Clinical trials: Acute Graft Versus Host Disease in Intestine
Inflammatory Bowel Diseases, Colitis, Ulcerative
Protein and Magnesium in Ulcerative Colitis
The aim of the study is to improve the quality of nutritional therapy for patients admitted with Acute Severe Ulcerative Colitis (ASUC) treated with high-dose steroids.
- Conditions
- Inflammatory Bowel Diseases, Colitis, Ulcerative, Magnesium Deficiency, Nutritional Deficiency
- Trial name
- PAMUC (NCT05271838)
- Testing
- Magnesium acetate mixture (30 mmol/ml), High-protein diet (2 g/kg/day)
- Where
- Denmark
- Volunteers
- 36 people
- Sponsor
- University of Aarhus
Pain, Postoperative, Acute Pain
EFFECT - EFFectiveness of ESPB (Erector Spinae Plane Block) in Laparoscopic Cοlectomies Trial
The aim of the trial is to study the efficacy of continuous bilateral Erector Spinae Plane Block (ESPB) in managing perioperative pain in patients who undergo elective laparoscopic colectomy.
- Conditions
- Pain, Postoperative, Acute Pain, Postoperative Complications, Pain
- Trial name
- EFFECT (NCT04879004)
- Testing
- Ropivacaine injection
- Where
- Greece
- Volunteers
- 40 people
- Sponsor
- Democritus University of Thrace
Severe Acute Malnutrition
Ready to Use Therapeutic Food (RUTF) in Severe Malnourished Children
1. RUTF would be more effective (quicker catch-up growth by promoting more tissue accrue resulting decrease stay in rehabilitation ward) in treating children with SAM during the rehabilitation phase than khichuri /halwa; 2.
- Trial name
- RUTF (NCT01331044)
- Testing
- Plumpy Nut, Khichuri and Halwa
- Where
- Bangladesh
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Acute Appendicitis, Acute Appendicitis With Rupture
Short Post-operative Antibacterial Therapy in Complicated Appendicitis: Oral Versus Intravenous
Short Post-operative Antibacterial Therapy in Complicated Appendicitis: Oral Versus Intravenous is a prospective randomized controlled trial comparing 24 hour intravenous antibacterial therapy to 24 hour oral antibacterial…
- Conditions
- Acute Appendicitis, Acute Appendicitis With Rupture, Acute Appendicitis Without Peritonitis, Acute Appendicitis With Appendix Abscess
- Trial name
- NCT04947748
- Testing
- Oral versus intravenous administration of antibacterial treatment
- Where
- Estonia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- North Estonia Medical Centre
Acute Appendicitis
Sensitivity and Specificity of the Alvarado Score for the Timely Differential Diagnosis of Acute Appendicitis in Samoa
Retrospective clinical data review design of all patients admitted to the Tupua Tamasese Meaole Hospital Surgical Unit for AA from January 2015 to December 2016.
- Trial name
- NCT05168410
- Testing
- Alvarado Score
- Volunteers
- 225 people
- Sponsor
- Dr Annette Kaspar
Solid Tumours of Epithelial Origin, Metastatic Colorectal Cancer
Phase I / II Study of Enadenotucirev by Sub-acute Fractionated IV Dosing in Cancer Patients
This is a multicentre, open-label, Phase I/II study of enadenotucirev in patients with either solid tumour of epithelial origin not responding to standard therapy or for whom no standard treatment exists (Phase I dose escalation…
- Conditions
- Solid Tumours of Epithelial Origin, Metastatic Colorectal Cancer, Metastatic Bladder Cancer
- Trial name
- EVOLVE (NCT02028442)
- Testing
- Enadenotucirev
- Where
- 6 sites in Belgium, Spain
- Volunteers
- 61 people
- Sponsor
- Akamis Bio
Severe Acute Malnutrition, Moderate Acute Malnutrition
Transfer of Healthy Gut Flora for Restoration of Intestinal Microbiota Via Enema for Patients in the Rehabilitative Phase of Malnutrition
This single-center, randomized, open-label trial will compare the safety of MTT delivered by rectal catheter enema in participants 12-60 months of age with malnutrition (moderate acute malnutrition [MAM] or severe acute…
- Trial name
- THRIVE (NCT03087097)
- Testing
- Fecal Microbiota Transplantation
- Where
- South Africa
- Volunteers
- 5 people
- Sponsor
- Microbiome Health Research Institute
Colorectal Cancer, Hematologic Malignancy
Natural Killer (NK) Cells in Combination With Interleukin-2 (IL-2) and Transforming Growth Factor Beta (TGFbeta) Receptor I Inhibitor Vactosertib in Cancer
One of the ways that cancer grows and spreads is by avoiding the immune system.NK cells are immune cells that kill cancer cells, but are often malfunctioning in people with colorectal cancer and blood cancers.
- Conditions
- Colorectal Cancer, Hematologic Malignancy, Rectum Cancer, Acute Myeloid Leukemia
- Trial name
- NCT05400122
- Testing
- Vactosertib, Fludarabine Phosphate, Cyclophosphamide
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- David Wald
Acute Coronary Syndromes (ACS)
Evaluation Through Innovative Examinations of Intestinal Dysbiosis Status in Patients Diagnosed With Cardiovascular Diseases and Evaluation of the Efficacy of Natural and Probiotic Extracts in the Non-pharmacological Approach to Improving Intestinal Dysbiosis Status.
The prospective experimental study aims to take an instantaneous photograph of the subject at time T0 and after 24 hours of intestinal permeability and dysbiosis indices in patients with acute coronary syndromes (ACS) which…
- Trial name
- DISBIO (NCT07429227)
- Testing
- Tea tree (Melaleuca alternifolia), Cinnamon (Cynnamomum zeylanicum) bark, Clove carnation (Eugenia caryopyllus) flowers, Red thyme (Thymus vulgaris) plant
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Casa di Cura Dott. Pederzoli
Acute Leukaemia
Amplification and Selection of Antimicrobial Resistance in the Intestine
The worldwide increase in the incidence of multidrug-resistant (MDR) pathogens is alarming. Antimicrobial treatment is a risk factor for the isolation of MDR pathogens and can therefore contribute to the observed trend.
- Trial name
- ASARI (NCT02058888)
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- University Hospital Tuebingen
Acute Appendicitis
Non-operative Treatment of Acute Non-perforated Appendicitis
Gold Standard treatment of appendicitis is appendectomy but non-operative treatment of non-perforated appendicitis with antibiotics is also under trial.
- Trial name
- NCT04030741
- Testing
- Meronem and flagyl, Appendectomy
- Where
- Pakistan
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- King Edward Medical University
Mesenteric Ischemia
Multislice Computed Tomography Angiography in Acute Mesenteric Ischemia
Acute mesenteric ischemia is a life-threatening condition with high mortality. Acute mesenteric ischemia is responsible for fewer than one in 1000 hospital admissions, but its mortality rate ranges between 30% and 90% .
- Trial name
- NCT03484442
- Volunteers
- 30 people
- Sponsor
- Assiut University
Solid Tumors and Hematologic Malignancy
An Open-Label, Dose-Escalation Study of INCB054329 in Patients With Advanced Malignancies
This was a study of INCB054329 given to patients with advanced malignancies that were conducted in three treatment groups. Each treatment group had a dose escalation (Part 1) and a dose expansion (Part 3), two of the treatment…
- Trial name
- NCT02431260
- Testing
- INCB054329 Monotherapy
- Where
- 12 sites in United States
- Volunteers
- 69 people
- Sponsor
- Incyte Corporation
Acute Appendicitis
Changes in the Treatment of Acute Appendicitis
The purpose of this study was to analyse the epidemiology, diagnostics, the type of surgical techniques and their development over time, and mortality in acute appendicitis in 68 hospitals in Germany based on routine data between…
- Trial name
- TreatApp (NCT06558760)
- Volunteers
- 31,988 people
- Sponsor
- Medizinische Hochschule Brandenburg Theodor Fontane
Crohn's Disease
High Dose Oral 4-Aminosalicylic Acid (PASER®) to Control Acute Flares of Mild to Moderate Crohn's Disease
The purpose of this 4 week study is to determine whether PASER®, an approved delayed-release oral formulation of 4-aminosalicylic acid, in doses of 4 grams three times daily for 2 weeks followed by 4 grams twice daily for 2…
- Trial name
- NCT00417690
- Testing
- 4-Aminosalicylic acid
- Where
- 5 sites in United States, Israel
- Volunteers
- 54 people
- Sponsor
- Jacobus Pharmaceutical
Appendicitis
Morphine Analgesia in Patients With Acute Appendicitis
The purpose of the study is to evaluate morphine effect on pain reduction and diagnostic accuracy in patients admitted to emergency ward with the diagnosis of acute appendicitis.
- Trial name
- NCT00477061
- Testing
- Morphine
- Where
- Iran
- Volunteers
- 71 people
- Sponsor
- Tehran University of Medical Sciences
Adult B Acute Lymphoblastic Leukemia, Chronic Lymphocytic Leukemia
Ibrutinib in Treating Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma in Patients With HIV Infection
This phase I trial studies the side effects and best dose of ibrutinib in treating B-cell non-Hodgkin lymphoma that has returned or does not respond to treatment in patients with human immunodeficiency virus (HIV) infection.
- Conditions
- Adult B Acute Lymphoblastic Leukemia, Chronic Lymphocytic Leukemia, Cutaneous B-Cell Non-Hodgkin Lymphoma, Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue
- Trial name
- NCT02109224
- Testing
- Ibrutinib, Laboratory Biomarker Analysis, Pharmacological Study
- Where
- 7 sites in United States
- Volunteers
- 72 people
- Sponsor
- National Cancer Institute (NCI)
Ulcerative Colitis, Telemedicine
The Use of Web-app Constant-Care in Patients With Acute Severe Ulcerative Colitis Treated With Rescue Therapy
The primary aim is to evaluate if introduction of eHealth in its form of the web application Constant-Care (https://ibd.constant-care.com) could reduce the length of hospitalization in patients with acute severe Ulcerative…
- Trial name
- NCT04165265
- Testing
- Constant-Care
- Where
- Denmark
- Volunteers
- 28 people
- Sponsor
- Nordsjaellands Hospital
Acute Appendicitis in Elderly
Clinicopathological Aspects of Acute Appendicitis in Patients Above Age of Thirty at Sulaimani Emergency Hospital
Aims of this study are : Estimate the incidence of A.A. in patients above age of 30 y in 4 age groups . Correlate between different clinical aspects and histopathological results.
- Trial name
- NCT04033198
- Testing
- Appendectomy
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Sulaimani
Gut Microbiota, Intra-abdominal Infections
Gut Microbiota Analysis in IAI Patients With Sepsis-associated Liver Dysfunction
With the rapid development of intensive care medicine, the mortality of patients with sepsis has decreased over the past decade, but it is still the leading cause of death in intensive care unit (ICU).
- Conditions
- Gut Microbiota, Intra-abdominal Infections, Acute Gastrointestinal Injury, Sepsis-associated Liver Dysfunction
- Trial name
- 2022-11-09 (NCT05628493)
- Testing
- Gut microbiota Analysis
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Chinese Medical Association