Clinical trials: Acute Ischemic Stroke Patients
Ischemic Stroke
Study of Efficacy and Safety of MEXIDOL® in Ischemic Stroke Therapy
The purpose of this study is to evaluate the efficacy and safety of long-term sequential therapy with Mexidol® in long-term sequential treatment of patients in the acute and early recovery periods of hemispheric ischemic stroke…
- Trial name
- EPICA (NCT02793687)
- Testing
- Mexidol
- Where
- 11 sites in Russia
- Volunteers
- 150 people
- Sponsor
- Pharmasoft
Acute Ischemic Stroke Due to Medium-vessel-occlusion
Dual IntraVenous Thrombolysis Approach (DIVA) in Patients With Medium-vessel-occlusion Strokes: a Retrospective Study
The purpose of this study (Dual IV thrombolysis Approach (DIVA) study) is to assess a new medical strategy for Medium-vessel-occlusion (MeVO) strokes, based on a second IV thrombolysis with tenecteplase (TNK) for persistent…
- Trial name
- DIVArétro (NCT05809921)
- Testing
- alteplase, Alteplase + possible complementary IVT with tenecteplase
- Where
- France
- Volunteers
- 294 people
- Sponsor
- Centre Hospitalier Sud Francilien
Myocardial Infarction
Studying the Effectiveness of Early Invasive Treatment in Elderly Patients With High-risk Non-ST-segment Elevation Acute Coronary Syndrome.
The goal of this is observational study is to compare about MACE events and predisposing factors related to MACE events in elderly patients with high-risk non-ST acute coronary syndromes receiving early versus late invasive…
- Trial name
- NCT06486233
- Where
- Vietnam
- Volunteers
- 385 people
- Sponsor
- Gia Dinh People Hospital
Acute Ischemic Stroke
CompARing Between CO2 Phenylephrine and Phenylephrine Only Treatment in Patients With proGrEssing Cerebral infarctioN
Progressing stroke is associated poor functional outcome and neurological deficit. Currently, no treatment for progressing stroke is recommended on the guideline. Carbogen is a mixture of 5% CO2 with 95% O2.
- Trial name
- NCT06770426
- Testing
- carbogen with or without phenyleprhine, phenylephrine
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Yonsei University
Acute Ischemic Stroke
Anisodine Hydrobromide for Patients With Acute Ischemic Stroke Undergoing Endovascular Therapy (HEAL)
This study is an investigator-initiated Phase 1b clinical trial employing an open-label, non-randomized, dose-escalation design.
- Trial name
- HEAL (NCT07513233)
- Testing
- Anisodine Hydrobromide
- Where
- 10 sites in China
- Volunteers
- 92 people
- Sponsor
- Capital Medical University
Cardiovascular Disease, Myocardial Infarction
EVOLVE-MI: EVOLocumab Very Early After Myocardial Infarction
The primary objective of this study is to evaluate the effectiveness of early treatment with evolocumab plus routine lipid management vs routine lipid management alone when administered in the acute setting to reduce myocardial…
- Conditions
- Cardiovascular Disease, Myocardial Infarction, Stroke, Coronary Revascularization
- Trial name
- EVOLVE-MI (NCT05284747)
- Testing
- Evolocumab, Routine Lipid Management
- Where
- 120 sites in United States, Brazil and 1 more
- Volunteers
- 6,019 people
- Sponsor
- Amgen
Acute Cerebrovascular Accident, Myocardial Infarction (MI)
Clinical Profile of a Patient After MI and ACVA Based on Outpatient Register Data
This is a retrospective observational study using the methodology of creating medical registries. The expected number of patients included in the registry is about 2000 patients with myocardial infarction and/or ACVD of any…
- Trial name
- NCT07159698
- Where
- Belarus
- Volunteers
- 1,520 people
- Sponsor
- State Institution "Republican Scientific and Practical Center" Cardiology, Belarus
Brain Ischemia With Non-valvular Atrial Fibrillation, Transient Ischemic Attack With Non-valvular Atrial Fibrillation
Prospective Record Of the Use of Dabigatran in Patients With Acute Stroke or TIA
The multi-center, prospective PRODAST study is investigating patients with non-valvular atrial fibrillation (AF) who experienced an ischemic stroke or a transient ischemic attack (TIA) recently (≤ 1 week) both with and without…
- Trial name
- PRODAST (NCT02507856)
- Where
- 90 sites in Germany
- Volunteers
- 10,044 people
- Sponsor
- University Hospital, Essen
Stroke
Study of NTx®-265: Human Chorionic Gonadotropin (hCG) and Epoetin Alfa (EPO) in Acute Ischemic Stroke Patients
The purpose of this study is: To assess the neurological outcome in acute ischemic stroke patients treated with NTx®-265, when compared with patients given a placebo control.
- Trial name
- REGENESIS-LED (NCT00938314)
- Testing
- human chorionic gonadotropin (hCG), then epoetin alfa (EPO)
- Where
- 23 sites in United States, Canada and 1 more
- Volunteers
- 96 people
- Sponsor
- Stem Cell Therapeutics Corp.
Acute Ischemic Stroke AIS
A Phase IIa Clinical Trial to Evaluate the Efficacy and Safety of Intravenous Infusion of hUC-MSCs in Patients With AIS
This is a Phase IIa clinical trial with a three-arm design that utilizes randomization, double-blinding, and placebo control. The primary objective of this study is to evaluate the efficacy of single and multiple intravenous…
- Trial name
- NCT07084012
- Testing
- hUC-MSCs treatment (high dose), hUC-MSCs treatment (low dose)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shenzhen Wingor Biotechnology Co., Ltd.
Acute Ischemic Stroke
Cerebrolysin REGistry Study in Stroke - a High-quality Observational Study of Comparative Effectiveness
This study investigates the clinical practices, safety and effectiveness of Cerebrolysin in routine treatment of patients with moderate to severe neurological deficits after acute ischemic stroke.
- Trial name
- C-REGS2 (NCT03480698)
- Testing
- Cerebrolysin
- Where
- 8 sites in Austria
- Volunteers
- 1,851 people
- Sponsor
- Ever Neuro Pharma GmbH
Acute Ischemic Stroke
Feasibility Study of RapidPulseTM Aspiration System as Frontline Approach for Patients With Acute Ischemic Stroke
A feasibility study to evaluate the initial safety and performance of the RapidPulseTM Aspiration System in the treatment of patients with Acute Ischemic Stroke (AIS) due to Large Vessel Occlusion (LVO) in the intracranial ICA…
- Trial name
- PULSE-F (NCT05577351)
- Testing
- RapidPulseTM Aspiration System
- Where
- 2 sites in Georgia
- Volunteers
- 5 people
- Sponsor
- RapidPulse, Inc
Stroke, Acute Ischemic, PCSK9 Inhibitor
The Effect of Early Administration of PCSK9 Inhibitor to Acute Ischemic Stroke Patients Associated With Atherosclerosis on the Stroke Prognosis and Lipid Profile
The goal of this clinical trial is to test the effect of proprotein convertase subtilisin/kexin type 9 (PCSK9 inhibitors) in acute ischemic stroke patients associated with atherosclerosis by investigating 1.
- Trial name
- NCT06083961
- Testing
- Alirocumab
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Sun U. Kwon
Acute Ischemic Stroke
Albumin for Patients With Acute Large Vessel Occlusive Stroke Undergoing Endovascular Reperfusion Therapy
The objective of this study is to evaluate the effectiveness and safety of endovascular therapy combined with 25% human albumin in the treatment of acute large vessel occlusive stroke.
- Trial name
- NCT06538844
- Testing
- Intravenous infusion of human albumin, Saline
- Where
- 8 sites in China
- Volunteers
- 134 people
- Sponsor
- Capital Medical University
Acute Ischemic Stroke, Thrombocytopenia
Antiplatelet Therapy for AIS Patients With Thrombocytopenia
The goal of this clinical trial is to test the safety and effectiveness of antiplatelet therapy in acute ischemic stroke (AIS) patients with thrombocytopenia.
- Trial name
- PERSIST (NCT06053021)
- Testing
- aspirin, clopidogrel, cilostazol, and dipyridamole
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Stroke
Study on the Efficacy of Alprostadil Injection in Patients With Acute Ischemic Stroke
Ischemic stroke has a variety of treatments and currently drug therapy is one of the main treatments.A number of clinical studies have proved that alprostadil (PGE1) has pharmacological effects of significant dilation of blood…
- Trial name
- NCT03252626
- Testing
- Alprostadil, Normal saline
- Volunteers
- 950 people
- Sponsor
- The First Hospital of Jilin University
Mechanical Thrombectomy, Acute Ischemic Stroke
High-Dose Atorvastatin for Vascular Wall Protection in Thrombectomy Patients
This project investigates the impact of statins on cerebral vascular wall damage after mechanical thrombectomy. The investigators will undertake a multi-center, prospective, parallel-controlled, open-label, superiority randomized…
- Trial name
- NCT05912686
- Testing
- Atorvastatin 80mg, Atorvastatin 20mg
- Where
- China
- Volunteers
- 162 people
- Sponsor
- Zhongda Hospital
Stroke, Cardiovascular Stroke
Exer-gaming on Upper Extremity Function and Activities of Daily Living in Sub-acute Stroke Patient.
Stroke is one of the leading cause of death, in adult stroke causes permanent disability. Stoke impact the life of a person significantly including the quality of life of an individual and especially performing the task of daily…
- Conditions
- Stroke, Cardiovascular Stroke, Cerebrovascular Accident
- Trial name
- NCT04750746
- Testing
- Control group, Experimental Group
- Where
- Pakistan
- Volunteers
- 32 people
- Sponsor
- Riphah International University
Acute Ischemic Stroke
Effect of Postoperative Prolonged Sedation With Dexmedetomidine After Successful Reperfusion With EVT on Long-term Prognosis in Patients With AIS (PPDET)
Dexmedetomidine can attenuate the activity of the sympathetic nervous system under stress response and improve ischemia-reperfusion injury.
- Trial name
- NCT04916197
- Testing
- Dexmedetomidine prolonged sedation, 0.9% saline
- Where
- China
- Volunteers
- 368 people
- Sponsor
- Beijing Chao Yang Hospital
Ischemic Stroke
Normobaric Oxygen in AIS Transferred for EVT
The primary objective of this study is to estimate the efficacy and safety of NBO on 3-month functional outcome after acute ischemic stroke
- Trial name
- AN-O2 (NCT06666764)
- Testing
- NBO, Control
- Where
- 112 sites in China
- Volunteers
- 1,500 people
- Sponsor
- Capital Medical University