Clinical trials: Acute Ischemic Stroke Patients
Acute Ischemic Stroke
A Multicenter, Three-Arm, Open-Label, Endpoint-Blinded Randomized Controlled Trial to Evaluate the Optimal Duration of Early Tirofiban After Intravenous Thrombolysis in Acute Ischemic Stroke
Acute ischemic stroke is a leading cause of disability and mortality among dults in China. Although intravenous thrombolysis serves as first-line reperfusion therapy, nearly half of patients fail to achieve vascular…
- Trial name
- INSTANT-2 (NCT07842185)
- Testing
- Tirofiban Injection, No Interventions
- Where
- 10 sites in China
- Volunteers
- 1,482 people
- Sponsor
- Xinqiao Hospital of Chongqing
Acute Stroke
Impact of Anesthesia Type on Outcome in Patients With Acute Ischemic Stroke (AIS) Undergoing Endovascular Treatment
Recent observational studies have found an association between general anaesthesia and increased post-operative mortality in acute ischemic stroke patients undergoing endovascular treatment.
- Trial name
- CANVAS (NCT02677415)
- Testing
- Intravenous anesthetics, local anesthesia, Controlled ventilation
- Where
- China
- Volunteers
- 640 people
- Sponsor
- Beijing Tiantan Hospital
Acute Ischemic Stroke
Albumin for Patients With Acute Large Vessel Occlusive Stroke Undergoing Endovascular Therapy -2
This study is a prospective, multicenter, open-label, randomized controlled clinical trial. The investigators will apply albumin to the reperfusion treatment of patients with acute ischemic stroke in the anterior circulation.
- Trial name
- ARISE-2 (NCT07263308)
- Testing
- Albumin, Endovascular treatment
- Where
- 61 sites in China
- Volunteers
- 1,192 people
- Sponsor
- Capital Medical University
Transcranial Magnetic Stimulation
Effects of Repetitive Transcranial Magnetic Stimulation on Cerebral Autoregulation in Patients With Acute Ischemic Stroke
The purpose of this study was to investigate the effect of repetitive transcranial magnetic stimulation on cerebral autoregulation in patients with acute ischemic stroke.
- Trial name
- NCT05843240
- Testing
- Repetitive transcranial magnetic stimulation
- Where
- China
- Volunteers
- 128 people
- Sponsor
- Yi Yang
Stroke Acute, Endovascular Treatment
Advancing Reperfusion Therapy for Ischemic Stroke: Safety and Efficacy of Anakinra for Futile Reperfusion Following Endovascular Treatment in Patients With Acute Ischemic Stroke
The investigators initiated a multicenter, prospective, randomized, open label, blinded-endpoint (PROBE) controlled trial to explore the safety and efficacy of different dose of Anakinra compared to standard medical care for…
- Trial name
- ARTS-SAFE (NCT07423975)
- Testing
- High-dose Anakinra, Low-dose Anakinra, Standard medical treatment
- Where
- 6 sites in China
- Volunteers
- 159 people
- Sponsor
- Beijing Tiantan Hospital
Acute Ischemic Stroke (AIS)
Tirzepatide in Thrombectomy-Treated Acute Ischemic Stroke: A Randomized Trial
Acute ischemic stroke caused by blockage of a large artery in the brain is one of the leading causes of death and long-term disability worldwide.
- Trial name
- TOPAZ (NCT07734792)
- Testing
- Tirzepatide, Standard Medical Care (SMC)
- Where
- China
- Volunteers
- 726 people
- Sponsor
- yifang zhu
Acute Ischaemic Stroke
Pragmatic Ischaemic Stroke Thrombectomy Evaluation
Ischaemic strokes (those caused by blockage in an artery in the brain caused by a blood clot) can be treated with very early use of clot-busting (thrombolytic) drugs to attempt to restore the blood supply and limit the damage…
- Trial name
- PISTE (NCT01745692)
- Testing
- Mechanical thrombectomy, Intravenous rtPA
- Where
- United Kingdom
- Volunteers
- 65 people
- Sponsor
- NHS Greater Glasgow and Clyde
Cerebrovascular Stroke, Atrial Fibrillation
Prediction and Detection of Occult Atrial Fibrillation in Patients After Acute Cryptogenic Stroke and TIA
PROACTIA is a prospective, event-driven observational study. It aims to propose a composite scoring system in order to evaluate the risk of paroxysmal atrial fibrillation (PAF) in patients after acute cryptogenic stroke and…
- Trial name
- PROACTIA (NCT02725944)
- Testing
- Implantation of ICRM
- Where
- Norway
- Volunteers
- 251 people
- Sponsor
- University Hospital, Akershus
Acute Ischemic Stroke
The Efficacy and Safety of HRS-4029 in Acute Ischemic Stroke Patients
This trial will evaluate the efficacy and safety of HRS-4029 compared with placebo in participants with acute ischemic stroke (AIS).
- Trial name
- NCT07739160
- Testing
- HRS-4029
- Where
- China
- Volunteers
- 340 people
- Sponsor
- Beijing Suncadia Pharmaceuticals Co., Ltd
Acute Ischemic Stroke
Association Between Circulating BDNF Levels and Cardioembolic Strokes in Patients Treated for Ischemic Stroke
Atrial fibrillation (AF) is associated with serious complications, including embolic strokes, heart failure, and mortality. Disruption of normal blood flow in the atrium, particularly in the context of an endocardium predisposed…
- Trial name
- METAPROFIL 1 (NCT07624396)
- Testing
- Circulating BDNF levels measured via blood sample
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Stroke, Acute Ischemic
Tirofiban for Successful Endovascular Stroke Thrombectomy
Up to 50% of acute ischemic stroke patients with large vessel occlusion failed to achieve functional independence even after successful reperfusion therapy, a phenomenon that is referred to as "futile recanalization".
- Trial name
- ADJUVANT-2 (NCT06373042)
- Testing
- Intraarterial and intravenous tirofiban
- Volunteers
- 712 people
- Sponsor
- Zhongming Qiu
Ischemic Stroke, Alteplase Adverse Reaction
the Predictors of Hemorrhagic Transformation Subtypes in Acute Embolic Stroke Patients
The investigators evaluated the impact of AF on different subtypes of post-alteplase hemorrhagic transformation of brain infarction.
- Trial name
- NCT06653946
- Testing
- Alteplase
- Where
- Egypt
- Volunteers
- 716 people
- Sponsor
- Kafrelsheikh University
Stroke, Acute Ischemic Stroke
Study on Anti-Thrombotic Regimens for Secondary Prevention in Ischemic Stroke Patients With Possible Benefit From Anticoagulation Therapy
To screen ischemic stroke patients likely to benefit from anticoagulation and compare the effectiveness and safety of anticoagulation versus antiplatelet therapy in preventing recurrent ischemic stroke within 3 months.
- Trial name
- NCT07746882
- Testing
- Rivaroxaban, or Edoxaban , or Apixaban , or Dabigatran, Aspirin
- Volunteers
- 680 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Stroke, Acute, Stroke, Ischemic
Carotid Artery Stenting During Endovascular Treatment of Acute Stroke
Rationale: Approximately 20% of the patients with acute ischemic stroke due to an intracranial large vessel occlusion (LVO) has a high-grade stenosis in the ipsilateral cervical carotid artery.
- Conditions
- Stroke, Acute, Stroke, Ischemic, Carotid Stenosis, Carotid Atherosclerosis
- Trial name
- CASES (NCT06511089)
- Testing
- carotid artery stenting during EVT, no carotid artery stenting during EVT
- Where
- Netherlands
- Volunteers
- 600 people
- Sponsor
- University Medical Center Groningen
Stroke, Stroke, Acute
BELgian CT-perFUSion Study to Select Acute Stroke Patients for Thrombectomy
The goal of this clinical trial is to test whether perfusion CT can be used as a selection tool in stroke patients with a major anterior circulation occlusion, to exclude patients from thrombectomy because of a predicted…
- Conditions
- Stroke, Stroke, Acute, Stroke, Ischemic
- Trial name
- BELFUS (NCT05685043)
- Testing
- perfusion CT
- Sponsor
- University Hospital, Ghent
Stroke, Lacunar
The Effect of Aerobic Exercise in Patients With Lacunar Stroke
In a randomized-controlled study the effect of high-intensity training, 5 days a week at home for 12 weeks is tested in patients with lacunar stroke.
- Trial name
- HITPALS (NCT02731235)
- Testing
- High-intensity training, prophylactic stroke medication, Recommendations for lifestyle changes
- Where
- Denmark
- Volunteers
- 71 people
- Sponsor
- Herlev Hospital
Stroke, Acute, Hypoxia-Ischemia, Brain
Normobaric Hyperoxia Combined With Endovascular Therapy in Patients With Stroke Within 6 Hours of Onset：Longterm Outcome
The overall incidence of good outcome for AIS following endovascular treatment is only proximately 50%. Whether NBO was safe and effective to improve acute ischemic stroke prognosis is still unclear.
- Conditions
- Stroke, Acute, Hypoxia-Ischemia, Brain, ENDOVASCULAR TREATMENT
- Trial name
- NBOL (NCT05039697)
- Testing
- oxygen
- Where
- China
- Volunteers
- 282 people
- Sponsor
- Capital Medical University
Stroke, Ischemic, Cerebrovascular Accident
Effects of High-intensity Interval Aerobic Training on Balance, Walking Capacity, and Quality of Life in Patients With Sub-acute Stroke
Hemiplegia is one of the most common sequelae of stroke. Stroke is the leading cause of disability in adults all around the world.
- Trial name
- NCT04835740
- Testing
- High intensity Interval Training
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- Akhtar Saeed Medical and Dental College
TIA, Stroke
Evaluation of the HARM for the Detection of a Cerebral Ischemia in TIA/TNA Patients
The research project investigates the incidence of the hyperintense acute reperfusion marker (HARM) in patients with transient ischemic attack (TIA) or transient neurological attack (TNA).
- Conditions
- TIA, Stroke, Ischemia, Diagnoses Disease
- Trial name
- NCT03555643
- Where
- Germany
- Volunteers
- 96 people
- Sponsor
- Universitätsmedizin Mannheim
Ischemic Stroke, Acute
MEXIDOL® in the Rehabilitation Treatment of Patients With Acute Cerebral Failure
The use of metabolic modulators creates prospects for increasing the efficiency of the rehabilitation treatment of patients with acute cerebral failure
- Trial name
- NCT06221826
- Testing
- Mexidol
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- Pharmasoft