Clinical trials: Acute Kidney Injury Following Cardiac Surgery
Acute Lung Injury, Sepsis
Extracardiac Complications After Cardiac Surgery
Hypothesis of the study is that patients undergoing major cardiac surgery can develop extracardiac complications correlated to cardiopulmonary by pass.
- Conditions
- Acute Lung Injury, Sepsis, Infections, Acute Kidney Injury
- Trial name
- NCT01187004
- Where
- Italy
- Volunteers
- 164 people
- Sponsor
- University of Turin, Italy
Systemic Inflammatory Response Syndrome, Coronary Artery Bypass Grafting
Immunomodulation of EA-230 Following On-pump Coronary Artery Bypass Grafting (CABG)
EA-230 is a newly developed synthetic compound with anti-inflammatory properties, it is a linear tetrapeptide derived from the human chorionic gonadotropin hormone (hCG).
- Trial name
- EASI (NCT03145220)
- Testing
- EA-230
- Where
- Netherlands
- Volunteers
- 180 people
- Sponsor
- Radboud University Medical Center
Cardiac Surgery Associated Acute Kidney Injury
Serum and Urine Metabolome Studies in Patients With Acute Kidney Injury After Cardiac Surgery
The goal of this observational study is to learn about serum and urine metabolome in patients after cardiac surgery.
- Trial name
- NCT06245720
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Acute Kidney Injury After Adult Cardiac Surgery
The Effect of High Single Dose of Dexamethasone in Prevention of Post-operative Acute Kidney Injury in Cardiac Surgeries Requiring Cardiopulmonary Bypass
The aim of the current study is to assess the effect of intra operative single high dose dexamethasone (1 mg/kg) in decreasing the incidence of post-operative acute kidney injury after cardiac surgeries with cardiopulmonary bypass
- Trial name
- NCT06783634
- Testing
- Dexamethasone
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Acute Kidney Injury Cardiac Surgery, Postoperative Complications
Vascular Aging and Acute Kidney Injury After Cardiac Surgery
This prospective observational cohort study will enroll adult patients undergoing cardiac surgery at Nanjing First Hospital, Nanjing Medical University.
- Conditions
- Acute Kidney Injury Cardiac Surgery, Postoperative Complications, Vascular Aging
- Trial name
- NCT07727772
- Testing
- Multidimensional Vascular Aging Assessment
- Where
- China
- Volunteers
- 472 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Heart Disease, Acute Renal Failure
N-Acetylcysteine for Preventing Renal Injury After Cardiac Surgery
Cardiac surgery improves the survival and quality of life of people with heart disease. Nonetheless, several complications continue to adversely affect outcomes following cardiac surgery.
- Trial name
- NCT00188630
- Testing
- N-acetylcysteine, 5% dextrose solution
- Where
- Canada
- Volunteers
- 176 people
- Sponsor
- University Health Network, Toronto
Acute Kidney Injury, Osmolality Disturbance
Hyperosmolality and Acute Kidney Injury After Cardiac Surgery
The goal of this randomized controlled trial is to test if a hyperosmolar prime solution used for cardiopulmonary bypass increases the risk for acute postoperative kidney injury.
- Conditions
- Acute Kidney Injury, Osmolality Disturbance, Cardiopulmonary Bypass
- Trial name
- NCT05914896
- Testing
- HighOsmo
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Umeå University
Ischemia Reperfusion Injury, Cardiac Surgery Associated - Acute Kidney Injury
A Study to Evaluate the Efficacy and Safety of BX-001N in Preventing Cardiac Surgery-Associated Acute Kidney Injury (CSA-AKI) and Major Adverse Kidney Events (MAKE)
This is a Randomized, Single-blind, Multi-center, Placebo-controlled, Phase 2a clinical trial of BX-001N to prevent patients from Cardiac Surgery Associated Acute Kidney Injury (CSA-AKI) and subsequent Major Adverse Kidney Events…
- Trial name
- NCT07164833
- Testing
- BX-001N Experimental group 1, BX-001N Experimental group 2
- Where
- 8 sites in South Korea
- Volunteers
- 50 people
- Sponsor
- Bilix Co.,Ltd.
Systemic Inflammatory Response Syndrome, Acute Kidney Injury
High Cut Off Dialysis in Systemic Inflammatory Response Syndrome Patients After Cardiac Surgery
A high cut off dialyzer (septeX) is tested in patients after cardio-thoracic surgery with incidence of "systemic inflammatory response syndrome" (SIRS) and associated increased risk for acute kidney injury (AKI).
- Trial name
- HICOSIRS (NCT01579396)
- Testing
- septeX, standard therapy
- Where
- Germany
- Sponsor
- Vantive Health LLC
Acute Kidney Injury After Adult Cardiac Surgery
HES and Acute Kidney Injury in Adult Cardiac Surgery
This study retrospectively assess the effect or using balanced hydroxyethyl sctarch (HES) 130/0.4 or a balanced crystalloid solution as a pump prime and for intraoperative fluid therapy on the risk of early acute postoperative…
- Trial name
- NCT02445820
- Testing
- HES, Crystalloid
- Volunteers
- 697 people
- Sponsor
- University of Liege
Kidney Failure, Acute
Preventing Acute Renal Failure After Cardiac Surgery in High Risk Patients Using Sodium Bicarbonate Therapy
The purpose of this study is to determine whether sodium bicarbonate is effective in reducing kidney injury that may occur during cardiac surgery.
- Trial name
- PARACHUTE (NCT00522756)
- Testing
- Sodium bicarbonate, Sodium chloride
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Myocardial Infarction, Coronary Revascularization
Transfusion Trigger After Operations in High Cardiac Risk Patients
The goal of the proposed study is to determine whether a liberal transfusion strategy (transfusion trigger at Hb < 10 gm/dl) in Veterans at high cardiac risk who undergo major open vascular and general surgery operations is…
- Conditions
- Myocardial Infarction, Coronary Revascularization, Acute Renal Failure
- Trial name
- TOP (NCT03229941)
- Testing
- Blood Transfusion
- Where
- 16 sites in United States
- Volunteers
- 1,424 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Acute Kidney Injury, Heart; Dysfunction Postoperative, Cardiac Surgery
Near Infrared Spectroscopy for the Detection of Acute Kidney Injury in Children Following Cardiac Surgery
One in a hundred children is born with a heart defect. Some children require heart surgery within the first few days of life, while others can wait until they are older.
- Conditions
- Acute Kidney Injury, Heart; Dysfunction Postoperative, Cardiac Surgery, Children
- Trial name
- NCT01382758
- Where
- United States
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Acute Kidney Injury
Effects of Oral Protein Load on Kidney Function in Patients Undergoing Cardiac Surgery
Acute kidney injury (AKI) occurs in approximately one-third of patients undergoing cardiac surgery (CS), and represents one of the most significant negative predictors of patient outcome in this population.
- Trial name
- NCT03102541
- Testing
- None intervention
- Volunteers
- 214 people
- Sponsor
- University of Giessen
Cardiac Surgery Associated - Acute Kidney Injury, CKD (Chronic Kidney Disease) Stage 5D
Incidence and Prognostic of Cardiac Surgery-Associated Acute Kidney Injury: A Spanish Multicenter Study (SCARS-AKI)
To predict the renal damage caused by cardiac surgery in patients to try to mitigate it as soon as possible
- Conditions
- Cardiac Surgery Associated - Acute Kidney Injury, CKD (Chronic Kidney Disease) Stage 5D, Acute Kidney Injury, Acute Kidney Disease
- Trial name
- SCARS-AKI (NCT07370831)
- Testing
- CARDIAC SURGERY
- Where
- Spain
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Universidad de Oviedo
Rheumatic Disease of Heart Valve, Ischemic Reperfusion Injury
Effect of Remote Ischemic Perconditioning on Acute Kidney Injury in Adult Valve Replace
The purpose of this study is to determine whether Remote Ischemic Perconditioning is effective on Acute kidney injury in adult valve replacement.
- Trial name
- NCT01476969
- Testing
- Remote ischemic postconditioning
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Central South University
Acute Kidney Injury
Preoperative Level of Hemoglobin A1c and Acute Kindey Injury After Coronary Artery Bypass Grafting Surgery
Background: The development of acute kidney injury (AKI) is an important indicator of clinical outcomes after cardiac surgery. Elevated preoperative hemoglobin A1c level may be associated with acute kidney injury in patients…
- Trial name
- NCT05390281
- Testing
- increase in serum creatinine
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Cardiac Surgery Associated - Acute Kidney Injury
Efficacy and Safety of ENN0403 in Patients At High Risk for Acute Kidney Injury Following Elective Cardiac Surgery
The is a two-stage study. Stage 1 is to evaluate the safety, tolerability, PK and PD of ENN0403 in patients at high risk of AKI following elective cardiac surgery requring cardiopulmonary bypass.
- Trial name
- NCT06632613
- Testing
- ENN0403 capsules, low dose, ENN0403 capsules, high dose
- Where
- China
- Volunteers
- 200 people
- Sponsor
- EnnovaBio
Kidney Failure, Acute, Renal Replacement Therapy
Use of Bicarbonate to Reduce the Incidence of Acute Renal Failure After Cardiac Surgery
The purpose of this study is to determine if the incidence of acute renal failure (ARF) in high risk patients who undergo coronary artery bypass grafting (CABG) is reduced by treating patients in the perioperative period with…
- Trial name
- NCT00484354
- Testing
- Sodium bicarbonate, Normal saline, Bicarbonate
- Where
- United States
- Volunteers
- 123 people
- Sponsor
- Wake Forest University Health Sciences
Acute Kidney Injury, Cardiac Surgery Associated - Acute Kidney Injury
Prevention and Treatment of AKI VEXUS Guided Post Cardiac Surgery
The main goal of this clinical trial is to learn if evaluation by ultrasound of venous congestion of liver and kidneys can guide treatment and prevent and treat acute kidney injury post cardiac surgery (CSA-AKI).
- Trial name
- VEXAKI (NCT06972082)
- Testing
- VEXUS
- Where
- Greece
- Volunteers
- 304 people
- Sponsor
- Onassis Cardiac Surgery Centre