Clinical trials: Acute Dyspnea
Venous Thromboembolism (VTE), Exercise Therapy
Early Exercise-Based Rehabilitation in Patients Hospitalized for Acute Pulmonary Embolism
Up to half of patients with pulmonary embolism (PE) suffer from impaired quality of life, reduced physical capacity, and symptoms like shortness of breath even three months after diagnosis, despite standard treatment with…
- Conditions
- Venous Thromboembolism (VTE), Exercise Therapy, Quality of Life (QOL), Anxiety Depression
- Trial name
- RehabPE (NCT07143539)
- Testing
- Exercise-based rehabilitation program
- Where
- 6 sites in Switzerland
- Volunteers
- 160 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Long COVID, Long Covid19
Stellate Ganglion Block to Treat Long COVID 19 Case Series
An assessment of the effectiveness of Stellate Ganglion Block in alleviating symptoms of Long COVID-19.
- Conditions
- Long COVID, Long Covid19, Post-COVID-19 Syndrome, Post Acute COVID-19 Syndrome
- Trial name
- NCT05812209
- Testing
- Stellate Ganglion Block
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Metamorphosis LTD
COVID-19, Hyperventilation Syndrome
Relationship Between Hyperventilation Syndrome and SARS-CoV-2 Infection
Following an acute COVID-19 infection, many patients suffer from long lasting physical symptoms that may greatly impair quality of life.
- Trial name
- Hypercovid (NCT05224830)
- Testing
- Nijmegen questionnaire score
- Where
- France
- Volunteers
- 2,846 people
- Sponsor
- Central Hospital, Nancy, France
Dyspnea, Respiratory Failure
Arterial pH Selectively Predicts Intensive Care Unit Transfer From the Emergency Department in Obese Patients With Acute Dyspnea
This study evaluates the prognostic value of arterial blood gas analysis in a cohort of Emergency Department patients presenting with shortness of breath of any cause, comparing obese and non-obese patients.
- Trial name
- NCT03239730
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Association pour la Formation du Personnel à la Medecine d'Urgence
Dyspnea, Hypoxia
Added Diagnostic Value of Point of Care Ultrasound in Acute Dyspnea
Dyspnea is a common diagnostic challenge in the Emergency Department (ED). Delay in diagnosis will increase time to correct treatment and could impact outcome.
- Trial name
- NCT05782478
- Testing
- Point of care Ultrasound according to study protocol
- Where
- 2 sites in Sweden
- Volunteers
- 160 people
- Sponsor
- Region Skane
Respiratory Failure, Delirium
Delirium, Agitation/Sedation, Pain and Dyspnea in Respiratory Intensive Care Unit (NIVILIUM)
Non-Invasive Mechanical Ventilation (NIV) has been increasingly used in the treatment of acute respiratory failure. Notwithstanding failure rates still remains high, ranging from 5% to 60%.
- Conditions
- Respiratory Failure, Delirium, Agitation,Psychomotor, Pain
- Trial name
- NIVILIUM (NCT03880084)
- Testing
- Observation
- Where
- Italy
- Volunteers
- 92 people
- Sponsor
- University of Modena and Reggio Emilia
Acute Dyspnea, Acute Heart Failure
Multimarker Approach for Acute Dyspnea in Elderly Patients Admitted in the Emergency Department
Elderly people constitute the largest proportion of emergency department (ED) patients, representing 12% of all ED admissions. The need for diagnostic tests or therapeutic interventions is much greater in this patient population.
- Trial name
- READ-MA (NCT04240067)
- Testing
- READ-MA Multimarker Approach
- Where
- France
- Volunteers
- 238 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Heart Failure, Cardiovascular Disease
Use of Nesiritide in the Management of Acute Diastolic Heart Failure
Primary objective is to assess the effect of nesiritide in decreasing left ventricular (LV) filling pressure, defined as pulmonary artery capillary wedge pressure (PCWP) in a group of patients admitted with acute diastolic heart…
- Conditions
- Heart Failure, Cardiovascular Disease, Acute Heart Failure, Diastolic Heart Failure
- Trial name
- NCT00083772
- Testing
- Nesiritide
- Volunteers
- 9 people
- Sponsor
- M.D. Anderson Cancer Center
Echocardiography, Acute Dyspnea
Live Stream of Prehospital Emergency Ultrasound in Patients With Acute Dyspnoea
Background: Acute dyspnoea is a common symptom in prehospital emergency medicine. As ultrasound gained in importance for diagnosis in patients with acute respiratory distress, it plays even a role in the prehospital setting.
- Trial name
- NCT04817488
- Testing
- Prehospital emergency ultrasound with tele-supervision, Prehospital emergency ultrasound without tele-supervision
- Where
- Austria
- Volunteers
- 350 people
- Sponsor
- Medical University of Vienna
Covid19, Postviral Syndrome
ExoFlo™ Infusion for Post-Acute COVID-19 and Chronic Post-COVID-19 Syndrome
This is a Phase I/II trial to evaluate the safety and efficacy of intravenous (IV) administration of bone marrow mesenchymal stem cell derived extracellular vesicles (EV), ExoFlo, as treatment for Post-Acute COVID-19 and Chronic…
- Conditions
- Covid19, Postviral Syndrome, Dyspnea
- Trial name
- NCT05116761
- Testing
- Bone Marrow Mesenchymal Stem Cell Derived Extracellular Vesicles, Saline
- Sponsor
- Direct Biologics, LLC
Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Interoceptive Awareness
Interoception and Symptom Perception in Acute COPD Exacerbation
Interoception refers to the process of perceiving and interpreting internal physiological signals and plays a central role in symptom perception.
- Trial name
- NCT07719231
- Testing
- No Intervention: Observational Cohort
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Saglik Bilimleri Universitesi
Heart Decompensation
A Study Testing the Effectiveness of Nesiritide in Patients With Acute Decompensated Heart Failure
The purpose of this study is to find out if nesiritide (a human B-type natriuretic peptide/hBNP) as compared to placebo, plus the usual treatment for acute decompensated heart failure, helps to improve breathing difficulties…
- Trial name
- NCT00475852
- Testing
- Nesiritide
- Where
- 328 sites in United States, Argentina and 26 more
- Volunteers
- 7,141 people
- Sponsor
- Scios, Inc.
Dyspnoea, Chest Pain
Sonography in an Unselected Population of Acute Admitted Patients With Respiratory Symptoms
The purpose of this study is to determine whether focused sonography of the heart, lungs and deep veins can increase the number of patients with respiratory symptoms correctly diagnosed in an emergency department.
- Conditions
- Dyspnoea, Chest Pain, Cough
- Trial name
- NCT01486394
- Testing
- Focused Sonography of the heart, lungs and deep veins
- Where
- Denmark
- Volunteers
- 315 people
- Sponsor
- Odense University Hospital
Breathlessness, COPD
Sentinel - Triaging Acute Breathlessness Using Multi-Modal Biomarkers
The Sentinel-001 study aims to identify a combination of biomarkers suitable for triage of breathlessness.
- Conditions
- Breathlessness, COPD, Asthma, Asthma Chronic
- Trial name
- NCT05304494
- Testing
- Biomarker tests for participant profiling
- Sponsor
- Sanome
Interstitial Lung Disease, Chronic Thromboembolic Pulmonary Hypertension
129Xe MRI Cardiopulmonary
The goal of this NIH-sponsored study is to characterize three biomarkers derived from 129Xe gas exchange MRI and to understand how they change in response to interventions.
- Conditions
- Interstitial Lung Disease, Chronic Thromboembolic Pulmonary Hypertension, Acute Pulmonary Embolism, Anemia
- Trial name
- NCT06038630
- Testing
- Hyperpolarized Xe129, Oxygen Administration
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Bastiaan Driehuys
Post COVID-19 Condition (PCC), Dysfunctional Breathing
Dysfunctional Breathing in Post COVID-19 Condition.
The goal of this observational study with a cross-sectional design is to investigate what signs, symptoms and assessment which can describe and explain dysfunctional breathing in patients with post COVID-19 condition.
- Conditions
- Post COVID-19 Condition (PCC), Dysfunctional Breathing, Breathing Pattern Disorder, Post-Acute COVID-19 Syndrome
- Trial name
- DB-PCC (NCT06776263)
- Where
- 2 sites in Sweden
- Volunteers
- 200 people
- Sponsor
- Karolinska Institutet
Acute Leukemia, Anorexia
Aromatherapy and Essential Oils in Improving Insomnia and Other Symptoms in Patients With Newly Diagnosed Acute Leukemia Undergoing Chemotherapy
This randomized clinical trial studies aromatherapy and essential oils in improving insomnia and other symptoms in patients with newly diagnosed acute leukemia.
- Conditions
- Acute Leukemia, Anorexia, Anxiety, Depression
- Trial name
- NCT02445378
- Testing
- Aromatherapy and Essential Oils, Questionnaire Administration
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
COVID-19 Pandemic, Diabetes
Study on the Effect of Incentive Spirometer-based Respiratory Training on the Long COVID-19
The COVID-19 pandemic has emerged as the most significant public health crisis of the 21st century. As of the end of January 2023, global confirmed cases have exceeded 670 million, with a domestic cumulative total of 10.24…
- Conditions
- COVID-19 Pandemic, Diabetes, Hypertension, Cardiac Disease
- Trial name
- NCT06231225
- Testing
- Incentive Spirometer respiratory training
- Volunteers
- 100 people
- Sponsor
- National Taipei University of Nursing and Health Sciences
Dyspnea
Monitoring Patients With Shortness of Breath With Repeated Ultrasound Examinations
Purpose of the study: The purpose of the trial is to investigate whether repeated ultrasound scans of the heart and lungs of patients with shortness of breath may help to optimize their treatment.
- Trial name
- MODUS (NCT04091334)
- Testing
- Focused ultrasound of the lungs (FLUS) and focused cardiac ultrasound (FoCUS), Standard care
- Where
- 2 sites in Denmark
- Volunteers
- 206 people
- Sponsor
- Slagelse Hospital
Long COVID
Feasibility of Personalised Health Behaviour Coaching to Support Symptoms and Activities of Daily Living in Those With Long COVID-19.
This pilot RCT aims to assess whether a simple PA behavioural modification intervention can be delivered safely and feasibly to individuals with Long COVID suffering long standing symptoms with concerns regarding their ability to…
- Trial name
- NCT05752331
- Testing
- Physical activity behavioural modification
- Where
- United Kingdom
- Volunteers
- 32 people
- Sponsor
- Bournemouth University