Clinical trials: Acute Necrotizing Pancreatitis
Pancreatitis,Acute Necrotizing
Randomized Trial of Immediate Endoscopic Necrosectomy vs. Step-up Endoscopic Interventions in Necrotizing Pancreatitis
This is a randomized trial comparing immediate endoscopic necrosectomy vs. step-up endoscopic interventions in patients with necrotizing pancreatitis.
- Trial name
- DESTIN (NCT05043415)
- Testing
- Immediate endoscopic necrosectomy, Step-up endoscopic interventions
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Orlando Health, Inc.
Acute Pancreatitis
Pentoxifylline Treatment of Acute Pancreatitis
The purpose of this study is to determine the effects (good and bad) of giving a drug called pentoxifylline to patients with acute pancreatitis, to see if it can improve blood tests associated with inflammation (tissue damage).
- Trial name
- NCT01292005
- Testing
- Pentoxifylline
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Mayo Clinic
Necrotizing Pancreatitis
Molecular Analysis of Microbial DNA in Infected Necrotizing Pancreatitis
Necrotizing pancreatitis is a severe form of inflammation of the pancreas with subsequent destruction of the pancreas (necrosis).
- Trial name
- NCT01815489
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Necrotizing Pancreatitis
Organ Dysfunction Changes in Acute Necrotizing Pancreatitis Patients With Sepsis Following Open Necrosectomy
The purpose of this retrospective study was to characterize the changes in organ dysfunction among patients with acute necrotizing pancreatitis complicated by sepsis who underwent open necrosectomy.
- Trial name
- NCT07201246
- Testing
- Necrotizing Pancreatitis patients' organdysfunction progression
- Where
- China
- Volunteers
- 700 people
- Sponsor
- West China Hospital
Acute Pancreatitis (AP)
Endoscopic Pancreatic Duct Stent Placement Versus Conventional Approach in the Treatment of Early Phase Acute Pancreatitis
The planned multicenter randomized study is aimed to assess the efficacy and safety of endoscopic pancreatic duct stenting in adult patients with acute pancreatitis.
- Trial name
- NCT07093996
- Testing
- Endoscopic pancreatic duct stent placement, Conventional treatment of acute pancreatitis in early phase
- Where
- 7 sites in China, Russia
- Volunteers
- 200 people
- Sponsor
- Almazov National Medical Research Centre
Acute Necrotizing Pancreatitis
CMV Reactivation in Acute Necrotizing Pancreatitis
Patients with the diagnosis of acute necrotizing pancreatitis (ANP) present with a wide spectrum of severity. These patients frequently require intensive care management.
- Trial name
- NCT05898048
- Where
- India
- Volunteers
- 41 people
- Sponsor
- Sanjay Gandhi Postgraduate Institute of Medical Sciences
Acute Necrotizing Pancreatitis
Effectiveness of Endorotor PED® System Versus Conventional Endoscopic Techniques for the Management of Walled-off Pancreatic Necrosis in Acute Necrotizing Pancreatitis: Randomized Single-blinded Controlled Superiority Trial and Cost-utility Analysis
This is a national single-blinded prospective multicenter randomized (1:1) controlled trial, with two parallel arms, using a PROBE methodology, including patients with complicated acute necrotizing pancreatitis who require DEN of…
- Trial name
- ROTONEC (NCT07253350)
- Testing
- Endorotor Group, Conventional group
- Where
- France
- Volunteers
- 64 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pancreatitis, Acute Necrotizing
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics Investigation of GSK3335065 Intravenous (IV) Infusion in Healthy Adults
GSK3335065 is being developed as a treatment for acute pancreatitis with the intent of reducing 3-hydroxykynurenine (3HK) levels to the normal range (or lower) and maintaining them at this level throughout the treatment period.
- Trial name
- NCT03245619
- Testing
- GSK3335065
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Pancreas Necrosis
Imaging Modalities for Pancreatic Collections
The purpose of this project is to provide appropriate administrative and technical supports for the warehousing and use of imaging data in pancreatic necrosis data for research purposes.
- Trial name
- NCT03556501
- Testing
- Endoscopy
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Necrotizing Pancreatitis
Endoscopic Large Caliber Drainage vs. Complete Necrosectomy for Treatment of Walled-off Pancreatic Necrosis
The purpose of this study is to determine optimal treatment strategies for symptomatic walled-off pancreatic necrosis( WON).
- Trial name
- NCT02564965
- Testing
- Double Pigtail Plastic Stent, AXIOS Metal Stent
- Sponsor
- Mayo Clinic
Pancreatic Necrosis, Pancreatitis
Surgical vs Endoscopic Resection of Walled Off Pancreatic Necrosis Using the Powered Endoscopic Debridement System
Goal: The goal of this clinical trial is to compare the effectiveness and safety of two different but highly effective treatment approaches for walled-off necrosis (WON) resulting from severe acute pancreatitis.
- Trial name
- SERPENT (NCT06691919)
- Testing
- Direct Endoscopic Necrosectomy with Powered Endoscopic Debridement, Transgastric Surgical Necrosectomy
- Sponsor
- Stanford University
Acute Pancreatitis
Imipenem Prophylaxis in Patients With Acute Pancreatitis
This is a prospective, single-center, randomized, placebo-controlled, double-blind clinical trial that aims to investigate the beneficial and harmful effects of prophylactic use of imipenem in patients with predicted severe acute…
- Trial name
- IMPROWE (NCT02897206)
- Testing
- Imipenem
- Where
- Croatia
- Volunteers
- 98 people
- Sponsor
- University Hospital Rijeka
Pancreatitis, Acute Necrotizing
The Study of Laparoscopic-assisted Percutaneous Catheter-directed Drainage to Treat Early Severe Acute Pancreatitis
The purpose of this study is to analyze the effect of laparoscopic-assisted percutaneous catheter drainage of early SAP(severe acute pancreatitis).We are going to select 60 cases SAP patients from April 2014 to April 2015 who…
- Trial name
- NCT02133014
- Testing
- laparoscopic-assisted percutaneous catheter drainage, 0.5% 5-fluorouracil normal saline
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Zhujiang Hospital
Pancreatitis, Acute Necrotizing
Evaluation of Effect of Integrated Treatment by Traditional Chinese and Western Medicine for Severe Acute Pancreatitis
With multicenter randomized control clinical evaluation investigations, the scheme of integrated medicine treatment of severe acute pancreatitis (SAP) was further improved, and the therapeutic effects, safety and indications…
- Trial name
- NCT00506337
- Testing
- Qingyi granules
- Where
- 3 sites in China
- Volunteers
- 300 people
- Sponsor
- Tianjin Nankai Hospital
Pancreatic Necrosis
Predicting Pancreatic Necrosis Using mitDNA
Multiple predictors have been used for early pancreatic necrosis, prediction, detection, and monitoring. These include clinical score systems and circulating biomarkers.
- Trial name
- NCT03788928
- Testing
- serum mitochondrial DNA
- Volunteers
- 25 people
- Sponsor
- Assiut University
Severe Acute Pancreatitis
Relationship Between Acute Severe Pancreatitis and Mitochondrial DNA
Plasma mtDNA analysis aids in predicting pancreatic necrosis in severe acute pancreatitis patients.After the onset of severe acute pancreatitis, pancreatic necrosis and the content of mtDNA in plasma will increase, showing a…
- Trial name
- NCT04079777
- Testing
- Clinical treatment
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- First People's Hospital of Chenzhou
Acute Pancreatitis, Acute Pancreatic Necrosis
coMpliAnce With evideNce-based cliniCal Guidelines in the managemenT of Acute biliaRy pancreAtitis
Acute pancreatitis (AP) is an inflammatory disease of the pancreas, most commonly caused by gallstones, or excessive use of alcohol. It represents a management challenge and a significant healthcare burden.
- Conditions
- Acute Pancreatitis, Acute Pancreatic Necrosis, Acute Pancreatitis Due to Gallstones, Acute Pancreatic Fluid Collection
- Trial name
- MANCTRA-1 (NCT04747990)
- Testing
- Early Definitive Treatment
- Where
- 3 sites in Italy, Spain
- Volunteers
- 600 people
- Sponsor
- University of Cagliari
Acute Pancreatitis, Pancreatic Pseudocyst
Registry of Patients Undergoing Endoscopic Management of Pancreatic Fluid Collections
Acute pancreatitis is one of the most common gastrointestinal disorders requiring hospitalization worldwide. Pancreatic fluid collections can occur as a consequence of acute and chronic pancreatitis and can result in significant…
- Conditions
- Acute Pancreatitis, Pancreatic Pseudocyst, Pancreatic Necrosis
- Trial name
- NCT06179459
- Testing
- Endoscopic management of pancreatic fluid collections
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Orlando Health, Inc.
Acute Pancreatitis
A Novel Surgical Strategy to Reduce Major Complications in Patients With Necrotizing Pancreatitis
The goal of this observational study is to compare patient outcomes between the groups of patients admitted before and after the full implementation of the novel surgical strategy in patients with necrotizing pancreatitis.
- Trial name
- NCT06241586
- Testing
- The novel PMMI surgical strategy, The conventional step-up strategy
- Where
- China
- Volunteers
- 271 people
- Sponsor
- Tianjin Nankai Hospital
Pancreatitis, Acute, Pancreatitis, Acute Necrotizing
The Role of Double Pigtail Plastic Stents During Endoscopic Transmural Drainage of Pancreatic Fluid Collections.
The goal of this clinical trial is to learn about clinical usefulness of double pigtail plastic stents during endoscopic transmural drainage of post-inflammatory pancreatic and peripancreatic fluid collections with use of…
- Conditions
- Pancreatitis, Acute, Pancreatitis, Acute Necrotizing, Pancreatic Pseudocyst, Pancreatic Necrosis
- Trial name
- NCT06134024
- Testing
- Introduction of double pigtail plastic stents through the LAMS during endoscopic transmural drainage of post-inflammatory pancreatic and peripancreatic fluid collections, Endoscopic transmural drainage of post-inflammatory pancreatic and peripancreatic fluid collections with use of LAMS only
- Volunteers
- 200 people
- Sponsor
- Nicolaus Copernicus University