Clinical trials: Acute Exacerbation COPD
Acute Exacerbation of Chronic Obstructive Pulmonary Disease
The Severity Assessment Model for AECOPD With Combination of Disease and Syndrome
The establishment of the AECOPD severity assessment model can quickly and accurately evaluate the condition, which is of great significance for standardizing diagnosis and treatment, improving efficacy, and improving prognosis.
- Trial name
- NCT06918353
- Testing
- Diagnosis and Severity Grading of AECOPD Disease
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Henan University of Traditional Chinese Medicine
COPD Exacerbation
Short-course Antibiotic Treatment in AECOPD: a Meta-analysis of Double-blind Studies
Chronic obstructive pulmonary disease (COPD) is a common disease worldwide and a leading cause of death and disability globally.
- Trial name
- NCT05380375
- Where
- Tunisia
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of Monastir
Chronic Obstructive Pulmonary Disease
Myotrace: An Evaluation of a Novel Critical Illness Monitoring System
There are 24,000 admissions each year to Intensive Care Units (ICU) in the United Kingdom due to pneumonia, asthma and a common condition called chronic obstructive pulmonary disease (COPD), with rates of death of 10%, 40% and…
- Trial name
- NCT01361451
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Chronic Obstructive Pulmonary Disease
PIFR-based Inhalation Therapy in Patients Recovering From AECOPD
This study is designed to determine whether the optimized inhalation therapy based on peak inspiratory flow rates (PIFR) measured against the simulated resistance can reduce the rate of treatment failure in patients recovering…
- Trial name
- NCT04000958
- Testing
- PIRF measured by InCheck DIAL, Regular treament
- Where
- China
- Volunteers
- 460 people
- Sponsor
- Shanghai Zhongshan Hospital
Chronic Obstructive Pulmonary Disease, Acute Exacerbation of COPD
Patient Factors Associated With Prescription of Antibiotics for Inappropriate Indication in Patients With AECOPD
Up to 90% of consulting Acute Exacerbation (AE) of COPD patients are prescribed an antibiotic(1). Rates of inappropriate antibiotic prescription percentage can be as high as 65%(2).
- Trial name
- NCT03077152
- Where
- Turkey (Türkiye)
- Volunteers
- 138 people
- Sponsor
- Izmir Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital
Chronic Obstructive Pulmonary Disease
Evaluation of FeNO During and Following Acute COPD Exacerbation
The purpose of this research study is to determine whether exhaled nitric oxide (FeNO) goes up during an acute exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD) and whether the level of exhaled nitric oxide returns…
- Trial name
- NCT01761006
- Testing
- NIOX MINO®
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Wake Forest University
Machine Learning, Chronic Obstructive Pulmonary Disease
Machine Learning-based Models in Prediction of DVT and PTE in AECOPD Patients
Chronic Obstructive Pulmonary Disease (COPD) is a common respiratory system disease characterized by persistent respiratory symptoms and irreversible airflow restriction, which seriously endangers people's health.
- Conditions
- Machine Learning, Chronic Obstructive Pulmonary Disease, Chronic Obstructive Pulmonary Disease With Acute Exacerbation, Unspecified, Pulmonary Thromboembolisms
- Trial name
- NCT05905874
- Testing
- Machine learning-based prediction model
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- West China Hospital
Chronic Obstructive Pulmonary Disease
A Study to Evaluate Efficacy and Safety Profile of Zabofloxacin Tablet 400mg and Moxifloxacin Tablet 400mg
The purpose of this study is to Evaluate the Efficacy and Safety Profiles of oral multiple dose of Zabofloxacin Tablet 400 mg.
- Trial name
- DW224-III-3 (NCT01658020)
- Testing
- Zabofloxacin, Moxifloxacin
- Where
- South Korea
- Volunteers
- 345 people
- Sponsor
- Dong Wha Pharmaceutical Co. Ltd.
Chronic Obstructive Lung Disease
COPD-EXA-REHAB. Early Pulmonary Rehabilitation of Patients With Acute Exacerbation of COPD
Purpose: In a randomized controlled trial we will assess the effect of early pulmonary rehabilitation in patient with an acute exacerbation of chronic obstructive lung disease (AECOPD).
- Trial name
- NCT02987439
- Testing
- Pulmonary rehabilitation
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- University Hospital, Gentofte, Copenhagen
COPD
Effects of Lysozyme on Acute Exacerbation of Chronic Obstructive Pulmonary Disease : A Randomised Placebo-Controlled Study
The aim of this study is to assess the effectiveness in preventing exacerbation of 52 weeks lysozyme administration in patients with COPD.
- Trial name
- NCT01645800
- Testing
- Lysozyme hydrochloride
- Where
- 25 sites in Japan
- Volunteers
- 408 people
- Sponsor
- Eisai Co., Ltd.
Exacerbation Copd, Acute Respiratory Distress
High Flow Nasal Cannula Versus Non-Invasive Ventilation in Exacerbations of Chronic Obstructive Pulmonary Disease
Chronic obstructive lung disease is a disabling disease that affects people usually after several years of smoke tobacco exposure and affects millions of patients worldwide.
- Conditions
- Exacerbation Copd, Acute Respiratory Distress, Acute Hypercapnic Respiratory Failure
- Trial name
- HiFOLD (NCT03033251)
- Testing
- Non Invasive Ventilation, High Flow Oxygen Cannula 50, High Flow Oxygen Cannula 30
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Unity Health Toronto
Chronic Obstructive Pulmonary Disease (COPD)
Effects of Advair® in Outpatients With Chronic Obstructive Pulmonary Disease (COPD) Acute Exacerbation
Short course of steroids in COPD exacerbation improves FEV1 and decreases the relapse rate. However, some concerns remain about using systemic steroids for all patients with acute exacerbation.
- Trial name
- NCT00531791
- Testing
- prednisone group, Advair group
- Where
- Canada
- Volunteers
- 14 people
- Sponsor
- Laval University
COPD
A Prospective Study of Cardiovascular Risk of Patients Admitted for Acute Exacerbation of COPD
This is a prospective study to assess the burden of existing or hidden cardiovascular (CV) and renal disease in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) in a Hong Kong public hospital…
- Trial name
- NCT07344285
- Testing
- Intervention Group, Usual Care
- Where
- Hong Kong
- Volunteers
- 150 people
- Sponsor
- Chinese University of Hong Kong
Acute Exacerbation of Chronic Obstructive Pulmonary Disease
The Effect of EDP on Diaphragmatic Function and Neural Respiratory Drive in Patient With AECOPD
Chronic Obstructive Pulmonary Disease (COPD) is a common respiratory disease characterized by airflow limitation that is progressive and not fully reversible.
- Trial name
- NCT03083418
- Testing
- control group, EDP
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Zhujiang Hospital
COPD, COPD Exacerbation Acute
Clopidogrel for the Prevention of Exacerbations in Severe COPD
Chronic Obstructive Pulmonary Disease (COPD) is a debilitating respiratory disorder characterized by gradual and progressive airflow limitation.
- Trial name
- CLOPEX (NCT06021990)
- Testing
- Clopidogrel Bisulfate 75Mg Tab
- Where
- 2 sites in Pakistan
- Volunteers
- 162 people
- Sponsor
- Lady Reading Hospital, Pakistan
Hyperglycemia Steroid-induced
Glucose Control During Glucocorticoid Therapy in Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Purpose of this study is to treat glucocorticoid induced hyperglycemia due to glucocorticoid pulse therapy in a efficacious, safe and convenient way.
- Trial name
- GluCon-COPD (NCT02253121)
- Testing
- Dapagliflozin, Sliding scale insulin
- Where
- 4 sites in Netherlands
- Volunteers
- 46 people
- Sponsor
- Slotervaart Hospital
Acute Exacerbation of COPD
Extracorporeal CO2 Removal With the Hemolung RAS for Mechanical Ventilation Avoidance During Acute Exacerbation of COPD
This study evaluates the safety and efficacy of using the Hemolung RAS to provide low-flow extracorporeal carbon dioxide removal (ECCO2R) as an alternative or adjunct to invasive mechanical ventilation for patients who require…
- Trial name
- VENT-AVOID (NCT03255057)
- Testing
- Hemolung Respiratory Assist System, Invasive mechanical ventilation
- Where
- 32 sites in United States
- Volunteers
- 113 people
- Sponsor
- Alung Technologies
Copd Exacerbation Acute, Mechanical Ventilation
Prednisone Reduction in ICU Patients With COPD Exacerbation
The aim of this multicenter, investigator-initiated, prospective, randomized, open-label, non-inferiority study is to evaluate a prednisone prescribing strategy, guided by eosinophil blood count compared to the standard…
- Trial name
- EoPred-ICU (NCT03981081)
- Testing
- Prednisone
- Where
- 4 sites in Morocco, Tunisia
- Volunteers
- 192 people
- Sponsor
- Hôpital Universitaire Fattouma Bourguiba
Acute Exacerbation Chronic Obstructive Pulmonary Disease
Is it Necessary to Set External PEEP in AECOPD Patients
Acute exacerbation of chronic obstructive pulmonary disease patients with intrinsic positive end-expiratory pressure (PEEPi), Neurally adjusted ventilatory assist (NAVA) reduce work of breathing and trigger delay at any external…
- Trial name
- NCT02114567
- Testing
- PEEP titration
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Southeast University, China
Chronic Obstructive Pulmonary Disease
Short Antibiotic Treatment Versus Duration Guided by Markers of Inflammation in the Treatment of AECOPD
Chronic obstructive pulmonary disease (COPD) is one of the most common diseases in the world. In a recent study, we showed that administration of levofloxacin is superior to placebo in the treatment of decompensation of COPD; it…
- Trial name
- AECOPD (NCT02067780)
- Testing
- Levofloxacin 500mg
- Where
- Tunisia
- Volunteers
- 310 people
- Sponsor
- University of Monastir