Clinical trials: Acute Myocardial Infarction (AMI)
Acute Coronary Syndrome, Myocardial Infarction
Point of Care (POC) Biomarkers of Ischemia
Acute coronary syndrome is defined as myocardial infarction or ischemia as evidenced by significant coronary artery disease on cardiac catheterization/revascularization or reversible defect seen on stress test.
- Trial name
- NCT02039882
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Myocardial Injury, Atherosclerosis Cardiovascular Disease
Multimodal Biomarkers in Coronary Artery Disease Pathogenesis: The Oxford Acute Myocardial Infarction Study (OXAMI Study)
Coronary artery disease is one of the most common causes of illness and death. It develops when fatty deposits, known as plaques, build up in the arteries that supply blood to the heart.
- Conditions
- Myocardial Injury, Atherosclerosis Cardiovascular Disease, Cardiac Imaging Techniques, Genetics
- Trial name
- OXAMI (NCT07772570)
- Testing
- blood sampling, Intracoronary Imaging, Cardiovascular Magnetic Resonance Imaging
- Where
- United Kingdom
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Myocardial Infarction
Complete Lesion Versus Culprit Lesion Revascularization
To investigate the clinical outcomes of acute myocardial infarction (AMI) patients with multivessel disease undergoing percutaneous coronary intervention (PCI) either in infarct-related artery only or in multivessel in Drug…
- Trial name
- COCUA (NCT01180218)
- Testing
- complete revascularization, Culprit revasularization
- Where
- South Korea
- Volunteers
- healthy volunteers welcome
- Sponsor
- Korea University Guro Hospital
Chronic Kidney Diseases, Acute Myocardial Infarction
Troponin Excretion in Urine in Patients With and Without Chronic Kidney Disease
In this study, in order to better understand the mechanism of troponin clearance and the reason for elevated troponin levels in patients with CKD, we aim to evaluate quantitatively the excretion of troponin in the urine in…
- Trial name
- NCT04211610
- Testing
- Blood and urine sampling
- Where
- Israel
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- Soroka University Medical Center
Cardiovascular Complications, Myocardial Infarction
Ankle-Brachial Index Estimating Cardiac Complications After Surgery
Introduction: Patients undergoing noncardiac surgery are at increased risk of cardiovascular complications. The development of methods that can accurately predict the occurrence of these events is of critical importance and large…
- Conditions
- Cardiovascular Complications, Myocardial Infarction, Acute Coronary Syndromes
- Trial name
- ABRACOS (NCT01452282)
- Where
- Brazil
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Coronary Arteriosclerosis, Myocardial Infarction
Impact of Daylight on Patients With Acute Myocardial Infarction
The study tests if intense light could be a potential therapy in humans after myocardial infarction by inducing Per2.
- Trial name
- NCT02490397
- Testing
- Day Light, Room Light
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Healthy Participants
SP16 SERPIN-like Peptide Administration in Healthy Individuals
This study is a randomized, double-blind, placebo-controlled Phase 1 Clinical Trial of 24 healthy individuals to test the safety, tolerability and pharmacokinetics of a single subcutaneous administration of Serpin Peptide 16…
- Trial name
- NCT03651089
- Testing
- SP16
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Serpin Pharma, LLC
Acute Myocardial Infarction, Acute Ischemic Stroke
DSS's Role in Evaluating the Diagnosis and Treatment System of Ischemic Cardiovascular and Cerebrovascular Diseases
Background: Acute ischemic cardiovascular and cerebrovascular diseases are a kind of diseases with high incidence, rapid progression, poor prognosis and high mortality and disability rate of the circulatory system, mainly…
- Conditions
- Acute Myocardial Infarction, Acute Ischemic Stroke, Ischemic Cardiovascular Disease
- Trial name
- NCT04359589
- Where
- 2 sites in China
- Volunteers
- 1,900 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Chest Pain, Acute Coronary Syndrome, Myocardial Infarction
Magnetocardiography in the Accurate Identification of Severe Coronary Lesions and Myocardial Necrosis
Magnetocardiography (MCG) is a promising noninvasive and accurate method for detecting myocardial ischemia. Although progress has been made in this area, there is a lack of studies using up-to-date examination instruments for the…
- Trial name
- NCT05392712
- Testing
- Magnetometer
- Where
- China
- Volunteers
- 430 people, healthy volunteers welcome
- Sponsor
- Qilu Hospital of Shandong University
PD1, Acute Myocardial Infarction
Comparison of PD1+T Cell Expression in Peripheral Blood for Cardiac Function Prognosis in Patients With Acute MI
Comparison of high PD1+ T cell and low PD1+ T cell expression in peripheral blood for cardiac function prognosis in Patients with acute myocardial infarction
- Trial name
- NCT05251987
- Testing
- PD1+ T Cell Expression
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Acute Myocardial Infarction
Bivalirudin in Acute Myocardial Infarction
The purpose of the study is to evaluate the efficacy and safety of bivalirudin in AMI patients with DES. This is a prospective, randomized, single-blind, active drug controlled multicenter clinical research and the study would…
- Trial name
- NCT02897037
- Testing
- Bivalirudin, heparin
- Where
- China
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- Shenzhen Salubris Pharmaceuticals Co., Ltd.
ST Elevation (STEMI) Myocardial Infarction
Microcirculation In Acute Coronary Syndromes
In this mechanistic pilot study in 40 patients the investigators will compare the findings in patients treated with very early high dose statin therapy with historic controls from the KOMPIS study published in EHJ 200925.
- Trial name
- MICROS (NCT01382472)
- Testing
- Rosuvastatin, Simvastatin
- Where
- 3 sites in Norway
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Helse Stavanger HF
Myocardial Infarction, Acute Coronary Syndrome
Aspirin Dose Comparison in Elderly PCI Patients: 30mg vs. 75mg in Acute Coronary Syndrome
Elderly patients undergoing percutaneous coronary intervention (PCI) face a high risk of both ischemic and hemorrhagic complications necessitating antiplatelet therapy.
- Trial name
- LowASA-PCI (NCT06254391)
- Testing
- Low-dose aspirin
- Where
- Poland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Medical University of Warsaw
Type2 Diabetes, Atherosclerosis
Coronary Artery Plaque Burden and Morphology in Type 2 Diabetes Mellitus.
Unstable plaque, the primary cause of myocardial infarction, is characterized by distinct a morphology including positive remodeling (PR), low attenuated plaque (LAP), napkin ring sign (NRS), and spotty calcifications (SC) The…
- Conditions
- Type2 Diabetes, Atherosclerosis, Plaque, Atherosclerotic, Plaque Vulnerability
- Trial name
- CARPEDIEM (NCT03016910)
- Where
- Denmark
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Svendborg Hospital
Myocardial Infarction, High-Density Lipoid Deficiency
Decrease in Paraoxonase Enzyme Level and Myocardial İnfarction
Myocardial infarction is a polygenic disease that may occur due to various environmental risk factors. Mortality risk of the disease; sex, age, smoking, systolic blood pressure, total cholesterol, and high-density lipoprotein…
- Trial name
- NCT04243876
- Testing
- paraoxanase enzyme level
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Acute Myocardial Infarction
68 Ga-NODAGA-E[c(RGDγK)]2: Positron Emission Tomography Tracer for Imaging of Myocardial Angiogenesis
The aim is to examine the expression of αvβ3 integrin using a novel selective radiotracer in patients with myocardial infarction and investigate if it is a suitable tool for predicting myocardial recovery and thus prognosis.
- Trial name
- NCT03445884
- Testing
- 68Ga-NODAGA-E[c(RGDyK)]2
- Where
- Denmark
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Acute Coronary Syndromes (ACS), Recent Myocardial Infarction
The Pharmacokinetics and Pharmacodynamics Study of Evategrel CG-0255 Besylate）and Plavix® in Healthy Participants
CG-0255 is a novel investigational prodrug of the active metabolite of Plavix®， but with different active metabolite conversion routes.
- Conditions
- Acute Coronary Syndromes (ACS), Recent Myocardial Infarction, Recent Stroke, Peripheral Arterial Disease
- Trial name
- NCT07619885
- Testing
- CG-0255 Besylate for Injection, CG-0255 Besylate Capsule, Clopidogrel
- Where
- United States
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Shanghai CureGene Pharmaceutical Co., Ltd.
STEMI
Erectile Dysfunction After Percutaneous Coronary Intervention Versus the Thrombolytic Therapy in Acute ST Elevation Myocardial Infarction
Erectile dysfunction is a common sexual problem affecting up to one-third of men throughout their life. It is now well recognized that risk factors for erectile dysfunction (ED) include the same risk factors as coronary artery…
- Trial name
- NCT03328156
- Where
- Egypt
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Assiut University
Myocardial Infarction, Chest Pain
Rapid Use of High-sensitive Cardiac Troponin I for ruling-in and Ruling-out of Acute Myocardial Infarction
Early rule-in or rule-out of myocardial infarction (MI) is essential in patients presenting to the Emergency Department with chest pain.
- Trial name
- RACING-MI (NCT03634384)
- Where
- Denmark
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Acute Myocardial Infarction
the Association of Intestinal Microbial Metabolites and Cardiac Function in Acute Myocardial Infarction
Recently, more and more studies have confirmed that intestinal flora is closely related to the occurrence and development of cardiovascular diseases.Bile acids (BAS), short chain fatty acids (SCFA) and trimethylamine oxide…
- Trial name
- NCT04955054
- Testing
- diagnose
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital