Clinical trials: Acute Hepatitis E
Acute on Chronic Hepatic Failure, Liver Failure
A Trial of Ribavirin in Patients With ACLF Due to Hepatitis E Virus
The term Acute on chronic liver failure (ACLF) describes a clinical entity characterized by an acute and rapid deterioration of liver function in a patient with previously well-compensated liver disease owing to the effects of a…
- Conditions
- Acute on Chronic Hepatic Failure, Liver Failure, Hepatitis E Infection
- Trial name
- HEVRibavirin (NCT01698723)
- Testing
- Ribavirin
- Where
- 2 sites in India
- Volunteers
- 40 people
- Sponsor
- All India Institute of Medical Sciences
Hepatitis E
Seroprevalence Hepatitis E Infection in Healthy Blood Donors
This is a HEV seroprevalence in the health donors in the Canton Ticino study. The pre-donation sampling pouch of each blood donor coming form the Cantone Ticino region will be collected and tested for HEV serology (IgM and IgG).
- Trial name
- NCT03601221
- Testing
- Sample collection
- Where
- Switzerland
- Volunteers
- 1,447 people
- Sponsor
- Ente Ospedaliero Cantonale, Bellinzona
Hepatitis E Infection
Safety and Immunogenicity of Hecolin® in Healthy Pregnant Women
This is a phase II randomized, observer-blinded, placebo-controlled study with 3 arms enrolling a total of 2,358 participants. The arms are composed of Arm 1, pregnant participants receiving Hecolin® (N=1,104) with immunogenicity…
- Trial name
- NCT05808166
- Testing
- Hecolin® (Recombinant Hepatitis E Vaccine (Escherichia coli))., Isotonic Sodium Chloride injection
- Where
- Pakistan
- Volunteers
- 2,358 people, healthy volunteers welcome
- Sponsor
- International Vaccine Institute
Hepatitis E Infection, Hepatitis; Epidemic
Hepatitis E Virus Infection in Oncological Patients
The goal of this clinical trial is to investigate the prevalence of hepatitis E infection in oncological patients in a rural region of Germany.
- Conditions
- Hepatitis E Infection, Hepatitis; Epidemic, Oncologic Disorders
- Trial name
- HepE-Onko-BB (NCT06631560)
- Testing
- ELISA testing
- Where
- Germany
- Volunteers
- 197 people, healthy volunteers welcome
- Sponsor
- Medizinische Hochschule Brandenburg Theodor Fontane
Acute Hepatitis A, Acute Hepatitis B
Randomized Placebo-controlled Trial Evaluating the Safety and Efficacy of Silymarin Treatment in Patients With Acute Viral Hepatitis
The purpose of this study is to assess whether two higher doses (280mg or 420mg three times daily)of silymarin therapy are safe and tolerable, and shorten the illness in patients with acute viral hepatitis compared to placebo.
- Conditions
- Acute Hepatitis A, Acute Hepatitis B, Acute Hepatitis C, Acute Hepatitis E
- Trial name
- NCT00755950
- Testing
- Silymarin, Lactose monohydrate
- Where
- 3 sites in Egypt
- Volunteers
- 70 people
- Sponsor
- University of Maryland, Baltimore
Hepatitis E Infection in Humans and in Environment
Hepatitis E Infection : Emergence Mechanisms in North-Eastern France of Polymorphic Clinical Forms.
The present research aims to collect virological and clinical data on hepatitis E virus (HEV) infections, either in acute or chronic forms of HEV infection in North-Eastern France, with liver- or non liver-related symptoms, plus…
- Trial name
- VHENE (NCT03524014)
- Testing
- Only advice for diagnosis and prevention
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Central Hospital, Nancy, France
Hepatitis E
HEV in Patients With Acute Non-A, Non-B, Non-C Hepatitis in Al-Rajhy University Hospital for Liver
Hepatitis E is the fifth known human viral hepatitis and is probably the most common cause of acute viral hepatitis in the world.
- Trial name
- NCT03488589
- Testing
- serum samples for HEV RNA PCR
- Volunteers
- 150 people
- Sponsor
- Mahmoud Abdel Rahman
Hepatitis A, Hepatitis E Virus Infection
Comparative Evaluation of Oral Ursodeoxycholic Acid in Reducing Bilirubin Levels Among Patients With Acute Viral Hepatitis
Hepatitis is an inflammatory condition of the liver that has emerged as a significant global health concern due to its widespread prevalence. Data on ursodeoxycholic acid in acute viral hepatitis remain limited.
- Trial name
- AVH (NCT07525401)
- Testing
- Ursodeoxycholic Acid, Supportive Care
- Volunteers
- 88 people
- Sponsor
- Combined Military Hospital, Pakistan
Hepatitis E Infection
Effectiveness Trial to Evaluate Protection of Pregnant Women by Hepatitis E Vaccine in Bangladesh.
The aim of the study is to determine the effectiveness of hepatitis E virus vaccine given in women of child bearing age in preventing HEV disease during pregnancy among women in rural Bangladesh.
- Trial name
- NCT02759991
- Testing
- Hecolin, Hepa-B
- Where
- Bangladesh
- Volunteers
- 19,460 people, healthy volunteers welcome
- Sponsor
- Norwegian Institute of Public Health
Hepatitis B, Chronic
A Study of Early Immunologic Response in Asian Patients With Chronic Hepatitis B, Treated With Pegasys (Peginterferon Alfa-2a (40KD)), Nucleoside Analogues, or Both
This open-label, randomized, parallel-arm study will assess the early immunologic response in treatment-naïve Asian male patients with chronic hepatitis B after initiation of treatment with Pegasys or tenofovir or Pegasys plus…
- Trial name
- NCT00962871
- Testing
- peginterferon alfa-2a [Pegasys], tenofovir
- Where
- 6 sites in United States, New Zealand and 2 more
- Volunteers
- 30 people
- Sponsor
- Hoffmann-La Roche
Hepatitis E
Ribavirin for Severe Acute and Chronic Hepatitis E Virus Infection.
The purpose of the study is to compare the efficacy, safety and recurrence rate of two therapeutic strategies with ribavirin in patients with chronic hepatitis E and severe acute hepatitis E: fixed duration of treatment for 12…
- Trial name
- NCT02558114
- Testing
- Ribavirin
- Where
- Spain
- Volunteers
- 5 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute