Clinical trials: Acute Coronary Disease
ST-segment Elevation Myocardial Infarction (STEMI)
Coronary Aspiration Catheter Clinical Trial
To evaluation of the efficacy and safety of an aspiration catheter in patients undergoing PCI for acute ST-segment elevation myocardial infarction (STEMI).
- Trial name
- NCT06951724
- Testing
- Aspiration Catheter, Export Advance Aspiration Catheter
- Where
- China
- Volunteers
- 144 people
- Sponsor
- BrosMed Medical Co., Ltd
Acute Kidney Injury
Remote Ischemic Preconditioning to Prevent Contrast Nephropathy
Contrast-medium induced nephropathy (CIN) is a frequent and devastating complication of coronary angiography, occurring in 10-50% of cases.
- Trial name
- RIPC-CIN (NCT02674451)
- Testing
- Remote ischemic preconditioning
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Johns Hopkins University
Acute Heart Failure
Early Aldosterone Blockade in Acute Heart Failure: An Exploratory Safety Study
Over one million hospitalizations for acute heart failure (AHF) occur over every year in the United States, resulting in high mortality, re-hospitalizations, and incurred financial costs; yet nearly every attempt over the last 10…
- Trial name
- NCT02299726
- Testing
- Spironolactone
- Sponsor
- Indiana University
Myocardial Infarction
Safety of TG100-115 for Heart Attack Treated With Angioplasty
TG100-115 is able to reduce the size of heart attacks in pre-clinical models. The hypothesis of this study is that TG100-115 can be given safely to patients who suffer a heart attack and undergo angioplasty to restore blood flow.
- Trial name
- NCT00103350
- Testing
- TG100-115
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- TargeGen
Myocardial Injury
Prospective Trial: Acute Myocardial Injury After Radical Prostatectomy
This prospective observational study investigates the incidence of acute myocardial injury after radical prostatectomy for prostate cancer.
- Trial name
- NCT06273735
- Testing
- Pre- and postoperative determination of troponin as part of the study and 24-month FU survey
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- Martini-Klinik am UKE GmbH
Myocardial Infarction
Nitroprusside for Prevention of no-Reflow in Primary Angioplasty
In patients admitted with acute myocardial infarction, there is a total occlusion of a coronary artery. Even after emergency catheterization and angioplasty, in some patients, the resumed blood flow is suboptimal and impacts on…
- Trial name
- NCT00128791
- Testing
- Nitroprusside
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Soroka University Medical Center
Acute Coronary Syndrome, Myocardial Infarction
High-Sensitivity Cardiac Troponin On Presentation to Rule Out Myocardial Infarction
Patients with suspected acute coronary syndrome account for a tenth of all presentations to the Emergency Department and up to 40 per cent of unplanned hospital admissions.
- Trial name
- HiSTORIC (NCT03005158)
- Testing
- Validation Phase, Randomization Phase, Implementation Phase
- Volunteers
- 31,492 people
- Sponsor
- University of Edinburgh
Coronary Thrombosis
In-hospital Clinical Outcome of Deferred Stenting Versus Immediate Stenting in the Management of Acute STEMI Presenting With High Thrombus Burden.
To compare the in hospital clinical outcomes in terms of efficacy and safety of deferred stenting versus non-deferred stenting in STEMI patients with high thrombus burden undergoing primary percutaneous intervention.
- Trial name
- NCT05647018
- Testing
- Primary Percutaneous coronary angiography
- Volunteers
- 440 people
- Sponsor
- Assiut University
Acute Coronary Syndrome, Periodontitis
Neutrophil Elastase, Elastase Alpha-1 Proteinase, Periodontitis, Gingival Crevicular Fluid and Acute Coronary Syndrome
Periodontitis may contribute to vascular damage, resulting in the destabilization of atherosclerotic plaque leading to acute coronary syndrome (ACS).
- Trial name
- NCT04785235
- Testing
- Non-Surgical Periodontal Therapy
- Volunteers
- 43 people
- Sponsor
- Baskent University
Acute Coronary Syndrome, Chest Pain
PARA-HEART Pilot Implementation
Approximately 8-10 million patients complaining of chest pain present to an Emergency Department (ED) annually in the United States.
- Trial name
- PARA-HEART (NCT02709135)
- Where
- United States
- Volunteers
- 511 people
- Sponsor
- Wake Forest University Health Sciences
ACS (Acute Coronary Syndrome), SGLT2 Inhibitors
CCTA Evaluation of SGLT2i-related Pericoronary Fat Changes Patients With Stage 4 CKM Syndrome
The aim of this clinical trial is to investigate whether dapagliflozin (a sodium-glucose cotransporter 2 inhibitor, SGLT2i) can reduce levels of coronary inflammation in patients with stage 4 CKM syndrome.
- Trial name
- DAPA-PCAT (NCT07351643)
- Testing
- Dapagliflozin
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Shenyang Northern Hospital
Acute Respiratory Failure Requiring Reintubation
CPAP Reduces Hypoxemia After Cardiac Surgery
The aim of study is to evaluate whether the application of a continuous positive airway pressure (CPAP) after extubation in patients undergoing cardiac surgery can reduce hypoxemia and re-intubation rate.
- Trial name
- CRHACS (NCT01726140)
- Testing
- Helmet CPAP, Venturi Mask
- Where
- Italy
- Volunteers
- 407 people
- Sponsor
- University of Turin, Italy
Acute Coronary Syndrome, Congestive Heart Failure
Mind-body Interventions in Cardiac Patients
This study is investigating whether a series of psychological exercises, called positive psychology, provides benefit to patients who have been hospitalized for heart disease (an 'acute coronary syndrome' or heart failure).
- Trial name
- NCT01270568
- Testing
- Positive Psychology, Relaxation Response, Recollection
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital
Acute Coronary Syndrome (ACS)
Self-Management Support for Acute Coronary Syndrome Patients After Hospital Discharge
This randomized controlled trial evaluates a "Hospital-to-Home" self-management support model for Acute Coronary Syndrome (ACS) patients, which is based on the integrated COM-B and HAPA theories.
- Trial name
- ACS (NCT07799376)
- Testing
- COM-B and HAPA-based Self-management Support Program, Routine Health Education
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Shortness of Breath, Chest Pain
Checklists Resuscitation Emergency Department
The study will systematically evaluate how an emergency manual-a collection of checklists and fact sheets-affects the performance of resuscitation teams during the management of priority one patients in an emergency department.
- Conditions
- Shortness of Breath, Chest Pain, Abdominal Pain, Altered Mental Status
- Trial name
- NCT05649891
- Testing
- Emergency Manual
- Volunteers
- 2,000 people
- Sponsor
- Region Skane
Heart Failure, Left Bundle-Branch Block
Optimised MultiSite Pacing Vector Study
The objective of this clinical investigation is to evaluate the clinical benefits of an MultiSite pacing (MSP) with patient specific left ventricular vector optimization in patients receiving cardiac resynchronization therapy…
- Conditions
- Heart Failure, Left Bundle-Branch Block, Systolic Dysfunction
- Trial name
- NCT03938090
- Testing
- Optimised MultiSite Pacing, Standard biventricular pacing
- Where
- United Kingdom
- Sponsor
- Barts & The London NHS Trust
Acute Coronary Syndrome, Tobacco Use
Post Acute Cardiac Event Smoking (PACES) Study
Summary of the Project : Quitting smoking following acute coronary syndrome (ACS) can reduce mortality up to 50%. However, depression and smoking are highly co-morbid and depressed mood may interfere with cessation and…
- Trial name
- NCT03413423
- Testing
- BAT-CS, Smoking Cessation and Health & Wellness
- Where
- United States
- Volunteers
- 233 people
- Sponsor
- Hennepin Healthcare Research Institute
Acute Heart Failure
A Phase IIb Study to Investigate the Efficacy and Tolerability of Lower Doses Cinaciguat (25 µg/h, 10 µg/h) Given Intravenously to Patients With Acute Decompensated Chronic Congestive Heart Failure (ADHF)
A placebo controlled, double-blind and randomized study to assess different doses of a new drug (BAY58-2667) given intravenously, to evaluate if it is safe and can help to improve the well-being of patients with acute…
- Trial name
- COMPOSE 2 (NCT01067859)
- Testing
- Cinaciguat (BAY58-2667)
- Where
- 30 sites in United States, Argentina and 7 more
- Volunteers
- 5 people
- Sponsor
- Bayer
Acute Coronary Syndrome, Chest Pain
Coronary CT Angiography for Improved Assessment of Suspected Acute Coronary Syndrome
Current evaluation of patients suspected of non-ST-elevation acute coronary syndrome is greatly dictated by the results of high-sensitivity troponins.
- Trial name
- COURSE (NCT03129659)
- Testing
- Coronary CT Angiography
- Where
- 2 sites in Netherlands
- Volunteers
- 230 people
- Sponsor
- Erasmus Medical Center
Congestive Heart Failure, Medication Adherence
Assay to Measure Beta Blocker Adherence
This study will assess the feasibility and efficacy of using serum assay developed by Quest Diagnostics to detect the presence of beta blockers, specifically carvedilol and metoprolol succinate, in patients with heart failure.
- Trial name
- NCT05251974
- Testing
- Quest beta blocker assay
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Summa Health System
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