Clinical trials: Acute Exacerbation Chronic Obstructive Pulmonary Disease
Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Clinical Outcome of Corticosteroids in the Treatment of COPD Exacerbations in China
This is a Post-hoc analysis based on the database of "A non-interventional, retrospective study on AECOPD treatment status in China".
- Trial name
- CONTAIN (NCT03633838)
- Where
- China
- Volunteers
- 5,067 people
- Sponsor
- AstraZeneca
Pulmonary Disease, Chronic Obstructive
Sputum Colour Charts to Guide Antibiotic Self-treatment of Acute Exacerbation of COPD (Colour COPD)
The primary objective of this study is to determine if a sputum colour chart can aid patient self-management of COPD exacerbations, such that use of the chart is non-inferior to usual care with respect to hospital admissions.
- Trial name
- NCT04705233
- Testing
- sputum colour chart
- Where
- United Kingdom
- Volunteers
- 2,954 people
- Sponsor
- University of Birmingham
Chronic Obstructive Pulmonary Disease Exacerbation
Neutrophil to Lymphocyte Ratio in Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) stands as one of the leading causes of mortality worldwide. Acute exacerbations of COPD (AECOPD) lead to rapid respiratory function decline and worsened disease status.
- Trial name
- NCT07125352
- Testing
- neutrophil lymphocyte ratio in COPD patients
- Where
- Egypt
- Volunteers
- 190 people
- Sponsor
- Ain Shams University
Chronic Obstructive Pulmonary Disease
Vibratory PEP Device and Hospital Length of Stay for Acute Exacerbation of COPD
This study is evaluating the use of a respiratory device, the Acapella Vibratory Positive Expiratory Pressure (PEP) Therapy device, in patients admitted to the hospital with a chronic obstructive pulmonary disease (COPD)…
- Trial name
- NCT03094806
- Testing
- Acapella Vibratory PEP Therapy Device plus usual care
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- New York Presbyterian Brooklyn Methodist Hospital
Chronic Obstructive Pulmonary Disease, Respiratory Failure
NHF vs NIV in Patients With Acute Exacerbation of COPD
Although non-invasive ventilation (NIV) usage has increased significantly over time in COPD exacerbation, a great percentage of patients (~30%) present contraindications to NIV or cannot tolerate it.
- Conditions
- Chronic Obstructive Pulmonary Disease, Respiratory Failure, Acute Exacerbation Copd
- Trial name
- NCT03466385
- Testing
- Nasal High Flow, Non-Invasive Ventilation
- Where
- 3 sites in Greece
- Volunteers
- 498 people
- Sponsor
- Evangelismos Hospital
COPD Exacerbation Acute
Treatment of Pneumocystis in COPD (the TOPIC Study)
Chronic obstructive pulmonary disease (COPD) is a progressive lung disease associated with chronic inflammation in the airways and lung, resulting in significant morbidity and mortality worldwide.
- Trial name
- NCT05418777
- Testing
- Trimethoprim Sulfamethoxazole
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Corewell Health East
COPD (Chronic Obstructive Pulmonary Disease), COPD Exacerbations
The REVIVE Pivotal Study
The goal of this study is to test whether a new treatment called the Ryme Medical Targeted Lung Denervation (TLD) Catheter is safe and effective for people with moderate to severe chronic obstructive pulmonary disease (COPD).
- Conditions
- COPD (Chronic Obstructive Pulmonary Disease), COPD Exacerbations, COPD Patients, COPD Acute Exacerbation
- Trial name
- REVIVE (NCT07361653)
- Testing
- Ryme TLD
- Volunteers
- 300 people
- Sponsor
- Ryme Medical, Inc.
COPD (Chronic Obstructive Pulmonary Disease)
The Effectiveness of Tele-pulmonary Rehabilitation Program on People With Chronic Obstructive Pulmonary Disease (COPD) After Hospitalization for Acute Exacerbation
Introduction: There are great impacts of chronic obstructive pulmonary disease (COPD) over healthcare and economic systems globally.
- Trial name
- NCT07762157
- Testing
- Tele-pulmonary rehabilitation
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- North District Hospital
Chronic Obstructive Pulmonary Disease
ECCO2R as an Adjunct to NIV in AECOPD
Chronic obstructive pulmonary disease (COPD) is one of the UKs commonest chronic diseases and is responsible for a significant number of acute hospital admissions.
- Trial name
- NCT02086084
- Testing
- NIV, ECCO2R
- Where
- United Kingdom
- Volunteers
- 21 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Decision-making and Optimization of Ventilatory Support for AECOPD Patients
The goal of this retrospective observational study is to learn about how respiratory support is selected and adjusted in hospitalized patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD).
- Trial name
- OPTIVENT-COPD (NCT07508943)
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Sir Run Run Shaw Hospital
Chronic Obstructive Pulmonary Disease, Chronic Obstructive Pulmonary Disease Exacerbation
Muscle Oxygenation in Chronic Obstructive Pulmonary Disease
The aim of our study is to examine the Peripheral Muscle Oxygenations at rest and in motion on the 2nd day of hospitalized patients and before discharge in Severe Acute Exacerbation of Chronic Obstructive Pulmonary Disease and to…
- Conditions
- Chronic Obstructive Pulmonary Disease, Chronic Obstructive Pulmonary Disease Exacerbation, Muscle Oxygenation
- Trial name
- NCT05808621
- Where
- Turkey (Türkiye)
- Volunteers
- 41 people
- Sponsor
- Bandırma Onyedi Eylül University
Chronic Obstructive Pulmonary Disease
Pulmonary Rehabilitation for Chronic Obstructive Pulmonary Disease (COPD) Exacerbation
This is a study to evaluate the effects of early pulmonary rehabilitation within 10 days after discharge from the hospital after a COPD exacerbation on exercise tolerance, exacerbations, re-admissions and the quality of life…
- Trial name
- NCT00413543
- Testing
- early pulmonary lung rehabilitation
- Where
- Netherlands
- Volunteers
- 17 people
- Sponsor
- Isala
Congestive Heart Failure, Copd
A Mobile Integrated Health Intervention to Manage Congestive Health Failure and Chronic Obstructive Pulmonary Disease
Episodic and disjointed medical care for older, community-dwelling adults with chronic obstructive pulmonary disease (COPD) and congestive heart failure (CHF) leave them vulnerable to adverse events such as worsening disease…
- Trial name
- NCT05540158
- Testing
- Mobile Integrated Health Intervention
- Sponsor
- University of Massachusetts, Worcester
COPD (Chronic Obstructive Pulmonary Disease), Acute Exacerbation of COPD
The Impact of Indoor Environmental Quality on Symptoms in Patients With Chronic Obstructive Pulmonary Disease
This prospective, monocenter pilot study will investigate the relationship between indoor environmental quality (including air quality, lighting, noise, and thermal conditions), wearable-derived health insights, and…
- Trial name
- COPD-AIR (NCT07799896)
- Testing
- Wearable mobile device, Indoor environmental quality sensor, CAT Questionnaire
- Where
- Belgium
- Volunteers
- 15 people
- Sponsor
- Ziekenhuis Oost-Limburg
Pulmonary Disease, Chronic Obstructive
Personalized Prediction Strategy for Acute Exacerbation of Chronic Obstructive Pulmonary Disease
This is a 3-year longitudinal study designed to establish a personalized prediction and prevention system for acute exacerbations of chronic obstructive pulmonary disease (AECOPD).
- Trial name
- NCT03240315
- Where
- China
- Volunteers
- 442 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
Chronic Obstructive Lung Disease, Respiratory Insufficiency
The Edi Level and Cardiopulmonary Function Between HHHFNC and Unheated Humidified High-Flow Oxygen Mask in COPD
Patients with COPD exacerbation usually need respiratory support after extubation. Recently, HHHFNC has been used in both adult and neonates with post-extubation respiratory support.
- Trial name
- NCT03811158
- Testing
- HHHFNC, UHFOM
- Where
- Taiwan
- Volunteers
- 2 people
- Sponsor
- Fu Jen Catholic University
Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Clinical Practice of AECOPD Management in China
The purpose of this study is observe clinical practice including glucocorticoids treatment in AECOPD in China.
- Trial name
- NCT02051166
- Where
- 13 sites in China
- Volunteers
- 5,095 people
- Sponsor
- AstraZeneca
Lower Respiratory Tract Infection (LRTI)
Procalcitonin Antibiotic Consensus Trial (ProACT)
The ProACT study is a 5 year, multicenter study that will test the effect of implementation of a novel procalcitonin guideline on antibiotic use and adverse outcomes in Emergency Department (ED) patients with Lower Respiratory…
- Trial name
- ProACT (NCT02130986)
- Testing
- Procalcitonin level, Results of procalcitonin (PCT) level to treating clinician, Provide procalcitonin guideline to treating clinician
- Where
- 13 sites in United States
- Volunteers
- 1,664 people
- Sponsor
- University of Pittsburgh
Chronic Obstructive Pulmonary Disease, Chronic Bronchitis
A Comparison Study of Two Respiratory Physical Therapy Methods and Standard Medical Treatment for Treating COPD Patients During Acute Exacerbation
One of the main goals of the respiratory physical therapy is to help people who are suffering from accumulating of secretions in their airways and lungs.
- Trial name
- NCT02140892
- Testing
- respiratory physical therapy manual technique- Autogenic Drainage, respiratory physical therapy technique- IPV
- Volunteers
- 75 people
- Sponsor
- Sheba Medical Center
Chronic Obstructive Pulmonary Disease
Exhaled Breath Condensate (EBC) Assessment in Acute Exacerbation of Chronic Obstructive Pulmonary Disease (COPD)
This study aimed to assess airway inflammation in patients during the course of acute exacerbations of chronic obstructive pulmonary disease (AECOPD) by serial analyses of their exhaled breath condensates (EBC).
- Trial name
- NCT00448500
- Where
- Hong Kong
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong