Clinical trials: Acute Ischemic Stroke Patients
Acute Stroke
TRUST-tPA: Therapeutic Trial Evaluating Efficacy of Telemedicine (TELESTROKE) of Patients With Acute Stroke
The objective is to evaluate decision making of i.v. tPA treatment in acute stroke within 3 hours of symptom onset either remotely via videoconferencing system (investigational arm) beginning of treatment on-site and then…
- Trial name
- NCT00279149
- Testing
- Visio conference system connected to the Tele-stroke network
- Where
- 9 sites in France
- Volunteers
- 400 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Ischemic Stroke
Effects of Remote Ischemic Conditioning on Cerebral Hemodynamics in Patients With Ischemic Stroke
The purpose of this study is to determine the impact of remote ischemic conditioning on cerebral hemodynamics in patients with ischemic stroke.
- Trial name
- RICCH-IS (NCT05915832)
- Testing
- Remote ischemic conditioning
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Yi Yang
Acute Stroke, Ischemic Stroke, Acute
Tirofiban for the Prevention of Early Neurological Deterioration After Intravenous Thrombolysis in Acute Ischemic Stroke
A prospective, multicenter, randomized, controlled, open-label, blinded endpoint trial to evaluate the safety and efficacy of intravenous administration of tirofiban for preventing early neurological deterioration after…
- Conditions
- Acute Stroke, Ischemic Stroke, Acute, Cerebral Infarction
- Trial name
- TREND-2 (NCT06587347)
- Testing
- Tirofiban Hydrochloride, Standard medical treatment (SMT)
- Where
- China
- Volunteers
- 302 people
- Sponsor
- Capital Medical University
Acute Ischemic Stroke
Study to Evaluate The Safety and Efficacy of Balovaptan in Participants With Acute Ischemic Stroke at a High Risk of Developing Malignant Brain Edema
This study is designed to evaluate the safety, efficacy, and pharmacokinetics of balovaptan compared with placebo in participants with acute ischemic stroke (AIS) at risk of developing Malignant Cerebral Edema (MCE)
- Trial name
- NCT05399550
- Testing
- Balovaptan
- Where
- United States
- Sponsor
- Hoffmann-La Roche
Stroke, Acute, Infarction, Middle Cerebral Artery
Autologous Bone Marrow Stem Cells in Ischemic Stroke.
The aim of the study is to determine the safety and tolerability of an autologous CD34+ subset bone marrow stem cell infusion into the middle cerebral artery in patients who have suffered acute total or partial anterior…
- Trial name
- NCT00535197
- Testing
- Infusion of autologous CD34+ stem cells into middle cerebral artery
- Where
- United Kingdom
- Volunteers
- 5 people
- Sponsor
- Imperial College London
Ischemic Stroke
Tirofiban for Patients Treated With Alteplase
After intravenous thrombolysis, the overall recanalization rate is 46%, and recclusion after initial recanalization occurs in 14-34%.
- Trial name
- MR TEA (NCT03357133)
- Testing
- Tirofiban, Alteplase
- Where
- 7 sites in China
- Volunteers
- 30 people
- Sponsor
- Capital Medical University
CVA (Cerebrovascular Accident)
Intravenous Thrombolytic Therapy in Acute Ischemic Stroke Patients on DOAC
Direct oral anticoagulants (DOAC) have emerged as safe and efficacious ischemic stroke prophylaxis for non-valvular atrial fibrillation (NVAF).
- Trial name
- DOAC-IVT (NCT06241677)
- Testing
- alteplase or tenecteplase
- Where
- Hong Kong
- Volunteers
- 260 people
- Sponsor
- Chinese University of Hong Kong
Subjects With Acute Ischemic Stroke
The Efficacy and Safety of Edaravone Dexborneol Sequential Therapy in the Treatment of Patients With AIS
SIM0308-302 is a multicenter, randomized, double-blind, placebo-controlled clinical III trial with the primary objective of evaluating the efficacy of Edaravone Dexborneol sequential therapy, consisting of Edaravone Dexborneol…
- Trial name
- NCT06176781
- Testing
- Edaravone Dexborneol Sequential Therapy
- Volunteers
- 880 people
- Sponsor
- Simcere Pharmaceutical Co., Ltd
Acute Ischemic Stroke Patients
Evaluation of rSO2 Between Frontal Lesion Area and Normal Area of Brain by NIRSITX Using NIRS in Acute Ischemic Stroke Patients.
The clinical trial is for acute ischemic stroke patients measuring cerebral oxygen saturation (rSO2) values using pulse oximeter of near-infrared spectroscopy in the frontal lesion area and normal area of brain.
- Trial name
- fNIRS (NCT06250608)
- Testing
- Pulse oximeter, NIRSITX
- Where
- 2 sites in South Korea
- Volunteers
- 35 people
- Sponsor
- OBELAB, Inc.
Stroke
1-year Clinical Outcomes in Recombinant Tissue Plasminogen Activator (Rt-PA) Treated Chinese Acute Ischaemic Stroke (AIS) Patients
The objective of the study is to find out the 1-year clinical outcomes among Acute Ischaemic Stroke (AIS) patients who were treated with intravenous (IV) Recombinant Tissue Plasminogen Activator (rt-PA) within 4.5 hours of…
- Trial name
- NCT05395338
- Testing
- rt-PA
- Where
- China
- Volunteers
- 12,551 people
- Sponsor
- Boehringer Ingelheim
Stroke, Intracranial Atherosclerosis
Intensive Statin Treatment in Acute Ischemic Stroke Patients With INtracranial Atherosclerosis
Purpose: Intracranial atherosclerosis is a common condition in Korean population consisting over 25% of ischemic stroke etiology.
- Trial name
- STAMINA-MRI (NCT02458755)
- Testing
- High-dose statin: Atorvastatin 40mg or Rosuvastatin 20mg
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Samsung Medical Center
Intracranial Atherosclerosis, Acute Ischemic Stroke
Trial of PCSK9 Inhibition in Patients with Acute Stroke and Symptomatic Intracranial Atherosclerosis
This study will evaluate whether low-density lipoprotein (LDL-C) lowering with alirocumab results in greater change from baseline in intracranial atherosclerotic plaque at week 26 than control in adults with acute ischemic stroke…
- Conditions
- Intracranial Atherosclerosis, Acute Ischemic Stroke, ICAS - Intracranial Atherosclerosis
- Trial name
- TOPICAL-MRI (NCT05001984)
- Testing
- Alirocumab
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Chang Gung Memorial Hospital
Stroke, Acute
Endovascular Treatment in Ischemic Stroke Follow-up Evaluation
Study like register with biomarkers samples for patient experiencing acute ischemic stroke, to assess clinical outcomes and different factors that may affect the clinical outcomes.
- Trial name
- ETIS (NCT03776877)
- Where
- 16 sites in France
- Volunteers
- 4,000 people
- Sponsor
- Hopital Foch
Acute Ischemic Stroke
Umbilical Cord-derived Mesenchymal Stem Cell Infusion for Treating Acute Ischemic Stroke
The goal of this clinical trial is to learn if drug mesenchymal stem cells (umbilical cord) injection works to treat acute ischemic stroke in adults.
- Trial name
- UMERIS (NCT06518902)
- Testing
- mesenchymal stem cells (umbilical cord) injection
- Volunteers
- 18 people
- Sponsor
- National Engineering Center of Cell Products
Ischemic Stroke, Covid19
Acute Revascularization Treatment in Ischemic Stroke Patients With COVID-19
Case-series and cohort studies have shown the feasibility of reperfusion therapies in patients with ischemic stroke and COVID-19, but due to the absence of a contemporary control group of non-COVID-19 patients, small sample size…
- Trial name
- NCT04895462
- Where
- Switzerland
- Volunteers
- 15,128 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Acute Ischemic Stroke
Intravenous rhPro-UK Before Stroke Thrombectomy in the Extended Time Window (BRIDGE-PUK EXTEND)
This randomized, double-blind, placebo-controlled phase III clinical trial aims to evaluate the efficacy and safety of intravenous recombinant human Prourokinase (rhPro-UK) in acute ischemic stroke patients with large vessel…
- Trial name
- NCT07389460
- Testing
- Intravenous rhPro-UK, Endovascular thrombectomy
- Where
- 10 sites in China
- Volunteers
- 820 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Quality of Life, Stroke, Acute
Cerebrovascular Disease: Quality of Life (CODE: QoL)
The goal of this observational study is to learn about quality of life, stress and caregiver burden in patients with stroke and their caregivers.
- Conditions
- Quality of Life, Stroke, Acute, Sexual Behavior, Stress
- Trial name
- CODE:QoL (NCT06443268)
- Testing
- questionnaire, hair samples, blood samples, clinical exam
- Where
- Switzerland
- Volunteers
- 680 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Stroke, Acute
Assessment of Hemostasis Disorders in rtPA-treated Patients Requiring Endovascular Treatment for Ischemic Stroke
Stroke treatment includes thrombolysis, thrombectomy for patients with proximal artery occlusion and sometimes neurosurgery. It rises questions regarding hemostasis: thrombolysis induces fibrinolysis but its effects on…
- Trial name
- HEMOLYSE (NCT02893631)
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Acute Ischemic Stroke
Tenecteplase Compared to Alteplase for Patients With Large Vesel Oclusion Suspicion Before Thrombectomy
Background: The TNKCAT trial represents an innovative approach to optimize timely reperfusion in the Mothership and Drip-and-Ship scenarios.
- Trial name
- NCT05626972
- Testing
- Tenecteplase
- Where
- Spain
- Volunteers
- 500 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Stroke, Stroke, Acute
Gut Microbiota in Acute Stroke Patients
This study is to find out the significance of gut-microbiota in acute stroke patients, including their neurological, radiological outcomes as well as their stroke mechanisms.
- Conditions
- Stroke, Stroke, Acute, Stroke, Ischemic, Microbiome
- Trial name
- NCT03934021
- Where
- Hong Kong
- Volunteers
- 120 people
- Sponsor
- Chinese University of Hong Kong