Clinical trials: Acute Coronary Disease
Coronary Artery Disease, Acute Coronary Syndrome
Personalized Vs. Standard Duration of Dual Antiplatelet Therapy and New-generation Polymer-Free vs- Biodegradable-Polymer DES
New-generation metallic drug-eluting stents represent the standard of care among patients undergoing percutaneous coronary intervention (PCI).
- Conditions
- Coronary Artery Disease, Acute Coronary Syndrome, Chronic Coronary Syndrome, Myocardial Infarction
- Trial name
- PARTHENOPE (NCT04135989)
- Testing
- Percutaneous coronary intervention with implantation of amphilimus-eluting stents for coronary artery disease., Percutaneous coronary intervention with implantation of everolimus-eluting stents for coronary artery disease., Personalized DAPT duration
- Where
- 13 sites in Italy
- Volunteers
- 2,106 people
- Sponsor
- Federico II University
Acute Heart Failure (AHF), Congestive Heart Failure(CHF)
Evaluating Residual Congestion at Discharge in Acute Heart Failure Patients
Treatment of congestion is one of the main goals in patients hospitalized for acute heart failure. Nevertheless, current evidence shows that decongestion is often not achieved and that residual congestion at discharge is strongly…
- Trial name
- NCT06993220
- Testing
- Evaluation of residual congestion at discharge
- Where
- Spain
- Volunteers
- 500 people
- Sponsor
- Consorci Sanitari Integral
Acute Coronary Syndromes
CER-001 Atherosclerosis Regression ACS Trial
The purpose of this study is to assess the impact of ten intravenous infusions of 3 mg/kg CER 001 vs. placebo, given at weekly intervals for ten weeks, on atherosclerotic plaque volume as measured by coronary IVUS, when…
- Trial name
- CARAT (NCT02484378)
- Testing
- CER-001
- Where
- 35 sites in United States, Australia and 2 more
- Volunteers
- 301 people
- Sponsor
- Cerenis Therapeutics, SA
Coronary Heart Disease, Acute Coronary Syndrome
Acarbose Cardiovascular Evaluation Trial
The purpose of this study is to determine whether acarbose therapy can reduce cardiovascular-related morbidity and mortality in patients with impaired glucose tolerance (IGT) who have established coronary heart disease (CHD) or…
- Conditions
- Coronary Heart Disease, Acute Coronary Syndrome, Impaired Glucose Tolerance, Type 2 Diabetes Mellitus (T2DM)
- Trial name
- ACE (NCT00829660)
- Testing
- Acarbose
- Where
- 177 sites in China, Hong Kong
- Volunteers
- 6,526 people
- Sponsor
- University of Oxford
Acute Kidney Injury (AKI), Coronary Artery Bypass Graft (CABG)
Effect of Cardiovascular Autonomic Neuropathy on AKI and Outcomes in Isolated CABG Surgery
This study aims to investigate the effects of Cardiovascular Autonomic Neuropathy (CAN) on Acute Kidney Injury (AKI) and clinical outcomes in patients undergoing isolated Coronary Artery Bypass Graft (CABG) surgery requiring…
- Conditions
- Acute Kidney Injury (AKI), Coronary Artery Bypass Graft (CABG), Cardiovascular Autonomic Neuropathy (CAN), Postoperative Outcomes
- Trial name
- CAN-AKI-CABG (NCT07254468)
- Where
- Turkey (Türkiye)
- Volunteers
- 912 people
- Sponsor
- Akdeniz University
Nonobstructive Coronary Artery Disease
Acute Vascular Response to Exercise in Women With Nonobstructive Coronary Artery Disease
The purpose of this study is to examine the acute effect of exercise on vascular function in women with nonobstructive coronary artery disease.
- Trial name
- NCT02450318
- Testing
- Slow-paced walking
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Florida
Heart Failure, Myocardial Infarction
Impact of Intracoronary Injection of Autologous BMMC for LV Contractility and Remodeling in Patients With STEMI
This is multicentre, randomised open-label, controlled, parallel-group phase III study. Its aim is to demonstrate that a triple intracoronary infusion of autologous bone marrow-derived mononuclear cells in addition to state of…
- Trial name
- RACE-STEMI (NCT02323620)
- Testing
- Intracoronary infusion of BM-MC
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- American Heart of Poland
Acute Coronary Syndrome, Sleep Disorder
Eszopiclone and Inflammatory Mediators in Patients With Acute Coronary Syndrome
The purpose of the study is to examine the effects of Eszopiclone, a sleep aid, on inflammatory mediators and coagulability in patients with a recent myocardial infarction.
- Trial name
- NCT00822679
- Testing
- Eszopiclone
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Arizona
Elderly, Homocysteinemia
Perioperative Homocysteine and Postoperative Complications/All-Cause Mortality in Elderly Non-Cardiac Surgery Patients
This study aims to explore the association between perioperative homocysteine (Hcy) levels and their pre-to-postoperative changes with postoperative complications and all-cause mortality in elderly patients undergoing non-cardiac…
- Conditions
- Elderly, Homocysteinemia, AKI - Acute Kidney Injury, Mortality
- Trial name
- NCT06959446
- Volunteers
- 29,156 people
- Sponsor
- Chinese PLA General Hospital
Sepsis, Septic Shock
Central Venous Catheter Colonisation Among Critically Ill Patients in Intensive Care Units
Background: Central Venous catheter insertion technique and indwelling time are major risk factors for CVC colonisation. Colonisation occurs through microbial migration and biofilm formation along the catheter insertion tract.
- Conditions
- Sepsis, Septic Shock, Post-cardiac Surgery, Post-Cardiorespiratory Arrest Coma
- Trial name
- NCT03270774
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Makerere University
Hypotension Symptomatic, Ischemic Heart Disease
A Validation Study of Nitroglycerin Induced Acute Drop of Pd/Pa (NTG-Pd/Pa) in Clinical Practice
Hyperemia with adenosine was an elemental process in FFR examination. Adenosine injection will induce some discomfort, and increase cost expenditure.
- Trial name
- NCT04700397
- Testing
- Nitroglycerine
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital Hsin-Chu Branch
Cardiogenic Shock, Acute Myocardial Infarction
National Cardiogenic Shock Initiative
This study evaluates the use of early mechanical circulatory support in patients presenting with acute myocardial infarction and cardiogenic shock.
- Conditions
- Cardiogenic Shock, Acute Myocardial Infarction, STEMI - ST Elevation Myocardial Infarction, NSTEMI - Non-ST Segment Elevation MI
- Trial name
- NCSI (NCT03677180)
- Where
- 75 sites in United States
- Volunteers
- 406 people
- Sponsor
- Henry Ford Health System
Acute Respiratory Distress Syndrome
Effect of Continuous Anterior Chest Compression on Ventilation/Perfusion Ratio and Hemodynamics
Intro: The mortality of acute respiratory distress syndrome (ARDS) remains high (40%), and may be aggravated by ventilation-induced lung injury (VILI), the main mechanisms of which are: 1. Anterior region overdistension, 2.
- Trial name
- HemodyCACC (NCT06699017)
- Testing
- Continuous anterior chest compression
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Coronary Syndrome, Chest Pain
Use of Visual Decision Aid for Shared Decision Making in Chest Pain
This study aims to evaluate the use of the chest pain choice (CPC) decision aid as a tool to facilitate discussion between the patient and his/her attending physician with regard to subsequent management plans.
- Conditions
- Acute Coronary Syndrome, Chest Pain, Myocardial Infarction, Angina Pectoris
- Trial name
- NCT03674021
- Testing
- Chest Pain Choice visual aid
- Where
- Singapore
- Volunteers
- 18 people
- Sponsor
- National University Hospital, Singapore
Cardiogenic Shock
Effect at 3 Months of Early Empagliflozin Initiation in Cardiogenic Shock Patients on Mortality, Rehospitalization, Left Ventricular Ejection Fraction and Renal Function.
Long term prognosis of cardiogenic shock is related to the resolution of haemodynamic failure, associated visceral failure and the recovery of an adequate myocardial function.
- Trial name
- EMPASHOCK (NCT05879276)
- Testing
- Empagliflozin 10 MG
- Where
- 8 sites in France
- Volunteers
- 164 people
- Sponsor
- Central Hospital, Nancy, France
Acute Myocardial Infarction (AMI)
Dexrazoxane to Protect Against Hemorrhagic STEMI
This Phase Ila trial evaluates whether the intravenous administration of Dexrazoxane can reduce permanent heart muscle damage in patients undergoing standard stent procedures (PCI) for a severe heart attack (STEMI).
- Trial name
- SHIELD-MI (NCT07502521)
- Testing
- Dexrazoxane, Normal Saline
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Rohan Dharmakumar
Cirrhosis, Liver, Acute-On-Chronic Liver Failure
Point-of-Care Echocardiography to Assess Impact of Dynamic Cardiac Function, Renal and Cardiac Biomarkers in Cirrhosis With Refractory Ascites
Point-of-care echocardiography (POC-Echo) is used to determine left ventricular systolic and diastolic dysfunction (LVDD), inferior vena cava (IVC) dynamics and volume status in cirrhosis and Acute-on-chronic liver failure ACLF…
- Conditions
- Cirrhosis, Liver, Acute-On-Chronic Liver Failure, Refractory Ascites, Ascites
- Trial name
- NCT05700708
- Testing
- Echocardiographic assessment
- Where
- India
- Volunteers
- 80 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Cardiac Surgery, Aortocoronary Bypass
Remote Ischemic Preconditioning After Cardiac Surgery
Acute kidney injury (AKI) is a well-recognized complication after cardiac surgery with cardiopulmonary bypass (CPB). The aim of this study is to reduce the incidence of AKI by implementing remote ischemic preconditioning and to…
- Trial name
- RIPCRenal (NCT02997748)
- Testing
- Remote ischemic preconditioning (RIPC)
- Where
- Germany
- Volunteers
- 180 people
- Sponsor
- University Hospital Muenster
Shock, Cardiogenic, Myocardial Infarction
Efficacy Study of LV Assist Device to Treat Patients With Cardiogenic Shock (ISAR-SHOCK)
The purpose of this study is to evaluate the efficacy and safety of a left ventricular assist device in comparison to a standard treatment with an intraaortic balloon pump (IABP) in patients with cardiogenic shock due to left…
- Trial name
- NCT00417378
- Testing
- Left Ventricular Assist Device Impella LP 2.5, Intraaortic Balloon Pump
- Where
- 2 sites in Germany
- Volunteers
- 26 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Acute Coronary Syndrome
Relevance of Plasma PCSK9 Concentration as a Biomarker in Acute Coronary Syndrome.
PCSK9 (Proprotein convertase subtilisin kexin type 9) plays a key role in LDL-cholesterol (LDLC) metabolism by inhibiting LDL receptor (LDLR) at post-transcriptional level.
- Trial name
- PC-SCA-9 (NCT01109706)
- Testing
- biological parameters dosage
- Where
- 2 sites in France
- Volunteers
- 175 people
- Sponsor
- Nantes University Hospital
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