Clinical trials: Acute Hypoxemic Respiratory Failure
COVID-19 Pneumonia
High Velocity Nasal Insufflation Versus Continuous Positive Airway Pressure in COVID 19 Pneumonic Patients
compare the efficacy of High-Velocity Nasal Insufflation (HVNI) versus Continuous Positive Airway Pressure (CPAP) in managing COVID 19 pneumonic patients with acute type 1 respiratory failure
- Trial name
- NCT07213518
- Testing
- High Velocity Nasal Insufflation, Continuous Positive Airway Pressure
- Where
- Egypt
- Volunteers
- 108 people
- Sponsor
- Mansoura University
Acute Hypoxemic Respiratory Failure, High-Flow Nasal Oxygen Therapy
Effects of Face Mask Continuous Positive Airway Pressure Vs. Noninvasive Ventilation Vs. High-flow Nasal Oxygen on Intubation-free Survival in Acute Hypoxemic Respiratory Failure: the TRIPOD Randomized Clinical Trial
Acute hypoxemic respiratory failure (AHRF) is a common indication for admission to an intensive care unit (ICU), with mortality exceeding 50% in cases where invasive mechanical ventilation is needed.
- Conditions
- Acute Hypoxemic Respiratory Failure, High-Flow Nasal Oxygen Therapy, Noninvasive Ventilation, Continuous Positive Airway Pressure (CPAP)
- Trial name
- TRIPOD (NCT06795971)
- Testing
- Continuous Positive Airway Pressure, High-flow nasal oxygen, Non-invasive ventilation
- Where
- China
- Volunteers
- 1,300 people
- Sponsor
- Southeast University, China
Acute Hypoxemic Respiratory Failure
Airway Closure During Extracorporeal Membrane Oxygenation: The AiCLOSE Study
About 65,000 Canadians develop acute respiratory failure requiring breathing machines (ventilators) to give oxygen to their lungs. Unfortunately, up to 50% of these individuals will not survive their illness.
- Trial name
- AiCLOSE (NCT05196074)
- Testing
- Acute hypoxemic respiratory failure patients on VV-ECMO
- Where
- Canada
- Volunteers
- 299 people
- Sponsor
- Lorenzo delSorbo
Respiratory Failure, ICU
A Wake Prone Positioning in Non-intubated Patients With Acute Hypoxemic Respiratory Failure
Patients admitted to the ICU with severe hypoxemia are at high risk for mortality. Few therapies have been proven to improve patient outcomes or duration of mechanical ventilation e.g.
- Trial name
- NCT05698004
- Testing
- prone positioning
- Volunteers
- 244 people
- Sponsor
- Montaser Gamal Ahmed
Acute Hypoxemic Respiratory Failure
Helmet CPAP vs Venturi O2 to Treat Early ALI/ARDS
Mechanical ventilation through an endotracheal tube is a lifesaving procedure for acute respiratory failure. However endotracheal intubation increases patient's discomfort and stress, and represents one of the most important…
- Trial name
- HelmetCPAP (NCT00342368)
- Testing
- CPAP delivered by an Helmet
- Where
- Italy
- Volunteers
- 190 people
- Sponsor
- Catholic University of the Sacred Heart
Prone Positioning, Covid19
Use of Combined Prone Positioning and High-Flow Nasal Cannula, and Non-invasive Positive Pressure Ventilation to Prevent Intubation in COVID-19 Infection
This research aims to understand if prone positioning combined with high-flow nasal cannula (HFNC) or non-invasive positive pressure ventilation (NIPPV) safely reduce the rate of intubation in acute hypoxemic and/or hypercapnic…
- Conditions
- Prone Positioning, Covid19, Hypoxemic Respiratory Failure, ARDS
- Trial name
- NCT04694638
- Testing
- Body position change
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Mayo Clinic
Pneumonia, Respiratory Failure
CPAP Versus HFNO for the Treatment of Acute Hypoxemic Respiratory Failure Due to Community Acquired Pneumonia
the study compares two non-invasive respiratory support modalities ie CPAP and High Flow nasal cannula oxygen for the treatment of severe hypoxemic respiratory failure attributed to Community acquired Pneumonia.
- Trial name
- NCT05755425
- Testing
- CPAP, HFNO
- Where
- 2 sites in Greece
- Volunteers
- 100 people
- Sponsor
- Evangelismos Hospital
ARDS (Acute Respiratory Distress Syndrome)
Continuous vs Bolus Neuromuscular Blockade Regimens in Moderate to Severe Hypoxemic Respiratory Failure and ARDS (COBRA)
Current clinical guidelines, such as those from the Surviving Sepsis Campaign and ARDSNet, recommend short-term NMBA use for patients with moderate to severe ARDS who exhibit persistent ventilator dyssynchrony or high plateau…
- Trial name
- COBRA (NCT07567768)
- Testing
- Neuromuscular Blocking Agent - Bolus Dosing, Neuromuscular Blocking Agent - Continuous Infusion
- Volunteers
- 100 people
- Sponsor
- University of Calgary
Community Acquired Pneumonia., Acute Hypoxemic Respiratory Failure
Efects of Noninvasive Mechanical Ventilation and Conventional Mechanical Ventilation in Patients With Severe Comunity Pneumonia
The purpose of this study is to determine whether the noninvasive ventilation is more effective in the treatment of severe comunity acquired pneumonia in comparison with the conventional mechanical ventilation with orotracheal…
- Trial name
- NIMV AND SCAP (NCT00523497)
- Testing
- Non invasive mechanical ventilation
- Where
- Argentina
- Sponsor
- Hospital Privado del Sur
AHRF
Optimization of Respiratory Effort With Titrated Sedation in AHRF
Prospective, observational, monocentric study to assess the physiological effects of dexmedetomidine and remifentanil in spontaneously breathing patients with acute hypoxemic respiratory failure receiving high-flow nasal oxygen.
- Trial name
- OPTIREST (NCT07679932)
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Respiratory Failure With Hypoxia, Respiratory Failure Without Hypercapnia
Prone Positioning During High Flow Oxygen Therapy in Acute Hypoxemic Respiratory Failure
Background High-flow nasal cannula (NHF) are a promising tool for administering oxygen to critically ill patients with high respiratory demand.
- Trial name
- Optiprone (NCT03095300)
- Testing
- Prone position
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Catholic University of the Sacred Heart
COVID, Acute Hypoxemic Respiratory Failure
Helmet CPAP Versus HFNC in COVID-19
We aim to investigate whether the use of Continuous Positive Airway Pressure using a Helmet device (Helmet CPAP) will increase the number of days alive and free of ventilator within 28 days compared to the use of a High Flow…
- Trial name
- COVID HELMET (NCT04395807)
- Testing
- Helmet CPAP, HFNC
- Where
- Sweden
- Volunteers
- 2 people
- Sponsor
- Lund University
Acute Hypoxemic Respiratory Failure
Respiratory Mechanics Assessment During Assisted Mechanical Ventilation
To verify the association between respiratory system mechanical properties (ΔP, ΔPL,dyn, Pmus, Pplat and CRS and CL,dyn) assessed during assisted modes of ventilation (as average over the first three days since enrollment) and…
- Trial name
- ICEBERG (NCT05203536)
- Where
- 8 sites in Canada, Germany and 3 more
- Volunteers
- 298 people
- Sponsor
- University of Milano Bicocca
COVID-19, Acute Hypoxemic Respiratory Failure
Helmet Non-Invasive Ventilation for COVID-19 Patients
Study hypothesis: Non-invasive positive pressure ventilation delivered by helmet will reduce 28-day all-cause mortality in patients with suspected or confirmed severe COVID-19 pneumonia and acute hypoxemic respiratory failure
- Trial name
- Helmet-COVID (NCT04477668)
- Testing
- Helmet non-invasive ventilation
- Where
- Saudi Arabia
- Volunteers
- 322 people
- Sponsor
- King Abdullah International Medical Research Center
Acute Hypoxic Respiratory Failure
Analysis of Advanced Physiological Ventilatory Parameters During Spontaneous Breathing Effort in Patients with Acute Hypoxemic Respiratory Failure
The aim of this prospective physiological cohort study conducted in a medical intensive care unit (ICU) at Hospital del Mar in Barcelona, Spain, was to analyze the proportion of time spent within the "safe" range of respiratory…
- Trial name
- NCT06490523
- Where
- Spain
- Volunteers
- 31 people
- Sponsor
- Hospital del Mar Research Institute (IMIM)
Hypoxemic Acute Respiratory Failure
High Flow Nasal Oxygen Therapy for Hypoxemy After Cardiac Surgery
The main objective of this study is to evaluate the gas exchange (ventilation-perfusion ratio) with the system Optiflow® compared to facial mask among patients having an acute respiratory failure after cardiac surgery.
- Trial name
- Optiflow (NCT01617252)
- Testing
- Optiflow / Facial mask
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Nantes University Hospital
COVID-19
I-SPY COVID-19 TRIAL: An Adaptive Platform Trial for Critically Ill Patients
The goal of this project is to rapidly screen promising agents, in the setting of an adaptive platform trial, for treatment of critically ill COVID-19 patients.
- Trial name
- I-SPY_COVID (NCT04488081)
- Testing
- Remdesivir, Imatinib Mesylate, Dexamethasone
- Where
- 36 sites in United States
- Volunteers
- 1,500 people
- Sponsor
- QuantumLeap Healthcare Collaborative
Coronavirus, Respiratory Distress Syndrome
LIBERATE Trial in COVID-19
The study aims to evaluate the reduction in severity and progression of lung injury with three doses of lipid ibuprofen in patients with SARS-CoV-2 infections.
- Conditions
- Coronavirus, Respiratory Distress Syndrome, SARS-CoV Infection
- Trial name
- LIBERATE (NCT04334629)
- Testing
- Ibuprofen
- Where
- United Kingdom
- Sponsor
- King's College London
Ventilatory Failure, Hypoxemic Respiratory Failure
PREdicting Failure of Non-inVasIve Ventilatory Support Using Non-invaSIve mONitoring in Non-intubated Patients With Acute Hypoxemic Respiratory Failure or Post-extubation Failure. The PREVISION Study
The goal of this observational study is to assess the potential non-invasive tools (e.g. regional ventilation, respiratory muscle response, lung mechanic's parameters) to identify the risk of failure when using high flow nasal…
- Conditions
- Ventilatory Failure, Hypoxemic Respiratory Failure, Weaning Failure, Respiratory
- Trial name
- PREVISION (NCT06716463)
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Unity Health Toronto
ARDS, Acute Hypoxemic Respiratory Failure
Incidence of Dyssynchronies in Early ARDS
Patients sedated under mechanical ventilation with acute hypoxemic respiratory failure with a PaO2/FiO2 equal or less than 200mmHg (Acute Respiratory Distress Syndrome, ARDS and non-ARDS) will be included in the study early in…
- Trial name
- BEARDS (NCT03447288)
- Where
- 14 sites in Canada, China and 8 more
- Volunteers
- 300 people
- Sponsor
- Unity Health Toronto