Clinical trials: Acute Fracture
Hip Fractures, Blood Loss
Early Administration Of Tranexamic Acid And Acute Blood Loss In Patients With Hip Fractures
The study is a prospective, randomized, double blinded, placebo controlled trial that aims to investigate the hypothesis that early administration of tranexamic acid (TXA) following diagnosis of hip fracture will lower pre and…
- Trial name
- NCT05518279
- Testing
- Tranexamic Acid Pill
- Sponsor
- Henry Ford Health System
Fracture
Buprenorphine for Analgesia in Older Adults With Acute Fractures in the Emergency Department
The goal of this clinical trial is to learn if buprenorphine can treat pain in older adults who have broken bones. The main questions it aims to answer are: Is buprenorphine as effective as opioids to treat pain? Are there less…
- Trial name
- NCT07430345
- Testing
- Buprenorphine 0.15 MG, Hydromorphone 0.25 mg IV
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- The Cooper Health System
Alcohol Use Disorder (AUD), Alcoholism
Cue Effects in Human Addiction: Pavlovian to Instrumental Transfer
Individuals with substance use disorders (SUD) have to cope with drug-related cues and contexts, which can affect instrumental drug seeking as shown with Pavlovian to instrumental transfer (PIT) paradigms in animals and humans.
- Conditions
- Alcohol Use Disorder (AUD), Alcoholism, Substance Use Disorders, Smoking, Tobacco
- Trial name
- ReCoDe (NCT05992272)
- Testing
- fMRI imaging (BOLD), sMRI (structure), Trier Social Stress Test
- Where
- 2 sites in Germany
- Volunteers
- 300 people
- Sponsor
- Charite University, Berlin, Germany
Acute Scaphoid Waist Fractures
Fluoroscopy vs. Computed Tomography for Diagnosis of Displacement and Instability of Acute Scaphoid Waist Fractures
Aim: The aim of this study is to analyze if fluoroscopy is as accurate as computed tomography in diagnosing displacement of acute scaphoid waist fractures.
- Trial name
- NCT02479009
- Testing
- Fluoroscopy
- Sponsor
- Massachusetts General Hospital
Osteoporotic Vertebral Fracture
The Influence of Vertebral Mobility on Low Back Pain in Patients With Acute Osteoporotic Vertebral Fractures
Many patients with acute osteoporotic vertebral fracture (acute OVFs) admitted because of low back pain. But there are only part of patients with acute OVFs, because some patients do not have low back pain although OVFs occurred.
- Trial name
- NCT01990365
- Where
- Japan
- Volunteers
- 300 people
- Sponsor
- Tomidahama Hospital
Rib Fracture Multiple, Trauma Chest
Lidocaine Infusions for Rib Fractures
Patients with traumatic rib fractures not receiving regional anesthesia through a epidural or nerve block catheter will be recruited for the study.
- Conditions
- Rib Fracture Multiple, Trauma Chest, Pain, Acute
- Trial name
- Lidocare (NCT03571919)
- Testing
- Lidocaine infusion, Saline infusion
- Where
- United States
- Sponsor
- Stanford University
Trauma, Trauma Injury
Liposomal Bupivacaine Intercostal Nerve Block vs Thoracic Epidural for Regional Analgesia in Multiple Rib Fractures
Management of traumatic rib fractures continues to be a challenge for trauma surgeons. Currently, many analgesic options are available to patients suffering from rib fractures.
- Conditions
- Trauma, Trauma Injury, Pain, Acute
- Trial name
- NCT03574376
- Testing
- Bupivacaine Liposome Injection, Bupivacaine
- Where
- United States
- Volunteers
- 258 people
- Sponsor
- Chadrick Evans
Deconditioning, Orthopedic Fractures
This Study Aims to Measure the Effect of Acute Hospitalisation on the Physical and Cognitive Functioning of Older Orthopaedic Patients (Aged 65 or Above).
This study aims to investigate the impact of hospitalisation on physical and cognitive performance in patients aged 65 and older admitted with an orthopaedic injury.
- Conditions
- Deconditioning, Orthopedic Fractures, Hospital Associated Deconditioning, Orthopaedic Injuries
- Trial name
- NCT06932224
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- University of Southampton
Finger Injuries, Finger Fracture
Comparison of New Suture Anchor Technique for Bony Mallet Injury Versus Conservative Treatment
This study aims to compare conservative treatment versus a new suture anchor technique for bony mallet finger in 29 patients.
- Conditions
- Finger Injuries, Finger Fracture, Finger Mallet
- Trial name
- NCT03228849
- Testing
- Suture anchor technique, Conservative Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 29 people
- Sponsor
- Istanbul University
Back Pain
Tapentadol IR vs Oxycodone IR vs Placebo in Acute Pain From Vertebral Compression Fracture Associated With Osteoporosis
The purpose of this study is to determine the effectiveness and safety of tapentadol immediate release (IR) as compared with placebo and oxycodone IR in patients with acute pain caused by vertebral compression fractures (VCF)…
- Trial name
- NCT00771758
- Testing
- oxycodone IR, tapentadol IR
- Where
- 37 sites in United States
- Volunteers
- 108 people
- Sponsor
- Ortho-McNeil Janssen Scientific Affairs, LLC
Acute Compartment Syndrome, Tibia Fracture
Biomarkers in the Diagnosis of Acute Compartment Syndrome
This prospective multinational, multicentre cohort study aims to investigate the hypothesis that biomarkers of muscle cell damage can predict acute compartment syndrome in patients with tibial fractures.
- Trial name
- BioFACTS (NCT04674592)
- Testing
- Blood samples and biopsies
- Where
- Sweden
- Volunteers
- 250 people
- Sponsor
- University Hospital, Linkoeping
Trauma (Including Fractures)
Stress in Trauma Patients in Triage Categories 3-5
The aim of this study is to better understand what causes patients the most concern immediately after an injury. We would like to find out how stressed patients are and whether the main causes of stress are pain, fear regarding…
- Trial name
- NCT07811830
- Testing
- Questionnaire and Physical Exam
- Where
- Croatia
- Volunteers
- 300 people
- Sponsor
- Gabriela Katharina Pomper
Cancer, Spinal Fractures
CAFE Study - Cancer Patient Fracture Evaluation
The primary objective of this study is to evaluate the safety and effectiveness of balloon kyphoplasty treatment for painful, acute, vertebral compression fractures (VCFs) as compared to standard non-surgical therapy in patients…
- Trial name
- CAFE (NCT00211237)
- Testing
- Balloon Kyphoplasty, Non Surgical Management
- Where
- 20 sites in United States, Australia and 6 more
- Volunteers
- 134 people
- Sponsor
- Medtronic Spine LLC
Fracture
Acute Pediatric Fracture Analgesia Study
A clinical trial comparing ibuprofen and acetaminophen with codeine for children after discharge from the emergency department. We hypothesize that Ibuprofen will provide 20% more effective analgesia compared to acetaminophen…
- Trial name
- NCT00520442
- Testing
- ibuprofen, acetamin w codeine
- Where
- United States
- Volunteers
- 335 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Patellar (or Kneecap) Instability and Mal-alignment, Patellar Dislocation
MPFL Reconstruction Versus Rehabilitation
This study involves patients between the ages of 16 and 25 and have been diagnosed with a first-time traumatic patellar dislocation within the past 3 months.
- Trial name
- ANTI-GLIDE (NCT06926699)
- Testing
- Medial Patellofemoral Ligament Reconstruction, Rehabilitation
- Sponsor
- McMaster University
Fracture Tibia, Fracture Femur
3D Planned Surgery of Acute Fractures Performed With 3D Guides Printed at the Point of Care
The aim of the study is to assess the accuracy of fracture reduction performed with surgical guides designed and 3D printed at the point of care in comminuted fractures of femur- and tibia-shaft.
- Conditions
- Fracture Tibia, Fracture Femur, Fracture, Comminuted
- Trial name
- 3DFRG (NCT05741892)
- Testing
- Fracture reposition with 3D printed patient specific repositions guides
- Where
- Switzerland
- Volunteers
- 15 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Pain, Postoperative, Pain, Acute
Cognitive Behavioural Therapy to Optimize Post-Operative Recovery Trial
Psychological factors such as stress, distress, anxiety, depression, and poor coping strategies may be associated with ongoing pain following injuries such as fractures.
- Conditions
- Pain, Postoperative, Pain, Acute, Pain, Chronic, Fractures, Closed
- Trial name
- COPE (NCT04274530)
- Testing
- Cognitive Behavioural Therapy
- Where
- 10 sites in United States, Canada
- Volunteers
- 1,024 people
- Sponsor
- McMaster University
Pain, Postoperative, Liposomal Bupivacaine
Liposomal Bupivacaine Plus Plain Bupivacaine Versus Dexamethasone Plus Plain Bupivacaine in the Supraclavicular Brachial Plexus Block in Patients With Risk Factors for Severe Acute Postoperative Pain
The supraclavicular brachial plexus block (BPB) is a frequently used anaesthetic method for upper limb surgeries, including distal radial fracture surgery.
- Conditions
- Pain, Postoperative, Liposomal Bupivacaine, Dexamethasone, Supraclavicular Brachial Plexus Block
- Trial name
- NCT07665762
- Testing
- 10ml 0.5% plain bupivacaine with 10ml 1.33% liposomal bupivacaine, 19ml 0.5% plain bupivacaine with 1ml (4mg) dexamethasone
- Where
- Hong Kong
- Volunteers
- 90 people
- Sponsor
- The University of Hong Kong
Hip Fracture, Vitamin D Deficiency
The Effect of Supplementation of Vitamin D Deficiency in Older People With Acute Hip Fracture:
This study will be done to evaluate the effect of load dose of vitamin D compared to the dose of usual clinical practice, in improving mobility and reducing disability in older people following a hip fracture.
- Trial name
- VITAMINA_D (NCT03213886)
- Testing
- Calcifediol (Vitamin D)
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Leonor Cuadra Llopart
Multiple Trauma, Acute Pain Due to Trauma
Evaluation of Effect of Intravenous Morphine vs Intravenous Ibuprofen and Acetaminophen vs Intravenous Ibuprofen
Pain is an inseparable symptom of fractures and is the most important and common symptom that brings patients to medical centers; Therefore, paying attention to pain and its control is very important in the examination and…
- Trial name
- NCT05630222
- Testing
- Ibuprofen 800 mg, Morphine Sulfate, Ibuprofen 400 mg plus Acetaminophen 1000 mg
- Where
- Iran
- Volunteers
- 150 people
- Sponsor
- Isfahan University of Medical Sciences