Clinical trials: Acute Hepatitis B
Hepatitis E
HEV in Patients With Acute Non-A, Non-B, Non-C Hepatitis in Al-Rajhy University Hospital for Liver
Hepatitis E is the fifth known human viral hepatitis and is probably the most common cause of acute viral hepatitis in the world.
- Trial name
- NCT03488589
- Testing
- serum samples for HEV RNA PCR
- Volunteers
- 150 people
- Sponsor
- Mahmoud Abdel Rahman
Chronic Hepatitis B, Acute Hepatitis B
Disease Loads and Status of Treatment
The aim of study is to evaluate the current prevalence of HDV infection, and comprehensively analyze the interaction between HDV and HBV infections in the era of NAs in Taiwan.
- Conditions
- Chronic Hepatitis B, Acute Hepatitis B, Hepatitis D
- Trial name
- NCT05264272
- Testing
- Prospective serological assays, Retrospective serological assays
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital
Drug Addiction, HIV/AIDS
Cohort Study on People Who Inject Drugs in Senegal
The main purpose of the CoDISEN cohort study is to propose a model of prevention and care for HIV and viral hepatitis adapted to the needs of people who inject drugs (PWID) in Dakar, Senegal.
- Conditions
- Drug Addiction, HIV/AIDS, Hepatitis C, Chronic, Hepatitis C, Acute
- Trial name
- CoDISEN (NCT03459768)
- Where
- Senegal
- Volunteers
- 208 people
- Sponsor
- French National Agency for Research on AIDS and Viral Hepatitis
Cirrhosis, End Stage Liver Disease
Mild Hypothermia and Acute Kidney Injury in Liver Transplantation
Acute kidney injury (AKI), or worsening kidney function, is a common complication after liver transplantation (20-90% in published studies).
- Conditions
- Cirrhosis, End Stage Liver Disease, Acute Kidney Injury, Liver Transplant; Complications
- Trial name
- MHALT (NCT03534141)
- Testing
- Esophageal cooling/warming device, Mild hypothermia, Normothermia
- Where
- 3 sites in United States
- Volunteers
- 175 people
- Sponsor
- University of California, San Francisco
Thrombocytopenia, Hepatitis B, Chronic
Efficacy and Safety of Avatrombopag for Treating TCP in HBV-ACLF Patients Receiving ALSS Treatment
This study aims to investigate the efficacy and safety of avatrombopag for treating thrombocytopenia in hepatitis b virus related acute-on-chronic liver failure patients receiving artificial liver support system treatment.
- Conditions
- Thrombocytopenia, Hepatitis B, Chronic, Acute-On-Chronic Liver Failure
- Trial name
- NCT05382013
- Testing
- Avatrombopag, Artificial Liver Support System, Comprehensive internal medical treatment.
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Procedural Pain, Pain, Acute
The Effect of Facilitated-tucking and ShotBlocker on Pain Caused by Vaccination in Healthy Infants
This study will be investigated the effects of facilitated tucking, ShotBlocker and combined facilitated tucking and ShotBlocker methods on procedural pain, crying time and duration of the procedure during Hepatitis B vaccine…
- Conditions
- Procedural Pain, Pain, Acute, Nursing Caries
- Trial name
- NCT06377748
- Testing
- Facilitated tucking position, ShotBlocker, Combined facilitated tucking and ShotBlocker
- Where
- Turkey (Türkiye)
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Istanbul Medeniyet University
Chronic HBV With Severe Exacerbation
Tenofovir Versus Lamivudine for Patients of Chronic Hepatitis B With Severe Acute Exacerbation
In Taiwan, 15% of general population had hepatitis B virus (HBV) infection, HBV is the leading cause of liver cirrhosis and hepatocellular carcinoma in Taiwan.
- Trial name
- HBSAE (NCT01848743)
- Testing
- Tenofovir, lamivudine
- Where
- 2 sites in Taiwan
- Volunteers
- 120 people
- Sponsor
- Kaohsiung Veterans General Hospital.
HBV Related Acute-on-chronic Liver Failure
Single Cell Landscape of HBV-related Acute-on-chronic Liver Failure Patients
This study aimed to profile the peripheral blood immune cells of patients with HBV related acute-on-chronic liver failure using single-cell RNA sequencing to reveal the immunopathological mechanisms of HBV related…
- Trial name
- NCT06865859
- Where
- China
- Volunteers
- 21 people
- Sponsor
- Qilu Hospital of Shandong University
Liver Failure, Acute on Chronic
Chinese CLIF-C Acute-on-Chronic Liver Disease and Liver Failure Study
Acute on chronic liver failure (ACLF) is a distinct entity encompassing the acute deterioration of liver function, culminating in multiple organs failure and high short-term mortality.
- Trial name
- Ch-CANONIC (NCT02457637)
- Testing
- Standary therapy
- Where
- 16 sites in China
- Volunteers
- 2,600 people
- Sponsor
- Hai Li
Acute on Chronic Liver Failure
Randomized Controlled Trial Comparing the Efficacy and Safety of FMT in Hepatitis B Reactivation Leads to Acute on Chronic Liver Failure.
Data for stool microbiome will be collected for all the chronic hepatitis B subjects (pre cirrhotic,compensated,decompensated and reactivation).
- Trial name
- NCT02689245
- Testing
- Tenofovir, Fecal Microbiota Transplantation (FMT)
- Where
- India
- Volunteers
- 64 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Acute-On-Chronic Liver Failure
Risk Factors Affecting MSC Efficacy in ACLF Patients
Mesenchymal stromal cells (MSCs) are potential therapy for many diseases, with the ability of tissue regeneration, repair and immunomodulation. Acute-on-chronic liver failure (ACLF) is a severe disease with high mortality.
- Trial name
- NCT07198854
- Testing
- Not applicable- observational study
- Where
- China
- Volunteers
- 446 people
- Sponsor
- Sun Yat-sen University
Liver Failure, Acute on Chronic, Liver Injury
A Retrospective Multicenter Study of HBV-related Pre-acute-on-chronic Liver Failure in China
The definition and diagnostic criteria of Acute-on-chronic liver failure (ACLF) has been well established by EASL CANONIC study. However, patients with high risk to develop ACLF has not been determined, yet.
- Trial name
- NCT03281265
- Testing
- standard treatment
- Volunteers
- 1,178 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Chronic-on-acute Liver Failure
Efficacy and Economic Evaluation of Nonbiological Artificial Liver Therapy in Acute-on-chronic Hepatitis B Liver Failure.
This was a non-blinded, prospective clinical study. From June 2020 to October 2021, 254 patients with HBV-ACLF were treated at the Department of Infectious Diseases, Xiangya Hospital, Central South University (Changsha, China).
- Trial name
- NCT05392673
- Testing
- KM-8800 plasma exchange device (Kuraray, Tokyo, Japan)
- Where
- China
- Volunteers
- 186 people
- Sponsor
- Xiangya Hospital of Central South University
Decompensated Cirrhosis, Bleeding Varices
Early TIPS With Polytetrafluoroethylene (PTFE) Covered Stents for Acute Variceal Bleeding in Patients With Advanced Cirrhosis
The purpose of this study is to determine whether early use of transjugular intrahepatic portosystemic shunt (TIPS) with Polytetrafluoroethylene (PTFE) covered stents is able to prolong the survival in patients with advanced…
- Trial name
- NCT01370161
- Testing
- TIPS treatment, Medical treatment
- Where
- China
- Volunteers
- 132 people
- Sponsor
- Air Force Military Medical University, China
Acute-On-Chronic Liver Failure
Platelet Transfusion in HBV-related acute-on Chronic Liver Failure
Acute-on-chronic liver failure (ACLF) is a syndrome that has recently been recognized as encompassing acute deterioration of liver function in patients with pre-existing chronic liver disease.
- Trial name
- NCT03713489
- Testing
- platelet
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Acute Liver Failure, Acute Liver Injury
Safety Study of Ornithine Phenylacetate to Treat Patients With Acute Liver Failure/Severe Acute Liver Injury
This Phase 2a clinical study is designed to provide data on OCR-002 in patients with acute liver failure/acute liver injury (ALF/ALI) in regard to: safety and tolerability; metabolism of the compound to glutamine and…
- Trial name
- STOP-ALF (NCT01548690)
- Testing
- Ornithine Phenylacetate
- Where
- 11 sites in United States
- Volunteers
- 47 people
- Sponsor
- William Lee
Hepatitis B, HIV
Hep Mec Cohort in Zambia
Observational cohort of adults with acute and chronic hepatitis B infection in Zambia, with and without HIV coinfection. Participants join the study at the time of diagnosis and before or at the time when they are starting…
- Trial name
- Hep Mec (NCT07589985)
- Where
- 3 sites in Zambia
- Volunteers
- 390 people
- Sponsor
- University of Alabama at Birmingham
Liver Failure
The Efficacy and Safety of Entecavir Treatment of Patients With Acute on Chronic Hepatitis B Liver Failure
To evaluate therapeutic efficacy and predicting factors of entecavir for treating patients with acute on chronic hepatitis B liver failure (ACHBLF).
- Trial name
- NCT01254994
- Testing
- entecavir, Traditional comprehensive medical treatment
- Where
- China
- Volunteers
- 108 people
- Sponsor
- Sun Yat-sen University
Hepatitis B, Chronic
A Study of Early Immunologic Response in Asian Patients With Chronic Hepatitis B, Treated With Pegasys (Peginterferon Alfa-2a (40KD)), Nucleoside Analogues, or Both
This open-label, randomized, parallel-arm study will assess the early immunologic response in treatment-naïve Asian male patients with chronic hepatitis B after initiation of treatment with Pegasys or tenofovir or Pegasys plus…
- Trial name
- NCT00962871
- Testing
- peginterferon alfa-2a [Pegasys], tenofovir
- Where
- 6 sites in United States, New Zealand and 2 more
- Volunteers
- 30 people
- Sponsor
- Hoffmann-La Roche
CHRONIC HEPATITIS B
Treatment on HBeAg Positive or HBeAg Negative in Chronic Hepatitis B
Phyllanthus Urinaria - Adenosma Glutinosum - Eclipta Prostrata - Ascorbic Acid combination plus Tenofovir in treatment of acute and chronic hepatitis B.
- Trial name
- HBV (NCT01198860)
- Testing
- CTH Chronic Hepatitis B
- Where
- 2 sites in United States, Vietnam
- Sponsor
- Nguyen Thi Trieu, MD