Clinical trials: Acute Coronary Disease
Atrial Fibrillation
PRECISION GOLD Post Market Study in Europe of Pulmonary Vein Ablation Catheter (PVAC GOLD)
PRECISION GOLD is a prospective, multi-center, single arm, unblinded interventional post market clinical study conducted in Europe.
- Trial name
- NCT01767558
- Testing
- Ablation / MRI
- Where
- 11 sites in Belgium, France and 4 more
- Volunteers
- 56 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Mitral Regurgitation, Acute Myocardial Infarction
MitraClip in Acute Mitral Regurgitation
Acute MR may develop in the setting of an acute myocardial infarction (AMI) as a result of papillary muscle dysfunction or rupture, and these patients are grossly underrepresented in MitraClip registries.
- Trial name
- NCT03107455
- Testing
- MitraClip
- Volunteers
- 50 people
- Sponsor
- Fundación Investigación Sanitaria en León
Coronary Artery Disease, Acute Coronary Syndrome
South East (Zuid Oost) Netherlands Heart Registry
Rationale: Patients undergoing percutaneous coronary intervention (PCI) for chronic coronary syndrome (CCS) or acute coronary syndrome (ACS) have a residual risk of ischemic events after PCI due to the progression of…
- Conditions
- Coronary Artery Disease, Acute Coronary Syndrome, Chronic Coronary Syndrome
- Trial name
- ZON-HR (NCT06512493)
- Where
- 4 sites in Netherlands
- Volunteers
- 99,999 people
- Sponsor
- Radboud University Medical Center
Acute Coronary Syndrome
Inducing and Relieving Factors of Chest Tightness (Pain) in Patients With Acute Coronary Syndrome
The research aims to investigate various aspects related to chest discomfort (pain) in patients diagnosed with Acute Coronary Syndrome (ACS). Firstly, it seeks to identify the factors that trigger such discomfort in ACS patients.
- Trial name
- ACS (NCT07142733)
- Where
- Taiwan
- Volunteers
- 142 people
- Sponsor
- National Taiwan University Hospital
Heart Diseases, Cardiovascular Diseases
Acute Cardiac Ischemia in Women in the ACI/TIPI Trial
To conduct a series of five inter-related studies on acute cardiac ischemia (ACI) in women.
- Conditions
- Heart Diseases, Cardiovascular Diseases, Angina Pectoris, Myocardial Ischemia
- Trial name
- NCT00005701
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Acute Coronary Syndromes
Pain Relief of Metoprolol Versus Metoprolol Plus Morphine in Acute Chest Pain
The primary aim was to evaluate the relief of chest pain during the first 30 minutes among patients who received metoprolol alone as compared with metoprolol plus morphine
- Trial name
- NCT00718406
- Testing
- Metoprolol, metoprolol plus morphine
- Where
- Sweden
- Sponsor
- Sahlgrenska University Hospital
CABG, Aortic Dissection
CLEAR Trial: CA330 Cytokine Adsorption Column for Anticoagulant/Antiplatelet Patients in Non-Elective CPB Surgery.
The goal of this clinical trial is to evaluate whether the CA330 cytokine adsorption column can reduce perioperative severe bleeding adverse events in patients receiving anticoagulant and/or antiplatelet therapy who undergo…
- Conditions
- CABG, Aortic Dissection, Valvular Heart Diseases
- Trial name
- CLEAR (NCT07284199)
- Testing
- CA330 Cytokine Adsorption Column
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Beijing Anzhen Hospital
Acute Coronary Syndrome, Myocardial Infarction
Clopidogrel and the Optimization of Gastrointestinal Events (COGENT-1)
The purpose of the COGENT-1 clinical trial is to determine whether CGT-2168 (clopidogrel and omeprazole) compared to clopidogrel is safe and effective in reducing the incidence of gastrointestinal bleeding and symptomatic ulcer…
- Conditions
- Acute Coronary Syndrome, Myocardial Infarction, Coronary Artery Disease, Percutaneous Coronary Intervention
- Trial name
- COGENT-1 (NCT00557921)
- Testing
- CGT-2168 (clopidogrel 75 mg/omeprazole 20 mg) and aspirin, Plavix (clopidogrel 75 mg) and aspirin
- Where
- 491 sites in United States, Australia and 14 more
- Volunteers
- 5,000 people
- Sponsor
- Cogentus Pharmaceuticals
Coronary Artery Disease, Acute Myocardial Ischemia
Reduction of Ischemic Myocardium With Ranolazine-Treatment in Patients With Acute Myocardial Ischemia
The aim of the RIMINI-Trial is to examine the effect of Ranolazine on ischemic myocardium in acute myocardial ischemia. A pilot-trial by Venkatamaran et al.
- Trial name
- RIMINI-Pilot (NCT01797484)
- Testing
- Ranolazine
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Acute Coronary Syndrome
Potential Drug Interactions With Bisoprolol in Egyptian Patients With ACS
Acute coronary syndrome (ACS) is any group of clinical symptoms compatible with acute myocardial ischemia and includes unstable angina (UA), non-ST-segment elevation myocardial infarction (NSTEMI), and ST-segment elevation…
- Trial name
- NCT05536284
- Testing
- Bisoprolol Fumarate Tablets
- Where
- Egypt
- Volunteers
- 128 people
- Sponsor
- Damanhour University
ACS - Acute Coronary Syndrome
Positive Psychology for Acute Coronary Syndrome Patients
This is a randomized controlled pilot trial in approximately 50 acute coronary syndrome patients to determine if a 12 week, telephone-delivered, combined positive psychology-motivational interviewing intervention is feasible and…
- Trial name
- PEACE-IV (NCT03122184)
- Testing
- Positive Psychology + Motivational Interviewing, Motivational Interviewing Health Education
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- Massachusetts General Hospital
General Surgery
The GUARDIAN Pilot Trial
The treatments will be: 1) norepinephrine or phenylephrine infusion to maintain intraoperative MAP ≥85 mmHg, delayed resumption of chronic antihypertensive medications, and a target ward MAP ≥80 mmHg (tight pressure management)…
- Trial name
- GUARDIAN (NCT04789733)
- Testing
- Tight pressure management, Routine pressure management
- Where
- China
- Volunteers
- 80 people
- Sponsor
- The Cleveland Clinic
Myocardial Infarction
Efficacy of Early Administration of Clotinab in Acute Myocardial Infarction
The ADMIRAL (Platelet glycoprotein IIb/IIIa inhibition with coronary stenting for acute myocardial infarction) study demonstrated that early administration of abciximab in patients with ST elevation acute myocardial infarction…
- Trial name
- ECLAT-STEMI (NCT00841438)
- Testing
- Clotinab
- Where
- 31 sites in South Korea
- Volunteers
- 786 people
- Sponsor
- Yonsei University
Coronary Artery Disease, Myocardial Infarction
Delayed Plaque Morphology in Patients With STEMI After Thrombus Aspiration During Primary PCI
The purpose of this study is to characterize the plaque morphology in patients with acute STEMI by OCT after aspiration thrombectomy.
- Trial name
- STEMI-OCT (NCT02384824)
- Testing
- Primary Percutaneous Intervention
- Volunteers
- 100 people
- Sponsor
- Jian'an Wang,MD,PhD
Coronary Disease, Acute Coronary Syndrome
Clinical Study Protocol - Debris Interventional Removal in ACS (DESIRE-ACS)
DebriS Interventional REmoval in ACS (DESIRE-ACS) Study to assess the safety and performance of the ECA Bell balloon in subjects undergoing coronary percutaneous interventions.
- Conditions
- Coronary Disease, Acute Coronary Syndrome, Coronary Occlusion
- Trial name
- DESIRE-ACS (NCT02325869)
- Testing
- Bell Balloon Catheter
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Angioslide Ltd.
Acute Decompensated Heart Failure, COPD Exacerbation
Use of ΔIVC for Early Diagnosis of AHF in AECOPD
Acute Heart failure (AHF) is a common cause of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). This association is frequently underestimated with regard to the difficulty of clinical diagnosis.
- Trial name
- NCT05327374
- Testing
- calculation of the inferior vena cava collapsibility index
- Where
- 3 sites in Tunisia
- Volunteers
- 401 people
- Sponsor
- University of Monastir
Coronary Artery Disease, Myocardial Ischemia
BIOFLOW-III Sweden Satellite Registry
This registry is a clinical post-market evaluation of the Orsiro LESS in subjects requiring coronary revascularization with Drug Eluting Stents (DES).
- Trial name
- NCT01667003
- Where
- 8 sites in Sweden
- Volunteers
- 406 people
- Sponsor
- Biotronik ApS
Cardiac Anaesthesia
Cardiac Anesthesia Registry Including Biosignal Database for Prognostication of Postoperative Renal Outcome
AKI(Acute Kidney Injury) is a common complication after cardiac surgery which is associated with increased mortality and morbidity.
- Trial name
- NCT06581289
- Where
- South Korea
- Volunteers
- 10,000 people
- Sponsor
- Yonsei University
Hydroxymethylglutaryl-CoA Reductase Inhibitors, Diabetes Mellitus
Statins in Patients With Type 2 Diabetes Mellitus and Previous History of Acute Coronary Syndrome
The purpose of this study was to compare the efficacy and safety of high dose atorvastatin (40 mg) versus high dose rosuvastatin (20 mg) in Egyptian type II diabetic patients with previous acute coronary syndrome history.
- Trial name
- NCT05306990
- Testing
- Atorvastatin 40 Mg Oral Tablet, Rosuvastatin 20 Mg Oral Tablet
- Where
- Egypt
- Volunteers
- 108 people
- Sponsor
- Helwan University
Ventricular Fibrillation
Acute Feasibility Investigation of a New S-ICD Electrode
This is an early-stage feasibility study. This study seeks to characterize the performance of the new electrode shock configuration with the S-ICD
- Trial name
- ASE (NCT03802110)
- Testing
- commercially released subcutaneous implantable cardioverter defibrillator (S-ICD) and the Investigational S-ICD Adapter.
- Where
- 4 sites in Netherlands
- Volunteers
- 42 people
- Sponsor
- Boston Scientific Corporation