Clinical trials: Acute Exacerbation COPD
COPD Exacerbation
Physical Activity Barriers in AECOPD
Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. Patients require good communication with the physician to improve control illness.
- Trial name
- NCT04162392
- Testing
- shared decision making, control group
- Volunteers
- 40 people
- Sponsor
- Universidad de Granada
COPD
Effects of Lysozyme on Acute Exacerbation of Chronic Obstructive Pulmonary Disease : A Randomised Placebo-Controlled Study
The aim of this study is to assess the effectiveness in preventing exacerbation of 52 weeks lysozyme administration in patients with COPD.
- Trial name
- NCT01645800
- Testing
- Lysozyme hydrochloride
- Where
- 25 sites in Japan
- Volunteers
- 408 people
- Sponsor
- Eisai Co., Ltd.
Chronic Obstructive Pulmonary Disease, COPD Exacerbation
Testing a Prediction Algorithm Into a Running Telehealth System for Patients With COPD
This trial will test a COPD prediction algorithm into a telehealth system from the previous Danish large-scale trial, TeleCare North (NCT01984840).
- Conditions
- Chronic Obstructive Pulmonary Disease, COPD Exacerbation, COPD Exacerbation Acute, COPD
- Trial name
- NCT05218525
- Testing
- Algorithm
- Where
- Denmark
- Volunteers
- 138 people
- Sponsor
- Aalborg University
Pulmonary Disease, Chronic Obstructive
Staphylococcus and Neisseria Tablets in the Treatment of Acute Exacerbations of Chronic Obstructive Pulmonary Disease.
It is planned to enroll 495 acute exacerbation of chronic obstructive pulmonary disease patients, and they will be randomly assigned to the high-dose test group, normal dose test group or control group at a ratio of 1:1:1, with…
- Trial name
- NCT05543343
- Testing
- High dose or normal dose staphylococcus albicans
- Where
- China
- Volunteers
- 495 people
- Sponsor
- Qu Yiqing
COPD Exacerbation
Evaluation of the Efficacy of Different Nebulization Techniques
COPD is the 3rd most common cause of death in the world, and the most common places of admission in our country with exacerbation of COPD are emergency services.
- Trial name
- NCT05507060
- Testing
- Vibrating MESH nebulizer (Aerogen Ultra), Jet nebulizers (Philips Respironics)
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Acute Respiratory Disease, COPD Exacerbation Acute
Study of Hospitalised Patients With Acute Respiratory Conditions
The goal of this observational study is to learn about the short- and long-term outcomes of people admitted to hospital with an acute respiratory condition, including exacerbations of chronic lung disease, and to understand…
- Conditions
- Acute Respiratory Disease, COPD Exacerbation Acute, Asthma, Pneumonia
- Trial name
- CHESTY (NCT05095090)
- Where
- United Kingdom
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Leicester
COPD, COPD Exacerbation Acute
The Reducing REVISITS Study: A Cluster RCT
This type II hybrid effectiveness-implementation trial will concurrently study the comparative effectiveness of virtual vs. in-person COPD care transition programs implemented via virtual mentored implementation approaches with…
- Trial name
- REVISITS (NCT05568043)
- Testing
- COPD Transitions of Care Intervention Bundle: Virtual Interventions, COPD Transitions of Care Intervention Bundle: In-Person Interventions
- Where
- United States
- Volunteers
- 384 people
- Sponsor
- University of Chicago
COPD, Hyperglycemia
Tight Glycemic Control in Acute Exacerbations of COPD
Glucose control has been shown as an important and independent prognostic factor in several acute conditions in hospitalized patients, including Acute MI, stroke, cardiac surgery and in critical care units.
- Trial name
- NCT00452296
- Testing
- tight insulin treatment in patients hospitalized with COPD exacerbation, tight glycemic control
- Volunteers
- 84 people
- Sponsor
- Soroka University Medical Center
COPD Exacerbation, Hypoxia
Oxygen Control and Weaning by O2matic to Patients Admitted With an Exacerbation of COPD
The aim of the study is to examine if automated oxygen delivery with O2matic allows for faster weaning from oxygen and better oxygen control than manually controlled oxygen therapy for patients admitted with an exacerbation of…
- Conditions
- COPD Exacerbation, Hypoxia, Hypoxemia, Hyperoxia
- Trial name
- O2MATIC-WEAN (NCT03661086)
- Testing
- O2matic
- Where
- 5 sites in Denmark
- Volunteers
- 157 people
- Sponsor
- Hvidovre University Hospital
Chronic Obstructive Pulmonary Disease
Smart Telehealth Exercise Intervention to Reduce COPD Readmissions
This is a prospective randomized controlled study to test the hypothesis that neuromuscular electrical stimulation (NMES) and remote pulmonary rehabilitation at home offered via a smart technology, called Smart TeleHealth…
- Trial name
- NCT03089853
- Testing
- Neuromuscular electrical stimulation (NMES)
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Alabama at Birmingham
Acute Exacerbation of COPD
Effects of Chair-Based Exercise Training on Exercise Capacity in Patients With Acute Exacerbation of COPD
Chronic obstructive pulmonary disease (COPD) is the leading cause of morbidity and mortality worldwide, a respiratory disease characterized by chronic airflow limitation that is not completely reversible.
- Trial name
- NCT05563493
- Testing
- Treatment group, Chair-Based Exercise Training, Control group, Breathing exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Necmettin Erbakan University
Chronic Obstructive Pulmonary Disease With Acute Exacerbation, Unspecified
Comparison of Two Oxygen Setting During Non-invasive Mechanical Ventilation of Chronic Obstructive Pulmonary Disease
Hypoxaemic patients with exacerbations of chronic obstructive pulmonary disease (COPD) are at some risk of carbon dioxide (CO2) retention during oxygen therapy.
- Trial name
- OXYSET (NCT02563314)
- Testing
- Non-invasive mechanical ventilation - Normoxia, Non-invasive mechanical ventilation - Controlled hypoxemia
- Where
- 4 sites in France
- Volunteers
- 1 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
COPD, Exacerbation
CRP-guided Antibiotic Treatment in COPD Exacerbations Admitted to the Hospital
Rationale: Acute exacerbations are key events in chronic obstructive pulmonary disease (COPD), resulting in poorer quality of life. Causes include irritants, viruses and bacterial pathogens.
- Conditions
- COPD, Exacerbation, Bronchitis, Sputum
- Trial name
- CATCH (NCT01232140)
- Testing
- CRP-guided antibiotic treatment
- Where
- Netherlands
- Volunteers
- 220 people
- Sponsor
- Medical Center Alkmaar
COPD Exacerbation Acute
Comparison of Bronchodilator Treatment Practices in Group E COPD Patients
COPD is a heterogeneous condition caused by airway (bronchitis/bronchiolitis) or alveolar (emphysema) abnormality, changes with chronic respiratory changes (dyspnea, dyspnoea, phlegm).
- Trial name
- NCT06178068
- Testing
- Comparison of bronchodilator effectiveness of nebulizer therapy devices
- Volunteers
- 39 people
- Sponsor
- Ataturk University
Acute Exacerbation of COPD
Randomized Controlled Study of Programmed Weaning From NIV for AECOPD
Purpose of research:to explore a reasonable programmed withdrawal process of noninvasive ventilation and thereby reduce the duration of noninvasive mechanical ventilation in patients with acute exacerbations of chronic…
- Trial name
- NCT06014034
- Testing
- Programmed Weaning From Noninvasive Mechanical Ventilation
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Peking University Third Hospital
Pulmonary Disease, Chronic Obstructive
A Study to Evaluate the Safety, Efficacy and Changes in Induced Sputum and Blood Biomarkers Following Daily Repeat Doses of Inhaled GSK2269557 in Chronic Obstructive Pulmonary Disease (COPD) Subjects With Acute Exacerbation
The purpose of this study is to evaluate specific alterations in immune cell mechanisms related to neutrophil function as detected by PI3Kdelta-dependent changes in messenger ribonucleic acid (mRNA) extracted from induced sputum…
- Trial name
- NCT02522299
- Testing
- GSK2269557, DISKUS, ELLIPTA
- Where
- 6 sites in Canada, Denmark
- Volunteers
- 44 people
- Sponsor
- GlaxoSmithKline
Chronic Obstructive Pulmonary Disease, Chronic Obstructive Pulmonary Disease Exacerbation
Wearable Devices in the Recovery Phase of Acute Exacerbations of COPD (AECOPDs)
The purpose the study is to successfully characterize the recovery phase of acute exacerbations of COPD in the outpatient setting using remotely captured physiologic data from wearable devices, to compare this with patient…
- Trial name
- NCT05776654
- Testing
- Biometric wearable devices
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
COPD Exacerbation Acute, COPD Exacerbation
PSV Versus ASV With Intellisync Mode for Delivery of NIV in AECOPD
Acute exacerbation of chronic obstructive pulmonary disease (COPD) is defined acute worsening of respiratory symptoms requiring additional therapy.
- Trial name
- PAINT-COPD (NCT06160687)
- Testing
- PSV mode during NIV, ASV intellisync
- Where
- India
- Volunteers
- 55 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Copd Exacerbation Acute
A Therapy for Improving Symptoms in Patients With Acute Exacerbations of COPD by Hydrogen-Oxygen Generator With Neburlizer.
The purpose for this study is to determine safety and effectiveness of the oxyhydrogen generator with nebulizer through a therapy for improving symptoms in patients with acute exacerbations of copd.
- Trial name
- NCT04000451
- Testing
- oxyhydrogen, Oxygen, Conventional treatment
- Where
- China
- Volunteers
- 108 people
- Sponsor
- Shanghai Asclepius Meditec Inc.
COPD
Early Supported Discharge and Enhanced Homecare After Emergency Department Admission for Acute Exacerbation of COPD
The prevalence of chronic obstructive pulmonary disease (COPD) is between 8 and 15% of the adult population in 2010. This prevalence is expected to increase over the coming decades as the population ages and exposure to the risk…
- Trial name
- EXADOM (NCT03474575)
- Testing
- Prevention
- Where
- France
- Volunteers
- 84 people
- Sponsor
- University Hospital, Grenoble