Clinical trials: Acute Graft Versus Host Disease in Intestine, active
Appendicitis Acute, Acute Abdomen in Children
The Impact of a Diagnostic Strategy for Acute Appendicitis in Children With Acute Abdominal Pain in Primary Care
BACKGROUND Acute appendicitis (AA) in an early stage is difficult to distinguish from other (self-limiting) causes of acute abdominal pain (e.g.
- Trial name
- ISAAK (NCT06762275)
- Testing
- Diagnostic strategy
- Where
- Netherlands
- Volunteers
- 566 people
- Sponsor
- University Medical Center Groningen
Acute Uncomplicated Appendicitis
Direct Visualization ERAT Versus Laparoscopic Appendectomy in Adults With Acute Uncomplicated Appendicitis
This study compares two ways of treating acute uncomplicated appendicitis, which is a mild form of appendicitis. In the Direct Visualization ERAT group, participants will receive Endoscopic Retrograde Appendicitis Therapy (ERAT).
- Trial name
- E-APPEND (NCT07230379)
- Testing
- Direct Visualization Endoscopic Retrograde Appendicitis Therapy, Laparoscopic appendectomy
- Where
- 14 sites in China
- Volunteers
- 376 people
- Sponsor
- Changhai Hospital
Appendicitis, Acute, Appendectomy
Video-Based Grading of Intraoperative Adverse Events in Pediatric Laparoscopic Appendectomy
Acute appendicitis is the most common surgical emergency in children, and laparoscopic appendectomy is its standard treatment. Although intraoperative adverse events (iAEs) are recognized as an important determinant of surgical…
- Conditions
- Appendicitis, Acute, Appendectomy, Intraoperative Complications, Patient Safety
- Trial name
- PedAppy-iAE (NCT07794618)
- Testing
- Laparoscopic appendectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Ahmet Burak Doğan, MD
Colorectal Cancer, Breast Cancer
Impact of Aerobic Exercise on the Anticancer Immune Response in Patients Receiving Cancer Treatment
The goal of this clinical trial is to determine to what extent anticancer immune cells mobilized by aerobic exercise exhibit migratory and functional capacity towards cancer cells in patients undergoing treatment for breast or…
- Conditions
- Colorectal Cancer, Breast Cancer, Non Metastatic Cancer
- Trial name
- Immuno-Ex (NCT06911970)
- Testing
- Exercise
- Where
- 2 sites in Canada
- Volunteers
- 44 people
- Sponsor
- Université de Sherbrooke
Appendicitis Acute, Postoperative Sore Throat, Cough, Hoarseness
Effect of Endotracheal Tube Cuff Pressure Management on Postoperative Sore Throat in Pediatric Laparoscopic Appendectomy
Abstract Objective: The aim of this study is to compare two different ways of adjusting the air-filled cushion (cuff) of the breathing tube used during general anesthesia in children undergoing laparoscopic appendectomy (closed…
- Conditions
- Appendicitis Acute, Postoperative Sore Throat, Cough, Hoarseness, Airway Complications, Respiratory Complications
- Trial name
- NCT07678086
- Testing
- Pressure Transducer, Traditional Palpation Method
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ankara Etlik City Hospital
Acute Pain, Abdomen, Acute
Intravenous Ketorolac Vs. Morphine In Children With Acute Abdominal Pain
Appendicitis is a common condition in children 6-17 years of age, and the top reason for emergency surgery in Canada. Children with appendicitis can have very bad pain in their belly.
- Conditions
- Acute Pain, Abdomen, Acute, Abdominal Pain, Appendicitis
- Trial name
- KETOAPP (NCT06160778)
- Testing
- Ketorolac Tromethamine, Morphine Sulfate, normal saline
- Where
- Canada
- Volunteers
- 495 people
- Sponsor
- University of Calgary
Acute Appendicitis
Antibiotics vs Surgery in Acute Appendicitis
The aim of this study is to identify clinical, laboratory, and imaging parameters that can predict the most appropriate treatment strategy in patients diagnosed with acute appendicitis.
- Trial name
- NCT07492329
- Testing
- surgery (any volume) and / or pharmaceuticals treatment initiated or planned or only dynamic observation, in accordance with current clinical guidelines, Antibiotic
- Where
- Turkey (Türkiye)
- Volunteers
- 400 people
- Sponsor
- Sebahattin Celik MD
Ulcerative Colitis
Efficacy of Subcutaneous Infliximab in Acute Severe Ulcerative Colitis: a Multicenter Retrospective Study
Around 25% of patients with ulcerative colitis will develop acute severe colitis during the course of their disease. The first-line treatment for acute severe colitis is intravenous corticosteroid therapy.
- Trial name
- ISAC (NCT06998797)
- Testing
- Data collection
- Volunteers
- 50 people
- Sponsor
- Central Hospital, Nancy, France
Acute Appendicitis
Prospective Comparison of Pro-Adrenomedullin, C-Reactive Protein, and Neutrophil-to-Lymphocyte Ratio for Diagnosing Acute Appendicitis
The goal of this prospective observational study is to evaluate the diagnostic accuracy of pro-adrenomedullin (Pro-ADM) in adults with acute appendicitis and compare its performance with conventional inflammatory biomarkers…
- Trial name
- PROADM-APP (NCT07889544)
- Testing
- Serum Pro-Adrenomedullin Measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Respiratory Syncytial Virus Infection, Bronchiolitis
Gut Microbiome and Immune Response in Severe RSV Infection in Vietnamese Infants
Respiratory syncytial virus (RSV) is a leading cause of severe lower respiratory tract infection in young children, and a substantial proportion of severe cases occur in previously healthy infants.
- Conditions
- Respiratory Syncytial Virus Infection, Bronchiolitis, Viral Lower Respiratory Tract Infection (LRTI)
- Trial name
- GUT-LUNG RSV (NCT07417657)
- Where
- Vietnam
- Volunteers
- 250 people
- Sponsor
- Phuc Huu Phan
Acute Lymphoblastic Leukemia
The Association Between Gut Microbiome Composition Signature and Cancer-related Symptoms in Children With Acute Lymphoblastic Leukemia
This study is a prospective longitudinal investigation. Data on disease-related information, gut microbiota composition, cancer-related symptoms, dietary intake, and levels of pro-inflammatory cytokines, LPS were collected…
- Trial name
- NCT07515430
- Testing
- Questionnaires set, fecal sample collecting
- Where
- 2 sites in China
- Volunteers
- 138 people
- Sponsor
- Sun Yat-sen University
Pneumococcal Pneumonia, Rotavirus Enteritis With Hypovolemic Shock
Artificial Intelligence-driven Virtual Standardized Pediatric Patients Trial
Background: China's healthcare system for children faces significant challenges, particularly due to the limited pediatric service capacity of primary healthcare institutions.
- Conditions
- Pneumococcal Pneumonia, Rotavirus Enteritis With Hypovolemic Shock, Hand-foot-and-mouth Disease, Acute Appendicitis
- Trial name
- NCT06699433
- Testing
- Virtual standardized patients (VSPs), Case teaching manuals, Case teaching videos
- Where
- 3 sites in China
- Volunteers
- 459 people, healthy volunteers welcome
- Sponsor
- Southern Medical University, China
Intra Abdominal Infections, Appendicitis Acute
Diagnosis of Abdominal Pain Using RNA Levels: The NATURAL Study
The NATURAL Study is a prospective, observational, pragmatic study of RNA biomarkers of infections to aid in the diagnosis of abdominal pain.
- Conditions
- Intra Abdominal Infections, Appendicitis Acute, Pyelonephritis, Diverticulitis
- Trial name
- NATURAL (NCT07579312)
- Testing
- TruNAV, an RNA-based blood test for host immune activation by infections
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- True Bearing Diagnostics, Inc.
Coronary Artery Disease, Percutaneous Coronary Intervention
Potassium-Competitive Acid Blocker Versus pROton-Pump Inhibitor for GastroproTECTion Strategies In Patients at High Gastro-Intestinal Bleeding Risk Receiving Antithrombotic Therapy
The primary aim of this study is to evaluate the efficacy and safety of novel P-CAB (tegoprazan 50 mg once daily) as compared with standard PPI (rabeprazole 20 mg once daily) for protection of GI events in patients with known…
- Conditions
- Coronary Artery Disease, Percutaneous Coronary Intervention, Acute Coronary Syndrome, Myocardial Infarction
- Trial name
- PROTECT-HBR (NCT04416581)
- Testing
- PPI, P-CAB 50
- Where
- 45 sites in South Korea
- Volunteers
- 3,320 people
- Sponsor
- Duk-Woo Park, MD
Acute Appendicitis
TACTILE : Validation of a Teleconsultation-Based Predictive Score for the Diagnosis of Acute Appendicitis in Children Using Artificial Intelligence Methods
Acute appendicitis is the most common abdominal surgical emergency in children and a frequent cause of pediatric emergency department visits.
- Trial name
- TACTILE (NCT07479849)
- Testing
- Score-based appendicitis risk classification in teleconsultation
- Where
- France
- Volunteers
- 1,500 people
- Sponsor
- University Hospital, Angers
Small Bowel Obstruction
Early Surgery Versus 3 Days Non-surgical Management in Acute Small Bowel Obstruction (SURGI-BOW)
For uncomplicated acute small bowel obstruction (aSBO), the "Bologna guidelines" recommend non-surgical management of 72 hours before considering surgery.
- Trial name
- SURGI-BOW (NCT06065150)
- Testing
- Standard support, Early surgery proposed according to the radiological score
- Where
- 14 sites in France
- Volunteers
- 630 people
- Sponsor
- University Hospital, Angers
Fecal Incontinence
Acute Genital Nerve Stimulation for Neurogenic Bowel Dysfunction in Individuals Living With Spinal Cord Injury
Bowel issues occur in nearly all people after spinal cord injury (SCI) and one major complication is fecal incontinence (accidents).
- Trial name
- NCT05626816
- Testing
- Genital Nerve Stimulation, Clinical exam, Collection of SCI common data elements
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- MetroHealth Medical Center
Blood Cancer
Development of a Multi-biomarker Panel for Prognostic Stratification and Treatment Response Prediction in Acute Graft Versus Host Disease of the Gut
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a life-saving treatment for many malignant hematologic diseases.
- Trial name
- GUT-PREDICTION (NCT07305090)
- Testing
- Adult and pediatric patients with hematological diseases treated with allogeneic hematopoietic cell transplantation
- Where
- Italy
- Volunteers
- 90 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Acute-graft-versus-host Disease
FMT in Gut aGVHD Treated
With the stem cell transplanting increasing, patients which effected with gut GVHD were also increased. To evaluation the safety and efficacy of FMT for gut GVHD,patients with gut GVHD were recruited.
- Trial name
- NCT03148743
- Testing
- Fecal microbiota
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Soochow University
Acute Graft Versus Host Disease in Intestine
FMT for Pediatric SR-aGVHD
This is a pilot, prospective, non-profit, multicenter, uncontrolled, open-label study to evaluate the safety and feasibility of FMT in patients aged between 3 months and 25 years suffering from acute intestinal GVHD resistant to…
- Trial name
- NCT07602751
- Testing
- Fecal Microbial Transplantation
- Where
- 3 sites in Italy
- Volunteers
- 20 people
- Sponsor
- Bambino Gesù Hospital and Research Institute