Clinical trials: Acute Coronary Disease
Heart Rate and Rhythm Disorders
Comparison of Diltiazem and Metoprolol in the Management of Acute Atrial Fibrillation or Atrial Flutter
Acute atrial fibrillation is the most common sustained, clinically significant dysrhythmia encountered in the emergency department (ED) and the most common dysrhythmia treated by emergency physicians.
- Trial name
- DiME (NCT01914926)
- Testing
- Metoprolol, Diltiazem
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Antonios Likourezos
Atrial Fibrillation
Performance of QDOT Micro™ Catheter With nGEN Generator for Patients With AFIB.
This workflow study will further evaluate the acute performance and safety of the QDOT MICRO™ catheter in a clinical setting used in combination with nGEN Generator. Subjects will be followed for 7 days post procedure.
- Trial name
- NCT04545619
- Testing
- QDOT MICRO System
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Biosense Webster, Inc.
Myocardial Infarction
Firibastat or Ramipril After Acute Myocardial Infarction for Prevention of Left Ventricular Dysfunction
This is a multicenter, randomized, double-blind, active-controlled, dose-titrating phase 2 study to evaluate the safety and efficacy of firibastat administered orally BID (2 daily doses) versus ramipril administered orally BID…
- Trial name
- QUORUM (NCT03715998)
- Testing
- Ramipril, Firibastat
- Where
- 7 sites in France, Germany and 5 more
- Volunteers
- 295 people
- Sponsor
- Quantum Genomics SA
Acute Kidney Injury
Deferoxamine for the Prevention of Cardiac Surgery-Associated Acute Kidney Injury
Multiple lines of evidence support a central role of iron in causing acute kidney injury (AKI), including the finding that prophylactic administration of iron chelators attenuates AKI in animal models.
- Trial name
- DEFEAT-AKI (NCT04633889)
- Testing
- Deferoxamine, Normal saline
- Where
- 3 sites in United States
- Volunteers
- 320 people
- Sponsor
- Brigham and Women's Hospital
Blood Transfusion Complications
Point-of-Care RBC Washing to Prevent Transfusion-Related Pulmonary Complications
This study is designed to determine if point-of-care washing of allogeneic Leukocyte-Reduced Red Blood Cells reduces pulmonary complications when compared to standard-of-care Leukocyte-Reduced Red Blood Cells in a cardiac…
- Trial name
- NCT02094118
- Testing
- Point-of-care washed red blood cell transfusion., Standard of care red blood cell transfusion.
- Where
- 2 sites in United States
- Volunteers
- 171 people
- Sponsor
- Mayo Clinic
Acute Coronary Syndrome
Rapid Assessment of Potential Ischaemic Heart Disease With CTCA
This study aims to investigate the effect of early CTCA in patients with suspected or confirmed Acute Coronary Syndrome (ACS) presenting to the Emergency Department (ED) or Medical Assessment Unit (MAU), upon interventions, event…
- Trial name
- RAPID-CTCA (NCT02284191)
- Testing
- CT Coronary Angiogram
- Where
- 37 sites in Jersey, United Kingdom
- Volunteers
- 1,749 people
- Sponsor
- University of Edinburgh
Pulmonary Embolism
Selective Pulmonary-artery Intervention to Reduce Acute Right-heart tEnsion-I
This study study is a prospective, single-arm, multicenter study to evaluate the safety and effectiveness of the Vertex Pulmonary Embolectomy System in participants presenting with clinical signs and symptoms of pulmonary…
- Trial name
- SPIRARE I (NCT06571760)
- Testing
- Vertex Pulmonary Embolectomy System
- Where
- 2 sites in Austria, Poland
- Volunteers
- 10 people
- Sponsor
- Neptune Medical
Cardiogenic Shock, Acute Myocardial Infarction
National Cardiogenic Shock Initiative
This study evaluates the use of early mechanical circulatory support in patients presenting with acute myocardial infarction and cardiogenic shock.
- Conditions
- Cardiogenic Shock, Acute Myocardial Infarction, STEMI - ST Elevation Myocardial Infarction, NSTEMI - Non-ST Segment Elevation MI
- Trial name
- NCSI (NCT03677180)
- Where
- 75 sites in United States
- Volunteers
- 406 people
- Sponsor
- Henry Ford Health System
Sleep Disturbance, Insomnia
The SleepWell Study - Chronotherapeutic Intervention to Improve Sleep Following ACS
This two-phase pilot study will test the feasibility of a "combined chronotherapy" (CC) intervention consisting of morning bright light therapy (BLT) and evening blue light blocking (BLB), administered daily for 4 weeks in…
- Conditions
- Sleep Disturbance, Insomnia, Acute Coronary Syndrome
- Trial name
- NCT05299723
- Testing
- BLT Intervention, BLB Intervention, Sleep Hygiene Education
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Columbia University
Acute Pain, Hyperalgesia
IV Acetaminophen as an Adjunct Analgesic in Cardiac Surgery
Patients undergoing cardiac surgery experience significant postoperative pain, which may impact postoperative outcomes. The aim of this single center, double-blind, randomized, placebo controlled trial is to determine if…
- Trial name
- CarDolMev (NCT01544062)
- Testing
- IV acetaminophen
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- University of Washington
Heart Failure
Safety, Pharmacokinetic and Pharmacodynamic Study of COR-1, an Anti-ß1 Receptor Antibody Cyclopeptide
Primary Trial objectives: To evaluate the pharmacokinetics and -dynamics of five strengths of COR-1 (10, 40, 80, 160, 240 mg) in 50 healthy, male volunteers after single intravenous administration (8 subjects on verum per dose…
- Trial name
- COR-1-01 (NCT01043146)
- Testing
- COR-1
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Corimmun GmbH
Acute Coronary Syndrome (ACS)
Improving Medication Adherence Through Graphically Enhanced Interventions in Acute Coronary Syndromes
Coronary heart disease (CHD) is the leading cause of death in the United States. Most people who die from CHD die of a heart attack.
- Trial name
- IMAGE-ACS (NCT00399880)
- Testing
- Health literacy intervention
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Vanderbilt University Medical Center
Acute Myocardial Infarction, Coronary Artery Disease
Myocardial Infarction, COmbined-device, Recovery Enhancement Study
Unplanned readmissions after hospitalization for acute myocardial infarction (AMI) are among the leading causes of preventable morbidity, mortality, and healthcare costs.
- Conditions
- Acute Myocardial Infarction, Coronary Artery Disease, Acute Coronary Syndrome, Myocardial Infarction
- Trial name
- MiCORE (NCT03760796)
- Testing
- Corrie Health Digital Platform
- Where
- 4 sites in United States
- Volunteers
- 200 people
- Sponsor
- Johns Hopkins University
Sleep Apnea
Mapping for Acute Transvenous Phrenic Nerve Stimulation Study
The Mapping for Transvenous Phrenic Nerve Stimulation Study (MAPS) is being conducted to evaluate the feasibility of transvascular stimulation of phrenic nerves via an electrophysiology (EP) catheter advanced into the great veins.
- Trial name
- MAPs (NCT01981590)
- Testing
- Stimulating the phrenic nerve intravenously using high frequency electrical pulses using an EP catheter connected to external pulse stimulator.
- Where
- 2 sites in Netherlands, Sweden
- Volunteers
- 15 people
- Sponsor
- Medtronic BRC
Acute Coronary Syndrome
Plaque Regression and Progenitor Cell Mobilization With Intensive Lipid Elimination Regimen (PREMIER), Phase I
The purpose of this randomized, multi-site, clinical trial is to determine whether intensive therapy consisting of cholesterol-lowering statin drugs plus apheresis to cleanse the blood of low-density lipoprotein (LDL) cholesterol…
- Trial name
- PREMIER (NCT01004406)
- Testing
- intensive LDL-lowering therapy, standard statin monotherapy
- Where
- 2 sites in United States
- Volunteers
- 59 people
- Sponsor
- VA Office of Research and Development
Heart Disease
Vet-Harts Pilot Intervention for Veterans With Coronary Heart Disease
The purpose of this research study is to survey patients to learn about their beliefs and behaviors related to the management of heart disease and to discuss options for making healthy lifestyle changes.
- Trial name
- VHPI (NCT01566214)
- Testing
- Motivational Interview
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- VA Office of Research and Development
Acute Coronary Syndrome
Clopidogrel to Prasugrel in Acute Coronary Syndrome (ACS) Patients
This study will evaluate the use of a prasugrel 60 mg loading dose (LD) administered during percutaneous coronary intervention (PCI) with and without a prior LD of clopidogrel on platelet inhibition in patients presenting with…
- Trial name
- NCT01115738
- Testing
- Prasugrel, Clopidogrel
- Where
- 3 sites in India
- Volunteers
- 282 people
- Sponsor
- Eli Lilly and Company
Coronary Artery Disease
The Dual Antiplatelet Therapy Study (DAPT Study)
The DAPT Study is a double blind randomized controlled trial intended to determine the appropriate duration for dual antiplatelet therapy (the combination of aspirin and a second anti-clotting medication) as well as the safety…
- Trial name
- NCT00977938
- Testing
- Clopidogrel & Aspirin, Prasugrel & Aspirin
- Where
- 256 sites in United States, Australia and 8 more
- Volunteers
- 25,682 people
- Sponsor
- Baim Institute for Clinical Research
Heart Failure
Interleukin (IL)-1 Blockade in Acute Heart Failure (Anakinra ADHF)
Anakinra ADHF is a double-blind randomized clinical trial of anakinra, recombinant human interleukin-1 receptor blocker, or placebo in patients with acute decompensated heart failure with the aim to quench the acute inflammatory…
- Trial name
- NCT01936844
- Testing
- Anakinra (high dose), Anakinra (standard dose)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Virginia Commonwealth University
Myocardial Infarction, Myocardial Infarction, Acute
BIO monitorinG in Patients With Preserved Left ventricUlar Function AfteR Diagnosed Myocardial Infarction
The BIO|GUARD-MI study investigates whether continuous arrhythmia monitoring and the consequent treatment after detected arrhythmias in patients after myocardial infarction with preserved cardiac function, but other risk factors…
- Conditions
- Myocardial Infarction, Myocardial Infarction, Acute, Myocardial Infarction Old
- Trial name
- BIO-GUARD-MI (NCT02341534)
- Testing
- BioMonitor
- Where
- 59 sites in United States, Australia and 12 more
- Volunteers
- 802 people
- Sponsor
- Biotronik SE & Co. KG