Clinical trials: Acute Infectious Diseases
Covid-19, Critical Illness
MIcrovascular Dysfunction in CRitically Ill cOVID-19 Patients
Microcirculatory dysfunction appears to play a key role in the development of organ failure leading to the death of patients with coronavirus disease 2019 (Covid-19).
- Conditions
- Covid-19, Critical Illness, Hemodynamics, SARS-CoV Infection
- Trial name
- MICROVID (NCT04819802)
- Testing
- Measurement of sublingual microcirculation, Plasma sampling
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Long COVID
Evaluating the Effects of a Fermented Diet on Microbiome Diversity in Individuals With Long COVID
The purpose of this study is to evaluate the effects of fermented foods on bacterial gut microbiome diversity of long-COVID subjects.
- Trial name
- NCT06560554
- Testing
- Fermented foods, Control
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Guillain Barré Syndrome, Acute Respiratory Failure
Early Mechanical Ventilation for Guillain Barré Syndrome
The purpose of this study is to determine whether early mechanical ventilation can prevent hospital acquired pneumonia in adults with Guillain Barré Syndrome.
- Trial name
- NCT00167622
- Testing
- mechanical ventilation, physiotherapy and oxygen if needed
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University of Versailles
COVID-19
Influence of Nutritional Indices on the Prognosis of Patients With SARS-CoV-2 Infection
With the decline of virulence after the mutation of the SARS-CoV-2 , based on the national life and health and national development needs, the domestic SARS-CoV-2 infection epidemic prevention policy has changed, and the number…
- Trial name
- NCT05835102
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Juan Kang
COVID-19
Prazosin to Prevent COVID-19 (PREVENT-COVID Trial)
The purpose of this study is to assess the efficacy and safety of prazosin to prevent cytokine storm syndrome and severe complications in hospitalized patients with Coronavirus disease 2019 (COVID-19).
- Trial name
- PREVENT (NCT04365257)
- Testing
- Prazosin, Standard of care
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Johns Hopkins University
Acute Otitis Media
Study to Compare Efficacy and Safety of AR01 to a Placebo Solution for Relief of Pain in Acute Otitis Media (AR01007)
Children ages 2 months to less than 19 years old, who have been diagnosed with a middle ear infection may receive either medicated ear drops (AR01) or glycerin (placebo) ear drops.
- Trial name
- NCT02074007
- Testing
- AR01
- Where
- 21 sites in United States
- Volunteers
- 178 people
- Sponsor
- Arbor Pharmaceuticals, Inc.
HIV Infections
Anti-HIV Medications and Structured Treatment Interruptions for People Recently Infected With HIV
People recently infected with HIV who are treated with anti-HIV medications may develop strong immune system responses to HIV and may be able to control the virus without continuing to take these medications.
- Trial name
- NCT00084032
- Testing
- Structured treatment interruption, Antiretroviral regimen
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
SARS CoV-2 Post-Acute Sequelae
Antiviral Strategies in the Prevention of Long-term Cardiovascular Outcomes Following COVID-19: The paxloviD/Remdesivir Effectiveness For the prEvention of loNg coviD Clinical Trial
The DEFEND trial will be the world's first clinical trial to study the effectiveness of Paxlovid or Veklury in the prevention of cardiovascular post-acute sequelae of SARS-CoV-2 among hospitalized adults.
- Trial name
- DEFEND (NCT06792214)
- Testing
- Nirmatrelvir/ritonavir, Remdesivir
- Where
- 4 sites in Canada
- Volunteers
- 118 people
- Sponsor
- Mount Sinai Hospital, Canada
Gastrointestinal Post Acute COVID-19 Syndrome
The Clinical Significance of Gut Permeability in Gastrointestinal Post Acute COVID-19 Syndrome
Severe acute respiratory syndrome coronavirus 2 (SARS- CoV-2) and the associated coronavirus disease 2019 (COVID-19) have been spreading all around the world for past 3 years.
- Trial name
- NCT05612087
- Testing
- Confocal laser endomicroscopy
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
HIV Infections
Outcomes of Anti-HIV Therapy During Early HIV Infection
The purpose of this study is to find out if it is effective to give aggressive anti-HIV therapy to patients who have been infected recently with HIV.
- Trial name
- NCT00001093
- Where
- 3 sites in United States
- Volunteers
- 48 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Infection, Acute Kidney Injury
The Vancomycin Piperacillin/Tazobactam (VPT) Patient Safety Trial (VPS)
The VPT Safety Trial (VPS) compares two common antibiotic combinations to see how they affect the kidneys of patients in the hospital with serious infections.
- Conditions
- Infection, Acute Kidney Injury, Sepsis
- Trial name
- VPS (NCT07556107)
- Testing
- Piperacillin + Tazobactam, meropenem
- Where
- 7 sites in United States
- Volunteers
- 852 people
- Sponsor
- Bassett Healthcare
Influenza
Acute Respiratory Infection Consortium
Recently, the emergence and rapid global dissemination of novel swine-origin influenza A virus (H1N1) with unique epidemiologic characteristics has heightened awareness and concern of this viral pathogen, and its potential for…
- Trial name
- ARIC (NCT01021098)
- Where
- 5 sites in United States
- Volunteers
- 2,018 people, healthy volunteers welcome
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Post-COVID-19 Syndrome, Long-COVID-19 Syndrome
Aerobic Training for Rehabilitation of Patients With Post Covid-19 Syndrome
Post-COVID-19 syndrome (PCS) occurs as a sequelae after acute infection with the SARS-CoV-2 virus (COVID-19 infection). PCS is defined as symptom persistence over a period of 12 weeks from infection and/or the appearance of new…
- Trial name
- NCT06016192
- Testing
- Aerobic Exercise Training
- Where
- Germany
- Volunteers
- 139 people
- Sponsor
- University of Witten/Herdecke
Coronavirus Infection, Pneumonia, Viral
HFNC Treatment in COVID-19 Pneumonia
coronavirus disease 2019 related pneumonia is causing acute respiratory failure and this is the most common reason for ICU admission. We have several different way for respiratory support.
- Conditions
- Coronavirus Infection, Pneumonia, Viral, Acute Respiratory Failure
- Trial name
- NCT04424836
- Testing
- high flow nasal cannula device
- Where
- Turkey (Türkiye)
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
HIV-Infection
Immediate Versus Deferred Antiretroviral Therapy in HIV-infected Patients Presenting With Acute AIDS-defining Events
The purpose of this study is to compare the early versus deferred initiation of antiretroviral combination therapy consisting of tenofovir, emtricitabine and atazanavir/ritonavir in treatment naive patients who present with an…
- Trial name
- IDEAL (NCT01417949)
- Testing
- Time of starting antiretroviral therapy
- Where
- 17 sites in Germany
- Volunteers
- 61 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Invasive Fungal Infections
A Russian Prospective Observational Study of Invasive Fungal Infections in Patients With Acute Leukemia and Hematopoietic Stem Cell Transplantation
Estimate the rate of occurrence of Invasive Fungal Infections (IFIs) in patients with acute leukemia for the first 6 months of chemotherapy (that usually correspond to four courses of chemotherapy), and hematopoietic stem cells…
- Trial name
- NCT01519648
- Where
- Russia
- Volunteers
- 808 people
- Sponsor
- National Hematological Society, Russia
COVID-19, Long COVID
Study of Vascular Endothelial Glycocalyx and Ophthalmic Injury, Prospective Cohort of Patients With Prolonged Post-COVID-19 Symptoms
The glycocalyx is a membrane coat composed of glycoproteins attached to the surface of cell membranes. Recent publications have drawn attention to the potential role of a degradation of the endothelial glycocalyx (a kind of gel…
- Trial name
- GLYCOVLONG (NCT05235698)
- Testing
- Ophthalmological examinations, GlycoCheck
- Where
- France
- Volunteers
- 44 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Acute on Chronic Liver Failure, Traditional Chinese Medicine
Study on the Optimal Strategy for Acute-on-chronic Liver Failure With Integrative Treatment
Background: Acute-on-chronic liver failure (ACLF) is a syndrome characterized by acute deterioration in the setting of chronic liver disease associated with high short-term mortality.
- Conditions
- Acute on Chronic Liver Failure, Traditional Chinese Medicine, Hepatitis B
- Trial name
- NCT03577938
- Testing
- Chinese herbal medicine, Control (blank)
- Where
- 15 sites in China
- Volunteers
- 516 people, healthy volunteers welcome
- Sponsor
- Beijing 302 Hospital
Covid19, SARS-CoV Infection
Prognosis and Course of COVID-19 Infection in Hospitalised Patients
The aim of the cohort prospective observational study is to define the major factors influencing the course of COVID-19 infections and its prognosis in hospitalised patients.
- Trial name
- NCT04752085
- Testing
- Chitotriosidase activity
- Where
- 2 sites in Russia
- Volunteers
- 345 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Pustular Psoriasis (PP), Generalized Pustular Psoriasis (GPP)
Evaluating Legit.Health Plus Support for Improving Diagnosis of Generalized Pustular Psoriasis and Other Skin Conditions Among Primary Care Physicians and Dermatologists
This study aims to determine if an artificial intelligence (AI) medical device can help healthcare professionals more accurately diagnose rare and complex skin conditions.
- Conditions
- Pustular Psoriasis (PP), Generalized Pustular Psoriasis (GPP), Eczema Atopic Dermatitis, Acute Generalized Exanthematous Pustulosis
- Trial name
- LegitHealth BI (NCT07428915)
- Testing
- AI-based medical device for aided diagnosis in Dermatology
- Where
- Spain
- Volunteers
- 15 people
- Sponsor
- AI Labs Group S.L
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