Clinical trials: Acute Diverticulitis
Biliary Disease, Gallstone; Cholecystitis, Acute
Multicentric Point of Care UltraSound by Surgeons Trial
Acute gallbladder pathology and acute diverticulitis are common conditions met in emergency departments and comprise the bulk of admissions throughout general surgical calls.
- Conditions
- Biliary Disease, Gallstone; Cholecystitis, Acute, Diverticulitis, Colonic, Abscess Pelvic
- Trial name
- POCUSS (NCT02682368)
- Testing
- Point of Care Ultrasound by Surgeons (POCUSS), Radiology report, Surgery-Intra-operative findings
- Where
- 5 sites in Ireland, Italy and 2 more
- Volunteers
- 183 people, healthy volunteers welcome
- Sponsor
- Connolly Hospital Blanchardstown
Acute Diverticulitis, Stoma Colostomy
Surgical Italian Guide for the Management of Complicated Acute Diverticulitis Emergency Setting (SIGMA-D). A Prospective Observational Multicenter Study on Behalf of the Italian Society of Colorectal Surgery (SICCR).
This study will include data collected from surgical units performing emergency surgery in Italy during 2024, with a one-year follow-up period for each patient.
- Conditions
- Acute Diverticulitis, Stoma Colostomy, Stoma Ileostomy
- Trial name
- SIGMA-D (NCT06344078)
- Testing
- sigmoid resection and anastomosis / stoma
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- Societa Italiana di Chirurgia ColoRettale
Acute Diverticulitis
Diagnostic Accuracy of Ultrasonography and Computed Tomography in the Diagnosis of Mild-moderate Acute Diverticulitis
Acute diverticulitis (AD) is the most common complication of diverticulosis and is divided into mild-moderate and complicated. Imaging methods are needed for its diagnosis, prognostic classification and therapeutic management.
- Trial name
- NCT05323968
- Testing
- Abdominal Ultrasonography, Abdominal Computerized Tomography
- Where
- Spain
- Volunteers
- 86 people
- Sponsor
- Hospital de Granollers
Acute Diverticulitis
Prospective and Multicentre Study on Clinical-biological Factors Predictive of Chronic Colon DIverticulitis
MAIN OBJECTIVE: Description of predicted markers of acute diverticulitis crisis, using bivariate and multivariate analyses. Analysis of acute diverticulitis predictor swings.
- Trial name
- DICRO (NCT04407793)
- Where
- Spain
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Sebastiano Biondo
Diverticulitis
Prospective Observational Analysis of Circulating Endocan Levels in Patients Presenting With Acute Diverticulitis
Quantify the level of endocan in blood samples collected from patients with acute diverticulitis in the emergency department. Determine if endocan levels are correlated with the severity of diverticulitis according to the WSES…
- Trial name
- DIVENDO (NCT07027007)
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- IRCCS Ospedale San Raffaele
Acute Diverticulitis
Laparoscopic Peritoneal Lavage vs Laparoscopic Sigmoidectomy in Perforated Acute Diverticulitis: a Multicenter Prospective Observational Study (STELLA Study)
Laparoscopic peritoneal lavage (LPL) has recently been emerging as an effective alternative to laparoscopic sigmoidectomy (LS) in patients with complicated acute diverticulitis (CAD) (Modified Hinchey's classification grade II…
- Trial name
- STELLA (NCT03008707)
- Testing
- Laparoscopic Peritoneal Lavage
- Where
- Italy
- Volunteers
- 66 people
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
Acute Diverticulitis
Comparision Among Classifications for Acute Diverticulitis: a Multicenter Study
Even though Hinchey classification requires operative intervention, yet remains the established and most universally used scoring system for acute diverticulitis. Several other classifications have been described.
- Trial name
- NCT04596280
- Testing
- Colonic Resection
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
Colonic Diverticulitis
Prospective Evaluation of Quality of Life in Patients With Acute Colonic Diverticular Disease
A multicenter prospective observational study. Aim of the study is to identify the clinical parameters correlating with favorable outcomes in patients undergoing surgery or medical treatment for diverticular disease.
- Trial name
- DDR (NCT04907383)
- Testing
- quality of life
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Niguarda Hospital
Acute Diverticulitis
Neutrophil to Lymphocyte Ratio as a Predictor of Complicated Acute Diverticulitis
Introduction: Various biomarkers have been studied to predict the severity of acute diverticulitis (AD), such as the leukocyte count and CRP, which are useful but lack sufficient sensitivity.
- Trial name
- NCT04663490
- Testing
- Neutrophil to Lymphocyte Ratio
- Where
- Argentina
- Volunteers
- 325 people
- Sponsor
- Clinica Universitaria Reina Fabiola, Universidad Catolica de Cordoba
Diverticulitis
Symptomatic Treatment of Acute Uncomplicated Diverticulitis
The purpose of this study is to determine the safety and efficacy of symptomatic treatment (i.e. without antimicrobial drugs) of acute uncomplicated diverticulitis.
- Trial name
- NCT02219698
- Testing
- Ibuprofen, Paracetamol
- Where
- Finland
- Volunteers
- 158 people
- Sponsor
- Helsinki University Central Hospital
Acute Diverticulitis
Prevention of Diverticulitis by Taking a Daily Probiotic
There is evidence to show that daily probiotic Lactobacillus casei Shirota (LcS) in the form of Yakult fermented milk supports a healthy balanced population of "friendly" gut bacteria.
- Trial name
- LACTOPRoD (NCT01609751)
- Testing
- Yakult
- Where
- United Kingdom
- Volunteers
- 26 people
- Sponsor
- University of Surrey
Diverticulitis
Trial Assessing the Efficacy of a Short Course of Intravenous Antibiotic Followed by Oral Antibiotic in Uncomplicated Acute Diverticulitis
Medical treatment of uncomplicated acute diverticulitis is not standardized and there is an enormous diversity in clinical practice.
- Trial name
- DANC-05 (NCT00917592)
- Testing
- amoxicillin plus clavulanic acid
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Consorci Sanitari de Terrassa
Diverticular Perforation, Open Abdomen
Damage Control Surgery Over the World in Acute Diverticulitis (DACOSAD)
To analyze the possible benefit of damage control surgery by performing bowel resection, open abdomen, and delayed anastomosis in the treatment of Hinchey III or IV diverticulitis.
- Trial name
- DACOSAD (NCT06428370)
- Testing
- Damage Control Surgery
- Where
- 9 sites in Chile, Italy
- Volunteers
- 300 people
- Sponsor
- Link Campus University
Diverticulitis
Diverticulitis: Antibiotics or Close Observation?
Rationale The prevalence of colonic diverticular disease is increasing in Western countries. Approximately 10 to 25% of patients with diverticular disease will eventually develop an episode of acute diverticulitis.
- Trial name
- DIABOLO (NCT01111253)
- Testing
- Amoxicillin-clavulanate
- Where
- 24 sites in Netherlands
- Volunteers
- 533 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Diverticulitis, Colonic, Acute Disease
Study to Evaluate the Duration of Treatment With Ertapenem in Acute Attacks of Sigmoid Diverticulitis
The purpose of this study is to compare the efficacy (by assessing the clinical success of treatment) of intravenous antibiotic therapy with ertapenem in patients with acute attacks of sigmoid diverticulitis for 4 vs. 7 days.
- Trial name
- NCT00097734
- Testing
- ertapenem
- Where
- Germany
- Volunteers
- 540 people
- Sponsor
- Klinikum Hanover-Siloah Hospital
Acute Diverticulitis
Validation of Actigraph Measured Sleep During Acute Diverticulitis
The purpose of this study is to investigate the accuracy of actigraph measured sleep compared to the golden standard (polysomnography) during Acute uncomplicated diverticulitis.
- Trial name
- NCT01840878
- Where
- Denmark
- Volunteers
- 13 people
- Sponsor
- Herlev Hospital
Diverticulitis, Diverticulitis of Sigmoid
Clinical Trial With MBK-01, Intestinal Microbiota Capsules, for the Treatment of Patients With Recurrent Diverticulitis
Patients with diverticulitis experience a prolonged course of the disease and report a variety of physical, psychological and social symptoms, which highly impacts in their quality of life.
- Trial name
- NCT06687382
- Testing
- MBK-01
- Where
- Spain
- Volunteers
- 81 people
- Sponsor
- Mikrobiomik Healthcare Company S.L.
Acute Diverticulitis
Incidence and Outcome of Acute Diverticulitis in Finland
The incidence of acute diverticulitis (AD), conservative vs. surgical treatment and outcome of patients are studied using national registries and patient charts from two hospitals between years 2009-19.
- Trial name
- NCT05162560
- Testing
- patients with acute diverticulitis
- Where
- Finland
- Volunteers
- 15,000 people
- Sponsor
- Kuopio University Hospital
Diverticulitis
Rifaximin Delayed Release for the Prevention of Recurrent Acute Diverticulitis and Diverticular Complications.
Colonic microbiota changes may play a key role in the pathogenesis of acute diverticulitis. A previous proof-of-concept study suggests that rifaximin, a low-absorbable oral antibiotic, may be beneficial for prevention of acute…
- Trial name
- ROAD (NCT03469050)
- Testing
- Rifaximin delayed released 400mg Tablet
- Where
- 64 sites in France, Germany and 4 more
- Volunteers
- 193 people
- Sponsor
- Alfasigma S.p.A.
Acute Diverticulitis
Heart Rate Variability During Acute Diverticulitis
The purpose of this study is to investigate heart rate variability during Acute uncomplicated diverticulitis by ECG-monitor (Holter), the investigators hypothesis is the inflammation causes a decrease of High Frequency(HF)-power…
- Trial name
- NCT01840917
- Where
- Denmark
- Volunteers
- 13 people
- Sponsor
- Herlev Hospital