Clinical trials: Acute Ischemic Stroke Patients
Acute Ischemic Stroke
TPA in Acute Stroke With COVID Verus Non-COVID-19 Patients
The investigator will recruit consecutively all patients coming with acute ischemic stroke either with or without COVID -19 infection and suitable for IV injection with Tissue plasminogen activators according to guideline and…
- Trial name
- rTPA (NCT05258565)
- Testing
- IV tPA (Activase)
- Where
- 2 sites in Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Stroke, Stroke, Acute
Data Collection of Patients Admitted to the Stroke Unit
The purpose of this prospective observational study is to create a database in which data will be collected from every patient admitted to the Stroke unit and who has explicitly given his or her informed consent for this data…
- Conditions
- Stroke, Stroke, Acute, Stroke, Ischemic, Stroke Hemorrhagic
- Trial name
- PRODA-STROKE (NCT04956185)
- Where
- Belgium
- Volunteers
- 5,000 people
- Sponsor
- University Hospital, Ghent
Dysphagia Following Cerebrovascular Accident
High Intensity Dysphagia Rehab for Acute Ischemic Stroke Patients
The purpose of this study is to determine a standardized protocol for swallowing therapy and this protocol's effects on recovery after a stroke
- Trial name
- NCT05970406
- Testing
- high intensity dysphagia therapy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Johns Hopkins University
Cerebral Stroke, Cerebrovascular Accident
Trial and Cost Effectiveness Evaluation of Intra-arterial Thrombectomy in Acute Ischemic Stroke
THRACE is a controled, multicenter and randomized trial. The primary objective of this study is to determine whether a combined approach intravenous thrombolysis (IV) + Mechanical thrombectomy is superior to the reference…
- Trial name
- THRACE (NCT01062698)
- Testing
- Alteplase (rt-PA)/Actilyse, Mechanic thrombectomy (MERCI, PENUMBRA, CATCH, SOLITAIRE)
- Where
- France
- Volunteers
- 412 people
- Sponsor
- Central Hospital, Nancy, France
Cerebral Stroke, Malondialdehyde
Effect of Astaxanthin Supplementation on Plasma Malondialdehyde Levels and NIHSS of Stroke Patients
This is an interventional randomized, controlled trial in analyzing the effects of astaxanthin supplementation on plasma malondialdehyde levels and NIHSS of acute ischemic stroke patients.
- Conditions
- Cerebral Stroke, Malondialdehyde, Oxidative Stress
- Trial name
- NCT03945526
- Testing
- Astaxanthine
- Where
- Indonesia
- Volunteers
- 24 people
- Sponsor
- Universitas Indonesia
Acute Ischemic Stroke Patients
Evaluation of rSO2 Between Frontal Lesion Area and Normal Area of Brain by NIRSITX Using NIRS in Acute Ischemic Stroke Patients.
The clinical trial is for acute ischemic stroke patients measuring cerebral oxygen saturation (rSO2) values using pulse oximeter of near-infrared spectroscopy in the frontal lesion area and normal area of brain.
- Trial name
- fNIRS (NCT06250608)
- Testing
- Pulse oximeter, NIRSITX
- Where
- 2 sites in South Korea
- Volunteers
- 35 people
- Sponsor
- OBELAB, Inc.
Stroke
Study on the Efficacy of Alprostadil Injection in Patients With Acute Ischemic Stroke
Ischemic stroke has a variety of treatments and currently drug therapy is one of the main treatments.A number of clinical studies have proved that alprostadil (PGE1) has pharmacological effects of significant dilation of blood…
- Trial name
- NCT03252626
- Testing
- Alprostadil, Normal saline
- Volunteers
- 950 people
- Sponsor
- The First Hospital of Jilin University
Ischemic Stroke, Thrombolysis
Hypothermia in Acute Ischemic Stroke - Surface Versus Endovascular Cooling (HAIS-SE)
HAIS-SE is evaluating for the first time ever in a randomized controlled trial efficacy, tolerability, practicability and safety of endovascular versus surface cooling in awake stroke patients.
- Conditions
- Ischemic Stroke, Thrombolysis, Hypothermia
- Trial name
- HAIS-SE (NCT01665885)
- Testing
- ZOLL Thermogard XP, BARD/Medivance Arctic Sun 5000
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University Hospital Heidelberg
Hypothermia, Stroke, Acute
Short-duration Selective Brain Cooling for Patients Undergoing Mechanical Thrombectomy
To determine the efficacy and safety of short-duration intra-artery selective brain cooling in addition to mechanical thrombectomy in patients with acute ischemic stroke.
- Trial name
- NCT03163459
- Testing
- selective brain cooling by cold saline perfusion, mechanical thrombectomy
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Capital Medical University
Stroke, Acute Ischemic Stroke
Intravenous Thrombosis and Patients with Prior Ischemic Stroke Within 3 Months
The primary hypothesis being tested in this trial is that ischemic stroke patients with prior ischemic stroke within 3 months will have improved clinical outcomes when given intravenous thrombolysis compared to standard care.
- Trial name
- NCT06841978
- Testing
- Intravenous Thrombolysis
- Volunteers
- 306 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Quality of Life, Stroke, Acute
Cerebrovascular Disease: Quality of Life (CODE: QoL)
The goal of this observational study is to learn about quality of life, stress and caregiver burden in patients with stroke and their caregivers.
- Conditions
- Quality of Life, Stroke, Acute, Sexual Behavior, Stress
- Trial name
- CODE:QoL (NCT06443268)
- Testing
- questionnaire, hair samples, blood samples, clinical exam
- Where
- Switzerland
- Volunteers
- 680 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Acute Brain Injury Coma, Neurocritical Care
Development and Validation of a Prognostic Model for Neurocritical Patients Using Multimodal Brain Monitoring
This study aims to develop and validate a prognostic model for neurocritical patients using multimodal brain monitoring data. By combining data from various monitoring techniques such as EEG, TCD, and NIRS, this model will help…
- Conditions
- Acute Brain Injury Coma, Neurocritical Care, Cerebral Infarction, Intracranial Hemorrhages
- Trial name
- NCT07115459
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Xiangya Hospital of Central South University
Stroke, Ischemic Attack, Transient
Platelet Reactivity in Acute Non-disabling Cerebrovascular Events
Ticagrelor is a reversible and direct-acting oral antagonist of the P2Y12 (Purinergic receptor P2Y, G-protein coupled, 12) receptor for adenosine diphosphate, which provides faster, greater, and more consistent P2Y12 inhibition…
- Trial name
- PRINCE (NCT02506140)
- Testing
- Ticagrelor and Acetylsalicylic acid, Clopidogrel and Acetylsalicylic acid
- Where
- 25 sites in China
- Volunteers
- 675 people
- Sponsor
- Beijing Tiantan Hospital
Acute Ischemic Stroke Patients Receiving Reperfusion Therapy
Optimal Post Tpa-Iv Monitoring in Ischemic Stroke
OPTIMISTmain is an investigator-initiated and conducted, international, multicentre, stepped wedge cluster randomized controlled trial comparing the effects of different intensities of nursing care monitoring for patients with…
- Trial name
- NCT03734640
- Testing
- Low-intensity monitoring strategy, Guideline recommended standard monitoring
- Where
- 54 sites in United States, Australia and 5 more
- Volunteers
- 4,922 people
- Sponsor
- Craig Anderson
TIA, Stroke
Evaluation of the HARM for the Detection of a Cerebral Ischemia in TIA/TNA Patients
The research project investigates the incidence of the hyperintense acute reperfusion marker (HARM) in patients with transient ischemic attack (TIA) or transient neurological attack (TNA).
- Conditions
- TIA, Stroke, Ischemia, Diagnoses Disease
- Trial name
- NCT03555643
- Where
- Germany
- Volunteers
- 96 people
- Sponsor
- Universitätsmedizin Mannheim
Acute Stroke
Evaluate the Safety and Explore Efficacy of Umbilical Cord Mesenchymal Stem Cells in Acute Ischemic Stroke
This study is a first-in-human assessment of safety of using umbilical cord mesenchymal stem cells (UCMSCs) in patients with Acute Ischemic Stroke via a combination of intra arterial (IA) and intravenous (IV) stem cell…
- Trial name
- NCT04434768
- Testing
- UMSC01
- Where
- Taiwan
- Volunteers
- 10 people
- Sponsor
- Ever Supreme Bio Technology Co., Ltd.
Acute Ischemic Stroke
An Application Provides Personalized Suggestions Based on Secondary Prevention Risk Factors to Stroke Patients
This study applied an application that provides personalized suggestions and explore the effect of this actual intervention on reducing the risk of stroke recurrence
- Trial name
- NCT07098143
- Testing
- Risk factor management
- Volunteers
- 5,092 people
- Sponsor
- Xuanwu Hospital, Beijing
Ischemic Stroke
REMOTE Ischemic Perconditioning Among Acute Ischemic Stroke Patients ( REMOTE-CAT)
Stroke is one of the leading causes of death worldwide and the main cause of incapacity. Currently, the only therapies for acute ischemic stroke (AIS) patients are the administration of recombinant tissue plasminogen activator…
- Trial name
- REMOTE-CAT (NCT03375762)
- Testing
- Remote ischemic perconditioning
- Where
- Spain
- Volunteers
- 572 people
- Sponsor
- Institut de Recerca Biomèdica de Lleida
Ischemic Stroke, Neurological Injury
Omega 3 and Ischemic Stroke; Fish Oil as an Option
In this trial, The investigators are going to investigate the improvement of neurological functions and infarced area of the brain in ischemic stroke patients after ingestion of omega 3 products that have high concentrations of…
- Conditions
- Ischemic Stroke, Neurological Injury, Stroke, Acute, Inflammatory Response
- Trial name
- OmegaStroke (NCT04386525)
- Testing
- Omega-3 fish oil
- Volunteers
- 60 people
- Sponsor
- King Fahad Medical City
Ischemic Stroke
Efficacy of Transcranial Direct Current Stimulation in Acute Ischemic Stroke
Non-invasive brain stimulation (tDCS) such as transcranial direct current stimulation (TDCS) has been reported to be effective in improving motor performance and safe in participants with cerebral infarction.
- Trial name
- DAS (NCT04938076)
- Testing
- Transcranial direct current stimulation
- Where
- South Korea
- Volunteers
- 172 people
- Sponsor
- Incheon St.Mary's Hospital