Clinical trials: Acute Exacerbation Chronic Obstructive Pulmonary Disease
Chronic Obstructive Pulmonary Disease
Evaluation of the Use of a Remote Monitoring and Follow-up Option for Patients With Chronic Obstructive Pulmonary Disease (BOREAL)
The purpose of this study is to evaluate the ability of the Bora Care remote monitoring solution to detect early acute exacerbations of Chronic Obstructive Pulmonary Disease (COPD).
- Trial name
- BOREAL (NCT05759247)
- Testing
- BORA Band (wristband)
- Where
- France
- Volunteers
- 64 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Chronic Obstructive Pulmonary Disease (COPD)
Effects of Advair® in Outpatients With Chronic Obstructive Pulmonary Disease (COPD) Acute Exacerbation
Short course of steroids in COPD exacerbation improves FEV1 and decreases the relapse rate. However, some concerns remain about using systemic steroids for all patients with acute exacerbation.
- Trial name
- NCT00531791
- Testing
- prednisone group, Advair group
- Where
- Canada
- Volunteers
- 14 people
- Sponsor
- Laval University
COPD
A Prospective Study of Cardiovascular Risk of Patients Admitted for Acute Exacerbation of COPD
This is a prospective study to assess the burden of existing or hidden cardiovascular (CV) and renal disease in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) in a Hong Kong public hospital…
- Trial name
- NCT07344285
- Testing
- Intervention Group, Usual Care
- Where
- Hong Kong
- Volunteers
- 150 people
- Sponsor
- Chinese University of Hong Kong
COPD Exacerbation, COPD Exacerbation Acute
Prehospital Non-invasive Ventilation for Acute Exacerbation of Chronic Obstructive Pulmonary Disease
The goal of this clinical trial is to test if treatment with prehospital Non-invasive ventilation (NIV) for patients with acute respiratory failure (ARF), due to acute exacerbation of chronic obstructive pulmonary disease…
- Conditions
- COPD Exacerbation, COPD Exacerbation Acute, Noninvasive Ventilation, Emergency Medical Services
- Trial name
- PRENIV (NCT06211920)
- Testing
- Non-invasive ventilation
- Where
- Denmark
- Volunteers
- 140 people
- Sponsor
- Central Denmark Region
Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Impact of HI-NPPV Vs LI-NPPV on Tolerance Among AECOPD Patients
To determine whether high-intensity NPPV, compared with low-intensity NPPV, could have an effect on the subjective tolerance in patients with an AECOPD and hypercapnia.
- Trial name
- NCT06692023
- Testing
- High-intensity NPPV, Low-intensity NPPV
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Beijing Chao Yang Hospital
COPD (Chronic Obstructive Pulmonary Disease)
Evaluation of the Paramedic Evaluation for Acute COPD Exacerbation
Chronic Obstructive Pulmonary Disease (COPD) is a serious lung condition that affects millions of people in the United States. Each year, it leads to about 150,000 deaths, nearly 900,000 emergency room visits, and 700,000…
- Trial name
- PEACE (NCT07072039)
- Testing
- Paramedic Evaluation for acute COPD Exacerbation, Usual Care
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Massachusetts, Worcester
COPD, AECOPD
Home Oscillatory Positive Expiratory Pressure - Aerobic Exercise Rehabilitation Study
The goal of this clinical trial is to evaluate the feasibility and effectiveness of home OPEP therapy and aerobic exercise training in patients with moderate to severe Chronic Obstructive Pulmonary Disease (COPD) who are at high…
- Trial name
- HOPE-AERO (NCT06970054)
- Testing
- OPEP, Aerobic Exercise
- Where
- China
- Volunteers
- 312 people
- Sponsor
- Sir Run Run Shaw Hospital
COPD Exacerbation Acute, COPD With Acute Lower Respiratory Infection
RCT of Vapendavir in Patients With COPD and Human Rhinovirus/Enterovirus Upper Respiratory Infection
Vapendavir (VPV) is a drug being developed to treat human rhinovirus (RV) infection, one virus responsible for the common cold. Vapendavir prevents the virus from entering cells and making more infectious copies of itself.
- Conditions
- COPD Exacerbation Acute, COPD With Acute Lower Respiratory Infection, Rhinovirus, Virus Diseases
- Trial name
- NCT06149494
- Testing
- Vapendavir
- Where
- United Kingdom
- Volunteers
- 52 people
- Sponsor
- Altesa Biosciences, Inc.
Mechanically Ventilated Patients
Nebulized Heparin and Salbutamol in Mechanically Ventilated Patients With AECOPD
This randomised study was designed to assess the efficacy of nebulised heparin and salbutamol in improving lung function in mechanically ventilated patients with AECOPD.
- Trial name
- NCT03333395
- Testing
- Nebulized heparin and salbutamol, Nebulized salbutamol
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Chronic Obstructive Pulmonary Disease
Bufei Yishen Granule for Reducing Acute Exacerbation in GOLD Stage 3 or 4 COPD
This study aims to establish the treatment scheme of Bufei Yishen granule for GOLD stage 3 or 4 chronic obstructive pulmonary disease (COPD), reducing acute exacerbation, improving exercise capacity and forming high quality…
- Trial name
- NCT03976713
- Testing
- Bufei Yishen granule, Tiotropium Bromide Powder for Inhalation
- Where
- China
- Volunteers
- 348 people
- Sponsor
- Henan University of Traditional Chinese Medicine
COPD Exacerbation, Chronic Obstructive Pulmonary Disease Exacerbation
Comparing Mortality for Low vs High Peripheral Oxygen Saturation in COPD-patients With Acute Exacerbation
Chronic obstructive pulmonary disease (COPD) is a common disorder that affects approximately 400,000 Danish citizens. About 3,000-3,500 Danes die yearly because of the disorder, and the costs associated with hospital admissions…
- Trial name
- O2flow-COPD (NCT04223050)
- Testing
- Oxygen gas
- Where
- 4 sites in Denmark
- Volunteers
- 23 people
- Sponsor
- Esbjerg Hospital - University Hospital of Southern Denmark
COPD Acute Exacerbation
The Role of Nebulized Budesonide in the Treatment of Acute Exacerbations of COPD
This study was designed to evaluate the hypothesis that nebulized budesonide) might be an alternative to systemic corticosteroids (SC) in the treatment of patients with acute exacerbations of COPD (AECOPD).
- Trial name
- NCT00274222
- Volunteers
- 120 people
- Sponsor
- Inonu University
Chronic Obstructive Pulmonary Disease
Transcutaneous Electrical Muscle Stimulation In Chronic Obstructive Pulmonary Disease (COPD)
Transcutaneous electrical muscle stimulation (TCEMS) is well established intervention for rehabilitation of clinically stable patients with chronic obstructive pulmonary disease.
- Trial name
- NCT01226342
- Testing
- Transcutaneous electrical muscle stimulation
- Where
- Slovenia
- Volunteers
- 19 people
- Sponsor
- The University Clinic of Pulmonary and Allergic Diseases Golnik
Acute Heart Failure, COPD Exacerbation
Use of PARniv for Early Diagnosis of LVF in AECOPD
Left ventricular failure (LVF) is a common cause of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). This association is frequently underestimated with regard to the difficulty of clinical diagnosis .
- Trial name
- NCT05189119
- Testing
- non invasive ventilation
- Where
- Tunisia
- Volunteers
- 80 people
- Sponsor
- University of Monastir
Bronchitis, Chronic
AVANTI - Avelox® in Acute Exacerbations of chroNic bronchiTIs
The objective of this global non-interventional study is to evaluate the impact of Acute Exacerbation of Chronic Bronchitis(AECB) on the patient and the community as well as the safety and effect of a treatment with Moxifloxacin…
- Trial name
- NCT00846911
- Testing
- Moxifloxacin (Avelox, BAY12-8039)
- Where
- 8 sites in Albania, Bosnia and Herzegovina and 6 more
- Volunteers
- 2,672 people
- Sponsor
- Bayer
Chronic Obstructive Pulmonary Disease
Noninvasive Ventilation Weaning Protocol in COPD
Noninvasive ventilation (NIV) has revolutionized the management of patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) with hypercapnic respiratory failure (HcRF).
- Trial name
- NCT07133711
- Testing
- Noninvasive ventilation
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Bronchitis
Outcome Study to Evaluate Klaricid XL® (Clarithromycin Modified Release) in Patients With Acute Exacerbation of Chronic Bronchitis
The objective of this study was to evaluate the role of Klaricid XL (clarithromycin modified release) in the treatment of acute exacerbation of chronic bronchitis (AECB) and its impact on improving the quality of life.
- Trial name
- NCT01354938
- Testing
- Clarithromycin modified release 500 mg
- Where
- 28 sites in Pakistan
- Volunteers
- 220 people
- Sponsor
- Abbott
COPD Exacerbation
Effect of High Flow Nasal During Exercise in COPD Patients
Early pulmonary rehabilitation is recommended after an episode of severe exacerbation of chronic obstructive pulmonary disease (COPD). However, its implementation is challenging particularly as regard exercise training.
- Trial name
- AiRehab (NCT03058081)
- Testing
- High Flow nasal cannula
- Where
- France
- Volunteers
- 19 people
- Sponsor
- Groupe Hospitalier du Havre
Pulmonary Disease, Chronic Obstructive
Task-specific Training for Patients With Acute Exacerbation of COPD
Patients with Chronic Obstructive Pulmonary Disease (COPD) experience a progressive deterioration in their quality of life. Task-specific training is a type of approach focused on chronic patients that allows the acquisition of…
- Trial name
- COPD (NCT06224075)
- Testing
- Task-specific training, Usual care
- Where
- Spain
- Volunteers
- 68 people
- Sponsor
- Universidad de Granada
COPD, COPD Exacerbation
Effectiveness of Low-Dose Theophylline for the Management of Biomass-Associated COPD
Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death worldwide, and over 90% of COPD-related deaths occurring in low- and middle-income countries (LMICs).
- Conditions
- COPD, COPD Exacerbation, COPD Exacerbation Acute, Pollution Related Respiratory Disorder
- Trial name
- NCT03984188
- Testing
- Theophylline ER, Standard of Care Treatment
- Where
- 2 sites in Uganda
- Volunteers
- 100 people
- Sponsor
- University of Miami