Clinical trials: Acute Lung Injury
Cardiac Output, Hemodynamic Optimization
Hemodynamic Effects of Two Modalities of Alveolar Recruitment Maneuvers - ICU Patients
The objective of this study was to investigate the hemodynamic effects of two alveolar recruitment maneuver strategies in critical care patients with acute respiratory distress syndrome.
- Conditions
- Cardiac Output, Hemodynamic Optimization, Monitoring Blood Pressure, Stroke Volume
- Trial name
- CHARM-ICU (NCT05365854)
- Testing
- Alveolar Recruitment Maneuver (ARM)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Clermont-Ferrand
Acute Respiratory Distress Syndrome
Different Effects of Three Recruitment Maneuvers on the Lung Heterogeneity of Acute Respiratory Distress Syndrome
Acute respiratory distress syndrome (ARDS) is the common disease in clinical, which pathophysiology is a lot of alveolar collapse and heterogeneity.
- Trial name
- DEOTRMOARDS (NCT02387437)
- Testing
- SI recruitment, IP recruitment, PCV recruitment
- Where
- 2 sites in China
- Volunteers
- 93 people
- Sponsor
- Southeast University, China
Acute Lung Injury, Adult Respiratory Distress Syndrome
Acute Lung Injury Ventilator Evaluation (ALIVE)
This study will compare two ventilator modes in mechanically ventilated patients with acute lung injury. Acute lung injury (ALI) is a condition in which the lungs are badly injured and are not able to absorb oxygen the way…
- Trial name
- ALIVE (NCT01901354)
- Testing
- Low-tidal-volume ventilation, Airway Pressure Release Ventilation (APRV)
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Wisconsin, Madison
ARDS
NMR Based Metabolomics Kinetics in ARDS Patients
Acute respiratory distress syndrome (ARDS) is a life-threatening condition requiring respiratory support to maintain oxygenation.
- Trial name
- NCT06036056
- Where
- India
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Sanjay Gandhi Postgraduate Institute of Medical Sciences
Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS), Pulmonary Complication
FSTL1 and PPCs on Pediatric Within LDLT:a Prospective Cohort Analysis
The goal of this observational study is to identify the association between FSTL1 elevation and acute lung injury (ALI) after pediatric liver transplantation.The main questions it aims to answer what the risk factors are for ALI…
- Conditions
- Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS), Pulmonary Complication, Liver Transplant; Complications
- Trial name
- NCT05807802
- Volunteers
- 400 people
- Sponsor
- Tianjin First Central Hospital
Dyspnea
Effectiveness of an Exercise Re-training Program on Dyspnea in Patients After Acute Respiratory Distress Syndrome Secondary to Severe COVID-19 Pneumonia in Post-ICU
Dyspnea is defined by a subjective sensation of respiratory discomfort, the intensity of which varies according to the terrain, the anamnesis and the cause.
- Trial name
- RECOVER (NCT04569266)
- Testing
- Specific exercise rehabilitation treatment, No specific exercise rehabilitation treatment
- Where
- 3 sites in France
- Volunteers
- 63 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Acute Respiratory Distress Syndrome (ARDS)
Clinical Features, Treatments, and Outcomes in Acute Respiratory Distress Syndrome (ARDS-CTO)
The goal of this observational prospective cohort study is to explore the clinical characteristics, treatment strategies, and outcomes of adult patients with acute respiratory distress syndrome (ARDS) admitted to the medical…
- Trial name
- ARDS-CTO (NCT07186140)
- Where
- South Korea
- Volunteers
- 800 people
- Sponsor
- Jee Hwan Ahn
Severe COVID-19 Disease
RAPA-501-Allo Therapy of COVID-19-ARDS
The first-in-human Phase 1 study component will evaluate two dose levels of RAPA-501-ALLO off the shelf cells in patients with COVID-19-related ARDS, with key endpoints of safety, biologic and potential disease-modifying effects.
- Trial name
- NCT04482699
- Testing
- RAPA-501-Allo off-the-shelf Therapy of COVID-19
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Rapa Therapeutics LLC
Acute Respiratory Distress
the Effect of High Dose Ascorbic Acid on Critically Ill Patients With ARDS
1. To access role of vitamin C supplementation in ARDS patients on the following: Oxidants/ antioxidants imbalance Length of hospital stay Mortality rate Weaning from mechanical ventilator Incidence of adverse drug reaction 2.
- Trial name
- NCT03780933
- Testing
- vitamin c
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Misr International University
Respiratory Failure, Acute Respiratory Distress Syndrome
Cross-section Survey of Mechanical Ventilation and Acute Respiratory Distress Syndrome in China
The characteristics and outcomes of a mixed group of critically ill patients who received mechanical ventilation are not known in China.
- Trial name
- NCT01666834
- Where
- China
- Volunteers
- 555 people
- Sponsor
- Southeast University, China
Oxygenation, Driving Pressure
Clinical Impact of Different Duration Prone Postition Treatment for Patients With ARDS.
Acute respiratory distress syndrome (ARDS) is a life-threatening disease, patients with ARDS usually need mechanical ventilation.
- Trial name
- NCT04391387
- Testing
- prone position
- Where
- Taiwan
- Volunteers
- 45 people
- Sponsor
- Kaohsiung Veterans General Hospital.
ARDS, COVID-19
ECMO for COVID-19 vs Influenza A H1N1 Associated ARDS
Objective: Veno-venous ECMO has been used as a rescue therapy for patients with severe ARDS associated to influenza A H1N1 and COVID19 viral pneumonia.
- Conditions
- ARDS, COVID-19, H1N1 Influenza
- Trial name
- InfluCOV_ECMO (NCT05080933)
- Where
- Italy
- Volunteers
- 308 people
- Sponsor
- University of Turin, Italy
Acute Respiratory Distress Syndrome, COVID-19
Trans Thoracic Manipulation of Ventilation/Perfusion: the V/Q System
The purpose of this pilot study is to measure the impact of non-invasive pneumatic manipulation of transthoracic pressure on oxygenation in patients with Acute Respiratory Distress Syndrome (ARDS) due to Coronavirus Disease 2019…
- Trial name
- NCT04369599
- Testing
- V/Q System
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Emory University
Mechanical Ventilation
Practice of Ventilation in Critically Ill Patients Without ARDS
The purpose of this international, multicenter study is to determine ventilation practice and outcomes of intubated and ventilated intensive care unit (ICU) patients.
- Trial name
- PRoVENT (NCT01868321)
- Where
- 13 sites in Austria, Belgium and 7 more
- Volunteers
- 1,030 people
- Sponsor
- Prof. Dr. Marcus J. Schultz
Acute Kidney Injury, Surgery
Risk Factors for AKI in Patients Undergoing VATS for Pulmonary Resection
This study aims to investigate the potential factors contributing to the development of Acute Kidney Injury (AKI) in patients undergoing pulmonary resection with Video Assisted Thoracoscopic Surgery (VATS) for lung malignancy.
- Conditions
- Acute Kidney Injury, Surgery, Lung Cancer
- Trial name
- NCT06341933
- Testing
- Duration of Surgery, Volume of Fluid in Surgery, Blood Loss
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Atatürk Chest Diseases and Chest Surgery Training and Research Hospital
Prone Position, Acute Respiratory Distress Syndrome
Prone Position in infantS/Children With Acute Respiratory Distress Syndrome
In adult patients with acute respiratory distress syndrome (ARDS), the beneficial effects of prone position (PP) have been well investigated and explored; it reduces intrapulmonary shunt (Qs/Qt) and enhances lung recruitment…
- Trial name
- PULSAR (NCT06020404)
- Testing
- supine position, prone position
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
ARDS, ARDS Disease Progression
Longitudinal Recovery Trajectories After an Acute Respiratory Distress Syndrome, a New Understanding
COVID-19 resulted in the largest cohort of critical illness survivors in history, heightened awareness of the importance of the respiratory sequelae after an acute distress respiratory syndrome (ADRS).
- Trial name
- TENACITY (NCT06083363)
- Where
- 3 sites in Spain
- Volunteers
- 246 people
- Sponsor
- Institut de Recerca Biomèdica de Lleida
Heart Diseases, Heart Valve Diseases
Acute Kidney Injury After Cardiac Surgery
The study aims to identify the Following: - 1. incidence and mortality of cardiac Surgery associated -AKI based on the new consensus diagnostic systems of KDIGO (Kidney Disease Improving Global Outcomes). 2.
- Conditions
- Heart Diseases, Heart Valve Diseases, Heart Shock, Cardiac Disease
- Trial name
- NCT05079724
- Testing
- Cardiac Surgery
- Volunteers
- 200 people
- Sponsor
- Assiut University
Respiratory Distress Syndrome, Pediatric, Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS)
Continuous Infusion Versus Intermittent Boluses of Cisatracurium in the Early Management of Pediatric ARDS
The aim of this work is to compare continuous infusion vs on need intermittent boluses of Cisatracurium in the early management of pediatric acute respiratory distress syndrome
- Trial name
- NCT05153525
- Testing
- Intermittent boluses of Cisatracurium, Intravenous infusion of Cisatracurium for 24 hours
- Where
- 2 sites in Egypt
- Volunteers
- 60 people
- Sponsor
- Tanta University
Acute Respiratory Failure, Coma
EASiVENT Study Comparing INTELLiVENT-ASV vs Non Automated Ventilation in Adult ICU Patients
The purpose of the study is to assess the safety and efficacy of INTELLiVENT-ASV (Adaptive Support Ventilation) in adult ICU patients comparing to non automated ventilation.
- Conditions
- Acute Respiratory Failure, Coma, Acute Respiratory Distress Syndrome (ARDS), Chronic Obstructive Pulmonary Disease (COPD)
- Trial name
- NCT04400643
- Testing
- INTELLiVENT-ASV, Non-automated ventilation
- Where
- Portugal
- Volunteers
- 62 people
- Sponsor
- Hamilton Medical AG