Clinical trials: Acute Heart Failure (AHF)
Acute Heart Failure (AHF), Congestion, Venous
Simple Urine Composition-based Personalized Algorithm for Effective Congestion Relief in Decompensated Heart Failure
The aim of this study is to evaluate the effectiveness of loop diuretic adaptative algorithm that is based on machine learning, urine output prediction tool, in decongestion of acute heart failure patients.
- Trial name
- SAFER-DHF (NCT07099885)
- Testing
- Standard of Care (SOC), Algorithhm-based decongestion
- Where
- 2 sites in Poland
- Volunteers
- 90 people
- Sponsor
- Wroclaw Medical University
Acute Heart Failure
Digoxin Short Term Treatment Assessment Randomized Trial in AHF
AHFS management is challenging and most of the used drugs has failed to decrease post-discharge mortality and readmission rates which represent the most important goal in AHFS.
- Trial name
- DIG-STA-AHF (NCT02544815)
- Testing
- Digoxin
- Where
- 2 sites in Tunisia
- Volunteers
- 500 people
- Sponsor
- University of Monastir
Acute Heart Failure (AHF), Decompensated Chronic Heart Failure
Assessment of Residual Congestion in Acute Decompensated Heart Failure
DESIGN: A prospective, multicenter, observational cohort study including 580 patients admitted for acute decompensated heart failure (ADHF).
- Trial name
- VExUS-AHF (NCT07682298)
- Where
- 3 sites in Denmark
- Volunteers
- 580 people
- Sponsor
- Aarhus University Hospital
Acute Heart Failure
Study of Polymorphisms of RAAS and MMPs in Acute Heart Failure
this study aim to investigate the: association of RAAS polymorphisms and AHF association of MMP 3 and 12 polymorphisms and AHF
- Trial name
- PRA-MMP (NCT02170961)
- Where
- Tunisia
- Volunteers
- 300 people
- Sponsor
- University of Monastir
Acute Heart Failure
Global Non-interventional Heart Failure Disease Registry
The clinical characteristics, initial presentation, management, and outcomes of patients hospitalized with new-onset (first diagnosis) heart failure (HF) or decompensation of chronic HF are poorly understood worldwide.
- Trial name
- REPORT-HF (NCT02595814)
- Where
- 346 sites in United States, Algeria and 42 more
- Volunteers
- 18,805 people
- Sponsor
- Novartis Pharmaceuticals
Cardiogenic Shock
Randomized Evaluation of Istaroxime for Stabilization in Acute Heart Failure-Cardiogenic Shock
The goal of this clinical trial is to learn if the drug istaroxime works to treat cardiogenic shock due to acute heart failure in adults. It will also learn about the safety of istaroxime.
- Trial name
- RESCUE HF-CS (NCT07583446)
- Testing
- istaroxime
- Where
- Armenia
- Volunteers
- 600 people
- Sponsor
- Seismic Pharmaceuticals Operations LLC
Acute Heart Failure (AHF)
Acute Heart Failure Registry
To evaluate the clinical utility of quantitative electrocardiography (Quantitative ECG, QCG) by analyzing its associations with clinical characteristics and laboratory findings in patients hospitalized with acute heart failure.
- Trial name
- B-AHF (NCT07601022)
- Where
- South Korea
- Volunteers
- 400 people
- Sponsor
- Jin Joo Park
Acute Heart Failure (AHF)
Protocolised Natriuresis-Guided Decongestion at Different Diuretic Intensities in Acute Heart Failure
The goal of this clinical trial is to learn how different doses of a water-removing medicine (diuretic) work in adults admitted to hospital with acute heart failure. It will also assess the safety of these treatment approaches.
- Trial name
- DESTINaTE-AHF (NCT07804654)
- Testing
- Furosemide - HIGH-dose Natriuresis-Guided Strategy, Furosemide - LOW-dose Natriuresis-Guided Strategy, Loop Diuretic - Standard of Care
- Where
- Malaysia
- Volunteers
- 109 people
- Sponsor
- Universiti Teknologi Mara
Acute Heart Failure (AHF), Cardiogenic Shock
Prolonged Nasogastric Administration of Ketones in Decompensated Heart Failure
This study will evaluate the feasibility and safety of achieving therapeutic concentrations of beta-hydroxybutyrate using continuous infusion of D-beta-hydroxybutyrate monoester administered via a nasogastric tube in patients…
- Conditions
- Acute Heart Failure (AHF), Cardiogenic Shock, Heart Failure, Ketones
- Trial name
- KADHEF-2 (NCT07527156)
- Testing
- Ketone Monoester (KE)
- Where
- Czechia
- Volunteers
- 12 people
- Sponsor
- Institute for Clinical and Experimental Medicine
Acute Heart Failure
Efficacy, Safety and Tolerability of Sexelaxin When Added to Standard Therapy in AHF
The purpose of the study was to evaluate the efficacy, safety and tolerability of intravenous infusion of serelaxin, when added to standard therapy, in acute heart failure (AHF) patients.
- Trial name
- RELAX-AHF-ASIA (NCT02007720)
- Testing
- Serelaxin, Standard of CareTherapy
- Where
- 132 sites in China, India and 9 more
- Volunteers
- 876 people
- Sponsor
- Novartis Pharmaceuticals
Acute Heart Failure (AHF), Heart Failure
Urinary Chloride and Sodium Changes and Residual Congestion in Acute Heart Failure
The goal of this observational study is to learn how changes in urinary sodium and chloride levels relate to fluid overload and short-term outcomes in patients hospitalized with acute heart failure (AHF).
- Conditions
- Acute Heart Failure (AHF), Heart Failure, Congestion
- Trial name
- CLORINA-IC (NCT07597512)
- Where
- 4 sites in Spain
- Volunteers
- 223 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Heart Failure
Comparative Evaluation of the Evolution of Emerging Biological Markers in Patients Hospitalized for Acute Heart Failure According to Conventional Management or Therapeutic Adjustment Via Daily Ultrasound.
This is a bi-centric, prospective randomized study to evaluate the contribution of rapid echocardioscopy at the patient's bedside to improving the prognosis of patients hospitalized for acute heart failure.
- Trial name
- JECICA2 (NCT05297630)
- Testing
- Evaluation of the evolution of biological markers from the biobank.
- Where
- 2 sites in France
- Volunteers
- 169 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Heart Failure, Acute Heart Failure (AHF)
OPTIMUM Study of Remote Patient Monitoring in Ambulatory Heart Failure Care
Heart failure is a leading cause of hospitalization and readmission, particularly among older adults with multiple comorbidities.
- Trial name
- OPTIMUM (NCT07439081)
- Testing
- Satelia® Cardio Remote Patient Monitoring System
- Where
- France
- Volunteers
- 504 people
- Sponsor
- Médipôle Lyon-Villeurbanne
Heart Failure, Acute Heart Failure (AHF)
American Registry of Ambulatory or Acutely Decompensated Heart Failure
The purpose of this study is to better characterize and understand the population of patients with ambulatory or acutely decompensated heart failure in the American continent, getting to know their sociodemographic, clinical and…
- Conditions
- Heart Failure, Acute Heart Failure (AHF), Chronic Heart Failure
- Trial name
- AMERICCAASS (NCT05295641)
- Where
- 119 sites in United States, Argentina and 19 more
- Volunteers
- 6,732 people
- Sponsor
- Fundacion Clinica Valle del Lili
Myocardial Infarction (MI), Heart Failure
Timing of Coronary Angiography in NSTEMI Complicated by Acute HF
Study objectives: To determine the optimal timing of coronary angiography (CAG) in patients with non-ST-segment elevation myocardial infarction (NSTEMI) complicated by acute decompensated heart failure (AHF).
- Trial name
- TIMING-AHF (NCT07002164)
- Testing
- Immediate coronary angiography, Delayed coronary angiography
- Where
- 20 sites in South Korea
- Volunteers
- 780 people
- Sponsor
- Chonnam National University Hospital
Acute Heart Failure (AHF)
Impact of Clinical Ultrasound in Patients With Heart Failure Treated in Home Hospitalization
The purpose of this study is to assess whether clinical ultrasound (CU)-guided treatment in acute heart failure (AHF) is superior to the standard care (SC)-guided treatment.
- Trial name
- AHF-CU (NCT05042752)
- Testing
- CLINICAL ULTRASOUND
- Where
- Spain
- Volunteers
- 140 people
- Sponsor
- Lara Palacios
Acute Heart Failure
Safety and Efficacy of Early, seQUential Oral dIuretic Nephron blockAde In Acute Heart Failure
The SEEQUOIA-AHF (Safety and Efficacy of Early, seQUential oral dIuretic nephron blockAde in Acute Heart Failure) trial is a multicenter, randomized, open-label, parallel-arm trial assessing the impact of early sequential nephron…
- Trial name
- SEEQUOIA-AHF (NCT04062760)
- Testing
- Standard diuretic therapy, Early sequential nephron blockade
- Where
- Italy
- Volunteers
- 206 people
- Sponsor
- University of Parma
Heart Failure Acute
Cardiac Output Autonomic Stimulation Therapy for Acute Heart Failure (COAST-AHF)
A feasibility study to investigate the safety and performance of the NeuroTronik Cardiac Autonomic Nerve Stimulation (CANS) Therapy System
- Trial name
- NCT03169803
- Testing
- NeuroTronik CANS Therapy™ System
- Where
- Panama
- Volunteers
- 40 people
- Sponsor
- NeuroTronik Inc.
Acute Heart Failure (AHF), Pulmonary Embolism (Diagnosis)
Pulmonary Embolism in Patients With Acute Heart Failure (PEHF Study)
This study focuses on two serious and common medical conditions: heart failure and pulmonary embolism (a blood clot in the lungs).
- Conditions
- Acute Heart Failure (AHF), Pulmonary Embolism (Diagnosis), Venous Thromboembolism
- Trial name
- PEHF (NCT07499661)
- Testing
- Systematic screening for pulmonary embolism in all patients using a guideline-recommended diagnostic algorithm
- Where
- 10 sites in France
- Volunteers
- 740 people
- Sponsor
- University Hospital, Angers
Acute Heart Failure (AHF), Sarcopenia
Sarcopenia in Older Patients Hospitalized for Acute Heart Failure.
Acute heart failure (AHF) is the leading cause of hospitalization in people over 65, with the group with preserved ejection fraction (HFpEF) being the most closely related to aging.
- Conditions
- Acute Heart Failure (AHF), Sarcopenia, Heart Failure
- Trial name
- MUSICA (NCT07530029)
- Where
- Spain
- Volunteers
- 110 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal