Clinical trials: Acute Coronary Syndromes
Chronic Coronary Syndrome, Coronary Artery Disease
Feasibility of a Deep Learning-based Algorithm for Non-invasive Assessment of Vulnerable Coronary Plaque
The primary objective of this study is to assess the accuracy in terms of sensitivity, specificity, negative and positive predicted values of the DL-based algorithm with respect to correct identification of the plaque and…
- Conditions
- Chronic Coronary Syndrome, Coronary Artery Disease, Stable Angina, Acute Coronary Syndrome
- Trial name
- FOCUS DL (NCT06186336)
- Testing
- Deep Learning-based Vulnerable Plaque Detection and Assessment Tool
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- GE Healthcare
Acute Coronary Syndrome
A2 AR as a Novel Biomarkers for Physician Decision-making Improvement Evaluation's Patients With Suspected Acute Coronary Syndrome But Negative Troponin.
One proposed strategy is the stratification of troponin-negative patients with biomarker testing at presentation to facilitate the clinically-appropriate rapid discharge from the emergency department of patients who present with…
- Trial name
- NCT03218007
- Testing
- blood samples
- Where
- France
- Volunteers
- 83 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Depression, Acute Coronary Syndrome
The Effect of MElatonin on Depression, Anxiety, CIrcadian and Sleep Disturbances in Patients After Acute Myocardial Syndrome
The objective of the study is to investigate whether prophylactic treatment with melatonin has an effect on depressive symptoms. Secondarily melatonin's effect on anxiety, sleep and circadian disturbances will be investigated.
- Trial name
- MEDACIS (NCT02451293)
- Testing
- Melatonin (N-acetyl-5-methoxytryptamine)
- Where
- 6 sites in Denmark
- Volunteers
- 252 people
- Sponsor
- Zealand University Hospital
Acute Coronary Syndrome, Chronic Heart Failure
Influenza Vaccination During Coronavirus Disease 2019 Outbreak After Acute Coronary Syndrome and Chronic Heart Failure
Study Description: Background: Well-known fact that the number of cardiovascular diseases is on the rise during influenza epidemic.
- Trial name
- IV-ACS&CHF (NCT05232292)
- Testing
- Ultrix Quadri
- Where
- Russia
- Volunteers
- 200 people
- Sponsor
- Samara Regional Cardiology Dispensary
Acute Coronary Syndrome
Suxiao Jiuxin Pills in Microvascular Obstruction in Patients With Acute Coronary Syndrome
Microvascular obstruction is the severe complication of percutaneous coronary intervention (PCI) in patients with acute coronary syndrome. Microvascular obstruction after PCI is often association with poor prognosis.
- Trial name
- NCT04814121
- Testing
- Suxiao Jiuxin Pills
- Volunteers
- 198 people
- Sponsor
- Guangzhou University of Traditional Chinese Medicine
Acute Coronary Syndromes
Evaluation of the Role of Brain Natriuretic Peptide in Acute Coronary Syndrome .
The measurements of the natriuretic peptide are useful and beneficial for risk stratification irrespective of the cause during admission time or during hospital stay course.
- Trial name
- NCT06734416
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Acute Coronary Syndrome
Safety and Tolerability of Sodium Thiosulfate in Patients With an ACS Undergoing CAG Via Trans-radial Approach.
The purpose of this trial is to evaluate the safety and maximum tolerable dose (MTD) of sodium thiosulfate in patients presenting with an acute coronary syndrome and treated with primary percutaneous coronary intervention (PPCI)…
- Trial name
- SAFE-ACS (NCT03017963)
- Testing
- Sodium Thiosulfate Pentahydrate
- Where
- Netherlands
- Volunteers
- 18 people
- Sponsor
- University Medical Center Groningen
Polyvascular Disease, Atherosclerosis
Clinical Register Studying the therApeutic Patient Population With Multifocal Atherosclerosis
Аn international, multicenter, non-interventional real-life clinical practice Register studying the Actual therapeutic patient population with Multifocal Atherosclerosis in the Russian Federation and Eurasian countries
- Conditions
- Polyvascular Disease, Atherosclerosis, Atherosclerosis Generalized, Cardiovascular Diseases
- Trial name
- KAMMA (NCT05189847)
- Where
- Russia
- Volunteers
- 3,059 people
- Sponsor
- Eurasian Association of Therapists
Obstructive Sleep Apnea of Adult, Acute Coronary Syndrome
OSA-ACS Project: Association of OSA and CPAP Therapy With Outcomes in ACS Patients
Obstructive sleep apnea (OSA) is an increasingly common chronic disorder in adults that has been strongly associated with various forms of cardiovascular disease.
- Trial name
- NCT03362385
- Testing
- Patients with OSA based on sleep study, Patients without OSA based on sleep study
- Where
- China
- Volunteers
- 2,160 people
- Sponsor
- Beijing Anzhen Hospital
Coronary Artery Diseases
Comparison of 18-F Sodium Fluoride Uptake in Culprit Plaques Between Acute Coronary Syndrome and Stable Angina
The purpose of this study is to evaluate the correlations between active calcification and vulnerable plaque.
- Trial name
- NCT01665248
- Testing
- 18-F Sodium Fluoride Uptake in Positron emission tomography
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- CHEOL WHAN LEE, MD, PhD.
Acute Coronary Syndrome
Diagnostic Performance of Coronary Calcification Detection on CT Scan
thoracic pain is one of the most frequent reasons for consulting the emergency room. Chest pain can be a sign of different pathologies with a wide range of severity, from life-threatening aortic dissection or myocardial…
- Trial name
- Calci-DT (NCT05538117)
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Strasbourg, France
Myocardial Infarction, Acute Coronary Syndrome
Pleiotropic Effects of Dapagliflozin in Patients With Acute Coronary Syndromes
Type 2 diabetes mellitus (T2DM) is one of the most important risk factors for atherosclerotic heart disease. Strategies focused solely on glycemic control have failed to demonstrate vascular events reduction in this population.
- Conditions
- Myocardial Infarction, Acute Coronary Syndrome, Diabetes, Ventricular Dysfunction
- Trial name
- NCT06286878
- Testing
- Dapagliflozin
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- University of Sao Paulo
Cardiac Arrest, Acute Coronary Syndrome
Mild Therapeutic Hypothermia for Patients With Acute Coronary Syndrome and Cardiac Arrest Treated With PCI
Mild Therapeutic Hypothermia for Patients with Acute Coronary Syndrome and Cardiac Arrest Treated with Percutaneous Coronary Intervention (UNICORN) study is designed to determine whether mild therapeutic hypothermia (MTH) applied…
- Trial name
- UNICORN (NCT02611934)
- Testing
- Mild Therapeutic Hypothermia (MHT)
- Where
- Poland
- Volunteers
- 90 people
- Sponsor
- Jacek Kubica
Acute Coronary Syndrome, STEMI
Efficacy and Safety of Individualized P2Y12 Receptor Antagonists Treatment Based on Agregometry Versus Fixed Dose Regimen in Patients After Acute Myocardial Infarction
The specific goal of this study is to determine whether the individualized approach and adjusting the dosage of the P2Y12 receptor inhibitors will improve the platelet inhibiton and the clinical outcome in patients with an ACS…
- Conditions
- Acute Coronary Syndrome, STEMI, NSTEMI - Non-ST Segment Elevation MI, PLATELET AGGREGATION
- Trial name
- SPARELIFE (NCT04369534)
- Testing
- Clopidogrel, Ticagrelor
- Where
- Croatia
- Volunteers
- 120 people
- Sponsor
- University of Zagreb
Acute Coronary Syndromes
Multicenter Real-World Cohort Study Evaluating the Impact of Early Intensive Lipid-Lowering Therapy on the Prognosis of Acute Coronary Syndrome Patients(ELITE-ACS)
The purpose of this clinical trial is to evaluate the impact of early initiation of PCSK9 inhibitor therapy for intensive lipid-lowering in Chinese patients with acute coronary syndrome (ACS) during hospitalization on the rate of…
- Trial name
- ELITE-ACS (NCT06738758)
- Testing
- PCSK9 inhibitor, Statin+Ezetimibe/Hybutimibe compound, Statin
- Where
- China
- Volunteers
- 6,000 people
- Sponsor
- Yun Dai Chen
Acute Coronary Syndromes (ACS)
Effect of Guided Imagery on Sleep Quality, State Anxiety, and Comfort in Patients With Acute Coronary Syndrome
The goal of this randomized controlled trial is to determine whether guided imagery, when added to routine care, can reduce state anxiety and improve sleep quality and comfort in adults with acute coronary syndrome who are being…
- Trial name
- NCT07794358
- Testing
- Guided Imagery
- Volunteers
- 64 people
- Sponsor
- Afyonkarahisar Health Sciences University
Cardiorenal Syndrome
Sodium-Glucose Cotransporter-2 Inhibitor for Acute Cardiorenal Syndrome: A Feasibility Study
The long-term objective of this study is to test whether the addition of SGLT2 inhibitors to usual care during acute heart failure management in patients who develop kidney injury shortens the time to achieving symptomatic…
- Trial name
- SGLT2i in CRS (NCT06111768)
- Testing
- Dapagliflozin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Yale University
Acute Decompensated Heart Failure (ADHF), Cardiorenal Syndrome (CRS)
Clinical Outcomes of Levosimendan Versus Dobutamine Versus Milrinone in Cases With Acute Decompensated Heart Failure With Impaired Renal Function
This study aimed to assess and compare the cardiac, renal, and clinical efficacy of Levosimendan (LEV), Dobutamine (DOB), and milrinone (MIL) in cases with acute decompensated heart failure (ADHF) complicated by renal impairment…
- Trial name
- NCT07186062
- Testing
- Levosimendan, Dobutamine, Milrinone
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Acute Coronary Syndrome, Coronary Artery Stenosis
Use of Magnetocardiography in Evaluation of Patients Going for Cardiac Catheterization
This is a multicenter, prospective trial to measure the test performance characteristics of the Magnetocardiography (MCG) CardioFlux cardiac diagnostic system in detecting clinically significant coronary artery obstruction in…
- Conditions
- Acute Coronary Syndrome, Coronary Artery Stenosis, Myocardial Ischemia
- Trial name
- NCT04044391
- Testing
- CardioFlux Magnetocardiograph
- Where
- 2 sites in United States
- Volunteers
- 101 people
- Sponsor
- Genetesis Inc.
Atherosclerosis and Blood Flow in Coronary Artery
Geometrical Influences on Atherosclerosis and Blood Flow
The study investigates the use of advanced imaging techniques and computational methods to identify high-risk plaques in coronary arteries.
- Trial name
- NCT07002697
- Where
- Bangladesh
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Bangladesh University of Engineering and Technology
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