Clinical trials: Acute Ischemic Stroke (AIS)
Acute Ischemic Stroke (AIS)
Acute Ischemic Stroke Involves Significant Inflammatory Response. This Prospective Cohort Study Evaluates the Predictive Value of Monocyte-, Neutrophil-, and Leukocyte-to-albumin Ratios for Stroke Severity and Functional Outcome Using NIHSS at Admission and Modified Rankin Scale During Follow-up.
Acute Ischemic Stroke is a leading cause of mortality and long-term disability worldwide. Increasing evidence suggests that systemic inflammation plays a significant role in the pathophysiology and progression of ischemic brain…
- Trial name
- ALARMS (NCT07471061)
- Volunteers
- 60 people
- Sponsor
- Sohag University
Acute Ischemic Stroke
Safety and Efficacy of J147 in Acute Ischemic Stroke
The goal of this clinical trial is to find out if the drug J147 improves outcomes for persons who have had an ischemic stroke. It also will learn about the safety of J147 when given by injection to stroke patients.
- Trial name
- JUMPSTART (NCT07430917)
- Testing
- J147 Emulsion for Injection
- Where
- 5 sites in United States
- Volunteers
- 196 people
- Sponsor
- Abrexa Pharmaceuticals, Inc.
Acute Ischemic Stroke
A Phase II Clinical Study of LT3001 for Injection in the Treatment of Acute Ischemic Stroke
This phase II clinical study is designed to evaluate the efficacy and safety of LT3001 in the treatment of acute ischemic stroke
- Trial name
- NCT07754825
- Testing
- LT3001 Drug:high dose, LT3001 Drug: low dose
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Shanghai Pharmaceuticals Holding Co., Ltd
Stroke, Acute
SPT-07A Injection in Patients With Acute Ischemic Stroke (AIS): A Phase III Clinical Trial
This is a multicenter, randomized, double-blind, placebo-controlled, parallel controlled clinical trial in Chinese patients with acute ischemic stroke.
- Trial name
- SPAIR-2 (NCT05159947)
- Testing
- SPT-07A injection
- Where
- China
- Volunteers
- 1,112 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Acute Stroke
Impact of Anesthesia Type on Outcome in Patients With Acute Ischemic Stroke (AIS) Undergoing Endovascular Treatment
Recent observational studies have found an association between general anaesthesia and increased post-operative mortality in acute ischemic stroke patients undergoing endovascular treatment.
- Trial name
- CANVAS (NCT02677415)
- Testing
- Intravenous anesthetics, local anesthesia, Controlled ventilation
- Where
- China
- Volunteers
- 640 people
- Sponsor
- Beijing Tiantan Hospital
Acute Ischemic Stroke
Heparin for RAO Post-Transradial Angiography in AIS
Cerebral angiography is a critical diagnostic tool in neurology, serving as the "gold standard" for evaluating cerebrovascular stenosis, hemodynamics, aneurysms, and arteriovenous malformations.
- Trial name
- NCT07162064
- Testing
- Heparin - Therapeutic dosage, Saline (0.9% NaCl)
- Where
- China
- Volunteers
- 440 people
- Sponsor
- Xiang Luo
Acute Ischemic Stroke (AIS) Related to a Distal Occlusion
Evaluation of Mechanical Thrombectomy in Acute Ischemic Stroke Related to a Distal Arterial Occlusion
Mechanical thrombectomy (MT) has shown its effectiveness for the treatment of acute ischemic stroke (AIS) related to large vessel occlusion and rapidly became a cornerstone in the management of these patients.
- Trial name
- DISCOUNT (NCT05030142)
- Testing
- Mechanical Thrombectomy, Best medical treatment alone
- Where
- France
- Volunteers
- 488 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Arterial Ischemic Stroke
A Proof of Concept Study to Evaluate the Safety of Afamelanotide in Patients With Acute Arterial Ischaemic Stroke (AIS)
The primary study objective is to assess the safety of afamelanotide while the secondary objective is to assess whether the therapy affects the size of the penumbra, by increasing blood flow, restoring oxygen supply to the brain…
- Trial name
- NCT04962503
- Testing
- Afamelanotide
- Where
- Australia
- Volunteers
- 6 people
- Sponsor
- Clinuvel Pharmaceuticals Limited
Acute Ischemic Stroke, Intracranial Arteriosclerosis
Stroke Imaging Package Study
Our study aims to explore the value of new imaging technique package in predicting early neurological deterioration (END) as well as 90-day unfavorable outcome in patients with acute ischaemic stroke.
- Conditions
- Acute Ischemic Stroke, Intracranial Arteriosclerosis, Cerebral Small Vessel Diseases
- Trial name
- SIPS (NCT02485275)
- Where
- 16 sites in China
- Volunteers
- 949 people
- Sponsor
- Wei-Hai Xu
Acute Ischemic Stroke (AIS)
Deep Learning Enabled Endovascular Stroke Therapy Screening in Community Hospitals
After onset of Acute Ischemic Stroke (AIS), every minute of delay to treatment reduces the likelihood of a good clinical outcome.
- Trial name
- NCT05838456
- Testing
- Viz.AI software
- Where
- United States
- Volunteers
- 443 people
- Sponsor
- The University of Texas Health Science Center, Houston
Acute Ischemic Stroke, Thrombocytopenia
Antiplatelet Therapy for AIS Patients With Thrombocytopenia
The goal of this clinical trial is to test the safety and effectiveness of antiplatelet therapy in acute ischemic stroke (AIS) patients with thrombocytopenia.
- Trial name
- PERSIST (NCT06053021)
- Testing
- aspirin, clopidogrel, cilostazol, and dipyridamole
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Traumatic Brain Injury, Ischemic Stroke
Shared Decision Making to Improve Goals-of-Care Decisions for Families of Severe Acute Brain Injury Patients
Severe acute brain injury (SABI), including large artery acute ischemic stroke, intracerebral hemorrhage, and severe traumatic brain injury continue to be the leading cause of death and disability in adults in the U.S.
- Conditions
- Traumatic Brain Injury, Ischemic Stroke, Intracerebral Hemorrhage
- Trial name
- NCT03833375
- Testing
- Decision Aid
- Where
- 2 sites in United States
- Volunteers
- 41 people
- Sponsor
- University of Massachusetts, Worcester
Acute Ischemic Stroke
Metformin in Acute Ischemic Stroke
The goal of this clinical trial is to study the efficacy of oral Metformin in Acute Ischemic Stroke (AIS). The main hypothesis is to study the efficacy of oral Metformin in patients with acute ischemic stroke presenting within 72…
- Trial name
- NCT07899307
- Testing
- Metfomin
- Where
- 4 sites in India
- Volunteers
- 440 people
- Sponsor
- All India Institute of Medical Sciences
Acute Ischemic Stroke
Human Umbilical Cord Blood Infusion in Patients with Acute Ischemic Stroke (AIS)
A Phase II, Randomized, Double-blind, Parallel, Placebo-controlled Study to Assess the Safety and Efficacy of Human Umbilical Cord Blood Infusion in Patients with Acute Ischemic Stroke
- Trial name
- NCT06040476
- Testing
- hUCB
- Volunteers
- 39 people
- Sponsor
- StemCyte, Inc.
Acute Ischemic Stroke
Safety and Efficacy Evaluation of the Ceretrieve Device in the Treatment of AIS Patients
The main objective of this clinical trial is to evaluate of the safety \& efficacy of the Ceretrieve device within 24 hours post thrombectomy procedure.
- Trial name
- NCT06733246
- Testing
- Aspiration 0
- Where
- Germany
- Volunteers
- 132 people
- Sponsor
- Ceretrieve Ltd.
Intravenous, Thrombosis
Intravenous TNK vs TPA for AIS Treatment on MSU,a Prospective Multicenter RCT
Acute ischemic stroke is one of the devastating diseases that increase hospitalization, disabilities, and deaths worldwide. Current treatment with intravenous thrombolytic agent can help reduce disabilities and improve quality of…
- Conditions
- Intravenous, Thrombosis, Acute Ischemic Stroke
- Trial name
- NCT06498323
- Testing
- tenecteplase
- Where
- Thailand
- Volunteers
- 160 people
- Sponsor
- Mahidol University
Ischemic Stroke, Arterial Occlusion
Multimodal Neuroimaging in the Selection of Acute Ischemic Stroke (AIS) Patients to Endovascular Treatment (EVT)
To study the feasibility and usefulness of multimodal MR compared to multimodal CT to select patients with acute ischemic stroke and favorable clinical outcome after mechanical thrombectomy.
- Conditions
- Ischemic Stroke, Arterial Occlusion, CTS, Magnetic Resonance Imaging
- Trial name
- IMAGECAT (NCT03745391)
- Testing
- MULTIMODAL MAGNETIC RESONANCE (Multimodal MR), MULTIMODAL COMPUTERIZED TOMOGRAPHY (Multimodal CT)
- Where
- Spain
- Volunteers
- 323 people
- Sponsor
- Germans Trias i Pujol Hospital
Stroke
Temporal Trends of Thrombolysis Treatment in Chinese Acute Ischemic Stroke (AIS) Patients From 2007-2017: Analysis of China National Stroke Registry (CNSR) I, II, and III; CTP-Draft Review Performed;
The present study is to be conducted based on the AIS patient data collected from CNSR I, II, and III. The primary objectives are: To investigate the temporal changes in the proportion of intravenous recombinant plasminogen…
- Trial name
- NCT04290494
- Testing
- IV rtPA (intravenous recombinant plasminogen activator)
- Where
- China
- Volunteers
- 42,188 people
- Sponsor
- Boehringer Ingelheim
Acute Ischemic Stroke Due to Intracranial Large Artery Occlusion
First-pass Recanalization With EmboTrap II in Acute Ischemic Stroke (FREE-AIS)
This study is a prospective, open-label, multi-center, registry study, designed to to documents that EmboTrap II usage as a thrombectomy device for emergency large vessel occlusion (ELVO) in terms of the rate of First Pass…
- Trial name
- NCT04310306
- Testing
- Thrombectomy using EmboTrap II
- Where
- South Korea
- Volunteers
- 310 people
- Sponsor
- Yonsei University
Acute Ischemic Stroke
The Trial of Ewata Balloon Guiding in the Application of Thrombectomy
To evaluate the efficacy and security of Ewata combined with a stent device in the treatment of acute ischemic stroke within 8 hours To prove whether the clinical efficacy and safety of Ewata r is not inferior to other guidings.
- Trial name
- NCT04315844
- Testing
- Ewata balloon guiding
- Where
- China
- Volunteers
- 122 people
- Sponsor
- Beijing Tiantan Hospital