Clinical trials: Acute Heart Failure (AHF)
Acute Decompensated Heart Failure
Efficacy and Safety of Ularitide for the Treatment of Acute Decompensated Heart Failure
The purpose of this study is to evaluate the efficacy and safety of a continuous intravenous (IV) ularitide infusion on the clinical status and outcome of patients with acute decompensated heart failure (ADHF).
- Trial name
- TRUE-AHF (NCT01661634)
- Testing
- Ularitide
- Where
- 163 sites in United States, Argentina and 20 more
- Volunteers
- 2,157 people
- Sponsor
- Cardiorentis
Pulmonary Edema, Congestive Heart Failure
DECONGEST-AHF: Vasodilatation or Loop Diuretics in Acute Heart Failure
DECONGEST-AHF compares three initial treatments for adults admitted with suspected pulmonary congestion due to acute heart failure: intravenous furosemide, intravenous isosorbide dinitrate, or both medicines together.
- Conditions
- Pulmonary Edema, Congestive Heart Failure, Acute Heart Failure
- Trial name
- DECONGEST-AHF (NCT05276219)
- Testing
- Furosemide Injection, Isosorbide Dinitrate, Furosemide and isosorbide dinitrate
- Where
- 5 sites in Denmark
- Volunteers
- 1,041 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Acute Heart Failure (AHF)
Impact of Clinical Ultrasound in Patients With Heart Failure Treated in Home Hospitalization
The purpose of this study is to assess whether clinical ultrasound (CU)-guided treatment in acute heart failure (AHF) is superior to the standard care (SC)-guided treatment.
- Trial name
- AHF-CU (NCT05042752)
- Testing
- CLINICAL ULTRASOUND
- Where
- Spain
- Volunteers
- 140 people
- Sponsor
- Lara Palacios
Acute Heart Failure, Left Ventricular Dysfunction
Bi Treatment With Hydralazine/Nitrates Versus Placebo in Africans Admitted With Acute Heart Failure
To investigate the effect of hydralazine isosorbide dinitrate on clinical outcomes, symptoms, cardiac parameters and functional status of African patients hospitalized with AHF and left ventricular dysfunction during 24 weeks of…
- Trial name
- B-AHEF (NCT01822808)
- Testing
- Hydralazine, Isosorbide Dinitrate
- Where
- South Africa
- Volunteers
- 500 people
- Sponsor
- University of Cape Town
Acute Decompensated Heart Failure, COPD Exacerbation
Use of ΔIVC for Early Diagnosis of AHF in AECOPD
Acute Heart failure (AHF) is a common cause of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). This association is frequently underestimated with regard to the difficulty of clinical diagnosis.
- Trial name
- NCT05327374
- Testing
- calculation of the inferior vena cava collapsibility index
- Where
- 3 sites in Tunisia
- Volunteers
- 401 people
- Sponsor
- University of Monastir
Acute Heart Failure (AHF)
Protocolised Natriuresis-Guided Decongestion at Different Diuretic Intensities in Acute Heart Failure
The goal of this clinical trial is to learn how different doses of a water-removing medicine (diuretic) work in adults admitted to hospital with acute heart failure. It will also assess the safety of these treatment approaches.
- Trial name
- DESTINaTE-AHF (NCT07804654)
- Testing
- Furosemide - HIGH-dose Natriuresis-Guided Strategy, Furosemide - LOW-dose Natriuresis-Guided Strategy, Loop Diuretic - Standard of Care
- Where
- Malaysia
- Volunteers
- 109 people
- Sponsor
- Universiti Teknologi Mara
Acute Heart Failure (AHF), Cardiac Arrhythmia
Arrhythmia Detection With MEMO Patch Plus in Patients With Acute Heart Failure
This prospective, multicenter, open-label, single-group exploratory clinical trial evaluates the clinical effectiveness of extended electrocardiographic monitoring with MEMO Patch Plus for detecting clinically significant…
- Trial name
- MMPP-HF (NCT07792772)
- Testing
- MEMO Patch Plus
- Where
- 3 sites in South Korea
- Volunteers
- 45 people
- Sponsor
- HUINNO Co., Ltd
Heart Failure
Dynamic Variation of Impedance Cardiography(DYVIC) as a Diagnostic Tool of Acute Heart Failure (AHF)
the study aimed to evaluate the diagnostic performance of cardiac output (CO) change after the use of trinitrine in the diagnosis of heart failure patients with acute dyspnea.
- Trial name
- dyvic2 (NCT04484298)
- Testing
- Reference position patient is put in a 30 degree supine position during 5 minutes, nitroglucerin
- Where
- Tunisia
- Volunteers
- 100 people
- Sponsor
- University of Monastir
Delirium in Intensive Care Unit, Acute Heart Failure (AHF)
Intravenous Infusion of Low Dose Ketamine Versus Dexmedetomedine for Delirium Treatment in Acute Heart Failure
Delirium is an acute, fluctuating disturbance in attention and cognition that commonly complicates the course of critically ill patients, particularly those admitted with acute heart failure (AHF).
- Trial name
- NCT07781462
- Testing
- Low dose ketamine infusion, Dexmedetomidine infusion
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Alexandria University
Acute Heart Failure
Efficacy, Safety and Tolerability of Sexelaxin When Added to Standard Therapy in AHF
The purpose of the study was to evaluate the efficacy, safety and tolerability of intravenous infusion of serelaxin, when added to standard therapy, in acute heart failure (AHF) patients.
- Trial name
- RELAX-AHF-ASIA (NCT02007720)
- Testing
- Serelaxin, Standard of CareTherapy
- Where
- 132 sites in China, India and 9 more
- Volunteers
- 876 people
- Sponsor
- Novartis Pharmaceuticals
Acute Heart Failure
Digoxin Short Term Treatment Assessment Randomized Trial in AHF
AHFS management is challenging and most of the used drugs has failed to decrease post-discharge mortality and readmission rates which represent the most important goal in AHFS.
- Trial name
- DIG-STA-AHF (NCT02544815)
- Testing
- Digoxin
- Where
- 2 sites in Tunisia
- Volunteers
- 500 people
- Sponsor
- University of Monastir
Heart Failure, Acute Heart Failure (AHF)
OPTIMUM Study of Remote Patient Monitoring in Ambulatory Heart Failure Care
Heart failure is a leading cause of hospitalization and readmission, particularly among older adults with multiple comorbidities.
- Trial name
- OPTIMUM (NCT07439081)
- Testing
- Satelia® Cardio Remote Patient Monitoring System
- Where
- France
- Volunteers
- 504 people
- Sponsor
- Médipôle Lyon-Villeurbanne
Heart Failure, Acute Heart Failure
Inferior Vena CAVA and Lung UltraSound-guided Therapy in Acute Heart Failure
Between 25% and 30% of patients hospitalized for acute heart failure (AHF) are readmitted within 90 days after discharge. Mostly due to persistent congestion on discharge.
- Trial name
- CAVAL US-AHF (NCT04549701)
- Testing
- CAVAL US-guided Therapy, Standard of care
- Where
- 2 sites in Argentina
- Volunteers
- 60 people
- Sponsor
- Instituto Cardiovascular de Buenos Aires
Acute Heart Failure, Volume Overload
Infusion of Furosemide to Improve Diuretic Efficiency in Acute Heart Failure
Acute heart failure is a condition where the heart suddenly cannot pump blood well enough for the body's needs. Many people admitted to the hospital with acute heart failure have too much fluid in the body.
- Trial name
- INFUSE-AHF (NCT07577596)
- Testing
- Intravenous furosemide continuous infusion, Intravenous furosemide bolus injections
- Where
- Denmark
- Volunteers
- 436 people
- Sponsor
- University of Aarhus
Acute Heart Failure (AHF)
Effect of Serelaxin Versus Standard of Care in Acute Heart Failure (AHF) Patients
This was a multinational, multicenter, randomized, open-label study to confirm and expand the efficacy, safety and tolerability evidence of 48 hours intravenous infusion of serelaxin (30 micrograms/kg/day) when added to Standard…
- Trial name
- RELAX-AHF-EU (NCT02064868)
- Testing
- Serelaxin, Standard of Care
- Where
- 357 sites in Austria, Belgium and 23 more
- Volunteers
- 2,666 people
- Sponsor
- Novartis Pharmaceuticals
Heart Failure
Acute Heart Failure Study in Patients Admitted to Emergency Department for Dyspnea
No studies have analyzed the predictive value of different anamnestic and clinical signs for the diagnosis of acute heart failure (AHF) in patients admitted to emergency department.
- Trial name
- PREDICA (NCT02835963)
- Testing
- Data collection
- Where
- 3 sites in France
- Volunteers
- 342 people
- Sponsor
- University Hospital, Toulouse
Acute Heart Failure (AHF), Fluid Over-load
Training Medical Residents in the Use of the Venous Excess UltraSound (VExUS) Score for Bedside Volume Assessment.
This randomized controlled trial evaluates the effectiveness of two training approaches (in-person versus remote) for teaching medical residents to apply the Venous Excess Ultrasound (VExUS) score for bedside volume assessment in…
- Conditions
- Acute Heart Failure (AHF), Fluid Over-load, Congestion, Congestion, Venous
- Trial name
- NCT07541768
- Testing
- In-person VExUS Training Program, Remote VExUS Training Program, No intervention
- Where
- Switzerland
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Dyspnea; Cardiac
Contribution LUS in the Diagnosis of Acute Heart Failure (AHF) in Patients Admitted to the ED
This study assesses the potential of lung ultrasonography to diagnose heart failure.
- Trial name
- NCT03717779
- Testing
- lung ultrasound
- Where
- Tunisia
- Volunteers
- 600 people
- Sponsor
- University of Monastir
Heart Failure, Heart Failure - NYHA II - IV
Urine Sodium-Driven Diuretic Adjustment Strategy in Acute Decompensated Heart Failure
The goal of this clinical trial is to learn if increasing the dose of diuretics to achieve a higher urine sodium target produces better clinical results when treating patients hospitalized with acute heart failure when compared…
- Conditions
- Heart Failure, Heart Failure - NYHA II - IV, Heart Failure Acute, Acute Heart Failure (AHF)
- Trial name
- US-DASH (NCT07263035)
- Testing
- Furosemide intravenous solution
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Lakeland Regional Health Systems, Inc.
Heart Failure, Acute Heart Failure (AHF)
American Registry of Ambulatory or Acutely Decompensated Heart Failure
The purpose of this study is to better characterize and understand the population of patients with ambulatory or acutely decompensated heart failure in the American continent, getting to know their sociodemographic, clinical and…
- Conditions
- Heart Failure, Acute Heart Failure (AHF), Chronic Heart Failure
- Trial name
- AMERICCAASS (NCT05295641)
- Where
- 119 sites in United States, Argentina and 19 more
- Volunteers
- 6,732 people
- Sponsor
- Fundacion Clinica Valle del Lili