Clinical trials: Acute Exacerbation COPD
Chronic Obstructive Pulmonary Disease (COPD), Inflammatory Disease
Endothelial Dysfunction in Acute Exacerbations of Chronic Obstructive Pulmonary Disease (COPD)
The purpose of the study is to determine a possible association between the clinical entity of exacerbation, markers of systemic inflammation and endothelial dysfunction in patients with COPD.
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Inflammatory Disease, Endothelial Dysfunction
- Trial name
- EDAECOPD (NCT01460082)
- Where
- Austria
- Volunteers
- 29 people
- Sponsor
- LudwLudwig Boltzmann Institute for COPD and Respiratory Epidemiology
Acute Exacerbation Copd
Procalcitonin-guided Antibiotic Therapy During Severe Exacerbation of COPD
This study assess whether a procalcitonin guided antibiotic therapy can reduce significantly unnecessary antibiotic prescription during severe exacerbation of COPD requiring mechanical ventilation without compromising patients'…
- Trial name
- NCT03440060
- Testing
- procalcitonin
- Where
- Tunisia
- Volunteers
- 100 people
- Sponsor
- University Hospital, Mahdia
COPD, AECOPD
The CANadian EXAcerbation of COPD Trial
The natural history of Chronic Obstructive Pulmonary Disease (COPD) is marked by acute, episodic attacks known as exacerbations of COPD.
- Trial name
- CAN-EXACT (NCT07850648)
- Where
- Canada
- Volunteers
- 125 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
COPD, Sleep Apnea Hypopnea Syndrome
Prediction of Exacerbations and Management of COPD Patients With SAH Based on Millimeter Wave Radar Monitoring
Millimeter wave radar will be used to conduct non-contact monitoring continuously for patients' vital signs (eg. respiratory rate, heart rate, and chest/abdominal movement).
- Conditions
- COPD, Sleep Apnea Hypopnea Syndrome, Acute Exacerbation of COPD
- Trial name
- NCT05019911
- Testing
- Polysomnography, Millimeter wave radar equipment
- Where
- China
- Volunteers
- 922 people
- Sponsor
- Peking University Third Hospital
Chronic Obstructive Pulmonary Disease
BACE Trial Substudy 2 - FarmEc Substudy
A second sub-analysis of the BACE trial will include a detailed cost-effectiveness study.
- Trial name
- FarmEc (NCT02205255)
- Testing
- Azithromycin
- Where
- 20 sites in Belgium
- Volunteers
- 350 people
- Sponsor
- Wim Janssens
Pulmonary Disease, Chronic Obstructive
Predictive Ability of the Chronic Obstructive Pulmonary Disease (COPD) Assessment Test (CAT) for Acute Exacerbations (PACE) in Patients With COPD
Chronic Obstructive Pulmonary Disease (COPD) is a major health concern, with a substantial impact on a patient's life. However, the impact of COPD is currently under-recognised and, as a result, COPD is under-treated.
- Trial name
- PACE (NCT01254032)
- Where
- 19 sites in Australia, China and 2 more
- Volunteers
- 70 people
- Sponsor
- GlaxoSmithKline
COPD Exacerbation
Platelet Activation and Reactivity in Acute Exacerbations of COPD
Chronic obstructive pulmonary disease (COPD) is known for development of severe cardiovascular co-morbidities. Systemic inflammation during acute exacerbations of COPD (AE-COPD) is thought to play a role in development of…
- Trial name
- NCT03017625
- Testing
- Blood is drawn
- Volunteers
- 30 people
- Sponsor
- Radboud University Medical Center
COPD Exacerbation, Hypercapnia
Comfort of Patients Under Non Invasive Ventilation According to the Mask
A sub-nasal mask with a skirt that fits the nostrils and with a dedicated port for the nasogastric tube has recently been introduced. This interface has never been compared to nasal-oral masks.
- Conditions
- COPD Exacerbation, Hypercapnia, Hypoventilation Obesity Syndrome, Acute Respiratory Failure
- Trial name
- ComPaNIV (NCT06212180)
- Testing
- mask
- Where
- 3 sites in France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
COPD
Physiotherapy in Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Chronic Obstructive Pulmonary Disease (COPD) is projected to be the fifth leading burden of disease worldwide by the year 2020. An acute exacerbation of COPD (AECOPD) is defined as an acute event characterized by a worsening of…
- Trial name
- NCT02515318
- Testing
- Physiotherapy program, Medical standard treatment
- Where
- 2 sites in Spain
- Volunteers
- 60 people
- Sponsor
- Universidad de Granada
Chronic Obstructive Pulmonary Disease
Short Compared With Standard Duration of Antibiotic Treatment for AECOPD
Chronic obstructive pulmonary disease (COPD) is one of the most common diseases in the world. Acute exacerbation of COPD (AECOPD) refers to an exaggeration of the symptoms of the disease.
- Trial name
- AECOPD (NCT03698682)
- Testing
- Levofloxacin 500mg
- Where
- Tunisia
- Volunteers
- 310 people
- Sponsor
- University of Monastir
Chronic Obstructive Pulmonary Disease With (Acute) Exacerbation
Effect of Roflumilast at Acute Exacerbations of Chronic Obstructive Pulmonary Disease
The purpose of this trial is to investigate if roflumilast can reduce the neutrophilic inflammation at acute exacerbations of Chronic Obstructive Pulmonary Disease (COPD).
- Trial name
- TREAT (NCT01473758)
- Testing
- Roflumilast
- Where
- 2 sites in United Kingdom
- Volunteers
- 81 people
- Sponsor
- AstraZeneca
Dyspnea, Decompensated Heart Failure ; COPD Exacerbation
Diagnosis of Heart Failure in Chronic Obstructive Pulmonary Disease Using the Lung Ultrasound
Acute Heart failure (AHF) is a common cause of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). This association is frequently underestimated with regard to the difficulty of clinical diagnosis.
- Trial name
- NCT05352490
- Testing
- calculate LUS score
- Where
- Tunisia
- Volunteers
- 350 people
- Sponsor
- University of Monastir
AECOPD, BIOMASS FUEL
Effect of Pulmonary Rehabilitation in Females With Acute Exacerbation of COPD Induced by Biomass Fuel Smoke
COPD represents an important public health challenge that is both preventable and treatable. GOLD is committed to improving the health of people at risk of and with COPD, wherever they happen to have been born, and wishes to do…
- Conditions
- AECOPD, BIOMASS FUEL, Pulmonary Rehabilitation
- Trial name
- AECOPD BIOMASS (NCT07509736)
- Testing
- Intervention 1 → Arm 1 (pulmonary rehabilitation group).
- Volunteers
- 60 people
- Sponsor
- Beni-Suef University
Pulmonary Disease, Chronic Obstructive
The Impact of a Home-based Pulmonary Telerehabilitation Program in Acute Exacerbations of COPD
COPD impacts a significant proportion of the Veteran population. Acute exacerbations, or flare-ups, of COPD are associated with impaired muscle function and worse quality of life.
- Trial name
- NCT03997513
- Testing
- Pulmonary Telerehabilitation
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- VA Office of Research and Development
Chronic Obstructive Pulmonary Disease
ECCO2R as an Adjunct to NIV in AECOPD
Chronic obstructive pulmonary disease (COPD) is one of the UKs commonest chronic diseases and is responsible for a significant number of acute hospital admissions.
- Trial name
- NCT02086084
- Testing
- NIV, ECCO2R
- Where
- United Kingdom
- Volunteers
- 21 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Chronic Obstructive Pulmonary Disease
Noninvasive Ventilation Weaning Protocol in COPD
Noninvasive ventilation (NIV) has revolutionized the management of patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) with hypercapnic respiratory failure (HcRF).
- Trial name
- NCT07133711
- Testing
- Noninvasive ventilation
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
COPD Acute Exacerbation
CO2 Removal in Severe Acute exacerbatIons of Chronic Obstructive Lung Diseases
The aim of the study is to determine which standard of care strategy will best benefit very severe Acute Exacerbation (AE) of Chronic Obstructive Pulmonary Disease (COPD), single versus reinforced with ECCO2R and assess the…
- Trial name
- CORAIL (NCT05546606)
- Testing
- ECCO2R
- Where
- 20 sites in France
- Volunteers
- 17 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
COPD Exacerbation Acute
CRP, Procalcitonin and Pro-BNP as Diagnostic and Prognostic Markers in AECOPD
Acute Exacerbations of Chronic Obstructive Pulmonary Disease (AECOPD) are one of the chief causes for admission to Emergency Department. AECOPD is a significant cause for mortality and morbidity worldwide.
- Trial name
- AECOPD (NCT06514599)
- Where
- Turkey (Türkiye)
- Volunteers
- 196 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Pulmonary Disease, Chronic Obstructive, Asthma
Smoking Cessation Intervention in Respiratory Inpatients
Prospective, open-label, parallel-group, 52-week trial comparing varenicline in combination with behavioral support with one session of behavioral support alone.
- Conditions
- Pulmonary Disease, Chronic Obstructive, Asthma, Community Acquired Pneumonia
- Trial name
- NCT02922387
- Testing
- Varenicline, Behavioral support
- Volunteers
- 101 people
- Sponsor
- General Hospital of Kavala
Pulmonary Disease, Chronic Obstructive, Infections, Bacterial
Observational Study Of An Electronic Questionnaire In Patients With Chronic Obstructive Pulmonary Disease (COPD)
The aim of the study is to develop a new patient-reported outcome (PRO) questionnaire measuring the impact of an acute exacerbation on daily lives of patients with chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT00259909
- Testing
- GSK questionnaire, St. George's Respiratory Questionnaire, Acute Short Form 12 version 2
- Where
- 123 sites in United States, Germany and 1 more
- Volunteers
- 259 people
- Sponsor
- GlaxoSmithKline