Clinical trials: Acute Ischemic Stroke, pill or tablet or capsule or oral, open to volunteers
- Condition Acute Ischemic Stroke
- Drug or intervention pill OR tablet OR capsule OR oral
- Status Open to volunteers
Ischemic Strokes, Traditional Chinese Medicine (TCM)
Spatiotemporal Evolution of Traditional Chinese Medicine Mechanisms in Acute Ischemic Stroke Treated With Dengzhan Xixin and Dengzhan Shengmai
To integrate large-scale RCT data on clinical symptoms, TCM syndromes, prognosis, and multi-omics profiles, construct a spatiotemporal dynamic network for disease-syndrome evolution of acute ischemic stroke (AIS) in the acute and…
- Conditions
- Ischemic Strokes, Traditional Chinese Medicine (TCM), Prognosis
- Trial name
- STEM-DZ (NCT07591883)
- Testing
- Dengzhan Shengmai - Erigeron breviscapus sequential intervention, corresponding control group sequential intervention
- Volunteers
- 358 people
- Sponsor
- Guangdong Provincial Hospital of Traditional Chinese Medicine
Acute Ischemic Stroke
Sublingual Edaravone Dexborneol for Inter-hospital Transfer Acute Ischemic Stroke (SLEDAIS)
This is a multicenter, randomized, double-blind, placebo-controlled clinical trial (SLEDAIS) involving 1,040 patients with acute ischemic stroke (AIS) who require inter-hospital transfer for potential endovascular therapy.
- Trial name
- SLEDAIS (NCT07682922)
- Testing
- Edaravone dexborneol sublingual tablet
- Where
- China
- Volunteers
- 1,040 people
- Sponsor
- Xinqiao Hospital of Chongqing
Acute Ichemic Stroke, Anterior Cerebral Artery Stroke
Safety and Efficacy of Baricitinib After Endovascular Treatment in Acute Anterior Circulation Large Vessel Occlusion: A Multicenter, Randomized Controlled Clinical Trial
The primary purpose of this study is to evaluate the efficacy and safety of Baricitinib combined with endovascular therapy in patients with acute anterior circulation large vessel occlusion, to address futile recanalization with…
- Conditions
- Acute Ichemic Stroke, Anterior Cerebral Artery Stroke, Baricitinib
- Trial name
- NCT07449910
- Testing
- 2mg Baricitinib, 4mg Baricitinib, Guideline-based therapy
- Where
- China
- Volunteers
- 750 people
- Sponsor
- The First Affiliated Hospital of University of Science and Technology of China
Stroke
Early Aggressive Strategy for Treatment of Lipid-Lowering in Acute Ischemic Stroke Delivered With Endovascular Therapy for Large Artery Occlusion
EAST-LDL is a prospective, multicenter, randomized, open-label clinical trial with blinded endpoint assessment evaluating whether early intensive lipid lowering with the PCSK9 inhibitor recaticimab, administered before…
- Trial name
- EAST-LDL (NCT07002476)
- Testing
- guideline-recommended SoC, Recaticimab (intensive)
- Where
- China
- Volunteers
- 978 people
- Sponsor
- Shanghai East Hospital
Acute Ischemic Stroke
Pro-urokinase for Extended-Window Posterior Circulation Stroke
This study aims to evaluate whether, in patients with imaging-confirmed acute ischemic stroke of the posterior circulation presenting within 4.5-24 hours after symptom onset and not scheduled for endovascular thrombectomy…
- Trial name
- PROMISE (NCT07617870)
- Testing
- rhPro-UK, Aspirin
- Where
- China
- Volunteers
- 586 people
- Sponsor
- The First Affiliated Hospital of Zhengzhou University
Ischemic Stroke
Efficacy and Safety Study of Ultra-early Mobile Stroke Unit Neuroprotection Combined With Revascularization for Acute Ischemic Stroke (EXCELLENT)
EXCELLENT was a prospective, multicenter, randomized, double-blind, placebo-controlled clinical study in which participants were randomized participants were randomized (1:1) to receive either IV thrombolysis + edaravone or IV…
- Trial name
- EXCELLENT (NCT07119021)
- Testing
- Intravenous thrombolysis + edaravone
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Ruijun Ji
Acute Ischemic Stroke
Safety and Feasibility of NRICM301 Added to Usual Care for Adults With Acute Ischemic Stroke
Acute ischemic stroke occurs when blood flow to part of the brain is blocked. This study will assess the safety and feasibility of adding NRICM301, a food-grade formula also called Taiwan Xingnao No.
- Trial name
- NCT07900503
- Testing
- NRICM301
- Where
- Taiwan
- Volunteers
- 45 people
- Sponsor
- En Chu Kong Hospital
Stroke, Stroke, Acute Ischemic
NeuroAiD Patient-Reported Outcomes in Patients With Mild to Moderate Ischemic Stroke
This is a randomized, controlled, open-label study of MLC901 (NeuroAiD™ II) in patients with mild to moderate ischemic stroke. Eligible participants will be randomized in a 1:1 ratio to receive MLC901 in combination with standard…
- Conditions
- Stroke, Stroke, Acute Ischemic, Stroke, Ischemic, Stroke, Cryptogenic
- Trial name
- NAiD-PRO (NCT07828210)
- Testing
- MLC901, Standard treatment for acute ischemic stroke
- Where
- Vietnam
- Volunteers
- 80 people
- Sponsor
- EVD Pharmacy and Medical Company Limited
Acute Ischemic Stroke, Cerebral Infarction
Early Antiplatelet Administration After Intravenous Thrombolysis for Acute Ischemic Stroke (TREND-IVT)
Stroke is the second leading cause of death worldwide, and ischemic stroke is the most frequent type. Intravenous thrombolysis with recombinant tissue plasminogen activator within 4.5 hours of symptom onset is the most effective…
- Trial name
- TREND-IVT (NCT06548971)
- Testing
- Aspirin, Best medical management
- Where
- 119 sites in China
- Volunteers
- 1,184 people
- Sponsor
- Capital Medical University
Stroke, Stroke (in Patients With Atrial Fibrillation)
Thrombolysis in Factor Xa-inhibitors Trial
This study looks at whether stroke patients who take FXa inhibitors (a type of blood thinner) can safely receive clot-busting treatment (IVT).
- Conditions
- Stroke, Stroke (in Patients With Atrial Fibrillation), Ischemic Stroke, Acute Ischemic Stroke
- Trial name
- SIFT (NCT06878066)
- Testing
- thrombolysis therapy
- Where
- 21 sites in Denmark, Norway and 1 more
- Volunteers
- 300 people
- Sponsor
- Guri Hagberg
Acute Ischemic Stroke
Effect of Ginkgo Biloba Extract on Cognitive Function in Acute Ischemic Stroke
The purpose of this study is to determine the effect of ginkgo biloba extract on cognitive function in acute ischemic stroke.
- Trial name
- NCT06140888
- Testing
- Ginkgo Biloba Extract
- Volunteers
- 356 people
- Sponsor
- Yi Yang
Ischemic Stroke
Aspirin Combined With Clopidogrel Versus Intravenous Alteplase for Acute Minor Stroke
An open-label, blinded endpoint, randomized controlled trial that includes patients diagnosed with non-disabling, non-large vessel occlusion, acute minor stroke within 4.5 hours of onset.
- Trial name
- AGREE (NCT05910125)
- Testing
- Aspirin, Clopidogrel, Alteplase
- Where
- China
- Volunteers
- 472 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Ischaemic Stroke
Efficacy and Safety of Minocycline in Patients With Acute Ischaemic Stroke Receiving Intravenous Thrombolysis
The aim of this study is to assess the efficacy and safety of minocycline in improving functional outcome among patients with acute ischaemic stroke receiving intravenous thrombolysis.
- Trial name
- EMPHASIS-2 (NCT07526987)
- Testing
- Minocycline Hydrochloride Capsule (50 mg per capsule)
- Where
- 3 sites in China
- Volunteers
- 934 people
- Sponsor
- Beijing Tiantan Hospital
Acute Coronary Syndrome, Myocardial Infarction
What is the Optimal Antithrombotic Strategy in Patients With Atrial Fibrillation Undergoing PCI?
The optimal antithrombotic management in patients with coronary artery disease (CAD) and concomitant atrial fibrillation (AF) is unknown.
- Conditions
- Acute Coronary Syndrome, Myocardial Infarction, Atrial Fibrillation, Atrial Flutter
- Trial name
- WOEST-3 (NCT04436978)
- Testing
- 30-day DAPT, Guideline-directed therapy
- Where
- 20 sites in Belgium, Netherlands
- Volunteers
- 2,000 people
- Sponsor
- St. Antonius Hospital
Acute Ischemic Stroke
Efficacy and Safety of Tenecteplase Among acutE Ischemic Stroke Patients With Recent Ingestion of Direct Oral Anticoagulant
The study will randomize patients with acute ischemic stroke and Direct Oral AntiCoagulants (DOAC) ingestion within 48 hours from enrollment (but otherwise eligible for thrombolysis) to administration of intravenous tenecteplase…
- Trial name
- ESTER-DOAC (NCT07621796)
- Testing
- Intravenous tenecteplase (TNK)
- Where
- United States
- Volunteers
- 660 people
- Sponsor
- Hackensack Meridian Health
Ischemic Stroke
Mexidol® Safety and Efficacy in Treatment of Hyperacute and Acute Ischemic Stroke
The primary objective of this study is to further define the mechanisms of action of Mexidol® (solution for intravenous and intramuscular injection, 50 mg/ml) and Mexidol® FORTE 250 (film-coated tablets, 250 mg) in the hyperacute…
- Trial name
- NCT07575984
- Testing
- Mexidol, Glycine
- Where
- 9 sites in Russia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Pharmasoft
Acute Ischemic Stroke, Endovascular Thrombectomy
Minocycline After Successful Endovascular Thrombectomy Recanalization in Posterior Circulation Arterial Occlusion (ATTRACTION-MINOP)
Acute ischemic stroke (AIS) is a leading cause of mortality and long-term disability worldwide. Among these, stroke caused by large vessel occlusion (LVO) are associated with particularly poor outcomes.
- Conditions
- Acute Ischemic Stroke, Endovascular Thrombectomy, Minocycline, Posterior Circulation
- Trial name
- NCT07594301
- Testing
- Minocycline hydrochloride capsule
- Where
- China
- Volunteers
- 234 people
- Sponsor
- Xiang Luo
Cerebral Small Vessel Disease, Ischemic Stroke
Treatment of Acute Ischemic Stroke With Edaravone Dexborneol Sublingual Tablets in Small Vessel Disease
This study is a multicenter, randomized, double-blind, placebo-controlled trial designed to evaluate the efficacy and safety of Edaravone Dexborneol Sublingual Tablets in patients with acute ischemic stroke due to small vessel…
- Trial name
- TASTE-SVD (NCT06674460)
- Testing
- Edaravone Dexborneol Sublingual Tablets
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Peking Union Medical College Hospital
Stroke (CVA) or Transient Ischemic Attack, Cerebral Hemorrhage
COAST Study - Cholesterol Optimization After Stroke
This study (acronym COAST Trial) is a multicenter observational registry aiming to document: patients' adherence and persistence to lipid-lowering therapy prescribed for secondary prevention; the proportion of patients achieving…
- Trial name
- COAST (NCT07256171)
- Testing
- low-fat diet, supplements, statins, ezetimibe, bempedoic acid, PCSK9 inhibitors, fibrates, or other lipid-lowering agents
- Volunteers
- 500 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Acute Ischemic Stroke, Cerebral Microbleeds
Intracranial Hemorrhage Risk of Intensive Statin in Acute Ischemic Stroke With Cerebral Microbleeds
This study is the first and largest secondary prevention trial about lipid-lowering therapy for acute ischemic stroke patients at high-risk of intracranial hemorrhage.
- Trial name
- NCT05589454
- Testing
- Atorvastatin Calcium tablets 80mg, Atorvastatin Calcium tablets 20mg
- Where
- 5 sites in China
- Volunteers
- 344 people
- Sponsor
- Sichuan Provincial People's Hospital