Clinical trials: Acute Gastrointestinal Bleeding
Volatile Organic Compound, Gastrointestinal Hemorrhage
Rapid Diagnostic Technology for AUGIB Based on Analysis of VOCs in Exhaled Breath
This study aims to develop a non-invasive and rapid diagnostic technology for acute upper gastrointestinal bleeding (AUGIB) by analyzing volatile organic compounds (VOCs) in exhaled breath.
- Trial name
- VOCsAUGIB (NCT06877507)
- Testing
- Gastroscopy, Gas Chromatography - Mass Spectrometry
- Volunteers
- 200 people
- Sponsor
- Beijing 302 Hospital
Gastric Ulcer, Duodenal Ulcer
Comparison of Ulcer Healing in Patients Taking Rabeprazole With Different Antiplatelets
Clopidogrel causes significantly less peptic ulcer disease (PUD) and ulcer bleeding than low-dose aspirin in general population.
- Trial name
- NCT01037491
- Testing
- rabeprazole plus aspirin versus rabeprazole plus clopidogrel
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Acute Upper Gastrointestinal Bleeding, Upper Gastrointestinal Bleeding
Trimebutine Maleate for Enhancing Gastric Visualization in Acute Upper Gastrointestinal Bleeding
Acute upper gastrointestinal bleeding is a medical emergency that requires an urgent upper endoscopy to locate and treat the source of the bleeding.
- Conditions
- Acute Upper Gastrointestinal Bleeding, Upper Gastrointestinal Bleeding, Gastrointestinal Hemorrhage
- Trial name
- NCT07749300
- Testing
- Trimebutine Maleate
- Volunteers
- 100 people
- Sponsor
- Assiut University
Esophageal and Gastric Varices, Gastrointestinal Hemorrhage
Comparison of 3 Days and 7 Days Intravenous Ceftriaxone Prophylaxis for Variceal Bleeding
Prophylactic antibiotics have been routinely recommended for cirrhotic patients with upper gastrointestinal bleeding recently. However, the regimen and duration of its use remain an inconclusive issue.
- Trial name
- NCT00838864
- Testing
- ceftrioxone
- Where
- Taiwan
- Volunteers
- 79 people
- Sponsor
- Far Eastern Memorial Hospital
Transfusion-related Acute Lung Injury, Chronic Liver Disease
Predicting Lung Injury From Transfusion in Patients With Liver Disease
A certain molecule floating in the blood may represent a risk of lung injury after a transfusion. We are determining whether detection of this molecule on a simple blood clotting test will predict the development of lung injury…
- Conditions
- Transfusion-related Acute Lung Injury, Chronic Liver Disease, Gastrointestinal Bleeding
- Trial name
- NCT01756690
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- University of Colorado, Denver
Cirrhosis, Liver, Portal Hypertension
Timing of Endoscopy for Acute Variceal Bleeding in Patients With Cirrhosis
Cirrhotic patients with AVB across 34 university medical centers in 30 cities in China from February 2013 to May 2020 who underwent endoscopy within 24 hours were included in this study.
- Conditions
- Cirrhosis, Liver, Portal Hypertension, Varice Bleed
- Trial name
- NCT04957875
- Testing
- emergency endoscopic therapy
- Where
- China
- Volunteers
- 3,300 people
- Sponsor
- Hepatopancreatobiliary Surgery Institute of Gansu Province
Acute on Chronic Liver Failure, Variceal Hemorrhage
Goal-Directed Hemostatic Resuscitation Trial in ACLF Induced Coagulopathy
In this project, we plan to evaluate whether a new, rotational thromboelastometry-guided algorithm (ROTEM) to guide hemostatic resuscitation decreases the use of allogeneic blood products, the total amount of bleeding…
- Conditions
- Acute on Chronic Liver Failure, Variceal Hemorrhage, Cirrhosis, Liver, Thromboelastometry
- Trial name
- GOODHEART-ACLF (NCT05124041)
- Testing
- Rotational thromboelastometry
- Where
- India
- Volunteers
- 262 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Myocardial Infarction, Helicobacter Pylori Infection
HELicobacter Pylori Screening to Prevent Gastrointestinal Bleeding in Patients With Acute Myocardial Infarction
Background: Potent antithrombotic therapy has improved prognosis for patients with acute myocardial infarction (MI) significantly, however, at a price of increased bleeding risk. Helicobacter pylori (H.
- Conditions
- Myocardial Infarction, Helicobacter Pylori Infection, GastroIntestinal Bleeding, Cardiovascular Diseases
- Trial name
- HELP-MI (NCT05024864)
- Testing
- Urea breath test (UBT)
- Where
- 35 sites in Sweden
- Volunteers
- 20,000 people
- Sponsor
- Karolinska Institutet
Gastrointestinal Hemorrhage
Transfusion in Gastrointestinal Bleeding
Aim: To evaluate the feasibility and safety of a restrictive versus liberal red blood cell (RBC) transfusion policy in adult patients admitted with Acute Upper Gastrointestinal Bleeding (AUGIB) in order to inform the design of a…
- Trial name
- TRIGGER (NCT02105532)
- Testing
- Restrictive transfusion policy, Liberal Transfusion Policy
- Where
- United Kingdom
- Volunteers
- 936 people
- Sponsor
- Dr Vipul Jairath
Upper Gastrointestinal Bleeding, Cirrhosis
Transfusion Requirements in Gastrointestinal (GI) Bleeding
Recently it has been suggested that a restrictive transfusion of units of Red Cells (URC) may improve the outcome of ICU patients with anemia.
- Conditions
- Upper Gastrointestinal Bleeding, Cirrhosis, Portal Hypertension
- Trial name
- NCT00414713
- Testing
- red blood cell transfusion
- Where
- Spain
- Volunteers
- 860 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Venous Thrombosis, Pulmonary Embolism
Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Pratice (Netherlands)
This prospective cohort study will provide information about: characteristics of Rivaroxaban use in patients who are prescribed Rivaroxaban for the first time compared to patients who are prescribed Acenocoumarol for the first…
- Conditions
- Venous Thrombosis, Pulmonary Embolism, Atrial Fibrillation, Acute Coronary Syndrome
- Trial name
- NCT01947985
- Testing
- Rivaroxoban (Xarelto, Bay59-7939), Standard of care
- Where
- Netherlands
- Volunteers
- 208,958 people
- Sponsor
- Bayer
Acute Coronary Syndrome
Relationship of Helicobacter Pylori Eradication Therapy and Long-term Outcome in Acute Coronary Syndrome
Objective: To investigate the relationship between Helicobacter pylori (Hp) infection and the prognosis of acute coronary syndrome (ACS) in a Chinese population and to explore the significance of Hp eradication therapy in…
- Trial name
- NCT02317445
- Volunteers
- 472 people
- Sponsor
- Capital Medical University
Gastroduodenal Ulcer, Marginal Ulcer
Comparison of Low Against High Regimen of Proton Pump Inhibitors for Treatment of Acute Peptic Ulcer Bleeding
Evaluate the efficacy of Two different regimens of proton pump inhibitors High against Low in the management of acute peptic ulcer bleeding
- Conditions
- Gastroduodenal Ulcer, Marginal Ulcer, Peptic Ulcer Hemorrhage
- Trial name
- NCT02724150
- Testing
- Omeprazole High dose, Omeprazole Low dose
- Where
- Syria
- Sponsor
- Damascus Hospital
Critical Illness, Acute Kidney Injury
Sup-Icu RENal (SIREN)
Data show that episodes of bleeding may often be observed in critically ill patients with dialysis-dependent acute renal failure (ARF) on renal replacement therapy (RRT).
- Conditions
- Critical Illness, Acute Kidney Injury, End-stage Renal Disease, Renal Replacement Therapy
- Trial name
- SIREN (NCT02718261)
- Testing
- Pantoprazole
- Where
- 2 sites in Denmark, Switzerland
- Volunteers
- 3,350 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Gastrointestinal Hemorrhage, Anemia
Iron Substitution After Upper Gastro-Intestinal Bleeding
The trial is a double-blind randomized trial designed to examine whether compliant iron therapy (intravenous or oral) for 3 months after discharge increases hemoglobin levels more and faster than no treatment - in patients with…
- Trial name
- NCT00978575
- Testing
- ferricarboxymaltose, Ferrosulfate
- Where
- Denmark
- Volunteers
- 97 people
- Sponsor
- University of Aarhus
Venous Thrombosis, Pulmonary Embolism
Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Practice (Germany)
This prospective cohort study will provide information about: characteristics of Rivaroxaban use in patients who are prescribed Rivaroxaban for the first time compared to patients who are prescribed Phenprocoumon for the first…
- Conditions
- Venous Thrombosis, Pulmonary Embolism, Atrial Fibrillation, Acute Coronary Syndrome
- Trial name
- NCT01947959
- Testing
- Rivaroxaban (Xarelto, Bay59-7939), Standard of care
- Where
- Germany
- Volunteers
- 665,533 people
- Sponsor
- Bayer
Coronary Artery Disease, Percutaneous Coronary Intervention
Potassium-Competitive Acid Blocker Versus pROton-Pump Inhibitor for GastroproTECTion Strategies In Patients at High Gastro-Intestinal Bleeding Risk Receiving Antithrombotic Therapy
The primary aim of this study is to evaluate the efficacy and safety of novel P-CAB (tegoprazan 50 mg once daily) as compared with standard PPI (rabeprazole 20 mg once daily) for protection of GI events in patients with known…
- Conditions
- Coronary Artery Disease, Percutaneous Coronary Intervention, Acute Coronary Syndrome, Myocardial Infarction
- Trial name
- PROTECT-HBR (NCT04416581)
- Testing
- PPI, P-CAB 50
- Where
- 45 sites in South Korea
- Volunteers
- 3,320 people
- Sponsor
- Duk-Woo Park, MD
GastroIntestinal Bleeding
Acute Gastrointestinal Bleeding Peripheral Pulse Volume Changes
The purpose and aim of this study are to compare changes in pulse volume to non-invasively predict active bleeding or high-risk stigmata in patients undergoing a gastrointestinal endoscopy to assess feasibility of the flow meter…
- Trial name
- NCT06441201
- Testing
- Pulse flowmeter
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Mayo Clinic
Gastro Intestinal Bleeding
The Role of Hypertonic Dextrose Spray as Endoscopic Topical Hemostatic Agent for Acute Non-Variceal Upper GI Bleeding
This study is conducted to evaluate the effectivity of hypertonic dextrose spray as an endoscopic topical hemostatic agent, compared to conventional agent (adrenaline injection, followed by hemoclip or thermocoagulation), in…
- Trial name
- NCT04979273
- Testing
- Dextrose 40 % in Water, Adrenaline 1 Mg/mL Solution for Injection, argon plasma coagulation
- Where
- Indonesia
- Volunteers
- 66 people
- Sponsor
- Dr Cipto Mangunkusumo General Hospital
Venous Thromboembolism, Gastro Intestinal Bleeding
Reducing Gastrointestinal Bleeding With Proton Pump Inhibitor Therapy in Acute Venous Thromboembolism
The investigators are studying whether treatment with a proton pump inhibitor called omeprazole reduces gastrointestinal bleeding in older adults taking blood thinners for a blood clot (venous thromboembolism).
- Conditions
- Venous Thromboembolism, Gastro Intestinal Bleeding, Blood Clot
- Trial name
- NCT06393868
- Testing
- Omeprazole 20 mg Oral Tablet
- Where
- 7 sites in Canada
- Volunteers
- 360 people
- Sponsor
- Ottawa Hospital Research Institute