Clinical trials: Acute Kidney Disease
Acute Kidney Injury
Neutrophil Gelatinase Associated Liocalin in Predicting AKI in Coronary Artery Disease
The aim of this work is to assess the clinical significance of serum levels of neutrophil gelatinase-associated lipocalin (NGAL) to predict AKI in patients exposed to PCI.
- Trial name
- NCT03266367
- Testing
- Neutrophil gelatinase-associated lipocalin (NAGL)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Assiut University
Acute Kidney Injury, Exercise-associated Hyponatremia
Non-steroidal Anti-inflammatory Affect on Kidneys in Endurance Distances
The specific aim of this study is to evaluate the safety of non-steroidal anti-inflammatory drugs (NSAIDs) and their impact on renal function and/or contribution to exercise-associated hyponatremia (EAH) during an ultramarathon…
- Conditions
- Acute Kidney Injury, Exercise-associated Hyponatremia, Perceived Exertion
- Trial name
- NAKED (NCT02272725)
- Testing
- Ibuprofen
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Stanford University
Acute Kidney Injury
Electronic Warning Systems in Diagnosis and Treatment of AKI
To set up electronic early warning system of AKI patients; To develop AKI's intervention, the follow-up process, and the renal physician is responsible for the implementation.
- Trial name
- NCT03119480
- Testing
- electronic alerts
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Glomerular Filtration Rate, Acute Kidney Injury
Pharmacokinetics of MP-3180 and Use of Noninvasive Fluorescence Detection Device in Healthy Volunteers
The purpose of this early feasibility study was to investigate the pharmacokinetics of MP-3180 administered in rising doses and to evaluate the use of the Optical Renal Function Monitor (ORFM), an investigational noninvasive…
- Trial name
- ORFM-1B (NCT02098187)
- Testing
- Below target dose MP-3180, At target dose MP-3180, 2 times above target dose MP-3180
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- MediBeacon
Acute Kidney Injury, Hypotension
A Pilot Analysis of the Association Between Anesthesia Induction Dosing and AKI in the Elderly Population
This study proposes to perform a pilot observational study looking at the doses of propofol used for the induction of general anesthesia and its association with the development of hypotension and AKI among elderly patients at…
- Conditions
- Acute Kidney Injury, Hypotension, Anesthesia; Adverse Effect
- Trial name
- NCT03699696
- Testing
- Propofol
- Where
- United States
- Volunteers
- 541 people, healthy volunteers welcome
- Sponsor
- Yale University
Acute Kidney Injury (Nontraumatic)
Comparison Between Right and Left Ventricular Systolic Dysfunction as a Risk Factors for Aki in Critical Care Patients
The cardio renal syndrome generally focuses on left ventricular function, and the importance of the right ventricle as a determinant of renal function is described less frequently.
- Trial name
- NCT03369561
- Testing
- Serum urea and creatinine and the calculated e GFR
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
Systemic Inflammatory Response Syndrome
INFLACOR - Clinical and Genetic Predictors of Inflammation Related Complications After Heart Surgery
The aim of the study is to evaluate a clinically and economically most effective diagnostic algorithm for prediction of inflammatory response related complications in patients undergoing heart surgery with use of cardiopulmonary…
- Trial name
- INFLACOR (NCT01020409)
- Testing
- cardiac surgery with CPB use
- Where
- Poland
- Volunteers
- 525 people, healthy volunteers welcome
- Sponsor
- Medical University of Gdansk
Acute Kidney Injury
Nitrite Infusion in High Risk Patients Undergoing Cardiopulmonary Bypass
The main objective of this study is to evaluate the efficacy of intravenous sodium nitrite compared with placebo in reducing the occurrence of CSA-AK as diagnosed by KDIGO criteria during the first 72 hrs after cardiac surgery in…
- Trial name
- NCT03331146
- Testing
- Saline, Sodium Nitrite
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Acute Kidney Injury, Congenital Heart Disease
Acute Kidney Injury After Cardiac Surgery on CPB
The purpose of this retrospective study is to determine the incidence and severity of acute kidney injuries (AKI) after heart surgery on cardiopulmonary bypass (CPB) in the pediatric intensive care unit (PICU) in Lausanne…
- Conditions
- Acute Kidney Injury, Congenital Heart Disease, Surgery, CBP
- Trial name
- NCT03513718
- Where
- Switzerland
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Acute Kidney Injury
Preventing Acute Kidney Injury
Acute kidney injury increases the risk for chronic kidney disease, length of stay, readmissions and mortality. Currently the only way to diagnose acute kidney injury is with a serum creatinine or drop in urine output.
- Trial name
- NCT04376619
- Testing
- remote ischemic preconditioning, KDIGO guidelines
- Volunteers
- healthy volunteers welcome
- Sponsor
- Atlantic Health System
Nephropathy, Hypoxia
Acute Effects of SGLT2 Inhibition on Renal Oxygenation and Autonomic Function in Type 1 Diabetes
Background: Inhibiting the sodium-glucose cotransporter-2 (SGLT2) has been observed to reduce risk of cardiovascular events and kidney failure in type 2 diabetes.
- Conditions
- Nephropathy, Hypoxia, Mitochondrial Alteration, Type 1 Diabetes
- Trial name
- Astronaut (NCT04193566)
- Testing
- Forxiga
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Steno Diabetes Center Copenhagen
Hematuria, Acute Cystitis With Hematuria
Women With isoLated acUte cyStitis and Macroscopic Hematuria. Is Further Investigation Needed?
This prospective multicenter observational study evaluates whether women ≥50 years with isolated acute hemorrhagic cystitis (AHC) and macroscopic hematuria require full malignancy workup.
- Conditions
- Hematuria, Acute Cystitis With Hematuria, Bladder Cancer, Urothelial Carcinoma
- Trial name
- BLUSH (NCT07037589)
- Testing
- investigation setting (cystoscopy + CTU + cytology), Cystoscopy - CTU - cytology (if needed)
- Where
- Sweden
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Vastra Gotaland Region
Acute Kidney Injury
Spironolactone on Acute Kidney Injury in Critically Ill Patients
This study was designed to evaluate the effect of spironolactone administration in the incidence and severity of AKI in patients critically ill with invasive mechanical ventilation (IMV) in the critical care unit.
- Trial name
- NCT03206658
- Testing
- Spironolactone 25 mg
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Acute Kidney Injury
Network Analysis of Urinary Molecular Signature Complements Clinical Data to Predict Postoperative Acute Kidney Injury
The risk for postoperative acute kidney injury (pAKI), as for any other postoperative complications (PC), comes from a number of interactions between a patient's health before surgery, strength to tolerate surgery and influences…
- Trial name
- NavigateAKI (NCT02114138)
- Testing
- pathogenesis of perioperative acute kidney injury, urine collection
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- University of Florida
Acute Kidney Injury
Risk of Acute Kidney Injury in Patients Undergoing Cytoreductive Surgery and Hyperthermic Intra-peritoneal Chemotherapy
Background: Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC) is an emerging surgical procedure for peritoneal carcinomatosis.
- Trial name
- NCT04941625
- Testing
- serum cystatin C, serum beta-microglubulin, urine
- Where
- Taiwan
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Early Diagnosis of Acute Kidney Injury
Early Prediction and Diagnosis of Acute Kidney Injury
The goal of this clinical trial is to estimate the accuracy of renal resistive index in early diagnosis and prediction of acute kidney injury in patients with hemorrhagic stroke.
- Trial name
- NCT07181174
- Testing
- Ultrasonographic examination and doppler ultrasonography will be performed using a convex transducer.
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Aswan University
Renal Insufficiency, Acute
Evaluation of the Renal Function in an Ultra-endurance Race.
During ultra endurance events, athletes experience extreme physical and mental demands, sometimes at the limits of the adaptive response to human physiology.
- Trial name
- INFERNAL (NCT03136315)
- Testing
- INFERNAL Intervention
- Where
- France
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Cystic Fibrosis (CF), Chronic Kidney Disease(CKD)
Kidney Function in People With Cystic Fibrosis in the Era of HEMT
The purpose of this study is to find out what causes kidney disease in people with CF. The investigators will study biomarkers in the blood and urine that can either predict who is at risk or detect kidney damage early before it…
- Conditions
- Cystic Fibrosis (CF), Chronic Kidney Disease(CKD), Acute Kidney Injury
- Trial name
- NCT06595420
- Where
- 3 sites in United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Heart Failure, Acute Kidney Injury
Sodium-Glucose Cotransporter-2 Inhibitor for Patients With Acute Cardiorenal Syndrome
The overall objective of this study is to determine whether the addition of SGLT2 inhibitors to usual care in hospitalized patients with heart failure associated acute kidney injury is safe and efficacious.
- Trial name
- NCT07273838
- Testing
- Dapagliflozin 10mg Tab
- Where
- 2 sites in United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Yale University
Acute Kidney Injury
Clinical Value of Plasma Humanin in Acute Kidney Injury
The goal of this observational study is to assess the clinical value of humanin in acute kidney injury. The main questions it aims to answer are:whether Humanin can be a novel marker for predicting AKI Researchers will compare…
- Trial name
- NCT06105229
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Guangdong Provincial People's Hospital