart failure (AHF).
- Conditions
- Acute Heart Failure (AHF), Heart Failure, Congestion
- Trial name
- CLORINA-IC (NCT07597512)
- Where
- 4 sites in Spain
- Volunteers
- 223 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Chest Pain, Acute Coronary Syndrome
Effectiveness and Safety of a Clinical Assessment and 0h/1h Troponin Rule-Out Protocol
Chest pain is a common presenting complaint at the Emergency Department (ED). Many of these patients undergo lengthy assessments in the ED or are admitted which contributes to ED and hospital crowding as well as a substantial…
- Conditions
- Chest Pain, Acute Coronary Syndrome, Myocardial Infarction, Unstable Angina
- Trial name
- ESC-TROP (NCT03421873)
- Testing
- 0h/1h hs-cTnT protocol
- Where
- 5 sites in Sweden
- Volunteers
- 16,000 people
- Sponsor
- Ulf Ekelund
Myocardial Infarction, Acute, Left Ventricular Thrombus
Direct Oral Anticoagulants for Prevention of lEft ventRIcular Thrombus After Anterior Acute Myocardial InFarction - APERITIF
APERITIF is a prospective randomized open-label, blinded end-point (PROBE) trial, nested in the ongoing the "FRENCHIE" registry, a French multicenter prospective observational study granted by "ANR-RHU Grand Emprunt", in which…
- Trial name
- APERITIF (NCT05077683)
- Testing
- Rivaroxaban 2.5 MG [Xarelto], DAPT strategy
- Where
- France
- Volunteers
- 560 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Heart Failure
Effects of Neuromuscular Electrostimulation in Patients With Acute Heart Failure
The investigators evaluated the effects of neuromuscular electrical stimulation (NMES) therapy on functional capacity and oxidative stress in patients hospitalized for an episode of acute heart failure (AHF).
- Trial name
- NCT04310072
- Testing
- Neuromuscular electrical stimulation
- Where
- Romania
- Volunteers
- 30 people
- Sponsor
- Ploesteanu Rodica Lucia
Acute Myocardial Infraction or Chest Pain, Chronic Obstructive Pulmonary Disease (COPD)
Developing Enhanced Prediction Models
In this study, patients will be prospectively enrolled for data collection to design prediction models that integrate claims data (inpatient, outpatient, and pharmacy), electronic health record data (on clinical, social, and…
- Conditions
- Acute Myocardial Infraction or Chest Pain, Chronic Obstructive Pulmonary Disease (COPD), Congestive Heart Failure (CHF), Diabetes
- Trial name
- PREDICT (NCT02983812)
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- University of Pennsylvania
Heart Failure, Acute Heart Failure
Telemonitoring Program in the Vulnerable Phase After Hospitalization for Heart Failure
This pragmatic clinical trial aims to evaluate the impact of a telemonitoring program with an electronic alert system compared to standard treatment on the perception of self-care in patients after hospitalization for…
- Trial name
- NCT05972746
- Testing
- Telemonitoring with electronic alerts, Standard of care
- Where
- Argentina
- Volunteers
- 110 people
- Sponsor
- Instituto Cardiovascular de Buenos Aires
Myocardial Infarction, Percutaneous Coronary Intervention
Comparison of Titanium-Nitride-Oxide Coated Bio-Active-Stent (Optimax™) to the Drug (Everolimus) -Eluting Stent (Synergy™) in Acute Coronary Syndrome
The purpose of the prospective, randomized and a multicenter trial is to compare clinical outcome in patients presenting with ACS, treated with PCI using Optimax-BAS versus Synergy-EES.
- Conditions
- Myocardial Infarction, Percutaneous Coronary Intervention, Atherosclerosis
- Trial name
- TIDES-ACS (NCT02049229)
- Testing
- percutaneous coronary intervention
- Where
- 6 sites in Finland
- Volunteers
- 1,800 people
- Sponsor
- The Hospital District of Satakunta
Cardiovascular Disease, Acute Rejection of Cardiac Transplant
Quantitative Detection of Circulating Donor-Specific DNA in Organ Transplant Recipients (DTRT-Multi-Center Study)
The primary goal of this Multicenter Study is to develop and to evaluate a method for measuring donor-specific cell free DNA in blood samples from transplant recipients as markers of rejection.
- Conditions
- Cardiovascular Disease, Acute Rejection of Cardiac Transplant, Cardiac Transplant Rejection, Heart Transplant Failure and Rejection
- Trial name
- DTRT (NCT02109575)
- Testing
- Blood Draw of up to 10 ml
- Where
- 8 sites in United States
- Volunteers
- 540 people
- Sponsor
- Medical College of Wisconsin
Coronary Artery Disease, Angina Pectoris
Study Comparing CT Scan and Stress Test in Patients With Known Coronary Artery Disease Hospitalized for Chest Pain
The purpose of this study is to determine whether coronary artery CT scanning or nuclear stress testing is better at diagnosing chest pain patients with known coronary artery disease to select appropriate candidates for coronary…
- Conditions
- Coronary Artery Disease, Angina Pectoris, Unstable Angina, Acute Coronary Syndrome
- Trial name
- PROSPECT-CAD (NCT01106612)
- Testing
- Coronary CT angiography, Myocardial perfusion imaging
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Montefiore Medical Center
Ischemic Heart Disease, Acute Coronary Syndromes
Effects of Optimized Antiplatelet Treatment After Percutaneous Coronary Intervention
Effects of dual antiplatelet therapy with aspirin and clopidogrel after percutaneous coronary intervention has been proven. However, patients with low response to those agents are reported be associated with adverse clinical…
- Trial name
- NCT00404781
- Testing
- cilostazol in addition to aspirin and clopidogrel
- Where
- China
- Volunteers
- 305 people
- Sponsor
- Shenyang Northern Hospital
Heart Failure, Acute Heart Failure
Pharmacological Optimization in Prevention in Heart Failure: A Sex-gap?
The goal of this clinical trial is to learn whether a rapid and intensive optimization of heart failure medications in women can improve outcomes after hospitalization for heart failure.
- Conditions
- Heart Failure, Acute Heart Failure, Heart Failure With Reduced Ejection Fraction (HFrEF), Heart Failure With Preserved Ejection Fraction (HFPEF)
- Trial name
- PopS-HF (NCT07295522)
- Testing
- Guideline-Directed Medical Therapy (GDMT)
- Where
- 12 sites in Italy
- Volunteers
- 368 people
- Sponsor
- IRCCS Policlinico S. Donato
STEMI - ST Elevation Myocardial Infarction
Use of the Methoxyflurane as Pain-killer in the Prehospital Management of Acute Myocardial Infarction
Chest pain is the main symptom of acute myocardial infarction. A precocious analgesic treatment is justified by patient's comfort and unfavorable hemodynamic consequences of persistent pain.
- Trial name
- MAMI (NCT07445737)
- Testing
- Methoxyflurane, Morphine
- Where
- France
- Volunteers
- 700 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris