Clinical trials: Acute Ischemic Stroke AIS
Acute Ischemic Stroke
A Study to Evaluate the Safety and Potential Efficacy of LT3001 Drug Product in Subjects With AIS
This is a multicenter, double-blind, single-dose, randomized, and placebo-controlled prospective Phase IIa clinical study, designed to evaluate LT3001 drug product versus placebo/control in subjects with AIS.
- Trial name
- NCT04091945
- Testing
- LT3001 Drug Product
- Where
- 10 sites in United States, Taiwan
- Volunteers
- 24 people
- Sponsor
- Lumosa Therapeutics Co., Ltd.
Acute Ischemic Stroke
ANAIS Study to Confirm the Safety and Performance of the ANA 5F Advanced Neurovascular Access®
Prospective, single-arm, multi-center study to assess the safety and performance of the ANA 5F Advanced Neurovascular Access®, in combination with a stent retriever in patients with acute ischemic stroke.
- Trial name
- ANAIS (NCT05409430)
- Testing
- Neurothrombectomy
- Where
- 3 sites in Spain
- Volunteers
- 43 people
- Sponsor
- Anaconda Biomed S.L.
Acute Ischemic Stroke
Effect of Postoperative Prolonged Sedation With Dexmedetomidine After Successful Reperfusion With EVT on Long-term Prognosis in Patients With AIS (PPDET)
Dexmedetomidine can attenuate the activity of the sympathetic nervous system under stress response and improve ischemia-reperfusion injury.
- Trial name
- NCT04916197
- Testing
- Dexmedetomidine prolonged sedation, 0.9% saline
- Where
- China
- Volunteers
- 368 people
- Sponsor
- Beijing Chao Yang Hospital
Acute Ischemic Stroke
A Phase II Clinical Study of LT3001 for Injection in the Treatment of Acute Ischemic Stroke
This phase II clinical study is designed to evaluate the efficacy and safety of LT3001 in the treatment of acute ischemic stroke
- Trial name
- NCT07754825
- Testing
- LT3001 Drug:high dose, LT3001 Drug: low dose
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Shanghai Pharmaceuticals Holding Co., Ltd
Acute Ischemic Stroke
Human Placenta-derived 3D Mesenchymal Stem Cells(Guojianqingke)
This is a Phase I/IIa clinical trial evaluating human placental-derived 3D mesenchymal stem cell (MSC) injection in patients with acute ischemic stroke (AIS).
- Trial name
- 3D MSC - QK01 (NCT07635758)
- Testing
- Human Placenta-derived 3D Mesenchymal Stem Cells (Guojiangqingke)
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Chinese PLA General Hospital
Acute Ischemic Stroke
Umbilical Cord-derived Mesenchymal Stem Cell Infusion for Treating Acute Ischemic Stroke
The goal of this clinical trial is to learn if drug mesenchymal stem cells (umbilical cord) injection works to treat acute ischemic stroke in adults.
- Trial name
- UMERIS (NCT06518902)
- Testing
- mesenchymal stem cells (umbilical cord) injection
- Volunteers
- 18 people
- Sponsor
- National Engineering Center of Cell Products
Acute Ischemic Stroke
Safety and Preliminary Efficacy of Hibernation-Like Therapy (Chlorpromazine and Promethazine) in Patients With Acute Ischemic Stroke (AIS) Eligible for Reperfusion Therapy.
This is a single-center, dose-escalation and dose-expansion Phase I study designed to evaluate the safety of hibernation-like therapy (Chlorpromazine and Promethazine, C+P) and observe improvements in infarct volume in patients…
- Trial name
- CHILL-S (NCT07364344)
- Testing
- Hibernation-like Therapy (Chlorpromazine and Promethazine, C+P)
- Volunteers
- 57 people
- Sponsor
- Ji Xunming,MD,PhD
Acute Ischemic Stroke AIS
Balloon Guide Versus Conventional Guide Catheter in Stroke Thrombectomy
The purpose of this clinical trial is to study the two main types of approaches used in stroke thrombectomy and to investigate if one approach is more effective than the other, as this is currently not known.
- Trial name
- 2Guide (NCT07085390)
- Testing
- Use of a Balloon Guide Catheter, Use of a Conventional (non-balloon) Guide Catheter
- Where
- 2 sites in United States
- Volunteers
- 186 people
- Sponsor
- University of South Florida
Acute Ischemic Stroke (AIS)
Deep Learning Enabled Endovascular Stroke Therapy Screening in Community Hospitals
After onset of Acute Ischemic Stroke (AIS), every minute of delay to treatment reduces the likelihood of a good clinical outcome.
- Trial name
- NCT05838456
- Testing
- Viz.AI software
- Where
- United States
- Volunteers
- 443 people
- Sponsor
- The University of Texas Health Science Center, Houston
Endovascular Therapy, Acute Ischemic Stroke
Randomized Clinical Trial of Endovascular Therapy for Acute Ischemic Stroke With Occlusion of the M2 Segment of Middle Cerebral Artery
RESCUE-M2O trial is a prospective, open label, blinded endpoint (PROBE), two-arm, randomized, controlled, post-market study to assess the efficacy and safety of endovascular therapy for acute ischemic stroke with occlusion of the…
- Conditions
- Endovascular Therapy, Acute Ischemic Stroke, Acute Ischemic Stroke (AIS) Related to a Distal Occlusion
- Trial name
- NCT07347665
- Testing
- Endovascular therapy
- Where
- 3 sites in Japan, Thailand and 1 more
- Volunteers
- 200 people
- Sponsor
- Hyogo Medical University
Acute Ischemic Stroke (AIS), Acute Ischemic Stroke From Large Vessel Occlusion
Prospective Registry of Endovascular Thrombectomy for eXtra-Large Ischemic Stroke
Since 2015, many randomized trials have shown that endovascular thrombectomy improve functional outcomes in acute ischemic stroke patients with large vessel occlusion.
- Trial name
- XL-STROKE (NCT06210633)
- Testing
- medical management, endovascular thrombectomy
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Zhongming Qiu
Endovascular Treatment
Endovascular Treatment for AIS in Chinese Municipal and County Hospitals： A "Real World" Study-ETERNITY Registry
To investigate the Endovascular Treatment difference between Chinese city and country hospital.
- Trial name
- NCT06078917
- Where
- China
- Volunteers
- 1,196 people
- Sponsor
- Wen-huo Chen
Stroke
Alteplase Treatment in Elderly Acute Ischaemic Stroke (AIS) Patients
The objective of this study is to find out if Chinese Acute Ischaemic Stroke (AIS) patients older than 80 years benefit from intravenous (IV) Recombinant Tissue Plasminogen Activator (rt-PA) treatment within 4.5 hours of symptom…
- Trial name
- NCT05401149
- Testing
- rt-PA
- Where
- China
- Volunteers
- 3,058 people
- Sponsor
- Boehringer Ingelheim
Ischemic Stroke
Normobaric Oxygen in AIS Transferred for EVT
The primary objective of this study is to estimate the efficacy and safety of NBO on 3-month functional outcome after acute ischemic stroke
- Trial name
- AN-O2 (NCT06666764)
- Testing
- NBO, Control
- Where
- 112 sites in China
- Volunteers
- 1,500 people
- Sponsor
- Capital Medical University
Acute Ischemic Stroke
Efficacy and Safety of Butylphthalide for Acute Ischemic Stroke Patients Receiving Intravenous Thrombolysis or Endovascular Treatment
Butylphthalide, as a well-known neuroprotective medication, is a family of compounds initially isolated from the seeds of Apium graveolens Linn, of which active ingredient is dl-3-N-butylphthalide (dl-NBP).
- Trial name
- BAST (NCT03539445)
- Testing
- Butylphthalide
- Where
- China
- Volunteers
- 1,216 people
- Sponsor
- Beijing Tiantan Hospital
Arterial Ischemic Stroke
A Proof of Concept Study to Evaluate the Safety of Afamelanotide in Patients With Acute Arterial Ischaemic Stroke (AIS)
The primary study objective is to assess the safety of afamelanotide while the secondary objective is to assess whether the therapy affects the size of the penumbra, by increasing blood flow, restoring oxygen supply to the brain…
- Trial name
- NCT04962503
- Testing
- Afamelanotide
- Where
- Australia
- Volunteers
- 6 people
- Sponsor
- Clinuvel Pharmaceuticals Limited
Acute Ischemic Stroke AIS, Impaired Consciousness
Bovis Calculus Stativus Treat Acute Cerebral Ischemic Stroke With Impaired Consciousness
Acute ischemic stroke (AIS) is a severe and life-threatening condition, with 35% of AIS patients experiencing impaired consciousness upon admission within 24 hours of onset.
- Trial name
- ASCENT-BC (NCT07240467)
- Testing
- Bovis Calculus Stativus (BCS)
- Volunteers
- 220 people
- Sponsor
- Xiang Luo
Ischemic Stroke
Single Bolus Recombinant Nonimmunogenic Staphylokinase (Fortelyzin) and Bolus Infusion Alteplase in Patients With AIS
The aim of the study is to determine if single-bolus recombinant nonimmunogenic staphylokinase is effective and save thrombolytic agent in patients with ischemic stroke in comparison to alteplase.
- Trial name
- NCT03151993
- Testing
- Recombinant staphylokinase, Alteplase
- Where
- 18 sites in Russia
- Volunteers
- 336 people
- Sponsor
- Supergene, LLC
Stroke, Acute
SPT-07A Injection in Patients With Acute Ischemic Stroke (AIS): A Phase III Clinical Trial
This is a multicenter, randomized, double-blind, placebo-controlled, parallel controlled clinical trial in Chinese patients with acute ischemic stroke.
- Trial name
- SPAIR-2 (NCT05159947)
- Testing
- SPT-07A injection
- Where
- China
- Volunteers
- 1,112 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Stroke, Acute
Protective Effects of Normobaric Hyperoxia on Blood Brain Barrier in Patients With Acute Ischemic Stroke
The purpose of this study is to find out a serum marker for the evaluation of blood brain barrier damage based on animal experiments and investigate the effect of NBO（Normobaric hyperoxia）on blood brain barrier in the acute…
- Trial name
- NCT02974283
- Testing
- Normobaric oxygen therapy
- Volunteers
- 40 people
- Sponsor
- Capital Medical University