Clinical trials: Acute Ischemic Stroke Patients
Stroke, Acute, Intracranial Hemorrhages
Safety, Tolerability and Pharmacokinetics of Y-2(Edaravone And Borneol) Sublingual Tablet
The primary objective is to evaluate the safety and tolerability of single ascending dose of Y-2 sublingual tablets in healthy male and female adult subjects.
- Trial name
- NCT03495206
- Testing
- Y-2(Edaravone And Borneol) Sublingual Tablet
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Yantai YenePharma Co., Ltd.
Acute Ischemic Stroke
SLGT2i for Neuroprotection in Patients With Acute Ischemic Stroke
Stroke is a leading cause of disability and mortality globally. With population aging, ischemic stroke (80% of cases) has become China's primary cause of adult disability.
- Trial name
- NCT07105917
- Testing
- SGLT-2 inhibitors, Standard medical treatment
- Volunteers
- 1,050 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Acute Ischemic Stroke
Evaluation of Xueshuantong in Patients With AcutE IschemiC STroke
The aim is to assess the effects and harms of Xueshuantong lyophilized powder versus placebo in patients with acute ischemic stroke when initiated within 72 hours of symptom onset.
- Trial name
- EXPECT (NCT04415164)
- Testing
- Xueshuantong lyophilized powder, Guidelines-based standard care
- Where
- China
- Volunteers
- 480 people
- Sponsor
- Dongzhimen Hospital, Beijing
Acute Ischemic Stroke, Atrial Fibrillation
Registration Study of Acute Ischemic Stroke/Transient Ischemic Attack (TIA) With Atrial Fibrillation
Patient Registration Study of Acute Ischemic Stroke/transient ischemic attack(TIA) With Atrial Fibrillation (AISWAF) is a single-center prospective, consecutively, observational study, was conducted in patients with acute…
- Trial name
- AISWAF (NCT04080830)
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Xuanwu Hospital, Beijing
Stroke
Safety and Efficacy of Alteplase When Administered in Chinese Patients With Acute Ischemic Hemispheric Stroke Where Thrombolysis is Initiated Between 3 and 4.5 Hours After Stroke Onset
To evaluate the safety and efficacy of alteplase when administered between 3 and 4.5 hours after onset of stroke symptoms in Chinese patients with acute ischemic stroke
- Trial name
- NCT02930837
- Testing
- alteplase
- Where
- 11 sites in China
- Volunteers
- 120 people
- Sponsor
- Boehringer Ingelheim
Acute Stroke
Effects of a Ketogenic Diet on Acute Stroke
The purpose of this controlled, randomized intervention is to investigate whether a fat-based (ketogenic) diet given for a week has a positive effect on blood sugar, mortality and function in patients hospitalized with acute…
- Trial name
- NCT01997749
- Testing
- Ketocal 4:1 (Nutricia), Control diet: Regular diet offered at the hospitals, Ketogenic meals
- Where
- Denmark
- Volunteers
- 64 people
- Sponsor
- University of Copenhagen
Acute Ischemic Stroke
Ischemic Post-conditioning in Acute Ischemic Stroke Thrombectomy
Ischemic post-conditioning is a neuroprotective strategy that has been proven to attenuate reperfusion injury in animal models of stroke.
- Trial name
- PROTECT (NCT05153655)
- Testing
- Local ischemic post-conditioning
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Capital Medical University
Acute Stroke
Remote Ischemic Conditioning Paired With Endovascular Treatment for Acute Ischemic Stroke
Ischemic stroke, which is due to the occlusion of a cerebral blood vessel, comprises nearly 80-90% of all strokes. Currently, reperfusion of the salvageable tissue via thrombolytic drug or endovascular treatment is the most…
- Trial name
- REVISE-2 (NCT03045055)
- Testing
- Remote ischemic conditioning., Endovascular treatment.
- Volunteers
- 180 people
- Sponsor
- Capital Medical University
Cerebral Infarction
Effect of Cilostazol in the Acute Lacunar Infarction Based on Pulsatility Index of Transcranial Doppler
RATIONALE: Elevation in pulsatility indices (PIs), measured by transcranial Doppler (TCD), has been postulated to reflect downstream increased vascular resistance caused by small-vessel disease (SVD).
- Trial name
- ECLIPse (NCT00741286)
- Testing
- Aspirin, cilostazol
- Where
- 8 sites in South Korea
- Volunteers
- 203 people
- Sponsor
- Inje University
Acute Stroke
Evaluating the Therapeutic Effect of Acupuncture on Acute Ischemic Stroke Patients
The investigators design a randomized, single blinded, control study to evaluate the therapeutic effect of acupuncture in acute ischemic stroke patients:
- Trial name
- NCT02210988
- Testing
- acupuncture
- Volunteers
- 38 people
- Sponsor
- Cathay General Hospital
Ischemic Stroke
Clopidogrel Response in Acute Ischemic Stroke
The aim of this study was to determine the prevalence rate and risk factors for chemical laboratory clopidogrel low-response (CLR) in the acute phase after an ischemic stroke.
- Trial name
- Bo-CRISP (NCT01846572)
- Volunteers
- 159 people
- Sponsor
- Ruhr University of Bochum
Brain Infarction, Brain Ischemia
Transcranial Direct Current Stimulation, Improve Functional Motor Recovery, Affected Arm
Overall goal of this study is to determine if transcranial direct current stimulation (tDCS) plus conventional occupational therapy improves functional motor recovery in the affected arm-hand in patients after an acute ischemic…
- Trial name
- NCT01201629
- Testing
- t DC stimulation, tDCStimulation
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Oklahoma
Cerebral Stroke, Stroke, Acute
Safety and Effectiveness of NXY-059 for the Treatment of Patients Who Have Suffered From a Stroke
This study will determine if NXY-059 will improve recovery from an acute stroke. The study is designed to look at both overall recovery and recovery of motor function, for example muscle strengthen and coordination.
- Conditions
- Cerebral Stroke, Stroke, Acute, Cerebrovascular Stroke, Ischemic Attack, Transient
- Trial name
- NCT00061022
- Testing
- NXY-059
- Where
- 256 sites in United States, Argentina and 28 more
- Volunteers
- 3,200 people
- Sponsor
- AstraZeneca
Atrial Fibrillation
This Study Uses the SITS Registry to Find Out When Patients With a Heart Rhythm Disorder (Atrial Fibrillation) Start Treatment With Dabigatran After They Had a Stroke
This is an observational study in patients with non-valvular atrial fibrillation (NVAF) presenting to the hospital with a first acute ischemic stroke based on existing data recorded in the SITS International Registry (located in…
- Trial name
- NCT03258645
- Testing
- Dabigatran
- Where
- Sweden
- Volunteers
- 1,489 people
- Sponsor
- Boehringer Ingelheim
Cerebrovascular Accident, Cerebrovascular Accident, Acute
Comparison of the Efficacy of Ticagrelor Combined With ASA to ASA Alone in Patients With Stroke
Cerebrovascular disease is the main cause of death and severe long-term disability worldwide. Antiplatelet drugs are the main drugs for ischemic stroke and TIA.
- Trial name
- NCT04962451
- Testing
- ticagrelor + ASA
- Where
- China
- Volunteers
- 13,000 people
- Sponsor
- Peking University Third Hospital
Acute Ischemic Stroke
Butylphthalide for Brain Edema After Endovascular Treatment
This is a prospective, multicenter, randomized controlled clinical study aimed at evaluating the efficacy of butylphthalide in improving the severity of cerebral edema and prognosis in patients with acute anterior circulation…
- Trial name
- NCT07528456
- Testing
- Butylphthalide
- Where
- 10 sites in China
- Volunteers
- 100 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Acute Ischemic Stroke
ATILA Project: Aspirin Versus Tirofiban in Endovascular Treatment for Patients With Acute Ischemic Stroke Due to Tandem Lesion
Patients with tandem lesions (TL) are defined as patients with an acute ischemic stroke (AIS) with occlusion of an intracranial vessel of the anterior circulation and an occlusion or severe stenosis (70-99%) of the origin of the…
- Trial name
- ATILA (NCT05225961)
- Testing
- Tirofiban, Acetylsalicylic acid
- Where
- 13 sites in Spain
- Volunteers
- 240 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Infarction, Middle Cerebral Artery, Infarction, Anterior Cerebral Artery
Effect of Mesenchymal Stem Cells(MSCs) Transplantation for Acute Cerebral Infarction Patients
This is a placebo controlled, randomized, double blinded study including Phase 1 and Phase 2. Phase I study is a safety assessment and Phase 2 study is incline to assess effectiveness of MSCs.
- Conditions
- Infarction, Middle Cerebral Artery, Infarction, Anterior Cerebral Artery, Cerebral Infarction, Stroke, Ischemic
- Trial name
- NCT04093336
- Testing
- human umbilical cord mesenchymal stem cells, standardized treatment
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Shanghai East Hospital
Acute Ischemic Stroke
Effectiveness and Safety of Xiaoshuanchangrong (XSCR) Capsule for the Treatment of Patients Who Have Suffered From a Stroke
This study will determine if Xiaoshuanchangrong (XSCR) capsule will improve recovery from an acute stroke. The study is designed to look at both overall recovery and recovery of motor function, for example muscle strength and…
- Trial name
- NCT00710164
- Testing
- XSCR capsule (Composed of Traditional Chinese Medicine Huangqi, Chuanxiong, Chishao, Danggui, Dilong, Taoren, Honghua.)
- Where
- 20 sites in China
- Volunteers
- 130 people
- Sponsor
- Fudan University
Acute Ischemic Stroke, Clopidogrel Resistance
Precision Antiplatelet Therapy Guided by Platelet Aggregation Function in Patients With Acute Ischemic STROKE
The objective of this clinical trial is to evaluate the efficacy and safety of platelet aggregation function - guided precision anti - platelet therapy in patients with acute cerebral infarction.
- Trial name
- PATH STROKE C (NCT06853535)
- Testing
- The ticagrelor, The Clopidogrel
- Where
- China
- Volunteers
- 5,138 people
- Sponsor
- Sichuan Provincial People's Hospital