Clinical trials: Acute Heart Failure, open to volunteers
Acute Decompensated Heart Failure
Add-on Diuretics in Acute Decompensated Heart Failure
The aim of this study is to compare the efficacy and safety of empagliflozin, acetazolamide, and metolazone as add-on therapies to loop diuretics in patients with acute decompensated heart failure.
- Trial name
- NCT07372040
- Testing
- empagliflozin, Acetazolamide, metolazone
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Tanta University
Heart Failure, Persistent Congestion
Effect of Acetazolamide on Diuresis and Natriuresis in Patients With Acute Heart Failure (SANDI STUDY)
The goal of this observational study is to assess the natriuretic effect of intravenous acetazolamide in patients admitted with heart failure and persistent congestion despite treatment with intravenous furosemide and…
- Trial name
- SANDI (NCT06285760)
- Testing
- Acetazolamide 500mg
- Where
- Spain
- Volunteers
- 64 people
- Sponsor
- Puerta de Hierro University Hospital
COPD, COPD Exacerbation Acute
The Italian Registry of Patients With Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) is a treatable but debilitating medical condition associated with persistent symptoms and chronic airflow obstruction.
- Conditions
- COPD, COPD Exacerbation Acute, Comorbid Chronic Lung Disease on Heart Failure, Mortality
- Trial name
- ICoRe (NCT06652776)
- Testing
- Pharmacological treatment
- Where
- Italy
- Volunteers
- 10,000 people
- Sponsor
- University of Milan
Acute Respiratory Distress Syndrome, Right Heart Failure
Incidence and Evolution of Heart-lung Interaction in Acute Respiratory Distress Syndrome
Acute respiratory distress syndrome (ARDS) is an inflammatory injury of the lungs caused by various serious illnesses, such as a bacterial or viral lung infection.
- Trial name
- IVOLIA (NCT07450846)
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Bicetre Hospital
ACS (Acute Coronary Syndrome), HF - Heart Failure
A Clinical Study on the Effect of Cardiopulmonary Function and Quality of Life in Patients With Acute Coronary Syndrome Complicated by Heart Failure by "Lying-Sitting-Standing" Sequential Baduanjin
This study investigates the effects of a sequential "lying-sitting-standing" Baduanjin intervention on patients with acute coronary syndrome complicated by heart failure.
- Trial name
- NCT07486791
- Testing
- standard treatment and routine rehabilitation nursing guidance, "Lying-Sitting-Standing" Sequential Baduanjin
- Where
- China
- Volunteers
- 65 people
- Sponsor
- Xiling Qi
Acute Heart Failure (AHF), Congestion, Venous
Simple Urine Composition-based Personalized Algorithm for Effective Congestion Relief in Decompensated Heart Failure
The aim of this study is to evaluate the effectiveness of loop diuretic adaptative algorithm that is based on machine learning, urine output prediction tool, in decongestion of acute heart failure patients.
- Trial name
- SAFER-DHF (NCT07099885)
- Testing
- Standard of Care (SOC), Algorithhm-based decongestion
- Where
- 2 sites in Poland
- Volunteers
- 90 people
- Sponsor
- Wroclaw Medical University
Acute Kidney Injury, Kidney Failure Chronic
French AKI Registry (FAKIR): A Multicenter Study on the In-Hospital Management and Outcomes of Severe Acute Kidney Injury in Nephrology Units
Acute Kidney Injury (AKI) is a common and serious condition in hospitalized patients, especially when it reaches stages 2 or 3 according to the KDIGO classification.
- Conditions
- Acute Kidney Injury, Kidney Failure Chronic, Cardiorenal Syndrome, Renal Replacement Therapies
- Trial name
- FAKIR (NCT07123324)
- Volunteers
- 750 people
- Sponsor
- University Hospital, Strasbourg, France
Acute Myocardial Infarction, Cardiogenic Shock
Assessment of ECMO in Acute Myocardial Infarction Cardiogenic Shock
Data from case series and large retrospective trials suggest that the early treatment of cardiogenic shock AMI patients with the association of VA-ECMO and IABP may significantly decrease mortality, which is still unacceptably…
- Trial name
- ANCHOR (NCT04184635)
- Testing
- VA-ECMO
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Heart Failure
Korean Heart Failure Registry III
KorHF III is a multi-center, nationwide, prospective registry of the Korean Society of Heart Failure, which enrolls patients with acute heart failure in Korea.
- Trial name
- KorHF-III (NCT04329234)
- Where
- South Korea
- Volunteers
- 10,000 people
- Sponsor
- Seoul National University Bundang Hospital
Acute Heart Failure (AHF), Decompensated Chronic Heart Failure
Assessment of Residual Congestion in Acute Decompensated Heart Failure
DESIGN: A prospective, multicenter, observational cohort study including 580 patients admitted for acute decompensated heart failure (ADHF).
- Trial name
- VExUS-AHF (NCT07682298)
- Where
- 3 sites in Denmark
- Volunteers
- 580 people
- Sponsor
- Aarhus University Hospital
Acute Decompensated Heart Failure (ADHF)
Efficacy and Safety of Compression Boots in Patients With Acute Decompensated Heart Failure.
The aim of this clinical trial is to investigate whether pulsatile compression therapy can support heart and kidney function in patients admitted with acute heart failure and fluid accumulation in the legs.
- Trial name
- COMPLEX (NCT07377019)
- Testing
- Pulsatile Compression Boots (PCB)
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Odense University Hospital
Acute Heart Failure (AHF)
Acute Heart Failure Registry
To evaluate the clinical utility of quantitative electrocardiography (Quantitative ECG, QCG) by analyzing its associations with clinical characteristics and laboratory findings in patients hospitalized with acute heart failure.
- Trial name
- B-AHF (NCT07601022)
- Where
- South Korea
- Volunteers
- 400 people
- Sponsor
- Jin Joo Park
Heart Failure With Preserved Ejection Fraction
Physical Rehabilitation for Older Patients With Acute Heart Failure With Preserved Ejection Fraction
The REHAB-HFpEF trial will determine whether a novel physical rehabilitation intervention will improve the primary outcome of combined all-cause rehospitalizations and mortality and the secondary outcome of major mobility…
- Trial name
- REHAB-HFpEF (NCT05525663)
- Testing
- Rehabilitation Intervention
- Where
- United States
- Volunteers
- 880 people
- Sponsor
- Wake Forest University Health Sciences
Ischemic Cardiovascular Disease, Multivessel Coronary Artery Disease
Temporary MCS With the iVAC 2L Transaortic Device in High-risk PCI
Patients with coronary artery disease and undergoing high-risk percutaneous coronary intervention (PCI) are at increased risk of hemodynamic instability and poor outcomes.
- Conditions
- Ischemic Cardiovascular Disease, Multivessel Coronary Artery Disease, Coronary Artery Disease, Cardiogenic Shock
- Trial name
- POTOK (NCT07149714)
- Testing
- iVAC 2L
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- National Medical Research Center for Cardiology, Ministry of Health of Russian Federation
Heart Failure, Muscle Atrophy
Changes in Skeletal Muscle Thickness in Patients With Acute Heart Failure
This study aims to determine, via skeletal muscle ultrasound (US), the extent, timing and relationship between skeletal muscle mass loss and outcomes after orthotropic heart transplantation (OHT) and left ventricular assist…
- Conditions
- Heart Failure, Muscle Atrophy, Skeletal Muscle Atrophy, Cardiogenic Shock
- Trial name
- NCT06253104
- Testing
- BodyMetrix Body Composition Ultrasound
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Tufts Medical Center
Acute Decompensated Heart Failure
Fluid Management of Acute Decompensated Heart Failure Subjects Treated With Reprieve System (FASTR-II) (IDE-G210258)
The objective of this study is to prospectively compare decongestive therapy administered by the Reprieve System to Optimal Diuretic Therapy (ODT) in the treatment of patients diagnosed with acute decompensated heart failure…
- Trial name
- FASTR-II (NCT06898515)
- Testing
- Reprieve System, furosemide infusion
- Where
- 50 sites in United States, Germany and 3 more
- Volunteers
- 400 people
- Sponsor
- Reprieve Cardiovascular, Inc
Acute Heart Failure
Acute Heart Failure With Preserved Ejection Fraction - COngestion Discharge Evaluation
The AHF-CODE preserved study is a prospective, non-randomized, monocenter study performed in patients with heart failure with preserved ejection fraction admitted for worsening heart failure.
- Trial name
- AHF-CODE-P (NCT04343430)
- Testing
- Clinical examination centered on congestion, Cardio-pulmonary, peritoneal, jugular and renal Doppler ultrasounds and liver elastography, Biological: Blood sample retrieved for biological assessment and biobanking
- Where
- France
- Volunteers
- 170 people
- Sponsor
- Central Hospital, Nancy, France
Heart Failure, Acute Myocardial Infarction (AMI)
Efficacy and Safety of Early Initiation of Vericiguat in Heart Failure After Acute Myocardial Infarction
Heart failure (HF) is a severe cardiovascular disease with extremely high morbidity and mortality rates worldwide, and ischemic cardiomyopathy is an important cause of heart failure.
- Conditions
- Heart Failure, Acute Myocardial Infarction (AMI), Acute Heart Failure (AHF)
- Trial name
- VIC-MI (NCT06812546)
- Testing
- Vericiguat
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Dongying Zhang
Stroke, Myocardial Injury
Mechanisms And Prognosis of Stroke-Heart Syndrome
The incidence of stroke-heart syndrome following acute stroke, which encompasses both acute ischemic stroke and acute intracerebral hemorrhage, is notably high and is strongly associated with increased mortality and poor outcomes…
- Conditions
- Stroke, Myocardial Injury, Heart Failure, Acute Coronary Syndromes
- Trial name
- MAP-SHS (NCT06954103)
- Where
- China
- Volunteers
- 658 people
- Sponsor
- Chensheng Pan
Acute Heart Failure, Congestive Heart Failure
The Role of intraABDOminal Pressure and Point Of Care UltraSound to Guide Decongestive Therapy in Heart Failure
Systemic venous congestion is the primary therapeutic target of intravenous loop diuretics in patients admitted for acute heart failure (AHF).
- Conditions
- Acute Heart Failure, Congestive Heart Failure, Intraabdominal Hypertension, Cardio-Renal Syndrome
- Trial name
- ABDOPOCUS-HF (NCT07008365)
- Testing
- Furosemide 20 Milligrams
- Where
- 2 sites in Spain
- Volunteers
- 168 people
- Sponsor
- Instituto de Investigación Sanitaria Aragón