Clinical trials: Acute Lung Injury
Covid19
Efficacy and Safety of Trimodulin in Subjects With Severe COVID-19
The objectives of the trial are to evaluate the efficacy and safety of trimodulin as add-on therapy to standard of care (SoC) compared to placebo treatment in adult hospitalized subjects with severe COVID-19.
- Trial name
- ESsCOVID (NCT04576728)
- Testing
- Trimodulin
- Where
- 17 sites in Brazil, France and 2 more
- Volunteers
- 166 people
- Sponsor
- Biotest
Severe Acute Respiratory Syndrome Coronavirus 2, Electric Impedance
Prone Positioning and Regional Ventilation in Mechanically Ventilated COVID-19 Patients
The consensus therapeutic strategy implies that COVID patients with acute lung injury due to coronavirus are routinely placed in prone position in an attempt to improve oxygenation by increasing ventilation homogeneity.
- Conditions
- Severe Acute Respiratory Syndrome Coronavirus 2, Electric Impedance, Prone Positioning
- Trial name
- COVID-19_EIT (NCT04359407)
- Testing
- Prone positioning
- Where
- Switzerland
- Volunteers
- 29 people
- Sponsor
- Walid HABRE
Lung Injury, Acute, Respiratory Distress Syndrome, Adult
Study of Enbrel (Etanercept) for the Treatment Sub-Acute Pulmonary Dysfunction After Allogeneic Stem Cell Transplant
The purpose of this study is to determine the effectiveness of etanercept in the treatment of patients with sub-acute lung injury following a bone marrow transplant.
- Conditions
- Lung Injury, Acute, Respiratory Distress Syndrome, Adult, Bronchiolitis Obliterans
- Trial name
- NCT00141726
- Testing
- Etanercept
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Michigan Rogel Cancer Center
Respiratory Distress Syndrome, Preterm Birth
Surfactant for Neonatal Respiratory Distress Syndrome(NRDS) and Neonatal Acute Respiratory Distress Syndrome(NARDS)
In preterm infants with neonatal respiratory distress syndrome (NRDS), exogenous pulmonary surfactant(PS) replacement therapy is one of the most important therapeutic breakthrough to reduce neonatal mortality.
- Conditions
- Respiratory Distress Syndrome, Preterm Birth, Acute Respiratory Distress Syndrome, Surfactant Dysfunction
- Trial name
- NCT04777760
- Testing
- one dose of surfactant replacement, two and more doses of surfactant replacement
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Sepsis, Acute Respiratory Distress Syndrome
European Registry for Hemadsorption in Sepsis With the Seraph Filter
Although new techniques like extracorporeal blood purification have lately emerged, septic patients still have very high hospital mortality rates. Sepsis can be induced by either viremia, bacteriemia or in some cases both.
- Conditions
- Sepsis, Acute Respiratory Distress Syndrome, Infections - Pathogen Unspecified, Disease
- Trial name
- NCT05608096
- Testing
- Hemoperfusion
- Where
- Croatia
- Volunteers
- 300 people
- Sponsor
- Croatian Society for Organ Support
COVID-19 Acute Respiratory Distress Syndrome
T-Cell Mitochondrial Respiration Response to Ketone Monoester Supplement in Healthy Volunteers and COVID-19
T-Cell Mitochondrial Respiration Response to Ketone monoester (Ketoneaid) in Healthy Volunteers and COVID-19
- Trial name
- NCT05798260
- Testing
- Agilent Seahorse XF Cell Mito Stress Test
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Duke University
ARDS, Sepsis Syndrome
Kinetics of Surfactant Proteins, Phosphatidylcholine and Body Water in Intensive Care Unit (ICU)
Analysis of kinetics of phosphatidylcholine and specific surfactant proteins, total body water and water turnover in patients with acute respiratory distress syndrome (ARDS) and in intensive care unit (ICU) patients by using non…
- Trial name
- NCT03371680
- Testing
- Injection of 1-13 Carbon Leucine and deuterated water
- Volunteers
- 21 people
- Sponsor
- University of Padova
Acute Respiratory Distress Syndrome, Lung Diseases
Molecular Epidemiology of Acute Respiratory Distress Syndrome (ARDS)
To examine the possible relationship between genetic factors and the acute respiratory distress syndrome (ARDS).
- Trial name
- NCT00006496
- Where
- United States
- Volunteers
- 4,000 people
- Sponsor
- Massachusetts General Hospital
Coronary Artery Disease, Coronary Artery Bypass Grafting
Effects of PEEP on Parameters of Tissue Perfusion in Patients Post Cardiac Surgery
Pulmonary dysfunction is a condition inherent in cardiac surgery because of various interventions, such as general anesthesia, a median sternotomy, cardiopulmonary bypass and establishment of internal thoracic artery dissection.
- Conditions
- Coronary Artery Disease, Coronary Artery Bypass Grafting, Acute Lung Injury
- Trial name
- NCT03753022
- Testing
- Group G5, Group G10, Group G15
- Volunteers
- 125 people
- Sponsor
- Federal University of São Paulo
ARDS (Acute Respiratory Distress Syndrome)
Comparative Analysis of Salivary and Bronchoalveolar Lavage IL-6 and TNF-α as Biomarkers in Pediatric Acute Respiratory Distress Syndrome
The aim of this study is to determine the degree of agreement in cytokines level measured through BAL and those measured through salivary glands excretion.
- Trial name
- NCT07380373
- Testing
- Bronchoscopy
- Where
- Egypt
- Volunteers
- 37 people
- Sponsor
- Ain Shams University
Lung Injury, Acute, Symptoms and Signs
Pulmonary and Inflammatory Responses Following Exposure to a Low Concentration of Ozone or Clean Air
Purpose: The primary purpose of this study is to measure pulmonary function, symptoms, and pulmonary inflammatory responses in healthy young adults during and immediately after exposure to a low concentration of ozone (0.070 ppm)…
- Conditions
- Lung Injury, Acute, Symptoms and Signs, Neutrophilia Acute
- Trial name
- LOCONOZ2 (NCT05680831)
- Testing
- 0.070 ppm ozone concentration, Clean air (0.0 ppm ozone)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Martin W. Case
ARDS (Acute Respiratory Distress Syndrome)
BALance: ARDS Deconvolution by Bronchoalveolar Lavage Multiomics and Radiomics
Acute respiratory distress syndrome (ARDS) is a major contributor to ICU mortality and is characterised by hypoxaemia and pulmonary oedema.
- Trial name
- BALance (NCT07633366)
- Testing
- sampling blood, Lavage with physiologic saline solution
- Where
- Austria
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
COVID-19
Noncoding RNAs in COVID-19 and COVID-19 Related Kidney Dysfunction
In this study, critically ill patients with highly suspected or confirmed COVID-19 will be included. Main goal is the identification of noncoding RNAs in COVID-19 associated organ dysfunction with an emphasis on acute kidney…
- Trial name
- MiRCOVID (NCT04381351)
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Acute Respiratory Distress Syndrome, Acute Lung Injury
Genetic Variability and Biomarkers in Children With Acute Lung Injury
Acute Lung Injury (ALI) and the more severe Acute Respiratory Distress Syndrome (ARDS) are a significant problem in Pediatric Intensive Care Units, affecting up to 16 of every 1000 children admitted to these units.
- Trial name
- BALI (NCT01048996)
- Where
- United States
- Sponsor
- Medical College of Wisconsin
Respiratory Distress Syndrome, Adult, Lung Diseases
Acute Respiratory Distress Syndrome Clinical Network (ARDSNet)
The purposes of this study are to assess rapidly innovative treatment methods in patients with adult respiratory distress syndrome (ARDS) as well as those at risk of developing ARDS and to create a network of interactive Critical…
- Trial name
- NCT00000579
- Testing
- Low Tidal Volume Ventilation, Positive End-Expiratory Pressure, Lysofylline
- Where
- 21 sites in United States, Canada
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
ARDS, TTM
TwichView-guided Atricurium Dose Adjustment Trial
The goal of this clinical trial is to learn if using a monitor that measures muscle response can lower the amount of muscle relaxant medicine needed in adults who are treated in an intensive care unit (ICU) and need a continuous…
- Conditions
- ARDS, TTM, ECMO, Neuromuscular Blockade Monitoring
- Trial name
- NCT07807046
- Testing
- EMG-based quantitative TOF-guided atracurium titration
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Fu Jen Catholic University Hospital
COVID-19, Acute Respiratory Distress Syndrome
Study of Decidual Stromal Cells to Treat COVID-19 Respiratory Failure
This is a research study to see how safe and effective decidual stromal cells are in treating patients with respiratory failure (breathing problem where not enough oxygen is passed from the lungs into the blood) caused by…
- Trial name
- NCT04451291
- Testing
- Decidual Stromal Cells (DSC)
- Where
- 3 sites in Canada
- Volunteers
- 19 people
- Sponsor
- University Health Network, Toronto
Acute Lung Injury, Acute Respiratory Distress Syndrome
Epidemiology Research on Acute Lung Injury/Acute Respiratory Distress Syndrome (ALI/ARDS) in Adult ICU in Shanghai
To survey the prevalence and the mortality of the Acute Lung Injury/ Acute Respiratory Distress Syndrome (ALI/ARDS) in 12 university hospital ICUs in Shanghai.
- Trial name
- NCT01186874
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Tongji University
Acute Disease, Sepsis
Acutelines: a Large Data-/Biobank of Acute and Emergency Medicine
Research in acute care faces many challenges, including enrollment challenges, legal limitations in data sharing, limited funding, and lack of singular ownership of the domain of acute care.
- Conditions
- Acute Disease, Sepsis, Pneumonia, Frailty
- Trial name
- Acutelines (NCT04615065)
- Where
- Netherlands
- Volunteers
- 35,000 people
- Sponsor
- University Medical Center Groningen
ARDS, Human, PEEP, Occult
Effect of Initial Empirical PEEP Setting on the Esophageal Pressure-guided PEEP Titration in ARDS
Esophageal manometry was used as surrogate of pleural pressure to titrate positive end-expiratory pressure (PEEP) in ARDS patients. However, Absolute values of esophageal pressure (Pes) could be affected by the PEEP setting.
- Conditions
- ARDS, Human, PEEP, Occult, Esophageal and Pleural Pressure
- Trial name
- NCT05442073
- Testing
- PEEP adjustment
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Peking Union Medical College Hospital