Clinical trials: Acute Decompensated Heart Failure
Acute Decompensated Heart Failure
Cardionomic STOP-ADHF Study
STOP-ADHF Study: An evaluation of the safety and performance of the Cardionomic Cardiac Pulmonary Nerve Stimulation (CPNS) system in patients with acute decompensated heart failure.
- Trial name
- NCT04814134
- Testing
- CPNS Therapy, Standard of care
- Where
- 15 sites in United States, Belgium and 2 more
- Volunteers
- 59 people
- Sponsor
- Cardionomic Inc.
Acute Heart Failure
Rivaroxaban Once Daily Versus Dose-adjusted Vitamin K Antagonist on the Biomarkers in Acute Decompensated Heart Failure and Atrial Fibrillation (ROAD HF-AF)
Vitamin K antagonists (VKAs) are used to reduce the risk of stroke (cerebral vascular dysfunction) in AF patients. However, VKAs interact with drugs/food and the drug level is influenced by worsening of renal function, liver…
- Trial name
- NCT03490994
- Testing
- Rivaroxaban, Warfarin + LMWH
- Where
- South Korea
- Volunteers
- 150 people
- Sponsor
- Yonsei University
Chronic Heart Failure
Safety and Efficacy Study of YM087 (Conivaptan) in Patients With Acute Decompensated Heart Failure
This is a randomized, double-blind, placebo-controlled, dose ranging pilot study to examine the effects of conivaptan in patients with acute decompensated heart failure.
- Trial name
- NCT00057356
- Testing
- conivaptan
- Where
- 26 sites in United States
- Volunteers
- 170 people
- Sponsor
- Cumberland Pharmaceuticals
Congestive Heart Failure
A Prospective, Single-center, Randomized, Controlled, Open-label, Pilot Study to Compare the Effectiveness and Safety of DIuretics Add-On Strategy in Acute Decompensated Heart Failure Patients (DIOS II)
To compare the effectiveness and safety of diuretics add-on strategy in chronic heart failure patients
- Trial name
- NCT02047422
- Testing
- Furosemide, metolazone, furosemid/spironolactone
- Sponsor
- Yonsei University
Heart Failure
B-line by Lung US in Patients With Acute Decompensated Heart Failure
The purpose of this study is to evaluate that B-line detected by lung ultrasound before extubation in patients with acute decompensated heart failure can predict future risk of reintubation and clinical outcomes during admission…
- Trial name
- NCT04322851
- Testing
- Lung ultrasound
- Where
- South Korea
- Volunteers
- 300 people
- Sponsor
- Asan Medical Center
Cardiorenal Syndrome, Acute Kidney Injury
Effect on Kidney Function Recovery Guiding Decongestion With VExUS in Patients With Cardiorenal Syndrome 1
During cardiorenal syndrome type 1 (CRS1) vascular congestion is the major contributor to worsening renal function, but promoting decongestion with routine clinical evaluation is ineffective in some patients.
- Conditions
- Cardiorenal Syndrome, Acute Kidney Injury, Decompensated Heart Failure, Fluid Overload
- Trial name
- NCT05927285
- Testing
- Vexus, Control group
- Where
- Mexico
- Volunteers
- 140 people
- Sponsor
- Hospital Civil de Guadalajara
Decompensated Chronic Heart Failure, Heart Failure NYHA Class III
Epidemiology and Prognostic of the Acute Heart Failure
EPICAL 2 (Epidemiology and prognostic of the Acute Heart Failure) is an epidemiological, observational, prospective and multicenter study.
- Conditions
- Decompensated Chronic Heart Failure, Heart Failure NYHA Class III, Acute Pulmonary Edema, Cardiogenic Shock
- Trial name
- EPICAL2 (NCT02880358)
- Where
- France
- Volunteers
- 2,500 people
- Sponsor
- Central Hospital, Nancy, France
Heart Failure, Diabetes
Thiamine and Acute Decompensated Heart Failure: Pilot Study
Heart failure remains an increasing cause of morbidity and mortality in the United States even in the face of recent advances in the treatment of cardiovascular disease.
- Trial name
- NCT00680706
- Testing
- Thiamine
- Where
- 2 sites in United States
- Volunteers
- 131 people
- Sponsor
- Baystate Medical Center
Acute Heart Failure
Intravenous Vasodilator vs. Inotropic Therapy in Patients With Heart Failure
Single center, prospective, randomized, non-blinded research study comparing intravenous vasodilator infusion vs. inotropic infusion in patients admitted to the hospital or in the emergency room at Montefiore Medical Center…
- Trial name
- PRIORITY-ADHF (NCT02767024)
- Testing
- Sodium nitroprusside, Dobutamine, Furosemide
- Where
- United States
- Sponsor
- Montefiore Medical Center
Acute Decompensated Heart Failure
Fluid Management of Acute Decompensated Heart Failure Subjects Treated With Reprieve Decongestion Management System (DMS)
The objective of this study is to prospectively compare decongestive therapy administered by the Reprieve DMS system to Optimal Diuretic Therapy (ODT) in the treatment of patients diagnosed with acute decompensated heart failure…
- Trial name
- FASTR (NCT05174312)
- Testing
- Reprieve Decongestion Management System, Diuretic
- Where
- 16 sites in United States
- Volunteers
- 100 people
- Sponsor
- Reprieve Cardiovascular, Inc
Acute Decompensated Heart Failure
Compression Therapy of the Lower Limbs in Patients With Decompensated Heart Failure
Randomized 1:1 multicenter double-blind clinical investigation evaluating the efficacy and safety of compression therapy of the lower limbs plus parenteral administration of diuretics vs.
- Trial name
- NCT06418932
- Testing
- UrgoK2 / UrgoK2 Lite, Controll
- Where
- 8 sites in Spain
- Volunteers
- 106 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Heart Failure, Dyspnea; Cardiac
Diagnostic Potential of UCHL1 in Acute Decompensated Heart Failure
Autophagy is considered an important component of Heart failure progression. Deubiquitination enzymes play an important role in autophagy. An important regulatory process within the autophagy pathway is ubiquitination.
- Trial name
- NCT04999995
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- VA Office of Research and Development
Heart Failure, Congestive
A Study of Ularitide in the Treatment of Subjects With Acute Decompensated Heart Failure
To determine the maximum tolerated dose (MTD) of ularitide in the treatment of subjects hospitalized with symptomatic acute decompensated heart failure (ADHF).
- Trial name
- NCT00487799
- Testing
- Ularitide
- Where
- 8 sites in United States
- Volunteers
- 32 people
- Sponsor
- Facet Biotech
Acute Decompensated Heart Failure (ADHF)
The Effect of Dapagliflozin on Patients With Cardiomyopathy
This randomized controlled trial evaluates the efficacy and tolerability of early initiation of dapagliflozin in adult patients hospitalized with acute heart failure (AHF).
- Trial name
- Dapagliflozin (NCT07076615)
- Testing
- Dapagliflozin (DAPA), Diuretic
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- May Mohamed Abdalla
Acute Decompensated Heart Failure, Heart Failure
The Influence of Beta Blocker Therapy on the Hemodynamic Response to Inotrope Infusion in Patients With Acute Decompensated Heart Failure
Purpose: To compare the hemodynamic effects of dobutamine and milrinone in hospitalized patients who are receiving Beta Blocker Participants: Patients who are admitted to the General Cardiology and Heart Failure Services at the…
- Trial name
- NCT01971944
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of North Carolina, Chapel Hill
Heart Failure
Ultrasound Evaluation of the IVC in Addition to Clinical Assessment to Guide Decongestion in ADHF
CAVA-ADHF is designed as a prospective, randomized, controlled, patient-blinded, multicenter, parallel-group trial. The objective is to test whether evaluation of the inferior vena cava diameter in addition to clinical assessment…
- Trial name
- CAVA-ADHF (NCT03140566)
- Testing
- Ultrasound evaluation of the inferior vena cava diameter
- Where
- Germany
- Volunteers
- 388 people
- Sponsor
- University of Luebeck
Chronic Heart Failure, Fluid Overload
Naturally Controlled Decongestion Using Renal Independent System in ADHF Patients, a European Registry
The AquaPass is a non-invasive, renal-intended system designed to enhance fluid transfer through the skin, by increasing sweat rate, to treat fluid overload in heart failure patients.
- Conditions
- Chronic Heart Failure, Fluid Overload, Acute Decompensated Heart Failure, Edema
- Trial name
- REFORM-HF II (NCT06401109)
- Testing
- AquaPass
- Volunteers
- 30 people
- Sponsor
- AquaPass Medical Ltd.
Heart Failure
Validity of Scales to Assess Severity in Acute Heart Failure
The scales measuring the severity of acute decompensate heart failure (ADHF) in emergency departments have not achieved an adequate discriminative ability for decision making.
- Trial name
- AHFRS (NCT02437058)
- Testing
- preidictive model
- Volunteers
- 1,854 people
- Sponsor
- Hospital Galdakao-Usansolo
Acute Decompensated Heart Failure
Efficacy and Safety of Ularitide for the Treatment of Acute Decompensated Heart Failure
The purpose of this study is to evaluate the efficacy and safety of a continuous intravenous (IV) ularitide infusion on the clinical status and outcome of patients with acute decompensated heart failure (ADHF).
- Trial name
- TRUE-AHF (NCT01661634)
- Testing
- Ularitide
- Where
- 163 sites in United States, Argentina and 20 more
- Volunteers
- 2,157 people
- Sponsor
- Cardiorentis
Chronic Heart Failure, Acute Decompensated Heart Failure
PREcision meDICine in Treatment in CardioVascular Disease
The main goal of PREDICT-CVS is to demonstrate that a personalized, AI-derived biomarker-guided medication treatment algorithm that provides advice to the treating professional is superior to prevent clinical events and improve…
- Trial name
- PREDICT-CVD (NCT07369141)
- Testing
- ASSIST-HF AI- algorithm, Standard of Care (Investigator Choice)
- Where
- 4 sites in Netherlands
- Sponsor
- Maastricht University Medical Center