Clinical trials: Acute Coronary Disease
Acute Coronary Syndrome
Diagnostic Performance of Coronary Calcification Detection on CT Scan
thoracic pain is one of the most frequent reasons for consulting the emergency room. Chest pain can be a sign of different pathologies with a wide range of severity, from life-threatening aortic dissection or myocardial…
- Trial name
- Calci-DT (NCT05538117)
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Strasbourg, France
Heart Failure with Reduced Ejection Fraction, Heart Failure
Prediction of Heart-Failure with Machine Learning
In this monocentric observational study the research question is to what extent data collected via Apple Watch can predict the heart failure status of decompensated HF patients.
- Conditions
- Heart Failure with Reduced Ejection Fraction, Heart Failure, Heart Failure，Congestive, Heart Failure Acute
- Trial name
- PRE-HF-ML (NCT06819618)
- Testing
- Monitoring with Apple Watch
- Where
- Germany
- Volunteers
- 32 people
- Sponsor
- University Medical Center Goettingen
Acute Coronary Syndrome
Preventive Intervention Value of DCB in Vulnerable Coronary Atherosclerotic Plaques
The PASSIVATE-CAP study is an investigator-initiated, prospective, randomized, multicenter, open-label superiority trial focusing on acute coronary syndrome (ACS) patients with nonflow-limiting vulnerable plaques in nonculprit…
- Trial name
- NCT06416813
- Testing
- GDMT+DCB
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Yong He
Familial Hypercholesterolemia, Cardiac Event
Familial Hypercholesterolemia Amongst Patients With Acute Coronary Syndrome
Familial hypercholesterolemia (FH) is a most prevalent genetic disorder, defines as high cholesterol level and premature death. The prevalence of FH has been reported in few countries however unknown in Iran.
- Conditions
- Familial Hypercholesterolemia, Cardiac Event, Acute Coronary Syndrome
- Trial name
- NCT02870660
- Testing
- Registry
- Where
- Iran
- Volunteers
- 500 people
- Sponsor
- Isfahan University of Medical Sciences
Acute Myocardial Infarction
Safety Study of Allogeneic Mesenchymal Precursor Cell Infusion in Myocardial Infarction
This was a double-blind, randomized, placebo-controlled study that was designed to enroll a total of 225 participants with de novo anterior wall acute ST-segment elevation myocardial infarction (STEMI) due to a lesion of the left…
- Trial name
- AMICI (NCT01781390)
- Testing
- Mesenchymal Precursor Cells (MPC) 12.5 M, Mesenchymal Precursor Cells (MPC) 25 M
- Volunteers
- 106 people
- Sponsor
- Mesoblast, Inc.
Acute Coronary Syndrome (ACS)
Prasugrel Switching Study in Patients With Acute Coronary Syndrome (ACS) Who Underwent Percutaneous Coronary Intervention (PCI)
This Phase IV, multicenter trial is designed to assess the efficacy of prasugrel in preventing the formation of blood clots in Taiwanese patients with ACS who have been treated with PCI.
- Trial name
- NCT03672097
- Testing
- Prasugrel
- Where
- 10 sites in Taiwan
- Volunteers
- 204 people
- Sponsor
- Daiichi Sankyo Taiwan Ltd., a Daiichi Sankyo Company
Acute Coronary Syndrome, Coronary Artery Stenosis
Use of Magnetocardiography in Evaluation of Patients Going for Cardiac Catheterization
This is a multicenter, prospective trial to measure the test performance characteristics of the Magnetocardiography (MCG) CardioFlux cardiac diagnostic system in detecting clinically significant coronary artery obstruction in…
- Conditions
- Acute Coronary Syndrome, Coronary Artery Stenosis, Myocardial Ischemia
- Trial name
- NCT04044391
- Testing
- CardioFlux Magnetocardiograph
- Where
- 2 sites in United States
- Volunteers
- 101 people
- Sponsor
- Genetesis Inc.
Acute Heart Failure, Congestive Heart Failure
Clinical Evaluation of the TRVD™ System in ADHF
A prospective, multi-national, open-label clinical study which is conducted to asses the safety, feasibility and performance of the TRVD™ System in hospital-admitted patients with Acute Decompensated Heart Failure (ADHF) and…
- Conditions
- Acute Heart Failure, Congestive Heart Failure, Heart Failure, Congestive
- Trial name
- TRVD (NCT03621436)
- Testing
- TRVD Therapy
- Where
- 3 sites in Belgium, Croatia and 1 more
- Volunteers
- 13 people
- Sponsor
- Magenta Medical Ltd.
Acute Coronary Syndrome
MCG for Risk Stratifications of Patients With Chest Pain
This prospective cohort study is aimed at identification and risk stratification of patients who have symptoms of acute chest pain suspected with acute coronary syndrome （ACS） using Magnetocardiography （MCG）.
- Trial name
- NCT06316011
- Testing
- Magnetocardiography
- Where
- China
- Volunteers
- 3,620 people
- Sponsor
- Qilu Hospital of Shandong University
Acute Coronary Syndrome, Myocardial Infarction
Zyban as an Effective Smoking Cessation Aid for Patients Following an Acute Coronary Syndrome: The ZESCA Trial
Patients who continue to smoke after a heart attack have a 35% increased risk of a recurrent event or death compared with those who quit. Many patients attempt to stop smoking after a heart attack, but relapse rates approach 66%.
- Conditions
- Acute Coronary Syndrome, Myocardial Infarction, Smoking
- Trial name
- ZESCA (NCT00689611)
- Testing
- Bupropion HCl ER
- Where
- 38 sites in United States, Bangladesh and 5 more
- Volunteers
- 392 people
- Sponsor
- Mark Eisenberg
Coronary Artery Diseases
BIOFLOW-III VIP Russia Registry Orsiro Stent System
Clinical evaluation of the Orsiro LESS in subjects requiring coronary revascularization with Drug Eluting Stents (DES). Along with it, an explanatory (hypothesis-finding) problem will be investigated, whether the patient's body…
- Trial name
- NCT02247492
- Where
- 7 sites in Russia
- Volunteers
- 200 people
- Sponsor
- Biotronik Russia
Myocardial Infarction, Heart Failure
Omega-3 Fatty Acids in Elderly Patients With Acute Myocardial Infarction
The aim of the present study is to investigate the possible effects of supplementation with 1.8 g/day of n-3 polyunsaturated fatty acids on cardiovascular morbidity and mortality during a follow-up period of 2 years in an elderly…
- Conditions
- Myocardial Infarction, Heart Failure, Myocardial Revascularization, Atrial Fibrillation
- Trial name
- OMEMI (NCT01841944)
- Testing
- Pikasol, Corn oil
- Where
- 4 sites in Norway
- Volunteers
- 1,027 people
- Sponsor
- Oslo University Hospital
Acute Myocardial Infarction
A Pilot Study of Transcoronary Myocardial Cooling
Patients with heart attacks caused by blocked coronary arteries are usually treated with a technique called primary angioplasty.
- Trial name
- NCT02312336
- Testing
- Cohort A - Room temperature coronary perfusate, Cohort B - Cooled coronary perfusate
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Cardiovascular Diseases, Coronary Disease
Epidemiology of Acute Phase Protein and CHD
To use the Multiple Risk Factor Intervention Trial (MRFIT) stored serum bank to do nested case-control studies of various serum risk factors in coronary heart disease incidence and mortality.
- Conditions
- Cardiovascular Diseases, Coronary Disease, Heart Diseases, Atherosclerosis
- Trial name
- NCT00005371
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Acute Myocardial Infarction
Effect of the Repeated Loading Dose of Clopidogrel and High Dose of Clopidogrel Continuous Therapy on the Platelet Aggregation Inhibition in Patients With Myocardial Infarction Undergoing Interventional Treatment.
REL-0609 trial's hypothesis is that repeated loading doses of clopidogrel (600 mg) administration in addition to high dose of clopidogrel continuous therapy (150 mg/day) results in higher inhibition of the platelets' aggregation…
- Trial name
- REL-0609 (NCT01636180)
- Testing
- Clopidogrel
- Where
- Poland
- Sponsor
- Fundacja Ośrodek Badań Medycznych
Coronary Artery Disease
Real-World Outcomes of Drug-Coated Balloon Angioplasty in Coronary Artery Disease
The Real-World Drug-Coated Balloon Registry (RW-DCB) is an investigator-initiated, multicenter, observational cohort study evaluating the use of drug-coated balloons (DCBs) during percutaneous coronary intervention (PCI) in…
- Trial name
- RW-DCB (NCT07875088)
- Testing
- Coronary Drug-Coated Balloon
- Where
- 5 sites in Mexico, Spain
- Volunteers
- 2,000 people
- Sponsor
- Kristian Rivera
Heart Failure
Management of Acute Heart Failure: Contribution of Ultrasound Daily "in Bed Patient" Adjustment on Therapy With Impact Measure on re Hospital Rate During 30 Days
Our hypothesis: a daily bedside echocardiographic assessment, protocolized, simple and reproducible estimation of filling pressures with an evaluation of mitral inflow and the inferior vena cava, allow a more reliable estimate of…
- Trial name
- JECICA (NCT02892227)
- Testing
- Transmitral flow estimation
- Where
- 2 sites in France
- Volunteers
- 250 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Acute Coronary Syndrom, Chronic Obstructive Pulmonary Syndrom
Pneumological Acute Coronary Syndrom (ACS) Phenotyping Aachen
In this open, monocentric, observational study acute coronary syndrom (ACS) patients will be characterized by pneumological examination concerning a concomitant chronic obstructive pulmonary disease (COPD).
- Trial name
- PAPA (NCT02587481)
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- RWTH Aachen University
Acute Coronary Syndrome
Study of LC23-1306 in Healthy Male Subjects
This will be a dose block-randomized, double-blind, active and placebo controlled, single and multiple dosing, dose-escalation study to evaluate tolerability, safety and pharmacokinetic/pharmacodynamic characteristics.
- Trial name
- NCT01526577
- Testing
- LC23-1306, Ticagrelor
- Where
- South Korea
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- LG Life Sciences
Dyspnea, Heart Failure
Dyspnea and Biomarkers in a Prehospital Setting
In patients presenting with acute dyspnea in a pre-hospital setting, the early and correct diagnosis may present a significant clinical challenge.
- Conditions
- Dyspnea, Heart Failure, Asthma, COPD
- Trial name
- NCT00878475
- Where
- Slovenia
- Volunteers
- 546 people
- Sponsor
- Community Healthcare Center dr. Adolf Drolc Maribor (HCM)
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