Clinical trials: Acute Mountain Sickness
Glucose Metabolism, High Altitude
High Altitude and Exogenous Carbohydrate Oxidation
Recent studies have reported that oxidation of exogenous carbohydrate is reduced under acute hypobaric hypoxic (high altitude; HA) conditions compared to normoxia (sea level; SL) in native lowlanders.
- Trial name
- NCT03851744
- Testing
- Sea Level, High Altitude
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
High Altitude
Effects of Non-steroidal Anti-inflammatory Drugs (NSAIDS) on Acclimatization to High Altitude
Ibuprofen is often taken by travelers to high altitude to treat the symptoms of acute mountain sickness such as headache and malaise.
- Trial name
- NCT02233582
- Testing
- Ibuprofen, Sugar pill
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Hypoxemia, Acute Mountain Sickness (AMS)
The Role of Acetazolamide in Mitigating Inflammation and Innate Immune Activation at High Altitude
High altitude travel can lead to inflammation in the body and activation of innate immune cells. The investigators' prior research demonstrates that 1 to 3 days at 3800 m elevation leads to increased expression of genes in blood…
- Conditions
- Hypoxemia, Acute Mountain Sickness (AMS), Inflammation, Immune Response
- Trial name
- NCT07517068
- Testing
- ACETAZOLAMIDE oral capsule
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of California, Riverside
Hypoxia, Altitude
Colour Vision Impairment During Acute Hypobaric Hypoxia
This study analyses the impairment of colour vision during hypobaric hypoxia in volunteers of different groups.
- Trial name
- NCT05584813
- Testing
- Hypobaric Hypoxia
- Where
- Germany
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Köln
Acute Mountain Sickness
The Effect of Continuous Positive Pressure Ventilation on Symptoms of Acute Mountain Sickness
Acute Mountain Sickness (AMS) is a common condition affecting individuals traveling to elevations greater than 2500 meters (8200 feet).
- Trial name
- NCT06145113
- Testing
- Continuous positive airway pressure (CPAP), ResMed AirMini
- Where
- Nepal
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
AMS, Acute Mountain Sickness
Efficacy of Prophylactic Treatment of Oral Prochlorperazine for Acute Mountain Sickness
A field-based trial was conducted to determine if oral prochlorperazine demonstrates efficacy in the prophylactic treatment of AMS, and/or decreases the incidence of the symptoms of acute mountain sickness including headache, GI…
- Trial name
- PAMS (NCT06310642)
- Testing
- Immediate descent from altitude., Diphenhydramine, Prochlorperazine 10 mg
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- CHRISTUS Health
Hypoxia
MEDEX Hidden Valley 2008
During a multi-week expedition to the Himalaya, we aim to investigate i) whether dietary supplementation with carbohydrate drinks and gels can improve physical performance; and ii) the underlying mechanisms for any observed…
- Trial name
- NCT00731510
- Testing
- Carbohydrate energy drink, Aspartame
- Where
- United Kingdom
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Medical Expeditions Ltd
Acute Mountain Sickness, Environmental Illness
Can Rhodiola Crenulata Intake Improve Oxygen Saturation and Decrease the Incidence of Acute Mountain Sickness
Traditional folk medicine in the Arctic and Himalayan areas used Rhodiola species to enhance physical endurance, prevent aging, resist acute mountain sickness (AMS), and to treat fatigue, depression, anemia, impotence and…
- Trial name
- NCT01536288
- Testing
- Rhodiola crenulata
- Where
- Taiwan
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Gastrointestinal Injury, Acute Mountain Sickness
Gut-microbiota Targeted Nutritional Intervention for Gut Barrier Integrity at High Altitude
The aim of this randomized, crossover clinical trial is to determine the efficacy of a gut microbiota-targeted nutritional intervention containing a blend of fermentable fibers and polyphenols (FP) for mitigating increases in GI…
- Trial name
- NCT04111263
- Testing
- FP, High altitude, Sea level
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Acute Mountain Sickness (AMS)
Efficacy of Positive Expiratory Pressure on Acute Mountain Sickness
This pilot study aims to evaluate the efficacy of positive expiratory pressure (PEP) therapy at 10 cmH₂O in improving peripheral oxygen saturation (SpO₂) and mitigating symptoms of acute mountain sickness (AMS) in healthy…
- Trial name
- NCT07148674
- Testing
- Positive Expiratory Pressure (10cmH2O) in hypobaric hypoxia
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- BiALP - Alpine, Disaster and Wilderness Medicine
Hypoxia, Normobaric Hypoxia
Effect of Acute Hypoxia on RIght VEntRicular Function in Healthy Adults.
More and more people are engaging in sports in the mountains, including individuals with heart or lung diseases. At the same time, such diseases are becoming more common in Switzerland.
- Conditions
- Hypoxia, Normobaric Hypoxia, Altitude Hypoxia, Right Heart Function
- Trial name
- RIVER-H (NCT07431567)
- Testing
- Normobaric Hypoxia
- Where
- 2 sites in Switzerland
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Mona Lichtblau
Acute Mountain Sickness
Study Looking at End Expiratory Pressure for Altitude Illness Decrease (SLEEP-AID)
The study is examining if an over-the-counter device (Theravent) worn while sleeping can reduce acute mountain sickness upon awakening in a high altitude trekking population.
- Trial name
- SLEEP-AID (NCT01842906)
- Testing
- Theravent, Control
- Where
- Nepal
- Volunteers
- 219 people, healthy volunteers welcome
- Sponsor
- Stanford University
Chronic Obstructive Pulmonary Disease, Altitude Sickness
Acetazolamide to Prevent Impending Altitude-illness in Patients With COPD
The purpose of this randomized, placebo-controlled double-blind trial is to evaluate efficacy of acetazolamide in preventing overt altitude-related adverse health effects (ARAHE) in lowlanders with chronic obstructive pulmonary…
- Conditions
- Chronic Obstructive Pulmonary Disease, Altitude Sickness, Altitude Hypoxia
- Trial name
- NCT04913389
- Testing
- Acetazolamide
- Where
- Kyrgyzstan
- Volunteers
- 100 people
- Sponsor
- University of Zurich
Acute Mountain Sickness
Sickness Evaluation at Altitude With Acetazolamide at Relative Doses
The specific aim of this study is to evaluate whether acetazolamide 125mg daily is no worse than acetazolamide 250mg daily in decreasing the incidence of acute mountain sickness (AMS) in travelers to high altitude.
- Trial name
- SEAWARDII (NCT03828474)
- Testing
- Acetazolamide Pill
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Stanford University
ARDS, Hypoxia, Altitude
Effect of Altitude on the Evolution of Acute Respiratory Distress Syndrome
The purpose of this piece of research is to assess the effect of altitude on the clinical evolution of ARDS. For this purpose, patients who live and receive care at sea level are compared with those who live and receive care at…
- Conditions
- ARDS, Hypoxia, Altitude, Altitude Sickness/Epidemiology
- Trial name
- NCT02871063
- Volunteers
- 170 people
- Sponsor
- Guillermo Ortiz Ruiz
Acute Mountain Sickness
Effect of Acetazolamide on Acute Mountain Sickness in Lowlanders Older Than 40 Years
Randomized, placebo controlled trial evaluating efficacy of acetazolamide in preventing acute mountain sickness in lowlanders older than 40 years travelling from 760 m to 3'100 m.
- Trial name
- NCT03561675
- Testing
- ACETAZOLAMIDE oral capsule
- Where
- Kyrgyzstan
- Volunteers
- 349 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Altitude Hypoxia, Hypoxia
Effect of Acute Hypoxia on RIght VEntRicular Function in HAPE.
More and more people are engaging in sports in the mountains, including individuals with heart or lung diseases. At the same time, such diseases are becoming more common in Switzerland.
- Conditions
- Altitude Hypoxia, Hypoxia, Normobaric Hypoxia, Right Ventricular Function
- Trial name
- RIVER-HAPE (NCT07431554)
- Testing
- Normobaric Hypoxia
- Where
- Switzerland
- Volunteers
- 18 people
- Sponsor
- Mona Lichtblau
Healthy
Measurement of Retinal Venous Pressure in Chronic Low-oxygen Environment
The hypothesis is that the pressure in the retinal veins increases from chronic lack of oxygen and leads to decreased blood flow. On the basis of high altitude mountaineering this hypothesis should be verified.
- Trial name
- NCT01771770
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Mountain Sickness
Three New Ideas to Protect Special Forces From the Stress of High Altitude
Acute Mountain Sickness (AMS) is a well-documented syndrome that affects 42% of non-acclimatized individuals traveling to altitudes above 10,000 feet.
- Trial name
- NCT02463357
- Testing
- Quercetin, Nifedipine extended release, Methazolamide
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Acute Mountain Sickness
Sickness Evaluation at Altitude With Acetazolamide at Relative Dosages
This double blind randomized trial will compare acetazolamide taken the morning of ascent to acetazolamide taken the evening prior to ascent for the prevention of acute mountain sickness (AMS).
- Trial name
- SEAWARD (NCT03424226)
- Testing
- Acetazolamide
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Stanford University