Clinical trials: Acute Heart Failure (AHF)
Acute Heart Failure With Reduced Ejection Fraction
A Study to Assess the Hemodynamic Effects, Safety, Tolerability, and Pharmacokinetics of Intravenous APD418 in Adult Participants With Heart Failure With Reduced Ejection Fraction
The purpose of this study is to evaluate the safety, pharmacokinetics, and effect on cardiac function of intravenous APD418 in adult participants with heart failure with reduced ejection fraction (HFrEF).
- Trial name
- NCT05139615
- Testing
- APD418
- Where
- 21 sites in United States, Germany and 3 more
- Volunteers
- 22 people
- Sponsor
- Pfizer
Acute Heart Failure (AHF), Fluid Over-load
Training Medical Residents in the Use of the Venous Excess UltraSound (VExUS) Score for Bedside Volume Assessment.
This randomized controlled trial evaluates the effectiveness of two training approaches (in-person versus remote) for teaching medical residents to apply the Venous Excess Ultrasound (VExUS) score for bedside volume assessment in…
- Conditions
- Acute Heart Failure (AHF), Fluid Over-load, Congestion, Congestion, Venous
- Trial name
- NCT07541768
- Testing
- In-person VExUS Training Program, Remote VExUS Training Program, No intervention
- Where
- Switzerland
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Acute Heart Failure
Ketone Ester for Treatment Of Acute Heart Failure
Ketones have been suggested to have significant physiological effects in patients with heart failure. Potential mechanisms for these effects include energy provision for the failing heart and direct protective effects on other…
- Trial name
- KETO-AHF (NCT07434466)
- Testing
- Ketone Ester (KetoneAid MonoEster)
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of Alberta
Cardiogenic Shock, Acute Heart Failure (AHF)
Multimodal Phenotyping In Patients Referred With Acute Cardiac faiLurE
The goal of this observational study is to learn whether information collected during routine hospital care, together with blood and urine samples, can help doctors better identify different types of cardiogenic shock and better…
- Trial name
- MIRACLE (NCT07515508)
- Where
- 4 sites in Germany
- Volunteers
- 600 people
- Sponsor
- University Heart Center Freiburg - Bad Krozingen
Acute Heart Failure (AHF)
TACTIC-HF: Sequential Diuretic Strategies in Ambulatory Worsening Heart Failure
TACTIC-HF is a prospective randomized crossover trial designed to compare three ambulatory diuretic strategies in patients with worsening heart failure treated in a specialized heart failure day-hospital program.
- Trial name
- TACTIC-HF (NCT07593612)
- Testing
- Intravenous furosemide bolus injections, ACETAZOLAMIDE oral capsule, Hydrochlorothiazide (HCT)
- Volunteers
- 60 people
- Sponsor
- Lucrecia Maria Burgos
Acute Heart Failure, Complementary Medicine
Effectiveness of Yiqi Fumai Lyophilized Injection for Acute Heart Failure
The goal of this cohort study is to observe the effectiveness of Yiqi Fumai Lyophilized Injection (YQFM) in patients with acute heart failure (AHF).
- Conditions
- Acute Heart Failure, Complementary Medicine, Chinese Medicine
- Trial name
- AUGUST-AHF (NCT05586048)
- Testing
- Yiqi Fumai Lyophilized Injection(YQFM)
- Where
- 3 sites in China
- Volunteers
- 1,200 people
- Sponsor
- China Academy of Chinese Medical Sciences
Acute Heart Failure
Effect of Dapagliflozin in Patients With Acute Heart Failure (DAPA-RESPONSE-AHF)
Dapagliflozin, a sodium-glucose cotransporter-2 inhibitor (SGLT2i), increases natriuresis alone and synergistically when combined with loop diuretics in patients with AHF without increasing renin angiotensin- aldosterone…
- Trial name
- NCT05406505
- Testing
- Dapagliflozin 10mg Tab
- Where
- Egypt
- Volunteers
- 87 people
- Sponsor
- Mansoura University
Delirium in Intensive Care Unit, Acute Heart Failure (AHF)
Intravenous Infusion of Low Dose Ketamine Versus Dexmedetomedine for Delirium Treatment in Acute Heart Failure
Delirium is an acute, fluctuating disturbance in attention and cognition that commonly complicates the course of critically ill patients, particularly those admitted with acute heart failure (AHF).
- Trial name
- NCT07781462
- Testing
- Low dose ketamine infusion, Dexmedetomidine infusion
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Alexandria University
Acute Heart Failure (AHF), Implementation Research
Implementation of Acute Heart Failure Checklist
Patients with acute heart failure (AHF) commonly present to the emergency department (ED) with difficulty breathing and often have poor outcomes or death.
- Trial name
- NCT07727304
- Testing
- CAEP Acute Heart Failure (AHF) Best Practices Checklist Implementation, Usual care
- Where
- Canada
- Volunteers
- 5,040 people
- Sponsor
- Ottawa Hospital Research Institute
Acute Heart Failure (AHF), Congestive Heart Failure(CHF)
Evaluating Residual Congestion at Discharge in Acute Heart Failure Patients
Treatment of congestion is one of the main goals in patients hospitalized for acute heart failure. Nevertheless, current evidence shows that decongestion is often not achieved and that residual congestion at discharge is strongly…
- Trial name
- NCT06993220
- Testing
- Evaluation of residual congestion at discharge
- Where
- Spain
- Volunteers
- 500 people
- Sponsor
- Consorci Sanitari Integral