Clinical trials: Acute Decompensated Heart Failure, open to volunteers
Acute Decompensated Heart Failure (ADHF)
Evaluation of FlowMod System While Intermittently Partially Occluding Vena Cava Blood Flow in Subjects With ADHF
FLOW-HF will assess the impact of intermittent partial occlusion of the SVC and/or IVC, the cardiac filling pressure and the difference of effects between the two occlusion locations (SVC and IVC) using the FlowMod flow…
- Trial name
- FLOW-HF (NCT07810335)
- Testing
- FlowMod System in subjects with acute decompensated heart failure (ADHF)
- Where
- 4 sites in Georgia, Uzbekistan
- Volunteers
- 30 people
- Sponsor
- FlowMod, Inc.
Acute Decompensated Heart Failure, Acute Myocardial Infarction
Using an Intervention Adapted to the Health Literacy Level to Improve Adherence to Medical Recommendations
Health literacy is the ability to access, understand, evaluate and apply information in order to communicate with health professionals and understand health instructions but also, promote, maintain and improve health throughout…
- Trial name
- ILIADE (NCT03951467)
- Testing
- Interventional educational toolkit specific to low Health Literacy patients, designed with patients and health professionals.
- Where
- 4 sites in France
- Volunteers
- 300 people
- Sponsor
- Hospices Civils de Lyon
Acute Heart Failure (AHF)
Early Gliflozin for Elderly Patients With Acute Decompensated Heart Failure in the Emergency Department
Background: SGLT2 inhibitors reduce CHF morbidity/mortality but are underutilized in elderly patients with acute decompensated CHF (ADCHF) admitted outside cardiology departments.
- Trial name
- GlifloFastER (NCT07392788)
- Testing
- Early initiation of dapagliflozin 10mg daily within 24h of emergency department admission, Telephone follow-up by cardiac nurse practitioner at 1 month, Standard acute decompensated heart failure care
- Volunteers
- 144 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Cardiogenic Shock, Acute Myocardial Infarction
Clinical Evaluation of NIRSense Tissue Oximetry Sensor Monitoring to Early Detect Cardiogenic Shock
This is a prospective, single-center, observational pilot study of the investigational NIRSense Tissue Oximetry Sensor System (Envello Core), a noninvasive wearable sensor patch that uses near-infrared spectroscopy (NIRS) and…
- Conditions
- Cardiogenic Shock, Acute Myocardial Infarction, Acute Decompensated Heart Failure
- Trial name
- NCT07825363
- Testing
- NIRSense Tissue Oximetry Sensor System
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- NIRSense Inc.
Acute Decompensated Heart Failure (ADHF)
Levosimendan in Acute Decompensated Heart Failure
Acute decompensated heart failure (ADHF) is one of the major causes of hospitalization and mortality worldwide. Despite advances in medical treatments, managing ADHF remains complex, especially in high-risk populations.
- Trial name
- NCT07262723
- Testing
- Levosimendan, Standard care
- Where
- 6 sites in Bangladesh
- Volunteers
- 332 people
- Sponsor
- Chittagong Medical College
Acute Heart Failure With Reduced Ejection Fraction, Decompensation; Heart, Congestive
The FOCUS-ADHF Registry
Acute heart failure (AHF) represents a significant clinical and economic burden due to its impact on patients' quality of life, poor prognosis, and high healthcare costs.
- Conditions
- Acute Heart Failure With Reduced Ejection Fraction, Decompensation; Heart, Congestive, Regurgitation, Mitral
- Trial name
- FOCUS-ADHF (NCT06726109)
- Where
- 4 sites in Belgium, Italy
- Volunteers
- 600 people
- Sponsor
- ASL Città di Torino
Heart Failure, Acute Decompensated Heart Failure
Early Discharge With Subcutaneous Furosemide Versus Standard Care in Acute Heart Failure
This will be a prospective, cluster-randomized, crossover, non-inferiority trial of 250 participants within 48 hours of an inpatient admission for heart failure or emergency department presentation for heart failure with plans…
- Trial name
- NCT07018297
- Testing
- Early Discharge with Lasix® ONYU (furosemide injection, for subcutaneous use) using SQIN-Infusor
- Where
- 2 sites in United States
- Volunteers
- 250 people
- Sponsor
- University of Texas Southwestern Medical Center
Acute Decompensated Heart Failure, Heart Failure, Diastolic
Comparative Efficacy and Safety of Acetazolamide Versus Metolazone as an Adjunct to Standard Therapy in Patients With Acute Decompensated Heart Failure
This clinical trial aims to compare the efficacy and safety of acetazolamide versus metolazone as adjunctive treatments to standard therapy in patients with acute decompensated heart failure (ADHF).
- Conditions
- Acute Decompensated Heart Failure, Heart Failure, Diastolic, Heart Failure, Systolic
- Trial name
- NCT07199088
- Testing
- Acetazolamide, Metolazone
- Where
- Pakistan
- Volunteers
- 320 people
- Sponsor
- University of Health Sciences Lahore
Cardiogenic Shock
Clinical Effects of Intra-aortic Balloon Support in Early Acute Coronary Syndrome and Non-Acute Coronary Syndrome Related Cardiogenic Shock
The goal of this randomized controlled trial is to appraise the impact of intra-aortic balloon pump (IABP) in the treatment of early stages of cardiogenic shock, irrespective of etiology.
- Trial name
- IABP ON-TIME (NCT06414187)
- Testing
- Intra-Aortic Balloon Pump
- Where
- Netherlands
- Volunteers
- 400 people
- Sponsor
- Erasmus Medical Center
Acute Heart Failure (AHF)
Restrictive Versus Liberal Fluid Intake in Acute Decompensated Heart Failure
The aim of this clinical trial is to learn whether a thirst-driven, liberal fluid-intake strategy is comparable to a fluid-restriction strategy in patients hospitalized for acute decompensated heart failure (ADHF).
- Trial name
- RELIEF-AHF (NCT07400991)
- Testing
- Fluid restriction strategy, Thirst-driven, liberal fluid intake
- Where
- Denmark
- Volunteers
- 420 people
- Sponsor
- Gødstrup Hospital
Acute Heart Failure (AHF), Cardiogenic Shock
Prolonged Nasogastric Administration of Ketones in Decompensated Heart Failure
This study will evaluate the feasibility and safety of achieving therapeutic concentrations of beta-hydroxybutyrate using continuous infusion of D-beta-hydroxybutyrate monoester administered via a nasogastric tube in patients…
- Conditions
- Acute Heart Failure (AHF), Cardiogenic Shock, Heart Failure, Ketones
- Trial name
- KADHEF-2 (NCT07527156)
- Testing
- Ketone Monoester (KE)
- Where
- Czechia
- Volunteers
- 12 people
- Sponsor
- Institute for Clinical and Experimental Medicine
Acute Myocardial Infarction, Acute Decompensated Heart Failure (ADHF)
Noninvasive Assessment of Pulmonary Fluid Levels by Remote Dielectric Sensing Technology to Improve Cardiac InsUfficieney During Ischemia-Reperfusion and Clinical Outcomes in MyocArdiaL Infarction
To explore whether a ReDS-guided strategy for AMI patients with cardiac insufficiency following coronary flow reperfusion is superior to routine care for improving outcomes.
- Trial name
- NATURAL (NCT06671067)
- Testing
- Remote dielectric sensing system
- Where
- 6 sites in China
- Volunteers
- 2,000 people
- Sponsor
- Shanghai 10th People's Hospital
Heart Decompensation, Acute, Acute Kidney Injuries
POCUS-Guided Diuresis for Decompensated Heart Failure
Heart failure occurs when the heart cannot pump blood effectively, leading to fluid buildup in the body. This can cause problems such as difficulty breathing, swelling, and extreme tiredness.
- Trial name
- POCUSHF-GD (NCT06921603)
- Testing
- Furosemide (Standard Diuretic) Treatment, POCUS-Assessed Diuretic Management
- Where
- 5 sites in United States
- Volunteers
- 588 people
- Sponsor
- University of Pittsburgh
Heart Failure, Acute Heart Failure
A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Hospitalized Heart Failure Patients
Finerenone will be compared to placebo to determine efficacy and safety of treatment in patients hospitalized with acute decompensated heart failure (HF) and mildly reduced or preserved left ventricular ejection fraction.
- Trial name
- REDEFINE-HF (NCT06008197)
- Testing
- Finerenone
- Where
- 356 sites in United States, Argentina and 24 more
- Volunteers
- 5,200 people
- Sponsor
- Colorado Prevention Center
Acute Decompensated Heart Failure (ADHF)
Bedside NT-proBNP Monitoring in Acute Heart Failure
The goal of this observational study is to investigate the association between dynamic changes in NT-proBNP levels and clinical decongestion status in patients with acute decompensated heart failure (ADHF) receiving…
- Trial name
- NCT07762521
- Testing
- Serial NT-proBNP Measurement
- Volunteers
- 50 people
- Sponsor
- Mao Chen
Cardiogenic Shock, Myocardial Infarction (MI)
BEAT-SHOCK Registry
This regulation defines the purpose, the operational processes, and the organization of the registry BEAT-SHOCK (Basel Evaluation of Acute Therapy in cardiogenic SHOCK).
- Conditions
- Cardiogenic Shock, Myocardial Infarction (MI), Fulminant Myocarditis, Acute Decompensated Heart Failure
- Trial name
- BEAT-SHOCK (NCT07643610)
- Testing
- no internvention
- Where
- Switzerland
- Volunteers
- 8,000 people
- Sponsor
- University Hospital, Basel, Switzerland
Heart Failure，Congestive, Atrial Fibrillation
The Cardio-share Telemedicine Cross-sector Collaboration Model for Managing Vulnerable Patients With Heart Failure
The goal of this observational study is to explore the potential of implementing a telemedicine-based cross-sector collaboration model to manage patients with frequent admissions with decompensated heart failure.
- Trial name
- ADHFQUAL-BFH (NCT06176131)
- Testing
- Telemedicine-based cross-sector collaboration for patient management
- Where
- Denmark
- Volunteers
- 300 people
- Sponsor
- University Hospital Bispebjerg and Frederiksberg
Heart Failure, Heart Failure - NYHA II - IV
Urine Sodium-Driven Diuretic Adjustment Strategy in Acute Decompensated Heart Failure
The goal of this clinical trial is to learn if increasing the dose of diuretics to achieve a higher urine sodium target produces better clinical results when treating patients hospitalized with acute heart failure when compared…
- Conditions
- Heart Failure, Heart Failure - NYHA II - IV, Heart Failure Acute, Acute Heart Failure (AHF)
- Trial name
- US-DASH (NCT07263035)
- Testing
- Furosemide intravenous solution
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Lakeland Regional Health Systems, Inc.
Heart Failure, Lung Congestion
Use of ReDS Technology in Patients With Acute Heart Failure
Background: Fluid overload, especially pulmonary congestion, is one of the main contributors into heart failure (HF) readmission risk and it is a clinical challenge for clinicians.
- Trial name
- NCT04305717
- Testing
- ReDS-guided strategy
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Acute Heart Failure, Decompensated Heart Failure
Characterisation of phenotYpes in aCute Heart faiLure patiEnts
An observational cohort study to evaluate the benefit of functional parameters, radiomics and blood biomarkers to predict the outcome of patients with acute heart failure.
- Conditions
- Acute Heart Failure, Decompensated Heart Failure, Cardiogenic Shock
- Trial name
- CYCLE (NCT07508891)
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf