Clinical trials: Acute Exacerbation Chronic Obstructive Pulmonary Disease
COPD
Prevalence of Respiratory Aspiration in Patients With COPD
The aim of the study is to estimate the prevalence of respiratory aspiration in patients with COPD, in a tertiary hospital of Buenos Aires.
- Trial name
- NCT02722629
- Testing
- FEESST
- Where
- Argentina
- Volunteers
- 330 people
- Sponsor
- Hospital Italiano de Buenos Aires
COPD
High Flow Nasal Cannula and Hypercapnia
In the present investigation, in 50 COPD with persistent hypercapnia after an acute exacerbation, the investigators want to assess the acceptability of HFNC and its effectiveness in further reducing the level of PaCO2, and to…
- Trial name
- NCT03759457
- Testing
- High Flow Nasal Cannula (AIRVO2)
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Safety, PK and PD Relationships of RLS-0071 in Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease
AECOPD is a major cause of hospital admission and mortality. They contribute to long-term decline in lung function, physical capacity, and quality of life (QoL).
- Trial name
- NCT06175065
- Testing
- RLS-0071
- Where
- 4 sites in United States
- Volunteers
- 24 people
- Sponsor
- ReAlta Life Sciences, Inc.
Lung Diseases, Obstructive, Blood Eosinophil Count
Corticosteroid Reduction in COPD
This study explores whether patients hospitalized with chronic obstructive pulmonary disease (COPD) exacerbation may have fewer days with prednisolone and with the same treatment effect by controlling the treatment by daily…
- Conditions
- Lung Diseases, Obstructive, Blood Eosinophil Count, Glucocorticoids, COPD
- Trial name
- Cortico-cop (NCT02857842)
- Testing
- Prednisolone
- Where
- 4 sites in Denmark
- Volunteers
- 318 people
- Sponsor
- Chronic Obstructive Pulmonary Disease Trial Network, Denmark
Chronic Obstructive Pulmonary Disease
Study on the Effects and Mechanisms of Modified Ma Xing Shi Gan Decoction in Treating Acute Exacerbations of Chronic Obstructive Pulmonary Disease
This study adopted a multi-center, randomized, controlled trial design. Patients with acute exacerbation of chronic obstructive pulmonary disease who met the inclusion criteria were randomly assigned to the experimental group and…
- Trial name
- NCT07403032
- Testing
- modified Ma Xing Shi Gan Decoction, The specific drug comes from "Chinese Expert Consensus on the Diagnosis and Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease (Revised Edition 2023)" and the GOLD guidelines
- Volunteers
- 200 people
- Sponsor
- Cuiling Feng
Chronic Obstructive Pulmonary Disease
Bufei Yishen Prescription on Patients With Frequent AECOPD in Stable Stage
To evaluate the clinical efficacy and health economic advantages of Lung Replenishing and Kidney Enhancing Formula for the treatment of patients with frequent acute exacerbations in the stabilized phase.
- Trial name
- NCT06326658
- Testing
- Bufei Yishen Prescription Granule
- Volunteers
- 848 people
- Sponsor
- Henan University of Traditional Chinese Medicine
Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Interoceptive Awareness
Interoception and Symptom Perception in Acute COPD Exacerbation
Interoception refers to the process of perceiving and interpreting internal physiological signals and plays a central role in symptom perception.
- Trial name
- NCT07719231
- Testing
- No Intervention: Observational Cohort
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Saglik Bilimleri Universitesi
Chronic Obstructive Pulmonary Disease
Comparing Treatment Efficacy With HD/MD Flu Plus Sal in Chronic Obstructive Pulmonary Disease (COPD) Patients
Chronic obstructive pulmonary disease is characterized as inflammatory airway with not fully reversible airflow limitation.Combination treatment with inhaled corticosteroid (ICS) and long-acting β2 agonists (LABA)attains an…
- Trial name
- NCT01131806
- Testing
- fluticasone/ salmeterol 125/25 mcg/puff, fluticasone/ salmeterol 250/25 mcg/puff
- Where
- Taiwan
- Volunteers
- 124 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Emergencies, Heart Failure
The Use of a Monitoring Device by General Practitioners During Out-of-hours Care
All calls that end up on the out-of-hours general practitioners' service (OHGPS), which contain a demand for an urgent home visit, are passed on to the on-call general practitioner (GP).
- Conditions
- Emergencies, Heart Failure, Pulmonary Embolism, Acute Exacerbation of Chronic Obstructive Pulmonary Disease
- Trial name
- NCT05222711
- Testing
- Use of the PICO(TM) monitoring device
- Where
- Belgium
- Volunteers
- 866 people
- Sponsor
- KU Leuven
COPD Exacerbation
Magnesium Sulfate Versus Ipratropuim Bromide in Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Treatment with short acting β2 agonists for exacerbations of COPD results in clinical improvement. It has not been established whether combining short acting β2 agonists to other bronchodilators is more effective than β2 agonists…
- Trial name
- NCT01136421
- Testing
- Ipratropium bromide, Magnesium Sulfate
- Where
- 2 sites in Tunisia
- Volunteers
- 124 people
- Sponsor
- University of Monastir
Pulmonary Disease, Chronic Obstructive
Antibiotics in Chronic Obstructive Pulmonary Disease (COPD)
It is not clear whether antibiotic therapy is needed in patients with mild to moderate exacerbation of chronic obstructive lung disease.
- Trial name
- TAExaCOP (NCT00952861)
- Testing
- Doxycycline
- Where
- Denmark
- Volunteers
- 140 people
- Sponsor
- Odense University Hospital
Pulmonary Disease, Chronic Obstructive
Evaluate the Efficacy of Xuebijing Injection in Acute Exacerbations of COPD
Objective: A prospective multicenter randomized controlled trial to assess the efficacy and safety of Xuebijing injection for acute exacerbation of chronic obstructive pulmonary disease(AECOPD).
- Trial name
- NCT02937974
- Testing
- Xuebijing
- Where
- China
- Volunteers
- 254 people
- Sponsor
- Chinese PLA General Hospital
Sleep Apnea, COPD Exacerbation
Impact of Continuous Positive Airway Pressure on the Occurrence of Acute Exacerbations of COPD in Patients With COPD-OSA Overlap Syndrome (CO-OS)
Chronic Obstructive Pulmonary Disease (COPD) and Obstructive Sleep Apnea (OSA) are both frequent respiratory diseases with estimated prevalences between 8 and 15% of the adult population.
- Conditions
- Sleep Apnea, COPD Exacerbation, Overlap Syndrome
- Trial name
- SLEEPOVEA (NCT05958563)
- Testing
- continuous positive airway pressure treatment
- Where
- 15 sites in France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Angers
Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Pulmonary Rehabilitation During Acute Exacerbations of Chronic Obstructive Pulmonary Disease: a Mixed-methods Approach
This study aims to i) assess the short-, mid- and long-term effectiveness of a patient-centred community-based pulmonary rehabilitation (PR) programme during during acute exacerbations of chronic obstructive pulmonary disease…
- Trial name
- NCT03751670
- Testing
- Pulmonary Rehabilitation, Daily medical treatment
- Where
- Portugal
- Volunteers
- 50 people
- Sponsor
- Aveiro University
Pulmonary Disease, Chronic Obstructive
Calprotectin I Serum as a Diagnostic Marker
Lower respiratory tract infection is the most common cause of acute exacerbations of chronic obstructive pulmonary disease (AECOPD).
- Trial name
- NCT03474484
- Where
- Norway
- Volunteers
- 113 people
- Sponsor
- St. Olavs Hospital
Chronic Obstructive Pulmonary Disease
Home Mechanical Ventilation vs Home Oxygen Therapy in COPD
This study is designed to investigate the effect of home mechanical ventilation (HMV) in patients with severe chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT00990132
- Testing
- Home mechanical ventilation, Long term oxygen therapy
- Where
- 7 sites in United Kingdom
- Volunteers
- 116 people
- Sponsor
- Patrick Murphy
Respiratory Disorders
Infectious Pathogens in Acute Respiratory Illness in Adults and Elderly
The aim of this study is to generate epidemiological data to further explore determinants of Chronic Obstructive Pulmonary Disease (COPD) and the contribution of bacterial and viral pathogens to Acute Exacerbation of COPD…
- Trial name
- NCT01360398
- Testing
- Blood sample, Sputum sample, Nasopharyngeal swab
- Where
- United Kingdom
- Volunteers
- 127 people
- Sponsor
- GlaxoSmithKline
Chronic Obstructive Pulmonary Disease Exacerbation, Pneumonia
Improved Diagnostics, Treatment and Follow-up of Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) is a chronic and often progressive pulmonary disease, where inflammation and recurrent infections are key pathophysiological contibutors in disease progression.
- Conditions
- Chronic Obstructive Pulmonary Disease Exacerbation, Pneumonia, Respiratory Tract Infections
- Trial name
- COPEXNOR (NCT06105814)
- Testing
- Rapid diagnostics
- Volunteers
- 200 people
- Sponsor
- Vestre Viken Hospital Trust
Pulmonary Disease, Chronic Obstructive
Nutritional Status in Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease
A cross sectional observation study of body composition in COPD patients consecutively hospitalized with acute exacerbation.
- Trial name
- NCT03709498
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- Evangelismos Hospital
COPD, Physical Activity
Transcutaneous Electrical Nerve Stimulation During Exercise in Patients With COPD
Early pulmonary rehabilitation is recommended after an episode of severe exacerbation of chronic obstructive pulmonary disease (COPD). However, its implementation is challenging particularly as regard exercise training.
- Conditions
- COPD, Physical Activity, Rehabilitation, TEN
- Trial name
- proTENS (NCT03548870)
- Testing
- CWRT with low frequency transcutaneous electrical nerve stimulation
- Where
- France
- Volunteers
- 2 people
- Sponsor
- Groupe Hospitalier du Havre