Clinical trials: Acute Graft-versus-host Disease
Sedative Adverse Reaction
Morphine, Midazolam and Dexmedetomidine in the Management of Acute Cardiogenic Pulmonary Edema, Safety and Efficacy
Acute cardiogenic pulmonary edema is a stressful scenario with progressive respiratory failure that may lead to cardiorespiratory collapse within hours, or minutes unless therapeutic action is taken As the initial events in…
- Trial name
- NCT06653244
- Testing
- Injection
- Where
- Egypt
- Volunteers
- 84 people
- Sponsor
- Menoufia University
Appendicitis, Abdominal Abscess
Irrigation Versus Suction in Complicated Acute Appendicitis
This study evaluates the intraabdominal abscess rate after laparoscopic appendectomy in complicated acute appendicitis performing irrigation of the abdominal cavity or only suction without lavage.
- Conditions
- Appendicitis, Abdominal Abscess, Acute Disease, Cecal Diseases
- Trial name
- ISAAC (NCT02688244)
- Testing
- Irrigation, No irrigation
- Where
- Spain
- Volunteers
- 210 people
- Sponsor
- Hospital Universitario Virgen de la Arrixaca
Acute Herpes Zoster Pain Managment
Ultrasound-Guided Erectro Spinae Plane Block Versus Stellate Ganglion Block for Patients With Upper Limb Acute Herpes Zoster Pain.
Herpes zoster (HZ) is a painful, eruptive, viral condition results from reactivation of the latent varicella zoster virus after the primary infection.
- Trial name
- NCT06307444
- Testing
- Ultrasound-Guided Stellate Ganglion Block, T2 T3 (High Thorathic) ESP Block
- Where
- Egypt
- Volunteers
- 93 people
- Sponsor
- Tanta University
Non-Hodgkin Lymphoma (NHL), Multiple Myeloma (MM)
Study Evaluating Venetoclax in Subjects With Hematological Malignancies
This study is evaluating the safety, pharmacokinetic profile and efficacy of venetoclax under a once daily dosing schedule in Japanese participants with hematological malignancies.
- Conditions
- Non-Hodgkin Lymphoma (NHL), Multiple Myeloma (MM), Chronic Lymphocytic Leukemia (CLL), Small Lymphocytic Lymphoma (SLL)
- Trial name
- NCT02265731
- Testing
- azacitadine, venetoclax, rituximab / IDEC-C2B8
- Where
- 14 sites in Japan
- Volunteers
- 38 people
- Sponsor
- AbbVie
Acute Myocardial Infarction, Chest Pain
Evaluation of Serial Troponin and Cardiac Multimarkers at the Point of Care in the Emergency Department
This is a multi-center study to assess the diagnostic accuracy of the Troponin I assay in the Biosite Triage Cardio3 Panel at the point-of-care (POC) in adults presenting to the emergency department with possible acute myocardial…
- Conditions
- Acute Myocardial Infarction, Chest Pain, Acute Coronary Syndrome
- Trial name
- ESTIMATE (NCT00907231)
- Where
- 6 sites in United States
- Sponsor
- Abbott RDx Cardiometabolic
Atopic Dermatitis, Immunoglobulin E Concentration, Serum
The Efficacy of Cimetidin for Acute - Extrinsic Atopic Dermatitis Treated With Standard Therapy
Extrinsic - atopic dermatitis is characterized by increased of IgE serum levels. Acute extrinsic - atopic dermatitis is a type 1 hypersensitivity that involve various inflammatory mediator including Interleukin-4, Interleukin-12…
- Trial name
- NCT04018131
- Testing
- Cimetidine
- Where
- Indonesia
- Volunteers
- 26 people
- Sponsor
- Fakultas Kedokteran Universitas Indonesia
Type A Aortic Dissection, Complication of Surgical Procedure
Safety and Efficacy of XJ-Procedure in Patients With Acute Type A Aortic Dissection Surgery
This is a national, multicenter, open-label, randomized, controlled, endpoint-blinded clinical trial of patients diagnosed with ATAAD and undergoing "Sun's procedure" coordinated by the First Affiliated Hospital of Xi'an Jiaotong…
- Conditions
- Type A Aortic Dissection, Complication of Surgical Procedure, Aortic Diseases
- Trial name
- ADVANCED-XJ-Ⅱ (NCT06199401)
- Testing
- Vascular Grafts Eversion and Built-in Technique(XJ-Procedure)
- Where
- China
- Volunteers
- 680 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Pulmonary Embolism, Covid-19
Prevalence and Characteristics of Pulmonary Embolism on COVID-19 Patients Presenting Respiratory Symptoms
Multicentric case-control study that is aims at: evaluating the prevalence of pulmonary embolism among a large population of consecutive patients admitted for COVID-19 pneumonia into two large university hospitals in Paris…
- Trial name
- COVID-EP (NCT04420312)
- Where
- France
- Volunteers
- 1,024 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Acute Myocardial Infarction (AMI)
Counterpulsation Reduces Infarct Size Pre-PCI for AMI
Subjects with anterior acute STEMI who receive an IABC before primary PCI will have decreased MI size.
- Trial name
- CRISP-AMI (NCT00833612)
- Testing
- Counterpulsation with IAB
- Where
- 40 sites in United States, Australia and 8 more
- Volunteers
- 339 people
- Sponsor
- Datascope Corp.
Functional Mitral Regurgitation, Heart Failure
The BOSS Study: An Acute Evaluation of Anatomical and Geometric Changes Using the Bladder on a Stick System (BOSS)
The objective of the BOSS Study is to assess acute anatomical and geometric annular and ventricular changes that occur when strategically positioned an external inflatable chambers are applied to the outside of the heart.
- Trial name
- BOSS (NCT03228381)
- Testing
- BOSS Device
- Where
- 3 sites in United States, Paraguay
- Volunteers
- 4 people
- Sponsor
- Mardil Medical
Lung Injury, Acute
a Study Conducted About a New Mode of Ventilation in Laparoscopic Surgeries
Carbon dioxide insufflations of abdomen are integral part of laparoscopic operations in minimally invasive surgery era. It does cause splinting effect on diaphragm movement and set it high inside thoracic cavity too.
- Trial name
- NCT03637530
- Testing
- inverse ratio ventilation
- Volunteers
- 128 people
- Sponsor
- All India Institute of Medical Sciences, Rishikesh
Covid19
Pulmonary Rehabilitation in COVID-19 Patients
It was aimed to evaluate the respiratory functions of patients who were given respiratory rehabilitation, bed positioning and early mobilization, and the time of leaving the hospital.
- Trial name
- NCT04832867
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Relapsed or Refractory B-cell Acute Lymphoblastic Leukemia, Relapsed or Refractory B-cell Non-hodgkin Lymphoma
CD19 Targeted Universal Chimeric Antigen Receptor T Cells Injection for CD19+ Refractory/Relapsed B-cell Malignancies
It is a single-arm, open-label clinical study to assess the safety and efficacy of the Anti-CD19 Universal CAR-T Cells injection for patients with CD19+ refractory/relapsed B cell acute lymphoblastic leukemia and B cell…
- Trial name
- NCT05105867
- Testing
- Anti-CD19 Universal CAR-T Cells injection
- Where
- China
- Volunteers
- 15 people
- Sponsor
- 920th Hospital of Joint Logistics Support Force of People's Liberation Army of China
Relapsed or Refractory Acute Myeloid Leukemia
Venetoclax, Chidamide, and Chiglitazar Sodium (VCC) in Patients With Relapsed/Refractory Acute Myeloid Leukemia
To evaluate the efficacy and safety of venetoclax, chidamide, and chiglitazar sodium (VCC) in patients with relapsed or refractory acute myeloid leukemia (R/R AML).
- Trial name
- NCT07783100
- Testing
- venetoclax, chidamide, and chiglitazar sodium (VCC)
- Where
- China
- Volunteers
- 30 people
- Sponsor
- The First Affiliated Hospital of Xiamen University
Postural Orthostatic Tachycardia Syndrome
Efficacy and Safety Study of Efgartigimod in Adults With Post-COVID-19 POTS
The study aims to investigate the safety, tolerability, efficacy, pharmacodynamics (PD), pharmacokinetics (PK), and immunogenicity of efgartigimod compared to placebo in participants with post-COVID-19 postural orthostatic…
- Trial name
- POTS (NCT05633407)
- Testing
- Efgartigimod
- Where
- 11 sites in United States
- Volunteers
- 53 people
- Sponsor
- argenx
Acute Coronary Syndrome (ACS) Undergoing Percutaneous Coronary Intervention (PCI), High Bleeding Risk
Genotype-Guided Abbreviated DAPT Versus Un-Guided De-escalation Therapy in Patients With ACS and HBR
The aim of this study is to assess the safety and efficacy of the CYP2C19 genotype-guided abbreviated dual antiplatelet therapy (DAPT) strategy versus the un-guided stepwise intensity de-escalation of DAPT strategy in patients…
- Trial name
- GUIDE-HBR (NCT06763744)
- Testing
- P2Y12 antagonist monotherapy, clopidogrel + aspirin
- Where
- South Korea
- Volunteers
- 3,000 people
- Sponsor
- Samsung Medical Center
Long COVID Syndrome
Does Taurine Supplementation Improve Vascular Function and Orthostatic Responses in Long COVID?
Millions have developed Long COVID (LC), and recent findings show an association between taurine deficiency (an amino acid) and symptoms in LC.
- Trial name
- NCT07312409
- Testing
- Taurine supplementation
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- York University
B-Cell ALL, B-Cell Acute Lymphoblastic Leukaemia
A Multi-site Study to Evaluate the Persistence of Protective Immunity to Routine Childhood Vaccinations in Participants With B-ALL/Ly Who Have Received Blinatumomab
The goal of this observational study is to establish a clear vaccination protocol for pediatric patients (less than 21 years old) who have received treatment for B-cell Acute Lymphoblastic Leukemia/Lymphoma.
- Conditions
- B-Cell ALL, B-Cell Acute Lymphoblastic Leukaemia, B-Cell Lymphoblastic Leukemia, B-Cell Lymphoblastic Leukemia/Lymphoma
- Trial name
- BOOSTER (NCT07422337)
- Where
- 2 sites in United States
- Volunteers
- 300 people
- Sponsor
- Arkansas Children's Hospital Research Institute
Acute Coronary Syndrome
Impact of OCT Imaging on Decision Making During PCI in ACS Patients
Optical coherence tomography (OCT) provides valuable information to guide percutaneous coronary intervention (PCI) in acute coronary syndrome (ACS) regarding lesion preparation, stent sizing, and stent optimization.
- Trial name
- NCT04444037
- Testing
- OCT-guided PCI
- Where
- Japan
- Volunteers
- 390 people
- Sponsor
- Assiut University
Leukemia
Hormone Therapy Plus Chemotherapy in Treating Children With Acute Lymphoblastic Leukemia
RATIONALE: Hormone therapy may stop the growth of cancer cells. Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die.
- Trial name
- NCT00003437
- Testing
- asparaginase, cyclophosphamide, cytarabine
- Where
- United Kingdom
- Volunteers
- 1,800 people
- Sponsor
- Medical Research Council
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