Clinical trials: Acute Kidney Injuries
Acute Kidney Injury
Prevention of Acute Kidney Injury Through Biomarker-guided Nephrological Intervention
This study examines the clinical relevance of early biomarkers to detect and prevent acute kidney injury. High-risk patients for developing acute kidney injury will be screened at initial presentation (emergency department and…
- Trial name
- NCT02730637
- Testing
- Early nephrologist consultation
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Robert Bosch Medical Center
ST Elevation (STEMI) Myocardial Infarction, Contrast Induced Nephropathy (CIN)
Beyond the Mehran Risk Score: Predictive Value of Total Ischemic Time for Contrast-Induced Nephropathy in ST Segment Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention.
Contrast-Induced Nephropathy (CIN) is a serious complication following primary percutaneous coronary intervention (PCI) in patients presenting with acute ST-segment elevation myocardial infarction (STEMI).
- Conditions
- ST Elevation (STEMI) Myocardial Infarction, Contrast Induced Nephropathy (CIN), Acute Kidney Injury
- Trial name
- NCT07826572
- Testing
- Total Ischemic Time Evaluation
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Assiut University
Sepsis, Trauma
Urinary Heparanase Activity as a Predictor of Acute Kidney Injury in Critically Ill Adults
Across the world, the most common cause of dying in the ICU is a disease called "sepsis". Sepsis is a disease in which the body's protective response to infection becomes too intense, unnecessarily damaging important organs in…
- Conditions
- Sepsis, Trauma, Shock, Acute Kidney Injury
- Trial name
- NCT01900275
- Testing
- Urine collection
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Denver Health and Hospital Authority
Abdominal Aortic Aneurysm, Acute Kidney Injury
Dexmedetomidine vs Propofol Sedation in Endovascular Aortic Repair
Endovascular aortic repair (EVAR) is increasingly performed under local anesthesia with intravenous sedation, but the optimal sedative agent has not been established.
- Trial name
- NCT07857005
- Testing
- Dexmedetomidine, propofol
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 282 people
- Sponsor
- Bursa City Hospital
Acute Renal Failure
Acute Renal Failure Trial Network (ATN) Study
This is a multi-center, prospective, randomized, parallel-group trial of an intensive strategy vs conventional strategy of renal replacement therapy for the treatment of acute renal failure secondary to acute tubular necrosis in…
- Trial name
- ATN (NCT00076219)
- Testing
- renal replacement therapy
- Where
- 22 sites in United States
- Volunteers
- 1,124 people
- Sponsor
- US Department of Veterans Affairs
Major Non-cardiac Surgery
Goal Directed Hemodynamic Management and Renal Outcome After Major Non-cardiac Surgery
This study is designed to compare renal outcome of patients following major non-cardiac surgery with different perioperative hemodynamic managements: a goal directed hemodynamic management group (using PiCCO) and a control group.
- Trial name
- IROM (NCT01035541)
- Testing
- PiCCO® Monitoring
- Where
- Germany
- Volunteers
- 180 people
- Sponsor
- Technical University of Munich
Acute Kidney Injury, Renal Insufficiency
A Methodological Study to Learn More About Kidney Function in Healthy People and in People With Reduced Kidney Function
The main purpose of this study is to investigate how reliable a test assessing the renal functional reserve (RFR) and the maximum glomerular filtration rate (maxGFR) are.
- Trial name
- NCT07368712
- Testing
- No investigational study intervention
- Where
- Germany
- Volunteers
- 58 people
- Sponsor
- Bayer
Covid19, AKI
Efficacy and Safety of a Highly Selective Semipermeable Membrane (AN-69 Oxiris) vs (Standard AN-69) in COVID-19
Abstract Title: Randomized,open-label, controlled trial to evaluate efficacy and safety of a highly selective semipermeable membrane (AN69-Oxiris) in comparison with a selective semipermeable membrane ( standard AN69) in COVID-19…
- Trial name
- oXAKI-COV (NCT04597034)
- Testing
- AN69-Oxiris, AN69-Standard
- Where
- Mexico
- Volunteers
- 35 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Acute Kidney Injury, Septic Shock
Does Urinary TIMP2 and IGFBP7 Can Identify High Risk Patients of Progression From Mild and Moderate to Severe Acute Kidney Injury During Septic Shock?
Septic shock is one of the leading causes of death in patients admitted to the intensive care unit (ICU). Acute kidney injury (AKI) occurs in almost 50% of septic patients and is associated with significant mortality.
- Trial name
- HEMOCHECK (NCT03547414)
- Testing
- Nephrocheck test
- Where
- France
- Volunteers
- 110 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Neonatal Acute Renal Failure in Preterm
Nephronic Reduction After Neonatal Acute Renal Failure in Preterm
The aim of this study is to evaluate the signs of nephronic reduction in preterm infants who have presented neonatal acute renal failure.
- Trial name
- IRENEO (NCT01785238)
- Testing
- renal echography, Blood sampling, collection of an urine sample
- Where
- France
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Nantes University Hospital
Acute Kidney Injury, Shock
Normal Saline Versus Balance Salt Solution Resuscitation on Kidney Function
The purpose of this study is to determine Acute kidney injury incidence between sterofundin and normal saline ; Resuscitation shock patients
- Trial name
- NCT02520804
- Testing
- sterofundin, normal saline
- Where
- Thailand
- Volunteers
- 107 people
- Sponsor
- Mahidol University
Acute Renal Failure
Clearance of Inflammatory Cytokines During Renal Replacement Therapy Using the EMIC®2 Filter
This study will be conducted in patients with sepsis and acute kidney injury needing renal replacement therapy. The aim is to investigate whether continuous renal replacement therapy with the EMIC®2 filter leads to removal of…
- Trial name
- ClicAKI (NCT03231748)
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Cardiac Surgery
Catecholamine-O-Methyl-Transferase(COMT)-Polymorphism in Cardiac Surgery
Although clinical risk factors for postoperative development of vasodilatory shock and acute renal failure have been identified; there is a considerable proportion of patients undergoing cardiac surgery where this syndrome cannot…
- Trial name
- NCT00334009
- Where
- Australia
- Volunteers
- 250 people
- Sponsor
- Austin Health
Acute Kidney Injury
Understanding the Role of Patient Behavior Change in Improving AKI Outcomes
This study is looking to improve the safety of patients with acute kidney injury via education provided on a mobile tablet. This study will additionally examine if electronic tools, such as mobile tablets, can help.
- Trial name
- Change AKI (NCT03114592)
- Testing
- mHealth tool
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Duke University
Contrast Induced Nephropathy, Acute Renal Failure
Cystatin C as an Early Marker of Contrast-Medium Nephropathy in Cardiac Catheterization Patients
Hypothesis: Cystatin C compared with creatinine is a better and earlier marker of contrast-induced nephropathy in high and intermedium risk cardiac catheterization patients.
- Trial name
- NCT00467311
- Where
- Mexico
- Volunteers
- 66 people
- Sponsor
- National Heart Institute, Mexico
Sepsis, Acute Kidney Injury
Immune Evaluation for Postoperative Sepsis-AKI
This prospective, multicenter, observational cohort study plans to enroll over 800 patients with postoperative sepsis from the ICUs of two tertiary hospitals in Beijing.
- Trial name
- NCT07811544
- Testing
- Not applicable- observational study
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Beijing Chao Yang Hospital
Kidney Diseases, Diabetes Mellitus
Efficacy and Safety of Alprostadil Prevent Contrast Induced Nephropathy
The aim of this prospective, randomized, controlled study is to investigate the effect of pretreatment with intravenous Alprostadil on the incidence of CIN in a high-risk population of patients with both type 2 diabetes mellitus…
- Conditions
- Kidney Diseases, Diabetes Mellitus, Acute Kidney Injury, Kidney Failure, Chronic
- Trial name
- NCT01722513
- Testing
- Alprostadil ﹠control
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Shanghai 10th People's Hospital
Acute Kidney Injury
Clinical Study to Evaluate the Efficacy and Safety of Mesenchymal Stromal Cells (Amimestrocel ) in Patients With Acute Kidney Injury
This trial is to evaluate the efficacy and safety of Amimestrocel (human umbilical cord mesenchymal stromal cells) in the treatment of AKI patients.
- Trial name
- MSC-AKI-001 (NCT06954740)
- Testing
- Amimestrocel
- Where
- 6 sites in China
- Volunteers
- 50 people
- Sponsor
- Chinese PLA General Hospital
Acute Kidney Injury
Specimen Stability Study
To collect and process urine samples from critically ill subjects for use in assessing the effects of various urine sample freezing and storage conditions on biomarker test results.
- Trial name
- NCT01846884
- Where
- 6 sites in United States
- Volunteers
- 124 people
- Sponsor
- Astute Medical, Inc.
Acute Kidney Injury, Chronic Kidney Diseases
Histopathological Analysis of Renal Biopsies With Dynamic Full-field Optical Coherence Tomography, a Comparison to Conventional Histopathological Findings for the Diagnosis of Either Acute Kidney Injury or Chronic Kidney Disease in Routine Practices (NEPHROCT)
Kidney biopsy play a key role for the investigation of either acute kidney injury or chronic kidney disease. Despite possible complications due to the invasive nature of the biopsy, such procedure is still essential in a number…
- Conditions
- Acute Kidney Injury, Chronic Kidney Diseases, Tomography, Optical Coherence
- Trial name
- NEPHROCT (NCT05728216)
- Testing
- Dynamic full-field optical coherence tomography analysis of kidney biopsy
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier William Morey - Chalon sur Saône