Clinical trials: Acute Coronary Syndrome (ACS)
Acute Coronary Syndrome, Myocardial Infarction
Biomarkers in Acute Cardiac Care
The primary aim of the study is to investigate new cardiac biomarkers and algorithms to diagnose acute coronary syndrome in patients with suspected acute myocardial infarction.
- Conditions
- Acute Coronary Syndrome, Myocardial Infarction, Chest Pain
- Trial name
- BACC (NCT02355457)
- Where
- Germany
- Volunteers
- 5,000 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Coronary Stenosis, Acute Coronary Syndrome
Multiomics and Imaging-based Assessment of Vulnerable Coronary Plaques in Acute Coronary Syndromes
The aim of Multiplaque clinical study is to assess the vulnerability degree of the atheromatous plaques, before and after a myocardial infarction (MI), based on multiomics analysis, associated with invasive and non-invasive data.
- Conditions
- Coronary Stenosis, Acute Coronary Syndrome, Acute Myocardial Infarction, Atheromatous Plaques
- Trial name
- MultiPlaque (NCT03391908)
- Testing
- cardiac imaging tests
- Where
- Romania
- Volunteers
- 100 people
- Sponsor
- Cardio Med Medical Center
ASCVD, NSTEMI
Telehealth Group Counseling and Preventive Care for Women
The purpose of this study is to utilize an innovative healthcare delivery strategy via telehealth group counseling sessions to improve engagement, adherence, and ultimately outcomes in female patients with atherosclerotic…
- Conditions
- ASCVD, NSTEMI, STEMI, Coronary Artery Disease
- Trial name
- NCT06404515
- Testing
- Telehealth Group Counseling
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Weill Medical College of Cornell University
Acute Coronary Syndrome, Myocardial Infarction
Future Optimal Research and Care Evaluation
Rationale: Acute coronary syndrome (ACS) is the leading cause of death worldwide. To improve cardiovascular care, research is needed.
- Trial name
- FORCE-ACS (NCT03823547)
- Where
- 4 sites in Netherlands
- Volunteers
- 99,999 people
- Sponsor
- J.M. ten Berg
Acute Coronary Syndrome
Myocardial Infarction Registry
The single-center MIR-registry was created to assess real-world prevalence, demographic characteristics and management of patients with acute coronary syndrome presenting in the emergency department (ED) of University of…
- Trial name
- MIR (NCT06128317)
- Testing
- no intervention is intended.
- Where
- Germany
- Volunteers
- 2,500 people
- Sponsor
- University Hospital Heidelberg
Delirium in Old Age, Delirium in the Intensive Care Unit
Multi-Component Delirium Prevention Bundle in Older Cardiac Intensive Care Unit Patients
The goal of this randomized controlled clinical trial is to learn whether a structured delirium prevention protocol can reduce the occurrence of delirium in older adults admitted to the cardiac intensive care unit (CICU).
- Conditions
- Delirium in Old Age, Delirium in the Intensive Care Unit, Delirium Confusional State, Delirium
- Trial name
- CICUDEL (NCT07776184)
- Testing
- Multicomponent Delirium Prevention Bundle, Control Group
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Tel Aviv Medical Center
Acute Coronary Syndrome
Intensive Lipid Lowering Treatment in Non-ST-elevation Acute Coronary Syndrome (NSTE-ACS) Patients
PCI has been one of the most common choice of treatments for patients with coronary artery disease, and studies indicated that intensive statin treatment before PCI could reduce adverse events as comparing to the placebo.
- Trial name
- ILLEPE-ACS (NCT01040936)
- Testing
- Atorvastatin
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Ischemic Heart Disease, Acute Coronary Syndrome
The Israeli MGuard Registry
the objective of the Israeli MGurad Registry is to evaluate the 'Real World' Clinical Performance of the InspireMD MGuard Coronary Stent System
- Conditions
- Ischemic Heart Disease, Acute Coronary Syndrome, Acute Myocardial Infarction
- Trial name
- NCT00922337
- Testing
- MGuard Coronary Stent system
- Where
- 2 sites in Israel
- Volunteers
- 86 people
- Sponsor
- InspireMD
Low Risk Acute Coronary Syndrome
Low Risk Acute Coronary Syndrome
A large number of patients are diagnosed with low risk ACS, and these individuals are at significant cardiovascular risk. Though guidelines recommend stress testing to manage low risk ACS patients, evidence supporting this…
- Trial name
- LOW ACT (NCT01703156)
- Testing
- Stress Test, No Stress Test
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Oklahoma
Acute Coronary Syndromes (ACS), Hypercholesterolemia
Triple vs Dual Lipid-Lowering Therapy for LDL-C Reduction in Acute Coronary Syndrome
The goal of this clinical trial is to evaluate whether triple lipid-lowering therapy (atorvastatin, ezetimibe, and bempedoic acid) is more effective than dual therapy (atorvastatin and ezetimibe) in reducing LDL cholesterol…
- Trial name
- TLD-ACS (NCT07508254)
- Testing
- Atorvastatin 40 Mg Oral Tablet, Ezetimibe 10 mg, Bempedoic Acid 180 MG Oral Tablet
- Where
- Pakistan
- Volunteers
- 120 people
- Sponsor
- Punjab Institute of Cardology
Non-valvular Atrial Fibrillation, Acute Coronary Syndrome
Rivaroxaban in Patients With Atrial Fibrillation Undergoing PCI
This study evaluates the antithrombotic therapy in patients suffering from atrial fibrillation after stent implantation in Germany.
- Conditions
- Non-valvular Atrial Fibrillation, Acute Coronary Syndrome, Percutaneous Coronary Intervention, Antithrombotic Therapy
- Trial name
- RIVA-PCI (NCT03315650)
- Where
- 13 sites in Germany
- Volunteers
- 1,632 people
- Sponsor
- IHF GmbH - Institut für Herzinfarktforschung
ACS (Acute Coronary Syndrome), Young Adults
Clinical Features and Long-Term Prognosis in Young Patients With Acute Myocardial Infarction
The incidence of acute myocardial infarction (AMI) in young patients is on the rise, placing a heavy health and economic burden on individuals, families, and society.
- Trial name
- AMI-Youth (NCT07128667)
- Volunteers
- 200 people
- Sponsor
- China-Japan Friendship Hospital
Acute Coronary Syndrome, Procedural Complication
Decrease Artery Occlusion by Distal Radial Arterial Cannulation in ACS Patients
The site of arterial access for coronary angiography and intervention has been the focus of research for decades as it is the source of major complications.
- Trial name
- DONATION (NCT05255939)
- Testing
- distal TRA group, conventional TRA group
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Shenzhen People's Hospital
Acute Coronary Syndrome
Class IV Laser Therapy on Ejection Fraction, Cardio Biomarkers and Functional Outcomes
A total of 60 Individuals with Acute coronary Syndrome who underwent angioplasty with or without stent will be recruited by purposive sampling method in a randomized double-blinded sham controlled trial.
- Trial name
- NCT05160519
- Testing
- Class IV Laser
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Asir John Samuel
A Total of 234 Patients With Acute Coronary Syndrome Who Will Undergo OPCAB.
Impact of High-dose Pretreatment of Rosuvastatin in Patients With Acute Coronary Syndrome Following Off-pump Coronary Artery Bypass: Results From the HIROP-ACS (HIgh-dose Pretreatment of Rosuvastatin During Off-Pump Coronary Bypass in Acute Coronary Syndrome) Study
Periprocedural treatment with high-dose statins is known to have cardioprotective and pleiotropic effects, such as anti-thrombotic and anti-inflammatory actions.
- Trial name
- NCT01971606
- Testing
- Rosuvastatin
- Where
- South Korea
- Volunteers
- 234 people
- Sponsor
- Yonsei University
Myocardial Infarction (MI), Acute Coronary Syndromes (ACS)
A Clinical Trial to Demonstrate the Efficacy of Cangrelor
The primary objective of this study is to demonstrate that the efficacy of cangrelor is superior, or at least non-inferior, to that of clopidogrel in subjects requiring PCI.
- Trial name
- PCI (NCT00305162)
- Testing
- Cangrelor (P2Y12 inhibitor), clopidogrel (oral P2Y12 inhibitor)
- Where
- United States
- Volunteers
- 8,882 people
- Sponsor
- The Medicines Company
Coronary Artery Disease
The TEACH (Texting After ACS Discharge) Pilot Randomized Trial
Although there have been substantial advances in the treatment of heart disease, heart attacks remain one of the leading causes of death and suffering around the world.
- Trial name
- NCT05628337
- Testing
- Motivational texting, Control
- Where
- Canada
- Volunteers
- 241 people
- Sponsor
- Sunnybrook Health Sciences Centre
Diabetes Mellitus, Acute Coronary Syndrome
The POST-ACS Study
Individuals with T2DM have a two-fold excess risk of cardiovascular (CV) events compared with their non-diabetic counterparts. Although it is the primary cause of death in T2DM, there is no significant evidence that intensive…
- Conditions
- Diabetes Mellitus, Acute Coronary Syndrome, Coronary Artery Disease
- Trial name
- NCT05322200
- Testing
- A computerized tomography (CT) coronary angiogram, Vicorder (Skidmore medical, UK), Blood tests for inflammation and oxidative stress markers
- Where
- United Kingdom
- Volunteers
- 140 people
- Sponsor
- Swansea Bay University Health Board
Acute Coronary Syndrome, Chest Pain
Cost Comparison of Cardiac Magnetic Resonance Imaging (MRI) Use in Emergency Department (ED) Patients With Chest Pain
The purpose of this study is to investigate the best way to evaluate patients with chest pain in the emergency department. It compares receiving treatment in an observation unit with admission to the hospital.
- Trial name
- NCT00678639
- Testing
- Observation unit care, coupled with cardiac MRI
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Wake Forest University Health Sciences
Coronary Disease, Hypercholesterolemia
Japan Assessment of Pitavastatin and Atorvastatin in Acute Coronary Syndrome (JAPAN-ACS)
The purpose of this study is to compare the effects of pitavastatin and atorvastatin on coronary plaque volume in patients with acute coronary syndrome and to clarify the relationship between coronary plaque volume, serum lipids…
- Trial name
- NCT00242944
- Testing
- Pitavastatin, Atorvastatin
- Where
- 3 sites in Japan
- Volunteers
- 307 people
- Sponsor
- Kyoto University